Details of the Target

General Information of Target

Target ID LDTP02829
Target Name Integrin beta-4 (ITGB4)
Gene Name ITGB4
Gene ID 3691
Synonyms
Integrin beta-4; GP150; CD antigen CD104
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGPRPSPWARLLLAALISVSLSGTLANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRR
CNTQAELLAAGCQRESIVVMESSFQITEETQIDTTLRRSQMSPQGLRVRLRPGEERHFEL
EVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSV
PQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAIL
QTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYR
TQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLE
EAFNRIRSNLDIRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDG
THVCQLPEDQKGNIHLKPSFSDGLKMDAGIICDVCTCELQKEVRSARCSFNGDFVCGQCV
CSEGWSGQTCNCSTGSLSDIQPCLREGEDKPCSGRGECQCGHCVCYGEGRYEGQFCEYDN
FQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCPLSNATCIDSNGGICNGRGHCECGR
CHCHQQSLYTDTICEINYSAIHPGLCEDLRSCVQCQAWGTGEKKGRTCEECNFKVKMVDE
LKRAEEVVVRCSFRDEDDDCTYSYTMEGDGAPGPNSTVLVHKKKDCPPGSFWWLIPLLLL
LLPLLALLLLLCWKYCACCKACLALLPCCNRGHMVGFKEDHYMLRENLMASDHLDTPMLR
SGNLKGRDVVRWKVTNNMQRPGFATHAASINPTELVPYGLSLRLARLCTENLLKPDTREC
AQLRQEVEENLNEVYRQISGVHKLQQTKFRQQPNAGKKQDHTIVDTVLMAPRSAKPALLK
LTEKQVEQRAFHDLKVAPGYYTLTADQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQL
LVEAIDVPAGTATLGRRLVNITIIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGG
KSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLRGRQVRRFH
VQLSNPKFGAHLGQPHSTTIIIRDPDELDRSFTSQMLSSQPPPHGDLGAPQNPNAKAAGS
RKIHFNWLPPSGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYG
AQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLV
NDDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQP
KRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPSVSDDTGCGWKFEPLLG
EELDLRRVTWRLPPELIPRLSASSGRSSDAEAPHGPPDDGGAGGKGGSLPRSATPGPPGE
HLVNGRMDFAFPGSTNSLHRMTTTSAAAYGTHLSPHVPHRVLSTSSTLTRDYNSLTRSEH
SHSTTLPRDYSTLTSVSSHDSRLTAGVPDTPTRLVFSALGPTSLRVSWQEPRCERPLQGY
SVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIES
QVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEM
AQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGG
PFPQLGSRAGLFQHPLQSEYSSITTTHTSATEPFLVDGLTLGAQHLEAGGSLTRHVTQEF
VSRTLTTSGTLSTHMDQQFFQT
Target Bioclass
Other
Family
Integrin beta chain family
Subcellular location
Cell membrane
Function
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.
Uniprot ID
P16144
Ensemble ID
ENST00000200181.8
HGNC ID
HGNC:6158

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8505C SNV: p.G507S DBIA    Probe Info 
ABC1 SNV: p.I434M DBIA    Probe Info 
AN3CA SNV: p.Y618C DBIA    Probe Info 
CCK81 SNV: p.E532A DBIA    Probe Info 
HCT15 SNV: p.M686V DBIA    Probe Info 
HEC1 SNV: p.P181L DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.Q501R; p.L629P DBIA    Probe Info 
KYSE410 Deletion: p.D1367EfsTer77 DBIA    Probe Info 
KYSE510 SNV: p.S1167F DBIA    Probe Info 
LNCaP clone FGC SNV: p.E404Ter .
LS180 SNV: p.W194Ter DBIA    Probe Info 
MEWO SNV: p.G782E DBIA    Probe Info 
MOLT4 SNV: p.D176N; p.D836N .
NCIH1155 SNV: p.D679E; p.A1135V DBIA    Probe Info 
NCIH2286 SNV: p.W251C .
OV90 SNV: p.A1033T DBIA    Probe Info 
PF382 SNV: p.C680G .
REH Deletion: p.F201SfsTer9 .
RKO SNV: p.P438H DBIA    Probe Info 
RL952 Deletion: p.P1130RfsTer30
SNV: p.S696N		 DBIA    Probe Info 
SSP25 SNV: p.S513F DBIA    Probe Info 
SW1783 SNV: p.R791C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-4
 Probe Info  		100.00  LDD0445  [1]
ONAyne
 Probe Info  		K1021(5.00); K785(1.96)  LDD0274  [2]
STPyne
 Probe Info  		K1021(9.25); K1272(1.85); K1279(10.00); K1299(10.00)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K392(0.94); K388(0.94); K151(1.53); K662(1.57)  LDD3494  [3]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [4]
Curcusone 37
 Probe Info  		2.47  LDD0188  [5]
Jackson_1
 Probe Info  		10.38  LDD0120  [6]
DBIA
 Probe Info  		C742(1.18); C748(1.18); C749(1.18); C288(0.93)  LDD0078  [7]
IA-alkyne
 Probe Info  		C551(0.00); C828(0.00); C288(0.00); C424(0.00)  LDD0162  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
NAIA_5
 Probe Info  		C1553(0.00); C288(0.00); C245(0.00); C828(0.00)  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C742(0.97); C748(0.94); C749(0.94); C596(0.74)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C742(1.13); C748(1.10); C749(1.09); C596(1.27)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C748(1.18); C749(1.15); C596(0.99); C598(0.98)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C748(1.31); C749(1.18); C596(0.77); C598(0.93)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C748(0.96); C749(1.03); C596(0.89); C598(0.88)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C748(1.29); C749(1.38); C596(0.77); C598(0.88)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C748(1.26); C749(1.16); C596(0.87); C598(0.94)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C748(1.06); C749(1.21); C596(0.89); C598(1.11)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C748(1.11); C749(1.27); C596(0.86); C598(0.98)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C748(1.42); C749(1.30); C596(1.22); C598(1.11)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C748(0.98); C749(1.00); C596(0.77); C598(1.05)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C748(1.08); C749(0.96); C596(0.67); C598(0.81)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C742(1.18); C748(1.17); C749(1.15); C596(1.30)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C748(1.20); C749(0.99); C596(0.63); C598(1.03)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C748(1.00); C749(1.05); C596(0.64); C598(0.89)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C748(1.04); C749(1.13); C596(0.92); C598(1.02)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C742(0.94); C748(0.96); C749(0.96); C596(1.05)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C742(1.04); C748(1.02); C749(1.05); C596(1.00)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C742(1.19); C748(1.15); C749(1.17); C596(0.96)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C742(1.40); C748(1.58); C749(1.41); C596(1.13)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C742(1.18); C748(1.09); C749(1.10); C596(1.00)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C742(0.96); C748(0.96); C749(0.99); C596(1.03)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C742(1.17); C748(1.13); C749(1.17); C596(1.04)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C742(1.00); C748(1.00); C749(0.99); C596(1.02)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C742(1.32); C748(1.31); C749(1.31); C596(1.08)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C742(0.88); C748(0.89); C749(0.85); C596(1.15)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C742(0.99); C748(0.97); C749(0.98); C596(1.13)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C742(1.00); C748(0.91); C749(0.93); C596(1.02)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C742(1.11); C748(1.04); C749(1.05); C596(0.95)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C742(1.10); C748(1.09); C749(1.09); C596(1.06)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C742(1.29); C748(1.21); C749(1.18); C596(1.29)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C742(1.25); C748(1.23); C749(1.21); C596(1.11)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C742(1.62); C748(1.45); C749(1.45); C1190(0.83)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C742(1.27); C748(1.26); C749(1.26); C1190(1.15)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C742(1.41); C748(1.37); C749(1.37); C1190(0.92)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C742(0.83); C748(0.97); C749(0.97); C1190(1.17)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C742(0.93); C748(1.10); C749(1.10); C1190(0.94)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C742(1.23); C748(1.24); C749(1.24); C1190(0.94)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C742(1.48); C748(1.53); C749(1.53); C1190(0.91)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C742(1.29); C748(1.34); C749(1.34); C1190(0.92)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C742(0.98); C748(1.13); C749(1.13); C1190(0.95)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C742(0.88); C748(1.11); C749(1.11); C1190(0.97)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C742(1.11); C748(1.29); C749(1.29); C1190(0.96)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C742(1.24); C748(1.41); C749(1.41); C1190(0.99)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C742(1.03); C748(0.99); C749(0.98); C596(1.10)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C742(1.18); C748(1.43); C749(1.43); C1190(0.91)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C742(0.99); C748(1.22); C749(1.22); C1190(0.93)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C742(0.83); C748(0.98); C749(0.98); C1190(1.24)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C742(1.02); C748(1.03); C749(1.03); C596(0.60)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C1190(0.77); C648(0.78); C651(0.78); C1213(0.86)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C648(0.62); C651(0.62); C1213(0.80); C551(0.83)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C596(0.66); C648(0.74); C651(0.74); C1213(0.87)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C1213(0.69); C1197(0.71); C632(0.84); C1190(0.85)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C648(0.61); C651(0.61); C1213(0.73); C536(0.81)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C1197(0.66); C648(0.68); C651(0.68); C1213(0.82)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C598(0.83); C543(0.86); C61(0.90); C72(0.90)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C38(0.72); C1197(0.79); C551(0.95); C452(0.97)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C648(0.66); C651(0.66); C551(0.84); C1213(0.90)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C536(0.82); C1213(0.83); C551(0.90); C1190(0.91)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C648(0.50); C651(0.50); C1197(0.60); C1213(0.62)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C742(1.45); C748(1.47); C749(1.45); C596(1.12)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C742(1.36); C748(1.41); C749(1.38); C596(1.12)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C742(1.08); C748(1.12); C749(1.11); C596(0.79)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C742(1.07); C748(1.08); C749(1.06); C596(1.02)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C1371(0.78); C457(0.83); C38(0.86); C452(0.89)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C1190(0.68); C457(0.73); C61(0.77); C72(0.77)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C457(0.75); C635(0.89); C632(0.93); C1190(0.94)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C596(0.52); C457(0.62); C452(0.69); C828(0.75)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C1197(0.90); C1213(0.90); C1190(0.92); C457(0.95)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C1197(0.76); C1213(0.76); C1371(0.81); C1190(0.88)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C457(0.77); C1190(0.91); C1371(0.93); C288(0.97)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C1190(0.82); C455(0.88); C452(0.92); C457(0.95)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C1371(0.64); C457(0.78); C1190(0.93); C288(0.94)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C1197(0.93); C1213(0.93); C651(0.96); C457(0.97)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C1197(0.65); C1213(0.65); C828(0.85); C1190(0.87)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C1197(0.68); C1213(0.68); C1190(0.82); C457(0.90)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C457(0.82); C1190(0.89); C828(0.89); C651(0.98)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C1190(0.75); C828(0.86); C457(1.00); C1197(1.04)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C596(0.59); C457(0.68); C536(0.74); C288(0.77)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C1197(0.64); C1213(0.64); C1190(0.73); C648(0.91)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C1197(0.84); C1213(0.84); C1190(0.86); C457(0.95)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C1197(0.60); C1213(0.60); C1190(0.63); C457(0.90)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C1197(0.59); C1213(0.59); C1190(0.87); C457(0.96)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C1197(0.69); C1213(0.69); C1190(0.84); C457(0.85)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C1371(0.77); C536(0.79); C598(0.83); C455(0.84)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C457(0.74); C1371(0.79); C455(0.83); C632(0.88)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C1371(0.46); C632(0.86); C455(0.91); C635(0.91)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C1371(0.84); C543(0.89); C596(0.90); C598(0.91)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C1371(0.71); C452(0.92); C61(0.93); C72(0.93)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C1190(0.61); C596(0.61); C457(0.64); C1197(0.73)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C1371(0.72); C536(0.82); C457(0.84); C452(0.90)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C1371(0.64); C455(0.80); C635(0.84); C457(0.85)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C457(0.85); C536(0.89); C1197(0.90); C635(0.91)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C457(0.82); C1371(0.84); C635(0.88); C61(0.90)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C1371(0.60); C457(0.88); C61(0.90); C72(0.90)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C1371(0.52); C1190(0.77); C452(0.83); C455(0.88)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C38(0.83); C596(0.94); C288(0.95); C457(0.95)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C1197(0.83); C38(0.91); C455(0.91); C1190(0.91)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C288(0.97); C1197(1.01); C38(1.02); C455(1.03)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C1197(0.68); C61(0.75); C648(0.82); C651(0.82)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C596(0.54); C1190(0.66); C1197(0.66); C1213(0.66)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C1190(0.73); C1213(0.76); C1197(0.78); C38(0.84)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C38(0.83); C455(0.84); C1197(1.04); C632(1.07)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C596(0.81); C455(0.85); C598(0.88); C61(0.88)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C38(0.71); C1197(0.83); C1213(0.88); C455(0.96)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C38(0.76); C1190(0.90); C61(0.90); C288(0.96)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C1197(0.79); C61(0.83); C1213(0.84); C648(0.86)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C61(0.73); C648(0.74); C651(0.74); C1213(0.75)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C596(0.77); C598(0.84); C457(0.87); C1197(0.88)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C596(0.71); C536(0.77); C543(0.77); C1197(0.80)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C38(0.72); C536(0.81); C543(0.81); C1190(0.83)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C1197(0.77); C1213(0.77); C536(0.81); C1190(0.82)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C596(0.83); C1190(0.85); C598(0.89); C635(0.92)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C38(0.70); C1190(0.89); C452(0.92); C596(0.94)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C38(0.65); C596(0.70); C536(0.73); C543(0.73)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C38(0.70); C596(0.85); C1190(0.86); C635(0.89)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C38(0.59); C596(0.72); C536(0.74); C543(0.74)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C596(0.43); C598(0.50); C536(0.73); C543(0.73)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C596(0.59); C38(0.66); C598(0.66); C536(0.75)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C536(0.40); C543(0.40); C596(0.40); C598(0.51)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C648(0.80); C651(0.80); C452(0.88); C457(0.88)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C38(0.65); C543(0.80); C452(0.80); C457(0.80)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C1197(0.81); C1213(0.81); C38(0.89); C61(0.96)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C38(0.56); C648(0.69); C651(0.69); C1213(0.73)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C648(0.51); C651(0.51); C543(0.94); C632(0.97)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C648(0.72); C651(0.72); C543(0.81); C596(0.90)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C648(0.52); C651(0.52); C543(0.62); C1213(0.65)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C648(0.49); C651(0.49); C543(0.65); C536(0.70)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C648(0.48); C651(0.48); C543(0.52); C536(0.61)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C648(0.62); C651(0.62); C38(0.66); C543(0.81)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C648(0.57); C651(0.57); C1213(0.74); C1197(0.81)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C648(0.65); C651(0.65); C38(0.69); C61(0.82)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C648(0.62); C651(0.62); C1213(0.89); C596(0.90)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C61(0.74); C72(0.74); C1197(0.79); C1213(0.79)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C596(0.86); C543(0.87); C632(0.88); C38(0.88)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C38(0.72); C543(0.89); C596(0.93); C648(0.94)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C543(0.25); C648(0.27); C651(0.27); C536(0.29)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C1197(0.59); C1213(0.59); C1190(0.64); C536(0.76)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C1197(0.43); C1213(0.43); C1190(0.67); C635(0.82)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C1197(0.45); C1213(0.45); C1190(0.69); C635(1.01)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C1197(0.36); C1213(0.36); C1190(0.66); C598(0.91)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C1197(0.35); C1213(0.35); C1190(0.85); C598(0.86)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C1197(0.37); C1213(0.37); C1190(0.70); C598(0.74)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C1197(0.41); C1213(0.41); C1190(0.69); C598(0.75)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C1197(0.28); C1213(0.28); C1190(0.71); C1371(0.91)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C1190(0.64); C536(0.70); C1197(0.75); C1213(0.75)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C1197(0.48); C1213(0.48); C1190(0.58); C536(0.86)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C1197(0.42); C1213(0.42); C1190(0.75); C551(0.90)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C1190(0.89); C635(0.93); C457(0.97); C632(0.99)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C1197(0.25); C1213(0.25); C635(0.92); C455(1.03)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C1190(0.80); C598(0.86); C596(0.91); C635(0.94)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C1197(0.28); C1213(0.28); C1190(0.72); C635(0.90)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C648(0.19); C651(0.19); C536(0.23); C543(0.27)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C648(0.47); C651(0.47); C1213(0.56); C1197(0.63)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C742(0.92); C748(0.87); C749(0.87); C596(1.04)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C543(0.71); C1197(0.89); C1213(0.89); C536(0.92)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C1197(0.72); C1213(0.72); C1190(0.80); C543(0.81)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C742(1.18); C748(1.18); C749(1.18); C288(0.93)  LDD0078  [7]
 LDCM0070  Cisar_cp37 MDA-MB-231 10.38  LDD0120  [6]
 LDCM0367  CL1 HCT 116 C1371(0.83); C648(0.86); C651(0.86); C38(0.88)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C1197(0.73); C1213(0.73); C1190(0.88); C598(1.02)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C1190(0.71); C457(0.73); C596(0.80); C452(0.80)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C38(0.77); C1197(0.87); C1213(0.87); C828(0.91)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C828(0.82); C543(0.90); C38(0.93); C1197(0.95)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C536(0.83); C543(0.90); C38(0.92); C452(0.95)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C38(0.89); C536(0.90); C543(0.94); C828(1.00)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C1190(0.75); C457(0.76); C1197(0.86); C1213(0.86)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C1190(0.75); C457(0.82); C38(0.89); C61(0.95)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C1190(0.72); C1371(0.77); C38(0.90); C457(0.95)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C1190(0.76); C1371(0.80); C38(0.91); C457(0.94)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C457(0.80); C1371(0.90); C1190(0.91); C38(0.96)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C1197(0.70); C1213(0.70); C598(0.80); C1190(0.81)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C1190(0.78); C1371(0.88); C1197(0.92); C1213(0.92)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C457(0.74); C1190(0.81); C1371(0.94); C288(0.97)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C828(0.76); C1190(0.83); C1197(0.94); C1213(0.94)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C1197(0.64); C1213(0.64); C1190(0.70); C457(0.87)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C1190(0.69); C1197(0.85); C1213(0.85); C828(0.87)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C1197(0.76); C1213(0.76); C1190(0.77); C828(0.85)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C1197(0.68); C1213(0.68); C1190(0.87); C828(0.91)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C1213(0.72); C61(0.76); C72(0.76); C1197(0.77)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C1371(0.75); C1190(0.77); C635(0.92); C452(0.93)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C1371(0.68); C536(0.87); C457(0.90); C455(0.90)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C1197(0.55); C1213(0.55); C1190(0.74); C598(1.01)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C1213(0.85); C1197(0.86); C455(0.86); C536(0.90)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C38(0.71); C288(0.90); C1197(0.91); C72(0.92)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C61(0.94); C38(0.94); C648(0.98); C651(0.98)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C1190(0.90); C1197(0.94); C1213(0.97); C632(1.04)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C38(0.83); C1197(0.88); C1190(0.91); C648(0.94)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C38(0.66); C635(0.91); C1371(0.92); C632(0.93)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C38(0.75); C635(0.80); C551(0.86); C536(0.86)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C536(0.70); C543(0.70); C38(0.81); C457(0.86)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C38(0.55); C457(0.86); C635(0.86); C1190(0.88)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C1197(0.65); C1213(0.65); C648(0.79); C651(0.79)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C648(0.73); C651(0.73); C1197(0.86); C1213(0.86)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C648(0.73); C651(0.73); C1197(0.82); C1213(0.82)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C596(0.90); C288(0.90); C61(0.92); C72(0.92)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C61(0.74); C72(0.74); C1197(0.97); C635(0.97)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C1371(0.87); C749(0.95); C748(0.96); C742(0.96)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C1197(0.87); C1190(0.90); C61(0.95); C72(0.95)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C598(0.85); C648(0.93); C651(0.93); C1371(0.96)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C1190(0.74); C1213(0.78); C1197(0.85); C61(0.91)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C1190(0.77); C1213(0.79); C1197(0.79); C61(0.94)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C1213(0.59); C1197(0.60); C1190(0.61); C61(0.79)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C536(0.43); C543(0.43); C61(0.86); C72(0.86)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C1190(0.73); C1197(0.74); C1213(0.76); C452(0.95)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C742(16.19); C748(14.76); C749(13.18); C596(1.78)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C742(1.39); C748(1.41); C749(1.39); C596(0.78)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C742(1.29); C748(1.26); C749(1.23); C596(1.63)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C742(2.07); C748(2.03); C749(2.03); C596(1.22)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C742(1.29); C748(1.26); C749(1.23); C596(1.15)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C742(1.88); C748(1.74); C749(1.59); C598(0.86)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C742(1.16); C748(1.18); C749(1.18); C596(0.94)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C742(1.36); C748(1.87); C749(1.87); C1190(0.93)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C742(1.50); C748(1.52); C749(1.52); C596(1.14)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C742(20.00); C748(12.20); C749(12.20); C596(0.70)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C742(2.49); C748(2.76); C749(2.76); C596(0.98)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C742(1.69); C748(1.49); C749(1.49); C596(0.93)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C742(1.63); C748(3.73); C749(3.73); C596(0.82)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C742(2.46); C748(2.74); C749(2.74); C596(0.79)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C742(2.80); C748(2.55); C749(2.55); C596(0.48)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C742(11.42); C748(10.67); C749(7.76); C598(0.55)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C742(2.09); C748(1.64); C749(1.64); C596(0.37)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C742(2.20); C748(1.80); C749(1.80); C596(0.48)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C742(4.46); C748(4.91); C749(4.91); C596(0.45)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C742(1.48); C748(1.79); C749(1.79); C596(0.42)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C742(1.83); C748(1.99); C749(1.99); C596(0.53)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C742(2.03); C748(2.41); C749(2.41); C596(0.50)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C742(0.98); C748(1.02); C749(1.02); C1190(1.34)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C742(0.87); C748(0.90); C749(0.90); C1190(1.14)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C742(1.29); C748(1.28); C749(1.28); C1190(1.12)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C742(1.53); C748(1.59); C749(1.59); C1190(1.21)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C742(1.02); C748(0.93); C749(0.84); C598(0.97)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C742(1.73); C748(1.71); C749(1.71); C1190(1.09)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C742(1.11); C748(1.27); C749(1.27); C1190(1.16)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C742(0.94); C748(1.26); C749(1.26); C1190(1.13)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C742(2.09); C748(2.53); C749(2.53); C1190(1.13)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C742(3.16); C748(3.69); C749(3.69); C1190(1.18)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C742(0.73); C748(1.02); C749(1.02); C1190(1.28)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C742(0.87); C748(0.90); C749(0.90); C1190(0.99)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C742(1.13); C748(1.17); C749(1.17); C1190(1.18)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C742(0.86); C748(0.89); C749(0.89); C1190(1.14)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C742(0.98); C748(0.97); C749(0.97); C1190(1.11)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C742(4.99); C748(4.90); C749(4.81); C598(0.89)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C742(1.34); C748(1.18); C749(1.18); C1190(1.06)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C742(0.99); C748(1.09); C749(1.12); C596(1.09)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C742(1.09); C748(1.11); C749(1.13); C596(1.30)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C742(5.36); C748(1.28); C749(3.96); C596(1.13)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C742(0.85); C748(5.10); C749(5.13); C596(1.36)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C742(0.93); C748(1.10); C749(1.13); C596(1.16)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C742(1.78); C748(1.80); C749(1.80); C596(1.37)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C742(1.26); C748(1.34); C749(1.36); C596(1.04)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C742(1.76); C748(1.71); C749(1.74); C596(1.45)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C742(1.98); C748(1.97); C749(2.03); C596(1.90)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C742(1.79); C748(1.60); C749(1.52); C598(1.13)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C742(1.17); C748(1.35); C749(1.37); C596(1.12)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C742(1.63); C748(1.72); C749(1.78); C596(1.13)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C742(1.07); C748(1.05); C749(1.06); C596(0.99)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C742(2.95); C748(3.03); C749(3.13); C596(1.28)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C742(1.15); C748(1.21); C749(1.22); C596(1.16)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C742(1.18); C748(1.13); C749(1.13); C596(0.65)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C742(3.48); C748(3.57); C749(3.57); C596(0.93)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C742(2.16); C748(1.63); C749(1.63); C596(0.71)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C742(1.39); C748(1.41); C749(1.41); C596(0.74)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C742(1.44); C748(1.26); C749(1.09); C598(1.18)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C742(0.96); C748(1.04); C749(1.04); C596(0.72)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C742(1.23); C748(1.34); C749(1.34); C596(0.98)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C742(1.67); C748(1.82); C749(1.82); C596(1.07)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C742(3.15); C748(4.61); C749(4.61); C596(0.85)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C742(10.04); C748(9.22); C749(9.22); C596(0.74)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C742(1.43); C748(1.43); C749(1.43); C596(0.74)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C742(1.22); C748(1.29); C749(1.29); C596(0.61)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C742(1.77); C748(1.69); C749(1.69); C596(0.62)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C742(1.76); C748(1.64); C749(1.64); C596(0.73)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C742(3.01); C748(2.81); C749(2.81); C596(0.75)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C742(1.61); C748(1.46); C749(1.31); C598(1.12)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C742(11.56); C748(12.62); C749(12.62); C596(0.54)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C742(1.31); C748(1.22); C749(1.22); C596(1.20)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C742(2.49); C748(2.62); C749(2.62); C596(1.37)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C742(2.04); C748(2.04); C749(2.04); C596(1.35)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C742(2.11); C748(1.95); C749(1.95); C596(0.83)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C742(3.09); C748(4.72); C749(4.72); C596(0.84)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C742(4.39); C748(4.52); C749(4.52); C596(1.26)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C742(4.77); C748(6.13); C749(6.13); C596(1.05)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C742(1.51); C748(1.58); C749(1.58); C596(0.96)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C742(1.16); C748(1.03); C749(1.03); C596(1.00)  LDD0811  [7]
 LDCM0033  Curcusone1d MCF-7 2.47  LDD0188  [5]
 LDCM0634  CY-0357 Hep-G2 C288(0.90)  LDD2228  [10]
 LDCM0468  Fragment33 HCT 116 C742(1.48); C748(1.46); C749(1.47); C596(1.40)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C742(2.59); C748(2.86); C749(2.86); C596(0.62)  LDD0744  [7]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [4]
 LDCM0022  KB02 769-P C1553(1.22); C828(1.32)  LDD2246  [11]
 LDCM0023  KB03 769-P C1553(1.15); C828(1.57)  LDD2663  [11]
 LDCM0024  KB05 HMCB C1553(1.21); C245(2.96); C828(1.64); C1678(1.60)  LDD3312  [11]
 LDCM0021  THZ1 HCT 116 C742(1.36); C748(1.36); C749(1.36); C1371(1.29)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Focal adhesion kinase 1 (PTK2) Tyr protein kinase family Q05397
Protein-glutamine gamma-glutamyltransferase K (TGM1) Transglutaminase family P22735
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Arrestin domain-containing protein 3 (ARRDC3) Arrestin family Q96B67
Integrin alpha-6 (ITGA6) Integrin alpha chain family P23229
MyoD family inhibitor (MDFI) MDFI family Q99750
Phospholipid scramblase 4 (PLSCR4) Phospholipid scramblase family Q9NRQ2
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
POU domain class 2-associating factor 1 (POU2AF1) POU2AF family Q16633
Myogenic factor 5 (MYF5) . P13349
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sphingosine 1-phosphate receptor 2 (S1PR2) G-protein coupled receptor 1 family O95136
Sphingosine 1-phosphate receptor 3 (S1PR3) G-protein coupled receptor 1 family Q99500
Other
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 12-3 (KRTAP12-3) KRTAP type 12 family P60328
Keratin-associated protein 2-4 (KRTAP2-4) KRTAP type 2 family Q9BYR9
Keratin-associated protein 3-1 (KRTAP3-1) KRTAP type 3 family Q9BYR8
Keratin-associated protein 4-2 (KRTAP4-2) KRTAP type 4 family Q9BYR5
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 9-2 (KRTAP9-2) KRTAP type 9 family Q9BYQ4
Keratin-associated protein 9-3 (KRTAP9-3) KRTAP type 9 family Q9BYQ3
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Plectin (PLEC) Plakin or cytolinker family Q15149
Keratin-associated protein 15-1 (KRTAP15-1) PMG family Q3LI76
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
Amyloid protein-binding protein 2 (APPBP2) . Q92624
Extracellular matrix protein 1 (ECM1) . Q16610
Keratin-associated protein 17-1 (KRTAP17-1) . Q9BYP8
Keratinocyte proline-rich protein (KPRP) . Q5T749

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
R1295 Small molecular drug DB05122

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
5 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
6 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840