Probe Name	Jackson_1					Probe Info
Probe concentration	10 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	SILAC
Competitor Name	Cisar_cp37					Competitor Info
Competitor Concentration	50 uM
In Vivo Experiment Model	Model Type			Living cell
	Derived Tissue			Breast
	Disease Model		Breast adenocarcinoma [ICD-11:2C60]
	Model Name		Human breast adenocarcinoma cells (MDA-MB-231)

Target ID	Target Name					Binding Ratio
LDTP12475	Histone-lysine N-methyltransferase ASH1L (ASH1L)					20.0
LDTP01503	Mitofusin-2 (MFN2)					20.0
LDTP09470	Pantothenate kinase 1 (PANK1)					20.0
LDTP00915	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (DHX16)					20.0
LDTP11819	STE20-like serine/threonine-protein kinase (SLK)					20.0
LDTP03519	UMP-CMP kinase (CMPK1)					10.6
LDTP04440	Peroxisomal multifunctional enzyme type 2 (HSD17B4)					10.5
LDTP04547	Nuclear pore complex protein Nup98-Nup96 (NUP98)					10.4
LDTP12048	Complex I assembly factor ACAD9, mitochondrial (ACAD9)					10.4
LDTP00273	Dynamin-1-like protein (DNM1L)					10.4
LDTP03681	DNA replication licensing factor MCM5 (MCM5)					10.2
LDTP15484	Saccharopine dehydrogenase-like oxidoreductase (SCCPDH)					5.1
LDTP05387	Glutathione S-transferase Mu 4 (GSTM4)					3.7
LDTP02350	Glutathione S-transferase Mu 1 (GSTM1)					3.3
LDTP05128	Glutathione S-transferase omega-1 (GSTO1)					3.0
LDTP06612	2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (DECR1)					2.8
LDTP19892	DGAT1/2-independent enzyme synthesizing storage lipids (TMEM68)					2.6
LDTP12293	Adipocyte plasma membrane-associated protein (APMAP)					2.5
LDTP01707	Thioredoxin domain-containing protein 12 (TXNDC12)					2.5
LDTP02175	Epoxide hydrolase 1 (EPHX1)					2.4
LDTP16070	Epimerase family protein SDR39U1 (SDR39U1)					2.3
LDTP01982	NADH-ubiquinone oxidoreductase chain 1 (MT-ND1)					2.2
LDTP06371	GTP-binding protein Rheb (RHEB)					2.1
LDTP07028	Long-chain fatty acid transport protein 3 (SLC27A3)					2.1

Target ID	Target Name					Binding Ratio
LDTP04502	Importin subunit alpha-5 (KPNA1)					20.0
LDTP00477	Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23)					20.0
LDTP19379	Mitochondrial import inner membrane translocase subunit Tim23B (TIMM23B)					20.0
LDTP07667	Transmembrane protein 205 (TMEM205)					20.0
LDTP04426	B-cell receptor-associated protein 31 (BCAP31)					10.6
LDTP01031	Importin subunit alpha-7 (KPNA6)					10.4
LDTP05591	Nuclear cap-binding protein subunit 1 (NCBP1)					2.8
LDTP06177	Clathrin interactor 1 (CLINT1)					2.5
LDTP10958	Sigma non-opioid intracellular receptor 1 (SIGMAR1)					2.5
LDTP10343	Vacuole membrane protein 1 (VMP1)					2.2
LDTP03546	Translocator protein (TSPO)					2.2
LDTP00865	Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20)					2.1
LDTP06945	Sigma intracellular receptor 2 (TMEM97)					2.0

Target ID	Target Name					Binding Ratio
LDTP09100	Cytoplasmic dynein 2 heavy chain 1 (DYNC2H1)					20.0
LDTP04105	Large ribosomal subunit protein uL15 (RPL27A)					20.0
LDTP02829	Integrin beta-4 (ITGB4)					10.4
LDTP04558	Arfaptin-1 (ARFIP1)					4.3
LDTP19963	TraB domain-containing protein (TRABD)					2.4
LDTP16078	Heme-binding protein 1 (HEBP1)					2.1
LDTP05400	Lamin-B2 (LMNB2)					2.1
LDTP10799	GPI transamidase component PIG-S (PIGS)					2.1

1	Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.