Details of the Target

General Information of Target

Target ID LDTP01053
Target Name Heterogeneous nuclear ribonucleoprotein C-like 1 (HNRNPCL1)
Gene Name HNRNPCL1
Gene ID 343069
Synonyms
HNRPCL1; Heterogeneous nuclear ribonucleoprotein C-like 1; hnRNP C-like-1; hnRNP core protein C-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASNVTNKMDPHSMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIAGCSVHKGFAFVQYDKE
KNARAAVAGEDGRMIASQVVDINLAAEPKVNRGNAGVKRSAAEMYGSSFDLDYGFQRDYY
DGMYSFPARVPPPPPIALAVVPSKRQRLSGNTSRRGKSGFNSKSGKRGSSKSGKLKGDDL
QAIKQELTQIKQKVDSLLENLEKIEKEQSKQEVEVKNAKSEEEQSSSSMKKDETHVKMES
EGGAEDSAEEGDPLDDDVNEDQGDDQLELIKDDEKEAEEGEDDRDSTNGQDDS
Target Bioclass
Other
Family
RRM HNRPC family, RALY subfamily
Subcellular location
Nucleus
Function May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs.
Uniprot ID
O60812
Ensemble ID
ENST00000317869.7
HGNC ID
HGNC:29295

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		8.34  LDD0486  [1]
FFF probe2
 Probe Info  		14.94  LDD0463  [1]
FFF probe3
 Probe Info  		6.37  LDD0464  [1]
FFF probe6
 Probe Info  		7.67  LDD0482  [1]
STS-2
 Probe Info  		N.A.  LDD0139  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Helicase ARIP4 (RAD54L2) SNF2/RAD54 helicase family Q9Y4B4
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heterogeneous nuclear ribonucleoprotein C-like 1 (HNRNPCL1) RRM HNRPC family O60812
Heterogeneous nuclear ribonucleoprotein C-like 2 (HNRNPCL2) RRM HNRPC family B2RXH8
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) RRM HNRPC family P07910
Uncharacterized protein C20orf202 (C20orf202) . A1L168

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
2 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.