Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name FFF probe11  Probe Info 
Probe concentration Probe:20uM; negative probe:20uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
SILAC
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 108 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 20.0
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 20.0
 LDTP06905  Acylglycerol kinase, mitochondrial (AGK) 20.0
 LDTP11127  ADP-dependent glucokinase (ADPGK) 20.0
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 20.0
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 20.0
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 20.0
 LDTP03424  ATP-binding cassette sub-family D member 3 (ABCD3) 20.0
 LDTP12681  ATPase family AAA domain-containing protein 3A (ATAD3A) 20.0
 LDTP02837  Beta-galactosidase (GLB1) 20.0
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 20.0
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 20.0
 LDTP12163  Calcyclin-binding protein (CACYBP) 20.0
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 20.0
 LDTP03145  Catechol O-methyltransferase (COMT) 20.0
 LDTP02198  Cathepsin D (CTSD) 20.0
 LDTP10329  Ceramide synthase 2 (CERS2) 20.0
 LDTP03610  Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) 20.0
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 20.0
 LDTP04144  Cytochrome b-c1 complex subunit Rieske, mitochondrial (UQCRFS1) 20.0
 LDTP00697  Cytochrome b5 type B (CYB5B) 20.0
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 20.0
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 20.0
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 20.0
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 20.0
 LDTP18087  Dephospho-CoA kinase domain-containing protein (DCAKD) 20.0
 LDTP05171  Dermcidin (DCD) 20.0
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 20.0
 LDTP00950  Dynamin-like 120 kDa protein, mitochondrial (OPA1) 20.0
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 20.0
 LDTP09886  Gamma-glutamyl hydrolase (GGH) 20.0
 LDTP02651  Gamma-interferon-inducible lysosomal thiol reductase (IFI30) 20.0
 LDTP07931  Heme A synthase COX15 (COX15) 20.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 20.0
 LDTP04531  Hexokinase-2 (HK2) 20.0
 LDTP02602  Histidine--tRNA ligase, cytoplasmic (HARS1) 20.0
 LDTP04581  Holocytochrome c-type synthase (HCCS) 20.0
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 20.0
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 20.0
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 20.0
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 20.0
 LDTP04183  Lanosterol synthase (LSS) 20.0
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 20.0
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) 20.0
 LDTP08799  Lysophosphatidylserine lipase ABHD12 (ABHD12) 20.0
 LDTP07504  Lysophospholipid acyltransferase 5 (LPCAT3) 20.0
 LDTP02539  Lysosomal acid phosphatase (ACP2) 20.0
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 20.0
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 20.0
 LDTP06810  Mitochondrial import inner membrane translocase subunit TIM50 (TIMM50) 20.0
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 20.0
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 20.0
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 20.0
 LDTP01561  NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10) 20.0
 LDTP01770  NADH-cytochrome b5 reductase 3 (CYB5R3) 20.0
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 20.0
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 20.0
 LDTP12610  Obg-like ATPase 1 (OLA1) 20.0
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 20.0
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 20.0
 LDTP04440  Peroxisomal multifunctional enzyme type 2 (HSD17B4) 20.0
 LDTP12608  Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) 20.0
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 20.0
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 20.0
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 20.0
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 20.0
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 20.0
 LDTP00988  Protein O-GlcNAcase (OGA) 20.0
 LDTP04892  Ras-related protein Rab-2A (RAB2A) 20.0
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 20.0
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 20.0
 LDTP00597  Serine palmitoyltransferase 1 (SPTLC1) 20.0
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 20.0
 LDTP06455  Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) 20.0
 LDTP03572  Succinate dehydrogenase flavoprotein subunit, mitochondrial (SDHA) 20.0
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 20.0
 LDTP12056  Thiol S-methyltransferase TMT1A (TMT1A) 20.0
 LDTP11874  Thioredoxin-related transmembrane protein 1 (TMX1) 20.0
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA) 20.0
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 20.0
 LDTP12954  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) 20.0
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 20.0
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 20.0
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 19.2
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 14.7
 LDTP02622  Creatine kinase U-type, mitochondrial (CKMT1A; CKMT1B) 14.5
 LDTP02942  ADP-ribosylation factor 4 (ARF4) 14.2
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 14.2
 LDTP04992  Ras-related protein Rab-11A (RAB11A) 12.9
 LDTP06501  Ras-related protein Rab-11B (RAB11B) 12.9
 LDTP02067  Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) 12.3
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 10.9
 LDTP10887  Synaptic vesicle membrane protein VAT-1 homolog (VAT1) 9.7
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 9.1
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) 8.6
 LDTP04243  Fatty acid synthase (FASN) 8.0
 LDTP04671  Trifunctional enzyme subunit beta, mitochondrial (HADHB) 7.7
 LDTP02188  Protein disulfide-isomerase (P4HB) 6.8
 LDTP05006  Ras-related protein Rab-1A (RAB1A) 6.8
 LDTP00684  ATP-dependent RNA helicase DHX15 (DHX15) 6.2
 LDTP05192  ADP-ribosylation factor 1 (ARF1) 6.1
 LDTP04907  ADP-ribosylation factor 3 (ARF3) 6.1
 LDTP05193  ADP-ribosylation factor 5 (ARF5) 6.1
 LDTP01768  Glutamate dehydrogenase 1, mitochondrial (GLUD1) 5.6
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 5.3
 LDTP09899  Probable ATP-dependent RNA helicase DDX17 (DDX17) 5.2
 LDTP02924  Probable ATP-dependent RNA helicase DDX5 (DDX5) 5.2
 LDTP01766  L-lactate dehydrogenase A chain (LDHA) 5.1
Transporter and channel
Click to Show/Hide to Show 68 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) 20.0
 LDTP02087  ADP/ATP translocase 2 (SLC25A5) 20.0
 LDTP02609  ADP/ATP translocase 3 (SLC25A6) 20.0
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 20.0
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 20.0
 LDTP03405  Calnexin (CANX) 20.0
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 20.0
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 20.0
 LDTP02057  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) 20.0
 LDTP01301  Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (SLC25A12) 20.0
 LDTP13393  Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) 20.0
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 20.0
 LDTP01366  Flotillin-1 (FLOT1) 20.0
 LDTP01574  Importin-7 (IPO7) 20.0
 LDTP10081  Leucine-rich repeat-containing protein 59 (LRRC59) 20.0
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 20.0
 LDTP02655  Lysosome-associated membrane glycoprotein 2 (LAMP2) 20.0
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 20.0
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 20.0
 LDTP06660  MICOS complex subunit MIC60 (IMMT) 20.0
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 20.0
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 20.0
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 20.0
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 20.0
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 20.0
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 20.0
 LDTP00821  Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) 20.0
 LDTP01748  Mitochondrial import receptor subunit TOM40 homolog (TOMM40) 20.0
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 20.0
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 20.0
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 20.0
 LDTP11213  Nucleoporin NDC1 (NDC1) 20.0
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 20.0
 LDTP03717  Prohibitin 1 (PHB1) 20.0
 LDTP02215  Prosaposin (PSAP) 20.0
 LDTP07236  Protein GPR107 (GPR107) 20.0
 LDTP12042  Proton-activated chloride channel (PACC1) 20.0
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 20.0
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 20.0
 LDTP00451  Secretory carrier-associated membrane protein 3 (SCAMP3) 20.0
 LDTP12090  Sideroflexin-1 (SFXN1) 20.0
 LDTP07531  Sideroflexin-4 (SFXN4) 20.0
 LDTP05238  Solute carrier family 25 member 3 (SLC25A3) 20.0
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 20.0
 LDTP14084  Sorting and assembly machinery component 50 homolog (SAMM50) 20.0
 LDTP13416  Stomatin-like protein 2, mitochondrial (STOML2) 20.0
 LDTP00592  Surfeit locus protein 4 (SURF4) 20.0
 LDTP00310  Syntenin-1 (SDCBP) 20.0
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 20.0
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 20.0
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 20.0
 LDTP04293  Transmembrane emp24 domain-containing protein 10 (TMED10) 20.0
 LDTP15948  Transmembrane protein 126A (TMEM126A) 20.0
 LDTP20002  Transmembrane protein 160 (TMEM160) 20.0
 LDTP04787  Transmembrane protein 33 (TMEM33) 20.0
 LDTP04553  Tricarboxylate transport protein, mitochondrial (SLC25A1) 20.0
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 20.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 20.0
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 20.0
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 16.1
 LDTP06462  Neutral amino acid transporter B(0) (SLC1A5) 15.9
 LDTP03870  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST) 12.4
 LDTP01969  Transferrin receptor protein 1 (TFRC) 12.3
 LDTP05384  Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11) 11.7
 LDTP04393  Annexin A11 (ANXA11) 9.6
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) 6.8
 LDTP04213  Phosphatidylinositol transfer protein beta isoform (PITPNB) 5.8
 LDTP04501  Importin subunit alpha-1 (KPNA2) 5.3
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03212  Splicing factor, proline- and glutamine-rich (SFPQ) 5.4
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) 5.1
Other
Click to Show/Hide to Show 57 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 20.0
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 20.0
 LDTP04356  Emerin (EMD) 20.0
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 20.0
 LDTP09938  Far upstream element-binding protein 2 (KHSRP) 20.0
 LDTP10408  Far upstream element-binding protein 3 (FUBP3) 20.0
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 20.0
 LDTP04495  Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) 20.0
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 20.0
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 20.0
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 20.0
 LDTP08058  Mitochondrial antiviral-signaling protein (MAVS) 20.0
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 20.0
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 20.0
 LDTP01432  Mitochondrial import receptor subunit TOM70 (TOMM70) 20.0
 LDTP13630  Neudesin (NENF) 20.0
 LDTP09787  Nicastrin (NCSTN) 20.0
 LDTP04241  Nuclear autoantigenic sperm protein (NASP) 20.0
 LDTP05375  Nucleobindin-1 (NUCB1) 20.0
 LDTP05160  Nucleobindin-2 (NUCB2) 20.0
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 20.0
 LDTP10924  Prohibitin-2 (PHB2) 20.0
 LDTP16080  Protein FAM114A2 (FAM114A2) 20.0
 LDTP10056  Protein FAM162A (FAM162A) 20.0
 LDTP08224  Protein LYRIC (MTDH) 20.0
 LDTP05277  Protein SET (SET) 20.0
 LDTP00105  Protein unc-119 homolog B (UNC119B) 20.0
 LDTP12412  Reticulon-4 (RTN4) 20.0
 LDTP03850  RNA-binding motif protein, X chromosome (RBMX) 20.0
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 20.0
 LDTP02297  Vimentin (VIM) 20.0
 LDTP10078  Far upstream element-binding protein 1 (FUBP1) 19.9
 LDTP03520  Phosphatidylethanolamine-binding protein 1 (PEBP1) 19.7
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 16.0
 LDTP03182  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) 15.2
 LDTP10684  RNA-binding protein 14 (RBM14) 15.2
 LDTP10962  Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB) 13.7
 LDTP03775  RNA-binding protein FUS (FUS) 13.4
 LDTP02734  Endoplasmin (HSP90B1) 12.4
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) 11.7
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 11.4
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 11.0
 LDTP04714  Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) 11.0
 LDTP02227  Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) 10.9
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) 10.4
 LDTP06032  Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) 9.9
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 9.2
 LDTP02596  Proliferating cell nuclear antigen (PCNA) 8.8
 LDTP01053  Heterogeneous nuclear ribonucleoprotein C-like 1 (HNRNPCL1) 8.3
 LDTP03065  Lamin-B1 (LMNB1) 8.1
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 6.4
 LDTP02364  Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) 6.1
 LDTP01319  Eukaryotic translation initiation factor 3 subunit G (EIF3G) 6.1
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) 5.6
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) 5.3
 LDTP04355  Rab GDP dissociation inhibitor beta (GDI2) 5.0
 LDTP05034  Ubiquitin-ribosomal protein eL40 fusion protein (UBA52) 5.0

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.