Details of the Target

General Information of Target

Target ID LDTP00105
Target Name Protein unc-119 homolog B (UNC119B)
Gene Name UNC119B
Gene ID 84747
Synonyms
Protein unc-119 homolog B
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSGSNPKAAAAASAAGPGGLVAGKEEKKKAGGGVLNRLKARRQAPHHAADDGVGAAVTEQ
ELLALDTIRPEHVLRLSRVTENYLCKPEDNIYSIDFTRFKIRDLETGTVLFEIAKPCVSD
QEEDEEEGGGDVDISAGRFVRYQFTPAFLRLRTVGATVEFTVGDKPVSNFRMIERHYFRE
HLLKNFDFDFGFCIPSSRNTCEHIYEFPQLSEDVIRLMIENPYETRSDSFYFVDNKLIMH
NKADYAYNGGQ
Target Bioclass
Other
Family
PDE6D/unc-119 family
Subcellular location
Cell projection, cilium
Function
Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells.
Uniprot ID
A6NIH7
Ensemble ID
ENST00000344651.5
HGNC ID
HGNC:16488

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y83(7.70)  LDD0257  [2]
DBIA
 Probe Info  		C193(0.68)  LDD0531  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C193(0.00); C201(0.00); C85(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [5]
Lodoacetamide azide
 Probe Info  		C193(0.00); C201(0.00); C85(0.00)  LDD0037  [4]
AOyne
 Probe Info  		11.40  LDD0443  [6]
NAIA_5
 Probe Info  		C193(0.00); C201(0.00)  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 159 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		9.00  LDD1711  [8]
C004
 Probe Info  		10.70  LDD1714  [8]
C006
 Probe Info  		6.32  LDD1715  [8]
C007
 Probe Info  		12.21  LDD1716  [8]
C011
 Probe Info  		6.63  LDD1720  [8]
C022
 Probe Info  		14.72  LDD1728  [8]
C026
 Probe Info  		22.94  LDD1732  [8]
C027
 Probe Info  		6.02  LDD1733  [8]
C028
 Probe Info  		6.45  LDD1734  [8]
C040
 Probe Info  		26.91  LDD1740  [8]
C041
 Probe Info  		19.29  LDD1741  [8]
C042
 Probe Info  		5.10  LDD1742  [8]
C044
 Probe Info  		5.70  LDD1743  [8]
C055
 Probe Info  		18.64  LDD1752  [8]
C060
 Probe Info  		6.68  LDD1757  [8]
C063
 Probe Info  		10.63  LDD1760  [8]
C082
 Probe Info  		9.25  LDD1774  [8]
C085
 Probe Info  		10.56  LDD1777  [8]
C087
 Probe Info  		23.59  LDD1779  [8]
C106
 Probe Info  		20.97  LDD1793  [8]
C107
 Probe Info  		13.27  LDD1794  [8]
C108
 Probe Info  		21.26  LDD1795  [8]
C129
 Probe Info  		7.84  LDD1811  [8]
C139
 Probe Info  		16.45  LDD1821  [8]
C140
 Probe Info  		12.47  LDD1822  [8]
C141
 Probe Info  		41.07  LDD1823  [8]
C142
 Probe Info  		6.32  LDD1824  [8]
C143
 Probe Info  		47.50  LDD1825  [8]
C145
 Probe Info  		18.13  LDD1827  [8]
C147
 Probe Info  		16.91  LDD1829  [8]
C153
 Probe Info  		18.00  LDD1834  [8]
C156
 Probe Info  		9.71  LDD1836  [8]
C158
 Probe Info  		9.51  LDD1838  [8]
C159
 Probe Info  		15.78  LDD1839  [8]
C160
 Probe Info  		20.97  LDD1840  [8]
C161
 Probe Info  		26.17  LDD1841  [8]
C163
 Probe Info  		23.75  LDD1843  [8]
C164
 Probe Info  		5.54  LDD1844  [8]
C165
 Probe Info  		26.35  LDD1845  [8]
C166
 Probe Info  		30.91  LDD1846  [8]
C167
 Probe Info  		6.19  LDD1847  [8]
C169
 Probe Info  		32.67  LDD1849  [8]
C170
 Probe Info  		10.63  LDD1850  [8]
C171
 Probe Info  		13.55  LDD1851  [8]
C173
 Probe Info  		8.75  LDD1853  [8]
C174
 Probe Info  		5.98  LDD1854  [8]
C177
 Probe Info  		8.51  LDD1856  [8]
C187
 Probe Info  		54.57  LDD1865  [8]
C191
 Probe Info  		21.26  LDD1868  [8]
C193
 Probe Info  		14.83  LDD1869  [8]
C194
 Probe Info  		16.22  LDD1870  [8]
C197
 Probe Info  		6.50  LDD1873  [8]
C198
 Probe Info  		39.95  LDD1874  [8]
C199
 Probe Info  		7.84  LDD1875  [8]
C208
 Probe Info  		5.98  LDD1883  [8]
C211
 Probe Info  		22.94  LDD1885  [8]
C212
 Probe Info  		14.93  LDD1886  [8]
C213
 Probe Info  		42.22  LDD1887  [8]
C215
 Probe Info  		8.75  LDD1889  [8]
C217
 Probe Info  		8.17  LDD1891  [8]
C218
 Probe Info  		32.00  LDD1892  [8]
C219
 Probe Info  		11.88  LDD1893  [8]
C220
 Probe Info  		26.54  LDD1894  [8]
C229
 Probe Info  		7.11  LDD1902  [8]
C233
 Probe Info  		9.65  LDD1906  [8]
C234
 Probe Info  		10.34  LDD1907  [8]
C235
 Probe Info  		18.25  LDD1908  [8]
C238
 Probe Info  		30.48  LDD1911  [8]
C239
 Probe Info  		9.65  LDD1912  [8]
C240
 Probe Info  		16.91  LDD1913  [8]
C241
 Probe Info  		9.13  LDD1914  [8]
C242
 Probe Info  		7.78  LDD1915  [8]
C243
 Probe Info  		10.85  LDD1916  [8]
C245
 Probe Info  		5.21  LDD1918  [8]
C252
 Probe Info  		21.26  LDD1925  [8]
C255
 Probe Info  		8.57  LDD1928  [8]
C256
 Probe Info  		7.21  LDD1929  [8]
C258
 Probe Info  		7.36  LDD1931  [8]
C261
 Probe Info  		9.25  LDD1933  [8]
C264
 Probe Info  		30.48  LDD1935  [8]
C266
 Probe Info  		12.04  LDD1937  [8]
C270
 Probe Info  		16.00  LDD1940  [8]
C271
 Probe Info  		7.62  LDD1941  [8]
C273
 Probe Info  		18.13  LDD1943  [8]
C277
 Probe Info  		18.64  LDD1947  [8]
C278
 Probe Info  		66.26  LDD1948  [8]
C279
 Probe Info  		13.45  LDD1949  [8]
C280
 Probe Info  		32.45  LDD1950  [8]
C281
 Probe Info  		5.03  LDD1951  [8]
C282
 Probe Info  		46.85  LDD1952  [8]
C284
 Probe Info  		62.25  LDD1954  [8]
C286
 Probe Info  		7.78  LDD1956  [8]
C287
 Probe Info  		18.77  LDD1957  [8]
C288
 Probe Info  		19.84  LDD1958  [8]
C289
 Probe Info  		25.81  LDD1959  [8]
C290
 Probe Info  		14.93  LDD1960  [8]
C292
 Probe Info  		5.50  LDD1962  [8]
C293
 Probe Info  		40.22  LDD1963  [8]
C296
 Probe Info  		16.91  LDD1966  [8]
C297
 Probe Info  		7.52  LDD1967  [8]
C299
 Probe Info  		10.56  LDD1968  [8]
C300
 Probe Info  		7.52  LDD1969  [8]
C303
 Probe Info  		15.24  LDD1972  [8]
C305
 Probe Info  		25.46  LDD1974  [8]
C307
 Probe Info  		13.74  LDD1975  [8]
C311
 Probe Info  		11.08  LDD1978  [8]
C320
 Probe Info  		9.65  LDD1986  [8]
C322
 Probe Info  		13.27  LDD1988  [8]
C326
 Probe Info  		13.74  LDD1990  [8]
C327
 Probe Info  		6.41  LDD1991  [8]
C328
 Probe Info  		4.99  LDD1992  [8]
C337
 Probe Info  		5.54  LDD2000  [8]
C338
 Probe Info  		11.55  LDD2001  [8]
C339
 Probe Info  		14.32  LDD2002  [8]
C342
 Probe Info  		9.13  LDD2004  [8]
C343
 Probe Info  		20.97  LDD2005  [8]
C344
 Probe Info  		7.62  LDD2006  [8]
C346
 Probe Info  		30.48  LDD2007  [8]
C347
 Probe Info  		5.03  LDD2008  [8]
C355
 Probe Info  		69.07  LDD2016  [8]
C356
 Probe Info  		21.86  LDD2017  [8]
C357
 Probe Info  		7.16  LDD2018  [8]
C358
 Probe Info  		6.68  LDD2019  [8]
C359
 Probe Info  		8.94  LDD2020  [8]
C360
 Probe Info  		12.73  LDD2021  [8]
C361
 Probe Info  		33.59  LDD2022  [8]
C363
 Probe Info  		15.56  LDD2024  [8]
C376
 Probe Info  		14.83  LDD2036  [8]
C378
 Probe Info  		10.70  LDD2037  [8]
C379
 Probe Info  		5.21  LDD2038  [8]
C380
 Probe Info  		12.55  LDD2039  [8]
C382
 Probe Info  		28.64  LDD2041  [8]
C390
 Probe Info  		28.64  LDD2049  [8]
C391
 Probe Info  		17.88  LDD2050  [8]
C396
 Probe Info  		5.35  LDD2055  [8]
C399
 Probe Info  		15.67  LDD2058  [8]
C403
 Probe Info  		17.39  LDD2061  [8]
C413
 Probe Info  		36.25  LDD2069  [8]
C414
 Probe Info  		11.55  LDD2070  [8]
C416
 Probe Info  		16.68  LDD2071  [8]
C419
 Probe Info  		30.27  LDD2074  [8]
C420
 Probe Info  		24.42  LDD2075  [8]
C422
 Probe Info  		13.83  LDD2077  [8]
C424
 Probe Info  		28.84  LDD2079  [8]
C426
 Probe Info  		50.21  LDD2081  [8]
C428
 Probe Info  		20.68  LDD2083  [8]
C429
 Probe Info  		22.32  LDD2084  [8]
C430
 Probe Info  		9.71  LDD2085  [8]
C431
 Probe Info  		20.53  LDD2086  [8]
C433
 Probe Info  		16.68  LDD2088  [8]
FFF probe11
 Probe Info  		20.00  LDD0486  [9]
FFF probe13
 Probe Info  		20.00  LDD0475  [9]
FFF probe14
 Probe Info  		20.00  LDD0477  [9]
FFF probe2
 Probe Info  		20.00  LDD0463  [9]
FFF probe3
 Probe Info  		20.00  LDD0464  [9]
FFF probe7
 Probe Info  		20.00  LDD0483  [9]
JN0003
 Probe Info  		19.56  LDD0484  [9]
VE-P
 Probe Info  		N.A.  LDD0396  [10]
OEA-DA
 Probe Info  		20.00  LDD0046  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C193(0.68)  LDD0531  [3]
 LDCM0215  AC10 PaTu 8988t C193(0.38)  LDD1094  [3]
 LDCM0216  AC100 PaTu 8988t C193(0.57)  LDD1095  [3]
 LDCM0217  AC101 PaTu 8988t C193(0.73)  LDD1096  [3]
 LDCM0218  AC102 PaTu 8988t C193(0.42)  LDD1097  [3]
 LDCM0219  AC103 PaTu 8988t C193(0.53)  LDD1098  [3]
 LDCM0220  AC104 PaTu 8988t C193(0.53)  LDD1099  [3]
 LDCM0221  AC105 PaTu 8988t C193(0.76)  LDD1100  [3]
 LDCM0222  AC106 PaTu 8988t C193(0.49)  LDD1101  [3]
 LDCM0223  AC107 PaTu 8988t C193(0.95)  LDD1102  [3]
 LDCM0224  AC108 PaTu 8988t C193(0.50)  LDD1103  [3]
 LDCM0225  AC109 PaTu 8988t C193(0.47)  LDD1104  [3]
 LDCM0226  AC11 PaTu 8988t C193(0.47)  LDD1105  [3]
 LDCM0227  AC110 PaTu 8988t C193(0.55)  LDD1106  [3]
 LDCM0228  AC111 PaTu 8988t C193(0.50)  LDD1107  [3]
 LDCM0229  AC112 PaTu 8988t C193(0.65)  LDD1108  [3]
 LDCM0237  AC12 PaTu 8988t C193(0.43)  LDD1116  [3]
 LDCM0259  AC14 PaTu 8988t C193(0.47)  LDD1138  [3]
 LDCM0270  AC15 PaTu 8988t C193(0.41)  LDD1149  [3]
 LDCM0276  AC17 PaTu 8988t C193(1.20)  LDD1155  [3]
 LDCM0277  AC18 PaTu 8988t C193(0.74)  LDD1156  [3]
 LDCM0278  AC19 PaTu 8988t C193(1.08)  LDD1157  [3]
 LDCM0279  AC2 HCT 116 C193(0.90)  LDD0596  [3]
 LDCM0280  AC20 PaTu 8988t C193(0.85)  LDD1159  [3]
 LDCM0281  AC21 PaTu 8988t C193(1.56)  LDD1160  [3]
 LDCM0282  AC22 PaTu 8988t C193(0.94)  LDD1161  [3]
 LDCM0283  AC23 PaTu 8988t C193(0.74)  LDD1162  [3]
 LDCM0284  AC24 PaTu 8988t C193(0.63)  LDD1163  [3]
 LDCM0285  AC25 HEK-293T C85(0.95); C201(1.02); C193(1.00); C117(0.97)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C85(0.92); C193(1.02); C117(1.10)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C85(1.03); C117(1.61)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C85(1.03); C193(1.16)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C85(1.02); C193(0.97)  LDD1528  [12]
 LDCM0290  AC3 HCT 116 C193(1.04)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C85(1.08); C201(1.07); C193(1.02); C117(1.00)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C85(1.04); C193(1.05); C117(1.09)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C85(0.97); C201(0.91); C193(0.93); C117(1.03)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C85(1.04); C201(1.04); C193(0.86); C117(1.05)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C85(1.00); C193(1.01); C117(1.00)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C85(0.93); C117(1.04)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C85(0.98); C193(0.98)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C85(1.07); C193(1.07)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C85(1.01); C201(1.26); C193(1.05); C117(1.32)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C85(1.01); C193(1.10); C117(1.14)  LDD1539  [12]
 LDCM0301  AC4 HCT 116 C193(0.70)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C85(0.92); C201(0.93); C193(0.99); C117(1.39)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C85(1.08); C201(1.28); C193(0.86); C117(0.87)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C85(1.01); C193(1.12); C117(1.16)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C85(0.81); C117(1.09)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C85(0.95); C193(1.15)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C85(1.02); C193(0.93)  LDD1546  [12]
 LDCM0308  AC46 PaTu 8988t C193(1.18)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C193(1.11)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C193(1.26)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C193(1.07)  LDD1190  [3]
 LDCM0312  AC5 HCT 116 C193(0.77)  LDD0629  [3]
 LDCM0313  AC50 PaTu 8988t C193(1.14)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C193(1.36)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C193(0.83)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C193(1.26)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C193(1.08)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C193(1.16)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C193(0.98)  LDD1198  [3]
 LDCM0320  AC57 HCT 116 C193(0.68)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C193(0.72)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C193(0.72)  LDD0639  [3]
 LDCM0323  AC6 PaTu 8988t C193(0.57)  LDD1202  [3]
 LDCM0324  AC60 HCT 116 C193(0.81)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C193(0.91)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C193(1.13)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C193(0.81)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C193(0.71)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C193(0.92)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C193(1.11)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C193(0.50)  LDD0648  [3]
 LDCM0334  AC7 PaTu 8988t C193(0.49)  LDD1213  [3]
 LDCM0345  AC8 PaTu 8988t C193(0.46)  LDD1224  [3]
 LDCM0349  AC83 HCT 116 C193(0.51)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C193(0.57)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C193(0.64)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C193(0.92)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C193(1.01)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C193(0.79)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C193(0.73)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C193(1.08)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C193(0.60)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C193(0.64)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C193(0.81)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C193(0.73)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C193(0.69)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C193(0.73)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C193(0.67)  LDD0681  [3]
 LDCM0365  AC98 PaTu 8988t C193(0.41)  LDD1244  [3]
 LDCM0366  AC99 PaTu 8988t C193(0.59)  LDD1245  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C193(0.49)  LDD1127  [3]
 LDCM0356  AKOS034007680 PaTu 8988t C193(0.59)  LDD1235  [3]
 LDCM0275  AKOS034007705 PaTu 8988t C193(0.38)  LDD1154  [3]
 LDCM0367  CL1 HEK-293T C85(1.01); C201(1.37)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C85(0.97); C201(0.94); C193(0.69); C117(1.17)  LDD1572  [12]
 LDCM0369  CL100 HCT 116 C193(0.62)  LDD0686  [3]
 LDCM0370  CL101 PaTu 8988t C193(0.48)  LDD1249  [3]
 LDCM0371  CL102 PaTu 8988t C193(0.54)  LDD1250  [3]
 LDCM0372  CL103 PaTu 8988t C193(0.40)  LDD1251  [3]
 LDCM0373  CL104 PaTu 8988t C193(0.64)  LDD1252  [3]
 LDCM0374  CL105 PaTu 8988t C193(0.94)  LDD1253  [3]
 LDCM0375  CL106 PaTu 8988t C193(0.88)  LDD1254  [3]
 LDCM0376  CL107 PaTu 8988t C193(0.95)  LDD1255  [3]
 LDCM0377  CL108 PaTu 8988t C193(0.83)  LDD1256  [3]
 LDCM0378  CL109 PaTu 8988t C193(0.85)  LDD1257  [3]
 LDCM0379  CL11 HEK-293T C85(0.99); C193(1.01); C117(1.46)  LDD1583  [12]
 LDCM0380  CL110 PaTu 8988t C193(0.71)  LDD1259  [3]
 LDCM0381  CL111 PaTu 8988t C193(0.59)  LDD1260  [3]
 LDCM0382  CL112 HEK-293T C85(0.86); C193(0.98)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C85(1.06); C201(0.99)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C85(0.91); C201(1.09)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C85(1.22)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C85(0.88); C193(1.12)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C85(1.04); C201(1.10)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C85(0.79); C201(1.11)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C85(1.05)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C85(0.96); C201(0.89); C193(0.90); C117(1.05)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C85(0.91); C193(1.11)  LDD1595  [12]
 LDCM0392  CL121 PaTu 8988t C193(1.10)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C193(1.16)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C193(1.32)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C193(0.98)  LDD1274  [3]
 LDCM0396  CL125 HCT 116 C193(1.30)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C193(1.76)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C193(1.52)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C193(0.93)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C85(0.87); C201(1.02)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C85(0.84); C201(1.00)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C85(0.96)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C85(0.95); C193(1.08)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C85(0.92); C201(1.10); C193(0.97); C117(1.01)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C85(0.89); C193(1.07); C117(1.17)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C85(0.98); C117(1.56)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C85(0.85); C201(0.91)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C85(0.97); C193(1.10)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C85(1.00); C193(0.89)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C85(0.98); C201(0.97); C193(0.98); C117(1.28)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C85(1.10); C193(1.08); C117(1.31)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C85(0.97); C201(1.12); C193(1.04); C117(1.32)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C85(1.06); C201(1.00)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C85(0.92); C201(1.24)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C85(1.11)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C85(0.93); C193(1.09)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C85(1.05); C201(1.02); C193(1.06); C117(1.04)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C85(1.12)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C85(1.06); C193(1.12); C117(0.96)  LDD1623  [12]
 LDCM0420  CL31 PaTu 8988t C193(1.56)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C193(1.05)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C193(0.66)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C193(0.64)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C193(0.99)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C193(0.33)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C193(0.61)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C193(0.75)  LDD1307  [3]
 LDCM0429  CL4 HEK-293T C85(0.93); C193(1.01)  LDD1633  [12]
 LDCM0430  CL40 PaTu 8988t C193(1.43)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C193(0.84)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C193(0.75)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C193(0.66)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C193(0.79)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C193(0.59)  LDD1314  [3]
 LDCM0436  CL46 PaTu 8988t C193(0.61)  LDD1315  [3]
 LDCM0437  CL47 PaTu 8988t C193(0.44)  LDD1316  [3]
 LDCM0438  CL48 PaTu 8988t C193(0.76)  LDD1317  [3]
 LDCM0439  CL49 PaTu 8988t C193(0.55)  LDD1318  [3]
 LDCM0440  CL5 HEK-293T C85(1.10); C201(1.19); C193(0.99); C117(1.47)  LDD1644  [12]
 LDCM0441  CL50 PaTu 8988t C193(0.45)  LDD1320  [3]
 LDCM0442  CL51 PaTu 8988t C193(0.54)  LDD1321  [3]
 LDCM0443  CL52 PaTu 8988t C193(0.57)  LDD1322  [3]
 LDCM0444  CL53 PaTu 8988t C193(0.82)  LDD1323  [3]
 LDCM0445  CL54 PaTu 8988t C193(0.42)  LDD1324  [3]
 LDCM0446  CL55 PaTu 8988t C193(0.60)  LDD1325  [3]
 LDCM0447  CL56 PaTu 8988t C193(0.08)  LDD1326  [3]
 LDCM0448  CL57 PaTu 8988t C193(0.23)  LDD1327  [3]
 LDCM0449  CL58 PaTu 8988t C193(0.39)  LDD1328  [3]
 LDCM0450  CL59 PaTu 8988t C193(0.28)  LDD1329  [3]
 LDCM0451  CL6 HEK-293T C85(0.96); C193(0.99); C117(0.94)  LDD1654  [12]
 LDCM0452  CL60 PaTu 8988t C193(0.28)  LDD1331  [3]
 LDCM0453  CL61 HEK-293T C85(1.00); C201(1.19)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C85(0.87); C201(1.02)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C85(1.13)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C85(0.82); C193(1.01)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C85(1.00); C201(0.84); C193(0.96); C117(0.97)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C85(0.95); C193(0.94); C117(0.91)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C85(0.92); C117(1.24)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C85(0.98); C193(0.98)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C85(0.96); C193(0.96)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C85(1.01); C117(0.93)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C85(0.95); C201(0.83); C193(0.99); C117(1.07)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C85(1.02); C193(0.88); C117(1.06)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C85(0.99); C201(0.89); C193(1.01); C117(1.07)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C85(1.07); C201(1.25)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C85(0.83); C201(1.14)  LDD1670  [12]
 LDCM0469  CL76 HCT 116 C193(0.66)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C193(0.84)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C193(0.74)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C193(0.66)  LDD0789  [3]
 LDCM0473  CL8 HEK-293T C85(0.85); C193(1.10)  LDD1676  [12]
 LDCM0474  CL80 HCT 116 C193(0.59)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C193(0.62)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C193(0.52)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C193(0.54)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C193(0.42)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C193(0.85)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C193(0.87)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C193(0.78)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C193(0.62)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C193(0.43)  LDD0800  [3]
 LDCM0484  CL9 HEK-293T C85(1.04); C193(0.96)  LDD1687  [12]
 LDCM0485  CL90 HCT 116 C193(0.98)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C193(0.76)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C193(0.84)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C193(0.89)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C193(0.69)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C193(0.61)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C193(0.67)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C193(0.56)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C193(0.69)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C193(0.58)  LDD0811  [3]
 LDCM0189  Compound 16 HEK-293T 25.32  LDD0492  [9]
 LDCM0184  Compound 20 HEK-293T 10.19  LDD0503  [9]
 LDCM0191  Compound 21 HEK-293T 8.13  LDD0508  [9]
 LDCM0186  Compound 31 HEK-293T 6.02  LDD0506  [9]
 LDCM0190  Compound 34 HEK-293T 5.24  LDD0510  [9]
 LDCM0192  Compound 35 HEK-293T 6.37  LDD0509  [9]
 LDCM0193  Compound 36 HEK-293T 7.69  LDD0511  [9]
 LDCM0194  Compound 37 HEK-293T 10.58  LDD0498  [9]
 LDCM0495  E2913 HEK-293T C85(1.20)  LDD1698  [12]
 LDCM0625  F8 Ramos C85(2.11)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C85(1.02)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C85(0.50)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C85(0.98)  LDD2191  [13]
 LDCM0576  Fragment14 Ramos C85(2.80)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C85(0.68)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C85(1.98)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C85(1.13)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C85(1.27)  LDD2197  [13]
 LDCM0590  Fragment32 Ramos C85(0.81)  LDD2201  [13]
 LDCM0468  Fragment33 HEK-293T C85(1.11)  LDD1671  [12]
 LDCM0596  Fragment38 Ramos C85(1.23)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C85(0.58)  LDD2184  [13]
 LDCM0427  Fragment51 PaTu 8988t C193(0.65)  LDD1306  [3]
 LDCM0610  Fragment52 Ramos C85(1.17)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C85(1.06)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C85(0.80)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C85(0.51)  LDD2188  [13]
 LDCM0022  KB02 HEK-293T C201(1.06); C85(1.08)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C201(1.06); C85(0.95)  LDD1497  [12]
 LDCM0024  KB05 MSTO-211H C85(0.98)  LDD3337  [14]

References

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2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
10 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
11 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840