Details of the Target

General Information of Target

Target ID LDTP04440
Target Name Peroxisomal multifunctional enzyme type 2 (HSD17B4)
Gene Name HSD17B4
Gene ID 3295
Synonyms
EDH17B4; SDR8C1; Peroxisomal multifunctional enzyme type 2; MFE-2; 17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD 4; D-bifunctional protein; DBP; Multifunctional protein 2; MFP-2; Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into:; 3R)-hydroxyacyl-CoA dehydrogenase; EC 1.1.1.n12; Enoyl-CoA hydratase 2; EC 4.2.1.107; EC 4.2.1.119; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVE
EIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIH
RVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAI
EGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVG
AGWIGKLRWERTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEVLS
KIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKD
LKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIPGLSINFAKVLHGEQYLELYKPLPRA
GKLKCEAVVADVLDKGSGVVIIMDVYSYSEKELICHNQFSLFLVGSGGFGGKRTSDKVKV
AVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFS
ARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISN
AYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNI
GAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNI
MLSQKLQMILKDYAKL
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Short-chain dehydrogenases/reductases (SDR) family
Subcellular location
Peroxisome
Function
Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates.
TTD ID
T59230
Uniprot ID
P51659
DrugMap ID
TTL1WGS
Ensemble ID
ENST00000414835.7
HGNC ID
HGNC:5213
ChEMBL ID
CHEMBL5814

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL78 SNV: p.K184Q DBIA    Probe Info 
EFO27 SNV: p.Y568H DBIA    Probe Info 
HELA SNV: p.F324S .
IGR37 SNV: p.P215T DBIA    Probe Info 
IGR39 SNV: p.P215T DBIA    Probe Info 
IPC298 Deletion: p.I442del DBIA    Probe Info 
JHH7 SNV: p.A19P .
LNCaP clone FGC SNV: p.H532Y DBIA    Probe Info 
MCC13 SNV: p.S107F DBIA    Probe Info 
MCC26 SNV: p.S437F DBIA    Probe Info 
RKO SNV: p.L178F; p.Y410C DBIA    Probe Info 
TE4 SNV: p.E366D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		3.29  LDD0215  [1]
TH211
 Probe Info  		Y733(8.29); Y505(20.00)  LDD0260  [2]
C-Sul
 Probe Info  		2.98  LDD0066  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
STPyne
 Probe Info  		K139(1.42); K184(10.00); K57(5.94); K636(6.25)  LDD0277  [5]
AZ-9
 Probe Info  		E629(0.91); E630(1.02); E80(1.27)  LDD2208  [6]
Probe 1
 Probe Info  		Y676(20.72)  LDD3495  [7]
DBIA
 Probe Info  		C214(4.29)  LDD3311  [8]
BTD
 Probe Info  		C189(1.65)  LDD1700  [9]
Jackson_1
 Probe Info  		10.51  LDD0120  [10]
AHL-Pu-1
 Probe Info  		C373(3.31)  LDD0170  [11]
5E-2FA
 Probe Info  		N.A.  LDD2235  [12]
AMP probe
 Probe Info  		N.A.  LDD0200  [13]
ATP probe
 Probe Info  		K184(0.00); K50(0.00); K139(0.00); K140(0.00)  LDD0199  [13]
m-APA
 Probe Info  		H312(0.00); H262(0.00)  LDD2231  [12]
1d-yne
 Probe Info  		N.A.  LDD0358  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C373(0.00); C277(0.00); C535(0.00); C189(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C277(0.00); C373(0.00)  LDD0032  [16]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [17]
IPIAA_L
 Probe Info  		C277(0.00); C535(0.00)  LDD0031  [17]
Lodoacetamide azide
 Probe Info  		C373(0.00); C277(0.00); C535(0.00); C189(0.00)  LDD0037  [15]
ATP probe
 Probe Info  		N.A.  LDD0035  [18]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [19]
NAIA_4
 Probe Info  		N.A.  LDD2226  [20]
TFBX
 Probe Info  		N.A.  LDD0027  [19]
Compound 10
 Probe Info  		N.A.  LDD2216  [21]
IPM
 Probe Info  		N.A.  LDD0005  [22]
NHS
 Probe Info  		K674(0.00); K707(0.00); K46(0.00); K663(0.00)  LDD0010  [22]
NPM
 Probe Info  		N.A.  LDD0016  [22]
SF
 Probe Info  		N.A.  LDD0028  [23]
Ox-W18
 Probe Info  		W511(0.00); W116(0.00); W652(0.00)  LDD2175  [24]
1c-yne
 Probe Info  		K565(0.00); K68(0.00)  LDD0228  [14]
Acrolein
 Probe Info  		H312(0.00); H120(0.00); C189(0.00); C425(0.00)  LDD0217  [25]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [25]
Crotonaldehyde
 Probe Info  		C189(0.00); H188(0.00)  LDD0219  [25]
Methacrolein
 Probe Info  		C189(0.00); H188(0.00)  LDD0218  [25]
NAIA_5
 Probe Info  		C373(0.00); C277(0.00); C189(0.00); C535(0.00)  LDD2223  [20]
PAL-AfBPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C158
 Probe Info  		11.96  LDD1838  [26]
C350
 Probe Info  		30.06  LDD2011  [26]
FFF probe11
 Probe Info  		8.07  LDD0471  [27]
FFF probe13
 Probe Info  		20.00  LDD0475  [27]
FFF probe14
 Probe Info  		12.27  LDD0477  [27]
FFF probe2
 Probe Info  		12.63  LDD0463  [27]
FFF probe3
 Probe Info  		15.77  LDD0464  [27]
FFF probe9
 Probe Info  		6.66  LDD0470  [27]
STS-1
 Probe Info  		1.26  LDD0136  [28]
STS-2
 Probe Info  		1.39  LDD0138  [28]
DFG-out-4
 Probe Info  		0.00  LDD0075  [29]
DA-2
 Probe Info  		N.A.  LDD0071  [30]
OEA-DA
 Probe Info  		3.29  LDD0046  [31]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C189(0.18); C277(0.45); C425(0.99)  LDD2142  [9]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C277(0.59); C425(0.93)  LDD2112  [9]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C189(0.52)  LDD2095  [9]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C189(0.90)  LDD2130  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C189(0.51); C425(1.03)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C189(1.12)  LDD2152  [9]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C425(0.98)  LDD2103  [9]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C189(0.75)  LDD2131  [9]
 LDCM0025  4SU-RNA DM93 C373(3.31)  LDD0170  [11]
 LDCM0026  4SU-RNA+native RNA HEK-293T C277(4.05)  LDD0173  [11]
 LDCM0214  AC1 HEK-293T C189(0.89); C277(0.88); C425(0.99); C455(1.06)  LDD1507  [32]
 LDCM0215  AC10 HEK-293T C189(0.92); C277(0.88); C425(1.07); C455(1.05)  LDD1508  [32]
 LDCM0226  AC11 HEK-293T C189(0.98); C277(0.88); C425(0.95); C455(1.12)  LDD1509  [32]
 LDCM0237  AC12 HEK-293T C189(0.95); C277(0.86); C425(0.99); C455(0.96)  LDD1510  [32]
 LDCM0259  AC14 HEK-293T C189(0.75); C277(0.80); C425(0.98); C455(0.90)  LDD1512  [32]
 LDCM0270  AC15 HEK-293T C189(0.99); C277(0.89); C425(1.02); C455(1.02)  LDD1513  [32]
 LDCM0276  AC17 HEK-293T C189(0.91); C277(0.88); C425(1.03); C455(0.92)  LDD1515  [32]
 LDCM0277  AC18 HEK-293T C189(0.93); C277(0.95); C425(1.05); C455(1.00)  LDD1516  [32]
 LDCM0278  AC19 HEK-293T C189(0.85); C277(0.84); C425(1.08); C455(0.91)  LDD1517  [32]
 LDCM0279  AC2 HEK-293T C189(0.96); C277(0.93); C425(0.95); C455(1.02)  LDD1518  [32]
 LDCM0280  AC20 HEK-293T C189(0.96); C277(0.84); C425(0.96); C455(0.94)  LDD1519  [32]
 LDCM0281  AC21 HEK-293T C277(0.95); C425(1.03); C455(0.98); C373(0.98)  LDD1520  [32]
 LDCM0282  AC22 HEK-293T C189(0.68); C277(0.84); C425(1.03); C455(1.05)  LDD1521  [32]
 LDCM0283  AC23 HEK-293T C189(0.92); C277(0.97); C425(1.00); C455(0.94)  LDD1522  [32]
 LDCM0284  AC24 HEK-293T C189(0.94); C277(1.08); C425(1.02); C455(0.98)  LDD1523  [32]
 LDCM0285  AC25 HEK-293T C189(0.87); C277(0.90); C425(1.05); C455(1.00)  LDD1524  [32]
 LDCM0286  AC26 HEK-293T C189(1.05); C277(0.89); C425(1.04); C455(0.85)  LDD1525  [32]
 LDCM0287  AC27 HEK-293T C189(0.93); C277(0.92); C425(0.96); C455(1.06)  LDD1526  [32]
 LDCM0288  AC28 HEK-293T C189(0.89); C277(0.91); C425(1.01); C455(1.09)  LDD1527  [32]
 LDCM0289  AC29 HEK-293T C277(0.92); C425(1.05); C455(1.01); C373(1.03)  LDD1528  [32]
 LDCM0290  AC3 HEK-293T C189(0.90); C277(0.92); C425(1.00); C455(1.18)  LDD1529  [32]
 LDCM0291  AC30 HEK-293T C189(0.71); C277(0.89); C425(1.05); C455(0.98)  LDD1530  [32]
 LDCM0292  AC31 HEK-293T C189(0.91); C277(0.88); C425(1.04); C455(0.99)  LDD1531  [32]
 LDCM0293  AC32 HEK-293T C189(1.20); C277(0.98); C425(1.08); C455(1.03)  LDD1532  [32]
 LDCM0294  AC33 HEK-293T C189(0.89); C277(0.84); C425(0.91); C455(0.94)  LDD1533  [32]
 LDCM0295  AC34 HEK-293T C189(1.04); C277(0.84); C425(0.97); C455(0.88)  LDD1534  [32]
 LDCM0296  AC35 HEK-293T C189(0.89); C277(0.85); C425(1.00); C455(1.09)  LDD1535  [32]
 LDCM0297  AC36 HEK-293T C189(0.92); C277(0.82); C425(0.94); C455(1.02)  LDD1536  [32]
 LDCM0298  AC37 HEK-293T C277(0.93); C425(1.01); C455(1.01); C373(0.99)  LDD1537  [32]
 LDCM0299  AC38 HEK-293T C189(0.91); C277(0.77); C425(0.92); C455(0.99)  LDD1538  [32]
 LDCM0300  AC39 HEK-293T C189(1.02); C277(0.91); C425(1.00); C455(1.01)  LDD1539  [32]
 LDCM0301  AC4 HEK-293T C189(0.87); C277(0.86); C425(0.94); C455(1.12)  LDD1540  [32]
 LDCM0302  AC40 HEK-293T C189(1.01); C277(0.87); C425(0.96); C455(0.99)  LDD1541  [32]
 LDCM0303  AC41 HEK-293T C189(0.88); C277(0.88); C425(1.06); C455(0.97)  LDD1542  [32]
 LDCM0304  AC42 HEK-293T C189(0.98); C277(0.83); C425(1.01); C455(0.96)  LDD1543  [32]
 LDCM0305  AC43 HEK-293T C189(0.98); C277(0.89); C425(0.98); C455(1.10)  LDD1544  [32]
 LDCM0306  AC44 HEK-293T C189(0.89); C277(0.90); C425(0.98); C455(1.06)  LDD1545  [32]
 LDCM0307  AC45 HEK-293T C277(0.91); C425(1.03); C455(1.05); C373(0.96)  LDD1546  [32]
 LDCM0308  AC46 HEK-293T C189(0.92); C277(0.80); C425(1.00); C455(0.94)  LDD1547  [32]
 LDCM0309  AC47 HEK-293T C189(0.90); C277(0.86); C425(0.99); C455(1.11)  LDD1548  [32]
 LDCM0310  AC48 HEK-293T C189(0.86); C277(0.97); C425(1.04); C455(1.05)  LDD1549  [32]
 LDCM0311  AC49 HEK-293T C189(0.87); C277(0.88); C425(1.06); C455(1.03)  LDD1550  [32]
 LDCM0312  AC5 HEK-293T C277(0.96); C425(1.04); C455(1.09); C373(0.95)  LDD1551  [32]
 LDCM0313  AC50 HEK-293T C189(0.88); C277(0.89); C425(1.06); C455(1.08)  LDD1552  [32]
 LDCM0314  AC51 HEK-293T C189(0.92); C277(0.96); C425(0.98); C455(1.03)  LDD1553  [32]
 LDCM0315  AC52 HEK-293T C189(0.98); C277(0.85); C425(0.93); C455(1.10)  LDD1554  [32]
 LDCM0316  AC53 HEK-293T C277(0.96); C425(1.07); C455(1.07); C373(0.95)  LDD1555  [32]
 LDCM0317  AC54 HEK-293T C189(1.09); C277(0.83); C425(1.05); C455(1.03)  LDD1556  [32]
 LDCM0318  AC55 HEK-293T C189(0.97); C277(0.88); C425(1.02); C455(1.00)  LDD1557  [32]
 LDCM0319  AC56 HEK-293T C189(1.11); C277(0.89); C425(1.02); C455(1.03)  LDD1558  [32]
 LDCM0320  AC57 HEK-293T C189(0.77); C277(0.87); C425(1.06); C455(0.98)  LDD1559  [32]
 LDCM0321  AC58 HEK-293T C189(0.91); C277(0.93); C425(0.99); C455(1.04)  LDD1560  [32]
 LDCM0322  AC59 HEK-293T C189(0.86); C277(0.85); C425(0.93); C455(1.17)  LDD1561  [32]
 LDCM0323  AC6 HEK-293T C189(0.86); C277(0.85); C425(0.97); C455(1.04)  LDD1562  [32]
 LDCM0324  AC60 HEK-293T C189(0.91); C277(0.83); C425(0.90); C455(1.06)  LDD1563  [32]
 LDCM0325  AC61 HEK-293T C277(0.91); C425(1.02); C455(1.00); C373(0.96)  LDD1564  [32]
 LDCM0326  AC62 HEK-293T C189(0.87); C277(0.82); C425(0.96); C455(0.97)  LDD1565  [32]
 LDCM0327  AC63 HEK-293T C189(0.88); C277(0.91); C425(0.89); C455(1.14)  LDD1566  [32]
 LDCM0328  AC64 HEK-293T C189(1.12); C277(0.94); C425(1.05); C455(1.07)  LDD1567  [32]
 LDCM0334  AC7 HEK-293T C189(0.93); C277(0.99); C425(0.90); C455(1.02)  LDD1568  [32]
 LDCM0345  AC8 HEK-293T C189(1.08); C277(0.92); C425(0.96); C455(0.98)  LDD1569  [32]
 LDCM0520  AKOS000195272 MDA-MB-231 C189(0.57)  LDD2113  [9]
 LDCM0248  AKOS034007472 HEK-293T C277(1.00); C425(1.01); C455(0.97); C373(0.97)  LDD1511  [32]
 LDCM0356  AKOS034007680 HEK-293T C189(0.89); C277(0.86); C425(1.07); C455(0.93)  LDD1570  [32]
 LDCM0275  AKOS034007705 HEK-293T C189(0.91); C277(0.89); C425(1.06); C455(0.96)  LDD1514  [32]
 LDCM0108  Chloroacetamide HeLa C189(0.00); H312(0.00); H120(0.00); C425(0.00)  LDD0222  [25]
 LDCM0070  Cisar_cp37 MDA-MB-231 10.51  LDD0120  [10]
 LDCM0632  CL-Sc Hep-G2 C189(20.00)  LDD2227  [20]
 LDCM0367  CL1 HEK-293T C189(0.85); C277(0.94); C425(0.89); C455(1.04)  LDD1571  [32]
 LDCM0368  CL10 HEK-293T C189(0.79); C277(1.10); C425(1.08); C455(0.94)  LDD1572  [32]
 LDCM0369  CL100 HEK-293T C189(1.01); C277(0.76); C425(0.91); C455(1.06)  LDD1573  [32]
 LDCM0370  CL101 HEK-293T C189(0.89); C277(0.98); C425(1.01); C455(1.03)  LDD1574  [32]
 LDCM0371  CL102 HEK-293T C189(0.89); C277(0.90); C425(0.96); C455(1.11)  LDD1575  [32]
 LDCM0372  CL103 HEK-293T C189(1.02); C277(0.90); C425(1.04); C455(1.01)  LDD1576  [32]
 LDCM0373  CL104 HEK-293T C189(0.88); C277(0.83); C425(1.00); C455(0.95)  LDD1577  [32]
 LDCM0374  CL105 HEK-293T C189(0.90); C277(0.99); C425(0.93); C455(0.94)  LDD1578  [32]
 LDCM0375  CL106 HEK-293T C189(0.91); C277(0.92); C425(1.09); C455(0.96)  LDD1579  [32]
 LDCM0376  CL107 HEK-293T C189(1.02); C277(1.00); C425(1.12); C455(1.07)  LDD1580  [32]
 LDCM0377  CL108 HEK-293T C189(0.82); C277(0.84); C425(1.06); C455(0.93)  LDD1581  [32]
 LDCM0378  CL109 HEK-293T C189(0.95); C277(0.95); C425(0.98); C455(1.05)  LDD1582  [32]
 LDCM0379  CL11 HEK-293T C189(1.04); C277(1.40); C425(0.96); C455(1.11)  LDD1583  [32]
 LDCM0380  CL110 HEK-293T C189(0.86); C277(0.86); C425(1.01); C455(0.94)  LDD1584  [32]
 LDCM0381  CL111 HEK-293T C189(1.03); C277(0.86); C425(1.06); C455(1.20)  LDD1585  [32]
 LDCM0382  CL112 HEK-293T C189(0.94); C277(0.83); C425(1.04); C455(0.89)  LDD1586  [32]
 LDCM0383  CL113 HEK-293T C189(0.93); C277(0.97); C425(0.94); C455(1.00)  LDD1587  [32]
 LDCM0384  CL114 HEK-293T C189(0.91); C277(0.86); C425(0.92); C455(1.27)  LDD1588  [32]
 LDCM0385  CL115 HEK-293T C189(1.00); C277(0.88); C425(1.08); C455(0.99)  LDD1589  [32]
 LDCM0386  CL116 HEK-293T C189(0.88); C277(0.78); C425(0.90); C455(1.00)  LDD1590  [32]
 LDCM0387  CL117 HEK-293T C189(0.94); C277(0.95); C425(1.00); C455(1.01)  LDD1591  [32]
 LDCM0388  CL118 HEK-293T C189(0.94); C277(0.93); C425(0.98); C455(1.00)  LDD1592  [32]
 LDCM0389  CL119 HEK-293T C189(1.02); C277(1.04); C425(1.14); C455(1.10)  LDD1593  [32]
 LDCM0390  CL12 HEK-293T C189(0.95); C277(1.12); C425(1.14); C455(1.08)  LDD1594  [32]
 LDCM0391  CL120 HEK-293T C189(0.87); C277(0.82); C425(0.91); C455(0.94)  LDD1595  [32]
 LDCM0392  CL121 HEK-293T C189(0.86); C277(0.96); C425(0.98); C455(0.95)  LDD1596  [32]
 LDCM0393  CL122 HEK-293T C189(0.89); C277(0.89); C425(1.00); C455(0.99)  LDD1597  [32]
 LDCM0394  CL123 HEK-293T C189(0.88); C277(0.83); C425(1.15); C455(0.95)  LDD1598  [32]
 LDCM0395  CL124 HEK-293T C189(0.93); C277(0.80); C425(1.05); C455(0.90)  LDD1599  [32]
 LDCM0396  CL125 HEK-293T C189(0.85); C277(0.99); C425(1.06); C455(1.09)  LDD1600  [32]
 LDCM0397  CL126 HEK-293T C189(0.87); C277(0.93); C425(0.94); C455(1.01)  LDD1601  [32]
 LDCM0398  CL127 HEK-293T C189(0.90); C277(0.97); C425(1.07); C455(0.95)  LDD1602  [32]
 LDCM0399  CL128 HEK-293T C189(0.87); C277(0.79); C425(0.95); C455(1.01)  LDD1603  [32]
 LDCM0400  CL13 HEK-293T C189(0.89); C277(0.92); C425(1.02); C455(1.00)  LDD1604  [32]
 LDCM0401  CL14 HEK-293T C189(0.90); C277(1.03); C425(0.98); C455(0.93)  LDD1605  [32]
 LDCM0402  CL15 HEK-293T C189(0.97); C277(0.93); C425(1.18); C455(1.26)  LDD1606  [32]
 LDCM0403  CL16 HEK-293T C189(0.83); C277(0.88); C425(0.86); C455(0.89)  LDD1607  [32]
 LDCM0404  CL17 HEK-293T C189(0.84); C277(0.88); C425(1.05); C455(0.94)  LDD1608  [32]
 LDCM0405  CL18 HEK-293T C189(0.95); C277(1.08); C425(1.06); C455(0.97)  LDD1609  [32]
 LDCM0406  CL19 HEK-293T C189(0.98); C277(1.02); C425(1.06); C455(1.02)  LDD1610  [32]
 LDCM0407  CL2 HEK-293T C189(1.00); C277(0.97); C425(0.96); C455(1.10)  LDD1611  [32]
 LDCM0408  CL20 HEK-293T C189(1.07); C277(1.13); C425(1.04); C455(0.95)  LDD1612  [32]
 LDCM0409  CL21 HEK-293T C277(1.34); C425(1.17); C455(0.96); C373(1.05)  LDD1613  [32]
 LDCM0410  CL22 HEK-293T C189(0.76); C277(1.29); C425(1.17); C455(0.91)  LDD1614  [32]
 LDCM0411  CL23 HEK-293T C189(1.07); C277(1.55); C425(1.07); C455(1.00)  LDD1615  [32]
 LDCM0412  CL24 HEK-293T C189(0.97); C277(1.11); C425(1.14); C455(1.00)  LDD1616  [32]
 LDCM0413  CL25 HEK-293T C189(0.84); C277(0.93); C425(0.92); C455(1.04)  LDD1617  [32]
 LDCM0414  CL26 HEK-293T C189(0.92); C277(1.02); C425(0.97); C455(0.94)  LDD1618  [32]
 LDCM0415  CL27 HEK-293T C189(0.99); C277(1.00); C425(1.01); C455(1.02)  LDD1619  [32]
 LDCM0416  CL28 HEK-293T C189(0.90); C277(0.93); C425(0.86); C455(0.95)  LDD1620  [32]
 LDCM0417  CL29 HEK-293T C189(0.83); C277(0.86); C425(1.07); C455(0.89)  LDD1621  [32]
 LDCM0418  CL3 HEK-293T C189(0.94); C277(0.91); C425(1.06); C455(1.13)  LDD1622  [32]
 LDCM0419  CL30 HEK-293T C189(0.89); C277(1.13); C425(1.04); C455(0.90)  LDD1623  [32]
 LDCM0420  CL31 HEK-293T C189(0.87); C277(1.08); C425(1.04); C455(1.02)  LDD1624  [32]
 LDCM0421  CL32 HEK-293T C189(1.10); C277(1.16); C425(1.12); C455(0.93)  LDD1625  [32]
 LDCM0422  CL33 HEK-293T C277(1.28); C425(1.13); C455(1.01); C373(1.03)  LDD1626  [32]
 LDCM0423  CL34 HEK-293T C189(0.79); C277(1.23); C425(1.13); C455(0.93)  LDD1627  [32]
 LDCM0424  CL35 HEK-293T C189(0.96); C277(1.61); C425(1.12); C455(0.90)  LDD1628  [32]
 LDCM0425  CL36 HEK-293T C189(0.84); C277(1.12); C425(1.15); C455(0.98)  LDD1629  [32]
 LDCM0426  CL37 HEK-293T C189(0.85); C277(0.99); C425(0.97); C455(1.06)  LDD1630  [32]
 LDCM0428  CL39 HEK-293T C189(1.00); C277(0.95); C425(1.03); C455(0.98)  LDD1632  [32]
 LDCM0429  CL4 HEK-293T C189(0.87); C277(0.81); C425(0.98); C455(1.02)  LDD1633  [32]
 LDCM0430  CL40 HEK-293T C189(0.99); C277(0.96); C425(0.90); C455(0.98)  LDD1634  [32]
 LDCM0431  CL41 HEK-293T C189(0.82); C277(0.92); C425(1.01); C455(0.97)  LDD1635  [32]
 LDCM0432  CL42 HEK-293T C189(0.90); C277(1.32); C425(1.06); C455(0.94)  LDD1636  [32]
 LDCM0433  CL43 HEK-293T C189(0.92); C277(1.12); C425(1.04); C455(1.11)  LDD1637  [32]
 LDCM0434  CL44 HEK-293T C189(0.97); C277(1.17); C425(1.00); C455(1.04)  LDD1638  [32]
 LDCM0435  CL45 HEK-293T C277(1.29); C425(1.11); C455(0.92); C373(0.87)  LDD1639  [32]
 LDCM0436  CL46 HEK-293T C189(0.81); C277(1.29); C425(1.09); C455(0.88)  LDD1640  [32]
 LDCM0437  CL47 HEK-293T C189(0.98); C277(1.52); C425(1.19); C455(1.03)  LDD1641  [32]
 LDCM0438  CL48 HEK-293T C189(0.97); C277(1.19); C425(1.12); C455(1.07)  LDD1642  [32]
 LDCM0439  CL49 HEK-293T C189(0.82); C277(0.93); C425(1.09); C455(1.03)  LDD1643  [32]
 LDCM0440  CL5 HEK-293T C189(0.96); C277(0.99); C425(1.01); C455(0.98)  LDD1644  [32]
 LDCM0441  CL50 HEK-293T C189(0.89); C277(0.93); C425(0.98); C455(1.00)  LDD1645  [32]
 LDCM0443  CL52 HEK-293T C189(0.92); C277(0.82); C425(0.89); C455(1.12)  LDD1646  [32]
 LDCM0444  CL53 HEK-293T C189(0.80); C277(0.81); C425(1.02); C455(0.97)  LDD1647  [32]
 LDCM0445  CL54 HEK-293T C189(0.85); C277(0.89); C425(1.12); C455(1.01)  LDD1648  [32]
 LDCM0446  CL55 HEK-293T C189(0.96); C277(1.02); C425(1.03); C455(1.09)  LDD1649  [32]
 LDCM0447  CL56 HEK-293T C189(1.07); C277(1.11); C425(0.98); C455(0.97)  LDD1650  [32]
 LDCM0448  CL57 HEK-293T C277(1.16); C425(1.08); C455(0.93); C373(0.92)  LDD1651  [32]
 LDCM0449  CL58 HEK-293T C189(0.68); C277(1.08); C425(1.10); C455(1.03)  LDD1652  [32]
 LDCM0450  CL59 HEK-293T C189(1.01); C277(1.41); C425(1.14); C455(1.01)  LDD1653  [32]
 LDCM0451  CL6 HEK-293T C189(0.96); C277(0.93); C425(1.01); C455(1.08)  LDD1654  [32]
 LDCM0452  CL60 HEK-293T C189(1.03); C277(1.14); C425(1.08); C455(1.01)  LDD1655  [32]
 LDCM0453  CL61 HEK-293T C189(0.81); C277(0.98); C425(0.97); C455(1.10)  LDD1656  [32]
 LDCM0454  CL62 HEK-293T C189(0.90); C277(1.02); C425(0.95); C455(1.02)  LDD1657  [32]
 LDCM0455  CL63 HEK-293T C189(1.02); C277(1.00); C425(1.09); C455(1.20)  LDD1658  [32]
 LDCM0456  CL64 HEK-293T C189(0.92); C277(0.75); C425(0.95); C455(1.00)  LDD1659  [32]
 LDCM0457  CL65 HEK-293T C189(0.90); C277(0.93); C425(1.03); C455(0.95)  LDD1660  [32]
 LDCM0458  CL66 HEK-293T C189(0.94); C277(1.00); C425(1.04); C455(0.94)  LDD1661  [32]
 LDCM0459  CL67 HEK-293T C189(0.95); C277(1.01); C425(1.01); C455(1.10)  LDD1662  [32]
 LDCM0460  CL68 HEK-293T C189(1.10); C277(1.09); C425(0.99); C455(0.88)  LDD1663  [32]
 LDCM0461  CL69 HEK-293T C277(1.35); C425(1.17); C455(0.94); C373(0.95)  LDD1664  [32]
 LDCM0462  CL7 HEK-293T C189(0.85); C277(0.98); C425(0.98); C455(1.09)  LDD1665  [32]
 LDCM0463  CL70 HEK-293T C189(0.79); C277(1.26); C425(1.06); C455(0.87)  LDD1666  [32]
 LDCM0464  CL71 HEK-293T C189(1.01); C277(1.38); C425(1.14); C455(1.01)  LDD1667  [32]
 LDCM0465  CL72 HEK-293T C189(1.02); C277(1.14); C425(1.07); C455(0.91)  LDD1668  [32]
 LDCM0466  CL73 HEK-293T C189(0.87); C277(0.94); C425(0.96); C455(1.10)  LDD1669  [32]
 LDCM0467  CL74 HEK-293T C189(0.86); C277(0.96); C425(0.99); C455(1.03)  LDD1670  [32]
 LDCM0469  CL76 HEK-293T C189(0.88); C277(0.84); C425(0.97); C455(1.01)  LDD1672  [32]
 LDCM0470  CL77 HEK-293T C189(0.84); C277(0.79); C425(1.01); C455(0.92)  LDD1673  [32]
 LDCM0471  CL78 HEK-293T C189(0.98); C277(1.07); C425(1.19); C455(1.09)  LDD1674  [32]
 LDCM0472  CL79 HEK-293T C189(0.99); C277(0.98); C425(1.03); C455(0.98)  LDD1675  [32]
 LDCM0473  CL8 HEK-293T C189(0.85); C277(0.94); C425(1.12); C455(1.11)  LDD1676  [32]
 LDCM0474  CL80 HEK-293T C189(0.98); C277(1.15); C425(1.03); C455(1.02)  LDD1677  [32]
 LDCM0475  CL81 HEK-293T C277(1.32); C425(1.21); C455(0.93); C373(0.98)  LDD1678  [32]
 LDCM0476  CL82 HEK-293T C189(0.94); C277(1.16); C425(1.11); C455(0.97)  LDD1679  [32]
 LDCM0477  CL83 HEK-293T C189(0.91); C277(1.25); C425(1.15); C455(0.97)  LDD1680  [32]
 LDCM0478  CL84 HEK-293T C189(0.86); C277(1.01); C425(1.15); C455(1.05)  LDD1681  [32]
 LDCM0479  CL85 HEK-293T C189(0.82); C277(0.97); C425(0.96); C455(1.22)  LDD1682  [32]
 LDCM0480  CL86 HEK-293T C189(0.77); C277(0.99); C425(1.01); C455(1.13)  LDD1683  [32]
 LDCM0481  CL87 HEK-293T C189(0.80); C277(0.86); C425(1.08); C455(0.97)  LDD1684  [32]
 LDCM0482  CL88 HEK-293T C189(0.84); C277(0.78); C425(0.89); C455(1.11)  LDD1685  [32]
 LDCM0483  CL89 HEK-293T C189(0.77); C277(0.87); C425(1.04); C455(0.92)  LDD1686  [32]
 LDCM0484  CL9 HEK-293T C277(1.35); C425(1.25); C455(0.94); C373(0.99)  LDD1687  [32]
 LDCM0485  CL90 HEK-293T C189(0.89); C277(0.77); C425(1.13); C455(1.05)  LDD1688  [32]
 LDCM0486  CL91 HEK-293T C189(0.82); C277(0.97); C425(1.03); C455(1.10)  LDD1689  [32]
 LDCM0487  CL92 HEK-293T C189(0.81); C277(0.96); C425(0.92); C455(1.01)  LDD1690  [32]
 LDCM0488  CL93 HEK-293T C277(1.14); C425(1.08); C455(0.98); C373(0.93)  LDD1691  [32]
 LDCM0489  CL94 HEK-293T C189(0.66); C277(1.04); C425(1.00); C455(0.96)  LDD1692  [32]
 LDCM0490  CL95 HEK-293T C189(0.86); C277(0.98); C425(1.11); C455(1.10)  LDD1693  [32]
 LDCM0491  CL96 HEK-293T C189(0.93); C277(0.96); C425(1.06); C455(1.03)  LDD1694  [32]
 LDCM0492  CL97 HEK-293T C189(0.89); C277(0.92); C425(1.01); C455(1.15)  LDD1695  [32]
 LDCM0493  CL98 HEK-293T C189(0.89); C277(0.96); C425(0.93); C455(1.07)  LDD1696  [32]
 LDCM0494  CL99 HEK-293T C189(0.89); C277(0.96); C425(1.01); C455(0.92)  LDD1697  [32]
 LDCM0017  DFG-out-2 A431 0.00  LDD0075  [29]
 LDCM0495  E2913 HEK-293T C189(1.08); C277(0.92); C425(1.00); C455(1.05)  LDD1698  [32]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C277(2.33)  LDD1702  [9]
 LDCM0625  F8 Ramos C189(1.21); C277(1.08)  LDD2187  [33]
 LDCM0572  Fragment10 Ramos C189(0.68); C277(0.91)  LDD2189  [33]
 LDCM0573  Fragment11 Ramos C189(0.80)  LDD2190  [33]
 LDCM0574  Fragment12 Ramos C189(0.63); C277(0.88)  LDD2191  [33]
 LDCM0575  Fragment13 Ramos C189(0.96); C277(0.51)  LDD2192  [33]
 LDCM0576  Fragment14 Ramos C189(0.69); C277(1.12)  LDD2193  [33]
 LDCM0579  Fragment20 Ramos C189(0.50); C277(0.68)  LDD2194  [33]
 LDCM0580  Fragment21 Ramos C189(0.92); C277(0.66)  LDD2195  [33]
 LDCM0582  Fragment23 Ramos C189(1.27); C277(0.74)  LDD2196  [33]
 LDCM0578  Fragment27 Ramos C189(1.73); C277(1.04)  LDD2197  [33]
 LDCM0586  Fragment28 Ramos C189(0.94); C277(0.80)  LDD2198  [33]
 LDCM0588  Fragment30 Ramos C189(1.35); C277(0.39)  LDD2199  [33]
 LDCM0589  Fragment31 Ramos C189(0.55); C277(0.87)  LDD2200  [33]
 LDCM0590  Fragment32 Ramos C189(1.09); C277(0.91)  LDD2201  [33]
 LDCM0468  Fragment33 HEK-293T C189(0.97); C277(0.96); C425(1.12); C455(1.24)  LDD1671  [32]
 LDCM0596  Fragment38 Ramos C189(1.71); C277(0.54)  LDD2203  [33]
 LDCM0566  Fragment4 Ramos C189(0.70); C277(0.51)  LDD2184  [33]
 LDCM0427  Fragment51 HEK-293T C189(0.85); C277(1.02); C425(0.94); C455(1.07)  LDD1631  [32]
 LDCM0610  Fragment52 Ramos C189(1.24); C277(0.31)  LDD2204  [33]
 LDCM0614  Fragment56 Ramos C189(1.56); C277(0.61)  LDD2205  [33]
 LDCM0569  Fragment7 Ramos C189(0.67); C277(0.44)  LDD2186  [33]
 LDCM0571  Fragment9 Ramos C189(0.51); C277(0.58)  LDD2188  [33]
 LDCM0107  IAA HeLa H312(0.00); H120(0.00); H262(0.00); C189(0.00)  LDD0221  [25]
 LDCM0022  KB02 HEK-293T C189(1.06); C277(0.98); C425(0.92); C535(1.02)  LDD1492  [32]
 LDCM0023  KB03 HEK-293T C189(0.99); C277(0.98); C425(0.95); C535(0.98)  LDD1497  [32]
 LDCM0024  KB05 G361 C214(4.29)  LDD3311  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C189(0.61)  LDD2121  [9]
 LDCM0109  NEM HeLa H312(0.00); H120(0.00); C189(0.00)  LDD0223  [25]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C189(0.65)  LDD2089  [9]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C189(1.09)  LDD2090  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C189(1.26)  LDD2092  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C189(1.05); C277(0.68)  LDD2093  [9]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C189(2.57); C425(1.11)  LDD2094  [9]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C189(0.25)  LDD2096  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C189(0.60)  LDD2097  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C189(0.88); C425(1.11)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C189(0.71)  LDD2099  [9]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C189(0.27); C277(0.95); C425(1.21)  LDD2100  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C189(0.74); C425(1.10)  LDD2101  [9]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C189(0.25); C277(0.77); C425(0.93)  LDD2104  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C189(2.08); C425(0.93)  LDD2105  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C425(0.87)  LDD2107  [9]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C189(0.15); C277(0.58); C425(0.88)  LDD2108  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C425(0.66)  LDD2109  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C189(0.82); C277(0.83)  LDD2111  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C277(0.60); C425(1.00)  LDD2114  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C189(0.61)  LDD2116  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C189(0.78)  LDD2118  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C189(2.11)  LDD2119  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C189(0.71); C425(0.89)  LDD2120  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C189(0.39); C277(0.90); C425(0.34)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C189(0.68)  LDD2123  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C189(0.48)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C189(0.62)  LDD2125  [9]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C189(0.37)  LDD2126  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C189(0.72); C425(1.19)  LDD2127  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C189(0.63)  LDD2128  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C189(0.86); C277(0.88)  LDD2129  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C189(0.75)  LDD2133  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C189(0.64)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C189(0.68)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C189(0.92); C425(1.32)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C189(0.67); C277(0.80)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C189(1.65)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C189(0.84)  LDD2140  [9]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C189(0.38); C277(1.19)  LDD2141  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C189(0.62); C277(1.34)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C189(1.70); C425(1.31)  LDD2144  [9]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C189(0.08); C425(1.13)  LDD2145  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C189(0.67); C277(1.02); C425(1.13)  LDD2146  [9]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C189(1.56)  LDD2147  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C189(0.61)  LDD2148  [9]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C189(0.44)  LDD2149  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C189(0.35)  LDD2150  [9]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C189(0.33)  LDD2151  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C373(0.76)  LDD2206  [34]
 LDCM0628  OTUB2-COV-1 HEK-293T C373(2.60); C277(0.13)  LDD2207  [34]
 LDCM0131  RA190 MM1.R C373(1.25)  LDD0304  [35]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(R)-3-hydroxydecanoyl-coa Small molecular drug DB03192
3r-hydroxydecanoyl-coa Small molecular drug D04TMV
Nicotinamide-adenine-dinucleotide Small molecular drug D0R6JE

References

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Mass spectrometry data entry: PXD037665
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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD047840
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD042377
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD029500 , PXD031647
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Mass spectrometry data entry: PXD006095 , PXD006096
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD022279
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD001377 , PXD005252
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD007570
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