Details of the Target

General Information of Target

Target ID LDTP05387
Target Name Glutathione S-transferase Mu 4 (GSTM4)
Gene Name GSTM4
Gene ID 2948
Synonyms
Glutathione S-transferase Mu 4; EC 2.5.1.18; GST class-mu 4; GST-Mu2; GSTM4-4; Leukotriene C4 synthase GSTM4; EC 4.4.1.20
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSMTLGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILENQAMDVSNQLARVCYSPDF
EKLKPEYLEELPTMMQHFSQFLGKRPWFVGDKITFVDFLAYDVLDLHRIFEPNCLDAFPN
LKDFISRFEGLEKISAYMKSSRFLPKPLYTRVAVWGNK
Target Bioclass
Enzyme
Family
GST superfamily, Mu family
Subcellular location
Cytoplasm
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4. Can also catalyzes the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions.
Uniprot ID
Q03013
Ensemble ID
ENST00000326729.9
HGNC ID
HGNC:4636
ChEMBL ID
CHEMBL2100

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KMS11 SNV: p.E130K; p.M134I .
SKNAS SNV: p.D165E DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
Jackson_1
 Probe Info  		3.67  LDD0120  [2]
DBIA
 Probe Info  		C115(4.23)  LDD0209  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C115(0.00); C174(0.00)  LDD0037  [4]
TFBX
 Probe Info  		C115(0.00); C78(0.00)  LDD0027  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
NAIA_5
 Probe Info  		C174(0.00); C115(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C87(0.43)  LDD1093  [8]
 LDCM0215  AC10 PaTu 8988t C78(0.61); C87(0.99)  LDD1094  [8]
 LDCM0216  AC100 PaTu 8988t C87(1.01)  LDD1095  [8]
 LDCM0217  AC101 PaTu 8988t C87(1.49)  LDD1096  [8]
 LDCM0218  AC102 PaTu 8988t C87(1.23)  LDD1097  [8]
 LDCM0219  AC103 PaTu 8988t C87(1.05)  LDD1098  [8]
 LDCM0220  AC104 PaTu 8988t C87(1.03)  LDD1099  [8]
 LDCM0221  AC105 PaTu 8988t C87(1.47)  LDD1100  [8]
 LDCM0222  AC106 PaTu 8988t C87(1.14)  LDD1101  [8]
 LDCM0223  AC107 PaTu 8988t C87(1.17)  LDD1102  [8]
 LDCM0224  AC108 PaTu 8988t C87(0.96)  LDD1103  [8]
 LDCM0225  AC109 PaTu 8988t C87(1.13)  LDD1104  [8]
 LDCM0226  AC11 PaTu 8988t C78(0.59); C87(0.74)  LDD1105  [8]
 LDCM0227  AC110 PaTu 8988t C87(1.17)  LDD1106  [8]
 LDCM0228  AC111 PaTu 8988t C87(0.85)  LDD1107  [8]
 LDCM0229  AC112 PaTu 8988t C87(1.04)  LDD1108  [8]
 LDCM0230  AC113 PaTu 8988t C87(0.89)  LDD1109  [8]
 LDCM0231  AC114 PaTu 8988t C87(1.14)  LDD1110  [8]
 LDCM0232  AC115 PaTu 8988t C87(0.81)  LDD1111  [8]
 LDCM0233  AC116 PaTu 8988t C87(1.00)  LDD1112  [8]
 LDCM0234  AC117 PaTu 8988t C87(0.96)  LDD1113  [8]
 LDCM0235  AC118 PaTu 8988t C87(1.03)  LDD1114  [8]
 LDCM0236  AC119 PaTu 8988t C87(0.70)  LDD1115  [8]
 LDCM0237  AC12 PaTu 8988t C78(0.72); C87(0.79)  LDD1116  [8]
 LDCM0238  AC120 PaTu 8988t C87(1.01)  LDD1117  [8]
 LDCM0239  AC121 PaTu 8988t C87(0.79)  LDD1118  [8]
 LDCM0240  AC122 PaTu 8988t C87(1.03)  LDD1119  [8]
 LDCM0241  AC123 PaTu 8988t C87(0.85)  LDD1120  [8]
 LDCM0242  AC124 PaTu 8988t C87(0.73)  LDD1121  [8]
 LDCM0243  AC125 PaTu 8988t C87(0.99)  LDD1122  [8]
 LDCM0244  AC126 PaTu 8988t C87(0.95)  LDD1123  [8]
 LDCM0245  AC127 PaTu 8988t C87(0.91)  LDD1124  [8]
 LDCM0246  AC128 PaTu 8988t C174(0.93); C78(1.34); C87(1.13)  LDD1125  [8]
 LDCM0247  AC129 PaTu 8988t C174(0.89); C78(0.94); C87(0.81)  LDD1126  [8]
 LDCM0249  AC130 PaTu 8988t C174(0.86); C78(0.85); C87(0.85)  LDD1128  [8]
 LDCM0250  AC131 PaTu 8988t C174(0.80); C78(1.11); C87(0.85)  LDD1129  [8]
 LDCM0251  AC132 PaTu 8988t C174(0.85); C78(0.97); C87(1.04)  LDD1130  [8]
 LDCM0252  AC133 PaTu 8988t C174(0.15); C78(0.53); C87(0.25)  LDD1131  [8]
 LDCM0253  AC134 PaTu 8988t C174(0.44); C78(0.66); C87(0.49)  LDD1132  [8]
 LDCM0254  AC135 PaTu 8988t C174(0.15); C78(0.75); C87(0.28)  LDD1133  [8]
 LDCM0255  AC136 PaTu 8988t C174(0.42); C78(0.63); C87(0.57)  LDD1134  [8]
 LDCM0256  AC137 PaTu 8988t C174(0.17); C78(0.65); C87(0.28)  LDD1135  [8]
 LDCM0257  AC138 PaTu 8988t C174(0.81); C78(1.37); C87(0.65)  LDD1136  [8]
 LDCM0258  AC139 PaTu 8988t C174(1.04); C78(1.59); C87(0.95)  LDD1137  [8]
 LDCM0259  AC14 PaTu 8988t C78(0.87); C87(0.88)  LDD1138  [8]
 LDCM0260  AC140 PaTu 8988t C174(0.89); C78(0.84); C87(0.94)  LDD1139  [8]
 LDCM0261  AC141 PaTu 8988t C174(0.75); C78(1.68); C87(0.85)  LDD1140  [8]
 LDCM0262  AC142 PaTu 8988t C174(0.66); C78(0.87); C87(0.70)  LDD1141  [8]
 LDCM0263  AC143 PaTu 8988t C174(0.92); C78(0.74); C87(0.98)  LDD1142  [8]
 LDCM0264  AC144 PaTu 8988t C174(0.94); C78(0.61); C87(1.11)  LDD1143  [8]
 LDCM0265  AC145 PaTu 8988t C174(1.03); C78(0.92); C87(0.94)  LDD1144  [8]
 LDCM0266  AC146 PaTu 8988t C174(0.80); C78(1.08); C87(1.16)  LDD1145  [8]
 LDCM0267  AC147 PaTu 8988t C174(0.90); C78(1.01); C87(0.92)  LDD1146  [8]
 LDCM0268  AC148 PaTu 8988t C174(0.65); C78(0.47); C87(0.81)  LDD1147  [8]
 LDCM0269  AC149 PaTu 8988t C174(0.48); C78(0.23); C87(0.92)  LDD1148  [8]
 LDCM0270  AC15 PaTu 8988t C78(0.84); C87(1.02)  LDD1149  [8]
 LDCM0271  AC150 PaTu 8988t C174(1.10); C78(0.47); C87(1.16)  LDD1150  [8]
 LDCM0272  AC151 PaTu 8988t C174(0.08); C78(0.25); C87(0.19)  LDD1151  [8]
 LDCM0273  AC152 PaTu 8988t C174(0.41); C78(0.23); C87(1.03)  LDD1152  [8]
 LDCM0274  AC153 PaTu 8988t C174(0.47); C78(0.45); C87(0.58)  LDD1153  [8]
 LDCM0621  AC154 PaTu 8988t C174(0.18); C78(0.17); C87(0.36)  LDD2166  [8]
 LDCM0622  AC155 PaTu 8988t C174(0.49); C78(0.24); C87(0.70)  LDD2167  [8]
 LDCM0623  AC156 PaTu 8988t C174(0.89); C78(0.54); C87(1.17)  LDD2168  [8]
 LDCM0624  AC157 PaTu 8988t C174(0.45); C78(0.27); C87(0.62)  LDD2169  [8]
 LDCM0276  AC17 PaTu 8988t C87(0.87)  LDD1155  [8]
 LDCM0277  AC18 PaTu 8988t C87(0.96)  LDD1156  [8]
 LDCM0278  AC19 PaTu 8988t C87(1.06)  LDD1157  [8]
 LDCM0279  AC2 PaTu 8988t C87(0.75)  LDD1158  [8]
 LDCM0280  AC20 PaTu 8988t C87(1.12)  LDD1159  [8]
 LDCM0281  AC21 PaTu 8988t C87(0.89)  LDD1160  [8]
 LDCM0282  AC22 PaTu 8988t C87(0.89)  LDD1161  [8]
 LDCM0283  AC23 PaTu 8988t C87(0.83)  LDD1162  [8]
 LDCM0284  AC24 PaTu 8988t C87(1.10)  LDD1163  [8]
 LDCM0285  AC25 PaTu 8988t C87(1.36)  LDD1164  [8]
 LDCM0286  AC26 PaTu 8988t C87(1.29)  LDD1165  [8]
 LDCM0287  AC27 PaTu 8988t C87(1.60)  LDD1166  [8]
 LDCM0288  AC28 PaTu 8988t C87(1.39)  LDD1167  [8]
 LDCM0289  AC29 PaTu 8988t C87(1.30)  LDD1168  [8]
 LDCM0290  AC3 PaTu 8988t C87(0.60)  LDD1169  [8]
 LDCM0291  AC30 PaTu 8988t C87(1.20)  LDD1170  [8]
 LDCM0292  AC31 PaTu 8988t C87(1.24)  LDD1171  [8]
 LDCM0293  AC32 PaTu 8988t C87(0.92)  LDD1172  [8]
 LDCM0294  AC33 PaTu 8988t C87(1.18)  LDD1173  [8]
 LDCM0295  AC34 PaTu 8988t C87(1.34)  LDD1174  [8]
 LDCM0296  AC35 PaTu 8988t C87(1.13)  LDD1175  [8]
 LDCM0297  AC36 PaTu 8988t C87(1.37)  LDD1176  [8]
 LDCM0298  AC37 PaTu 8988t C87(1.25)  LDD1177  [8]
 LDCM0299  AC38 PaTu 8988t C87(1.39)  LDD1178  [8]
 LDCM0300  AC39 PaTu 8988t C87(1.28)  LDD1179  [8]
 LDCM0301  AC4 PaTu 8988t C87(0.72)  LDD1180  [8]
 LDCM0302  AC40 PaTu 8988t C87(1.27)  LDD1181  [8]
 LDCM0303  AC41 PaTu 8988t C87(0.88)  LDD1182  [8]
 LDCM0304  AC42 PaTu 8988t C87(0.99)  LDD1183  [8]
 LDCM0305  AC43 PaTu 8988t C87(1.25)  LDD1184  [8]
 LDCM0306  AC44 PaTu 8988t C87(1.26)  LDD1185  [8]
 LDCM0307  AC45 PaTu 8988t C87(1.10)  LDD1186  [8]
 LDCM0308  AC46 PaTu 8988t C78(1.01); C87(1.07)  LDD1187  [8]
 LDCM0309  AC47 PaTu 8988t C78(1.04); C87(1.12)  LDD1188  [8]
 LDCM0310  AC48 PaTu 8988t C78(0.90); C87(1.23)  LDD1189  [8]
 LDCM0311  AC49 PaTu 8988t C78(0.71); C87(1.12)  LDD1190  [8]
 LDCM0312  AC5 PaTu 8988t C87(0.53)  LDD1191  [8]
 LDCM0313  AC50 PaTu 8988t C78(0.69); C87(0.89)  LDD1192  [8]
 LDCM0314  AC51 PaTu 8988t C78(1.37); C87(0.75)  LDD1193  [8]
 LDCM0315  AC52 PaTu 8988t C78(0.79); C87(1.10)  LDD1194  [8]
 LDCM0316  AC53 PaTu 8988t C78(0.73); C87(0.96)  LDD1195  [8]
 LDCM0317  AC54 PaTu 8988t C78(0.50); C87(0.62)  LDD1196  [8]
 LDCM0318  AC55 PaTu 8988t C78(0.90); C87(1.15)  LDD1197  [8]
 LDCM0319  AC56 PaTu 8988t C78(1.60); C87(0.98)  LDD1198  [8]
 LDCM0320  AC57 PaTu 8988t C87(1.17)  LDD1199  [8]
 LDCM0321  AC58 PaTu 8988t C87(1.11)  LDD1200  [8]
 LDCM0322  AC59 PaTu 8988t C87(1.27)  LDD1201  [8]
 LDCM0323  AC6 PaTu 8988t C78(1.26); C87(1.06)  LDD1202  [8]
 LDCM0324  AC60 PaTu 8988t C87(1.33)  LDD1203  [8]
 LDCM0325  AC61 PaTu 8988t C87(1.06)  LDD1204  [8]
 LDCM0326  AC62 PaTu 8988t C87(1.13)  LDD1205  [8]
 LDCM0327  AC63 PaTu 8988t C87(0.98)  LDD1206  [8]
 LDCM0328  AC64 PaTu 8988t C87(1.28)  LDD1207  [8]
 LDCM0329  AC65 PaTu 8988t C87(1.05)  LDD1208  [8]
 LDCM0330  AC66 PaTu 8988t C87(1.00)  LDD1209  [8]
 LDCM0331  AC67 PaTu 8988t C87(1.20)  LDD1210  [8]
 LDCM0332  AC68 PaTu 8988t C87(1.04)  LDD1211  [8]
 LDCM0333  AC69 PaTu 8988t C87(1.04)  LDD1212  [8]
 LDCM0334  AC7 PaTu 8988t C78(0.78); C87(1.02)  LDD1213  [8]
 LDCM0335  AC70 PaTu 8988t C87(0.96)  LDD1214  [8]
 LDCM0336  AC71 PaTu 8988t C87(1.11)  LDD1215  [8]
 LDCM0337  AC72 PaTu 8988t C87(1.30)  LDD1216  [8]
 LDCM0338  AC73 PaTu 8988t C87(0.90)  LDD1217  [8]
 LDCM0339  AC74 PaTu 8988t C87(1.10)  LDD1218  [8]
 LDCM0340  AC75 PaTu 8988t C87(1.18)  LDD1219  [8]
 LDCM0341  AC76 PaTu 8988t C87(1.03)  LDD1220  [8]
 LDCM0342  AC77 PaTu 8988t C87(1.01)  LDD1221  [8]
 LDCM0343  AC78 PaTu 8988t C87(1.15)  LDD1222  [8]
 LDCM0344  AC79 PaTu 8988t C87(1.01)  LDD1223  [8]
 LDCM0345  AC8 PaTu 8988t C78(0.79); C87(0.89)  LDD1224  [8]
 LDCM0346  AC80 PaTu 8988t C87(1.08)  LDD1225  [8]
 LDCM0347  AC81 PaTu 8988t C87(1.11)  LDD1226  [8]
 LDCM0348  AC82 PaTu 8988t C87(1.06)  LDD1227  [8]
 LDCM0365  AC98 PaTu 8988t C87(1.43)  LDD1244  [8]
 LDCM0366  AC99 PaTu 8988t C87(1.01)  LDD1245  [8]
 LDCM0248  AKOS034007472 PaTu 8988t C78(1.31); C87(0.72)  LDD1127  [8]
 LDCM0356  AKOS034007680 PaTu 8988t C78(0.43); C87(1.13)  LDD1235  [8]
 LDCM0275  AKOS034007705 PaTu 8988t C78(0.48); C87(0.92)  LDD1154  [8]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0070  Cisar_cp37 MDA-MB-231 3.67  LDD0120  [2]
 LDCM0367  CL1 PaTu 8988t C174(1.34); C78(0.76); C87(0.82)  LDD1246  [8]
 LDCM0368  CL10 PaTu 8988t C174(0.54); C78(0.30); C87(1.34)  LDD1247  [8]
 LDCM0369  CL100 PaTu 8988t C87(0.69)  LDD1248  [8]
 LDCM0370  CL101 PaTu 8988t C78(0.73); C87(1.00)  LDD1249  [8]
 LDCM0371  CL102 PaTu 8988t C78(0.76); C87(1.12)  LDD1250  [8]
 LDCM0372  CL103 PaTu 8988t C78(0.80); C87(0.57)  LDD1251  [8]
 LDCM0373  CL104 PaTu 8988t C78(0.67); C87(0.93)  LDD1252  [8]
 LDCM0374  CL105 PaTu 8988t C87(1.03)  LDD1253  [8]
 LDCM0375  CL106 PaTu 8988t C87(0.87)  LDD1254  [8]
 LDCM0376  CL107 PaTu 8988t C87(0.92)  LDD1255  [8]
 LDCM0377  CL108 PaTu 8988t C87(0.94)  LDD1256  [8]
 LDCM0378  CL109 PaTu 8988t C87(1.00)  LDD1257  [8]
 LDCM0379  CL11 PaTu 8988t C174(1.62); C78(0.81); C87(0.93)  LDD1258  [8]
 LDCM0380  CL110 PaTu 8988t C87(0.96)  LDD1259  [8]
 LDCM0381  CL111 PaTu 8988t C87(0.73)  LDD1260  [8]
 LDCM0382  CL112 PaTu 8988t C87(1.11)  LDD1261  [8]
 LDCM0383  CL113 PaTu 8988t C87(1.13)  LDD1262  [8]
 LDCM0384  CL114 PaTu 8988t C87(1.01)  LDD1263  [8]
 LDCM0385  CL115 PaTu 8988t C87(0.91)  LDD1264  [8]
 LDCM0386  CL116 PaTu 8988t C87(1.36)  LDD1265  [8]
 LDCM0387  CL117 PaTu 8988t C87(1.16)  LDD1266  [8]
 LDCM0388  CL118 PaTu 8988t C87(1.03)  LDD1267  [8]
 LDCM0389  CL119 PaTu 8988t C87(1.04)  LDD1268  [8]
 LDCM0390  CL12 PaTu 8988t C174(1.02); C78(0.64); C87(1.21)  LDD1269  [8]
 LDCM0391  CL120 PaTu 8988t C87(1.04)  LDD1270  [8]
 LDCM0392  CL121 PaTu 8988t C78(0.97); C87(1.18)  LDD1271  [8]
 LDCM0393  CL122 PaTu 8988t C78(1.84); C87(1.09)  LDD1272  [8]
 LDCM0394  CL123 PaTu 8988t C78(0.67); C87(1.11)  LDD1273  [8]
 LDCM0395  CL124 PaTu 8988t C78(0.72); C87(0.98)  LDD1274  [8]
 LDCM0396  CL125 PaTu 8988t C87(0.92)  LDD1275  [8]
 LDCM0397  CL126 PaTu 8988t C87(1.13)  LDD1276  [8]
 LDCM0398  CL127 PaTu 8988t C87(1.03)  LDD1277  [8]
 LDCM0399  CL128 PaTu 8988t C87(1.20)  LDD1278  [8]
 LDCM0400  CL13 PaTu 8988t C174(0.10); C78(0.24); C87(1.26)  LDD1279  [8]
 LDCM0401  CL14 PaTu 8988t C174(0.07); C78(0.57); C87(1.20)  LDD1280  [8]
 LDCM0402  CL15 PaTu 8988t C174(0.78); C78(0.68); C87(0.96)  LDD1281  [8]
 LDCM0403  CL16 PaTu 8988t C174(0.75); C87(0.73)  LDD1282  [8]
 LDCM0404  CL17 PaTu 8988t C174(1.13); C87(1.12)  LDD1283  [8]
 LDCM0405  CL18 PaTu 8988t C174(0.39); C87(0.71)  LDD1284  [8]
 LDCM0406  CL19 PaTu 8988t C174(0.27); C87(0.42)  LDD1285  [8]
 LDCM0407  CL2 PaTu 8988t C174(1.09); C78(0.74); C87(0.89)  LDD1286  [8]
 LDCM0408  CL20 PaTu 8988t C174(0.06); C87(0.16)  LDD1287  [8]
 LDCM0409  CL21 PaTu 8988t C174(0.05); C87(0.14)  LDD1288  [8]
 LDCM0410  CL22 PaTu 8988t C174(0.16); C87(0.29)  LDD1289  [8]
 LDCM0411  CL23 PaTu 8988t C174(0.12); C87(0.38)  LDD1290  [8]
 LDCM0412  CL24 PaTu 8988t C174(1.14); C87(1.63)  LDD1291  [8]
 LDCM0413  CL25 PaTu 8988t C174(1.21); C87(1.43)  LDD1292  [8]
 LDCM0414  CL26 PaTu 8988t C174(0.12); C87(0.28)  LDD1293  [8]
 LDCM0415  CL27 PaTu 8988t C174(0.64); C87(0.80)  LDD1294  [8]
 LDCM0416  CL28 PaTu 8988t C174(0.05); C87(0.17)  LDD1295  [8]
 LDCM0417  CL29 PaTu 8988t C174(0.05); C87(0.18)  LDD1296  [8]
 LDCM0418  CL3 PaTu 8988t C174(1.77); C78(1.02); C87(0.84)  LDD1297  [8]
 LDCM0419  CL30 PaTu 8988t C174(0.94); C87(0.88)  LDD1298  [8]
 LDCM0420  CL31 PaTu 8988t C87(1.11)  LDD1299  [8]
 LDCM0421  CL32 PaTu 8988t C87(1.23)  LDD1300  [8]
 LDCM0422  CL33 PaTu 8988t C87(1.01)  LDD1301  [8]
 LDCM0423  CL34 PaTu 8988t C87(1.22)  LDD1302  [8]
 LDCM0424  CL35 PaTu 8988t C87(1.12)  LDD1303  [8]
 LDCM0425  CL36 PaTu 8988t C87(0.66)  LDD1304  [8]
 LDCM0426  CL37 PaTu 8988t C87(1.00)  LDD1305  [8]
 LDCM0428  CL39 PaTu 8988t C87(1.29)  LDD1307  [8]
 LDCM0429  CL4 PaTu 8988t C174(1.12); C78(2.13); C87(1.04)  LDD1308  [8]
 LDCM0430  CL40 PaTu 8988t C87(1.24)  LDD1309  [8]
 LDCM0431  CL41 PaTu 8988t C87(1.03)  LDD1310  [8]
 LDCM0432  CL42 PaTu 8988t C87(0.84)  LDD1311  [8]
 LDCM0433  CL43 PaTu 8988t C87(0.68)  LDD1312  [8]
 LDCM0434  CL44 PaTu 8988t C87(1.16)  LDD1313  [8]
 LDCM0435  CL45 PaTu 8988t C87(1.01)  LDD1314  [8]
 LDCM0436  CL46 PaTu 8988t C87(1.17)  LDD1315  [8]
 LDCM0437  CL47 PaTu 8988t C87(1.10)  LDD1316  [8]
 LDCM0438  CL48 PaTu 8988t C87(1.29)  LDD1317  [8]
 LDCM0439  CL49 PaTu 8988t C87(1.29)  LDD1318  [8]
 LDCM0440  CL5 PaTu 8988t C174(0.17); C78(0.26); C87(0.96)  LDD1319  [8]
 LDCM0441  CL50 PaTu 8988t C87(1.42)  LDD1320  [8]
 LDCM0442  CL51 PaTu 8988t C87(1.30)  LDD1321  [8]
 LDCM0443  CL52 PaTu 8988t C87(1.28)  LDD1322  [8]
 LDCM0444  CL53 PaTu 8988t C87(1.24)  LDD1323  [8]
 LDCM0445  CL54 PaTu 8988t C87(1.22)  LDD1324  [8]
 LDCM0446  CL55 PaTu 8988t C87(1.12)  LDD1325  [8]
 LDCM0447  CL56 PaTu 8988t C87(0.60)  LDD1326  [8]
 LDCM0448  CL57 PaTu 8988t C87(0.68)  LDD1327  [8]
 LDCM0449  CL58 PaTu 8988t C87(1.10)  LDD1328  [8]
 LDCM0450  CL59 PaTu 8988t C87(0.79)  LDD1329  [8]
 LDCM0451  CL6 PaTu 8988t C174(0.74); C78(0.47); C87(1.00)  LDD1330  [8]
 LDCM0452  CL60 PaTu 8988t C87(0.92)  LDD1331  [8]
 LDCM0453  CL61 PaTu 8988t C87(1.10)  LDD1332  [8]
 LDCM0454  CL62 PaTu 8988t C87(1.00)  LDD1333  [8]
 LDCM0455  CL63 PaTu 8988t C87(1.01)  LDD1334  [8]
 LDCM0456  CL64 PaTu 8988t C87(1.04)  LDD1335  [8]
 LDCM0457  CL65 PaTu 8988t C87(1.08)  LDD1336  [8]
 LDCM0458  CL66 PaTu 8988t C87(1.07)  LDD1337  [8]
 LDCM0459  CL67 PaTu 8988t C87(0.92)  LDD1338  [8]
 LDCM0460  CL68 PaTu 8988t C87(0.93)  LDD1339  [8]
 LDCM0461  CL69 PaTu 8988t C87(0.84)  LDD1340  [8]
 LDCM0462  CL7 PaTu 8988t C174(0.30); C78(0.28); C87(1.00)  LDD1341  [8]
 LDCM0463  CL70 PaTu 8988t C87(1.17)  LDD1342  [8]
 LDCM0464  CL71 PaTu 8988t C87(0.93)  LDD1343  [8]
 LDCM0465  CL72 PaTu 8988t C87(1.10)  LDD1344  [8]
 LDCM0466  CL73 PaTu 8988t C87(1.00)  LDD1345  [8]
 LDCM0467  CL74 PaTu 8988t C87(1.06)  LDD1346  [8]
 LDCM0469  CL76 PaTu 8988t C87(0.99)  LDD1348  [8]
 LDCM0470  CL77 PaTu 8988t C87(0.99)  LDD1349  [8]
 LDCM0471  CL78 PaTu 8988t C87(1.19)  LDD1350  [8]
 LDCM0472  CL79 PaTu 8988t C87(1.22)  LDD1351  [8]
 LDCM0473  CL8 PaTu 8988t C174(0.97); C78(0.72); C87(0.99)  LDD1352  [8]
 LDCM0474  CL80 PaTu 8988t C87(1.27)  LDD1353  [8]
 LDCM0475  CL81 PaTu 8988t C87(1.07)  LDD1354  [8]
 LDCM0476  CL82 PaTu 8988t C87(1.18)  LDD1355  [8]
 LDCM0477  CL83 PaTu 8988t C87(1.21)  LDD1356  [8]
 LDCM0478  CL84 PaTu 8988t C87(0.90)  LDD1357  [8]
 LDCM0479  CL85 PaTu 8988t C87(1.07)  LDD1358  [8]
 LDCM0480  CL86 PaTu 8988t C87(0.97)  LDD1359  [8]
 LDCM0481  CL87 PaTu 8988t C87(0.85)  LDD1360  [8]
 LDCM0482  CL88 PaTu 8988t C87(1.04)  LDD1361  [8]
 LDCM0483  CL89 PaTu 8988t C87(0.84)  LDD1362  [8]
 LDCM0484  CL9 PaTu 8988t C174(0.41); C78(0.47); C87(0.92)  LDD1363  [8]
 LDCM0485  CL90 PaTu 8988t C87(0.79)  LDD1364  [8]
 LDCM0486  CL91 PaTu 8988t C87(0.62)  LDD1365  [8]
 LDCM0487  CL92 PaTu 8988t C87(0.61)  LDD1366  [8]
 LDCM0488  CL93 PaTu 8988t C87(0.67)  LDD1367  [8]
 LDCM0489  CL94 PaTu 8988t C87(0.60)  LDD1368  [8]
 LDCM0490  CL95 PaTu 8988t C87(0.54)  LDD1369  [8]
 LDCM0491  CL96 PaTu 8988t C87(0.60)  LDD1370  [8]
 LDCM0492  CL97 PaTu 8988t C87(0.66)  LDD1371  [8]
 LDCM0493  CL98 PaTu 8988t C87(0.68)  LDD1372  [8]
 LDCM0494  CL99 PaTu 8988t C87(0.70)  LDD1373  [8]
 LDCM0468  Fragment33 PaTu 8988t C87(0.97)  LDD1347  [8]
 LDCM0427  Fragment51 PaTu 8988t C87(1.37)  LDD1306  [8]
 LDCM0107  IAA HeLa N.A.  LDD0221  [6]
 LDCM0022  KB02 22RV1 C78(1.29); C115(1.42)  LDD2243  [9]
 LDCM0023  KB03 Jurkat C115(4.23)  LDD0209  [3]
 LDCM0024  KB05 HMCB C78(1.29); C115(1.35)  LDD3312  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glutathione S-transferase Mu 3 (GSTM3) Mu family P21266
Glutathione S-transferase Mu 5 (GSTM5) Mu family P46439
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amitriptyline Small molecular drug DB00321
Deoxycholic Acid Small molecular drug DB03619
Glutathione Small molecular drug DB00143
Glutathione Disulfide Small molecular drug DB03310
Investigative
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gamma-glutamyl[S-(2-iodobenzyl)Cysteinyl]Glycine Small molecular drug DB03597
S-hexylglutathione Small molecular drug DB04132
1-hydroxy-2-s-glutathionyl-3-para-nitrophenoxy-propane . DB03706
Glutathione Sulfonic Acid . DB03003
S-octylglutathione . DB03032

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840