Details of the Probe

General Information of Probe

Probe ID
LDPC0529
Probe Name
C300
Synonyms
Z3433405940
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 321.8
Lipid-water partition coefficient (xlogp) 2.2
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C15H20ClN5O
IUPAC Name
N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]-2-(4-chloro-5-ethyl-2-methylpyrazol-3-yl)acetamide
Canonical SMILES
CCC1=NN(C(=C1Cl)CC(=O)NCCC2(N=N2)CCC#C)C
InChI
InChI=1S/C15H20ClN5O/c1-4-6-7-15(19-20-15)8-9-17-13(22)10-12-14(16)11(5-2)18-21(12)3/h1H,5-10H2,2-3H3,(H,17,22)
InChIKey
OXBRGAZDPQBVCD-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

14 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
DNA replication licensing factor MCM4 (MCM4) LDTP03680 7.16  LDD1969 
DNA replication licensing factor MCM4 (MCM4) LDTP03680 7.16  LDD1969 
Glyoxalase domain-containing protein 4 (GLOD4) LDTP16040 5.74  LDD1969 
Glyoxalase domain-containing protein 4 (GLOD4) LDTP16040 5.74  LDD1969 
Heme oxygenase 2 (HMOX2) LDTP03540 6.15  LDD1969 
Heme oxygenase 2 (HMOX2) LDTP03540 6.15  LDD1969 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 7.21  LDD1969 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 7.21  LDD1969 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 7.57  LDD1969 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 7.57  LDD1969 
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA) LDTP04246 14.22  LDD1969 
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA) LDTP04246 14.22  LDD1969 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 8.46  LDD1969 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 8.46  LDD1969 
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⏷ Show the Full List of 14 Enzyme
16 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 12.38  LDD1969 
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 12.38  LDD1969 
Lysosome membrane protein 2 (SCARB2) LDTP06034 7.67  LDD1969 
Lysosome membrane protein 2 (SCARB2) LDTP06034 7.67  LDD1969 
Metaxin-1 (MTX1) LDTP05900 5.10  LDD1969 
Metaxin-1 (MTX1) LDTP05900 5.10  LDD1969 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 6.15  LDD1969 
Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) LDTP00865 6.15  LDD1969 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 6.50  LDD1969 
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) LDTP01059 6.50  LDD1969 
Mpv17-like protein 2 (MPV17L2) LDTP14952 5.66  LDD1969 
Mpv17-like protein 2 (MPV17L2) LDTP14952 5.66  LDD1969 
Protein GPR107 (GPR107) LDTP07236 5.46  LDD1969 
Protein GPR107 (GPR107) LDTP07236 5.46  LDD1969 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 4.99  LDD1969 
Sigma intracellular receptor 2 (TMEM97) LDTP06945 4.99  LDD1969 
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⏷ Show the Full List of 16 Transporter and channel
20 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Apolipoprotein L2 (APOL2) LDTP11076 6.28  LDD1969 
Apolipoprotein L2 (APOL2) LDTP11076 6.28  LDD1969 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 5.78  LDD1969 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 5.78  LDD1969 
Centrosomal protein 43 (CEP43) LDTP01652 5.54  LDD1969 
Centrosomal protein 43 (CEP43) LDTP01652 5.54  LDD1969 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 5.17  LDD1969 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 5.17  LDD1969 
Large proline-rich protein BAG6 (BAG6) LDTP04094 6.68  LDD1969 
Large proline-rich protein BAG6 (BAG6) LDTP04094 6.68  LDD1969 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 7.01  LDD1969 
Mammalian ependymin-related protein 1 (EPDR1) LDTP13606 7.01  LDD1969 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 5.35  LDD1969 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 5.35  LDD1969 
Nucleobindin-2 (NUCB2) LDTP05160 5.74  LDD1969 
Nucleobindin-2 (NUCB2) LDTP05160 5.74  LDD1969 
Poly(U)-binding-splicing factor PUF60 (PUF60) LDTP13311 18.38  LDD1969 
Poly(U)-binding-splicing factor PUF60 (PUF60) LDTP13311 18.38  LDD1969 
Protein unc-119 homolog B (UNC119B) LDTP00105 7.52  LDD1969 
Protein unc-119 homolog B (UNC119B) LDTP00105 7.52  LDD1969 
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⏷ Show the Full List of 20 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1969 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587