Details of the Target

General Information of Target

Target ID LDTP10799
Target Name GPI transamidase component PIG-S (PIGS)
Gene Name PIGS
Gene ID 94005
Synonyms
GPI transamidase component PIG-S; Phosphatidylinositol-glycan biosynthesis class S protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAARATTPADGEEPAPEAEALAAARERSSRFLSGLELVKQGAEARVFRGRFQGRAAVIK
HRFPKGYRHPALEARLGRRRTVQEARALLRCRRAGISAPVVFFVDYASNCLYMEEIEGSV
TVRDYIQSTMETEKTPQGLSNLAKTIGQVLARMHDEDLIHGDLTTSNMLLKPPLEQLNIV
LIDFGLSFISALPEDKGVDLYVLEKAFLSTHPNTETVFEAFLKSYSTSSKKARPVLKKLD
EVRLRGRKRSMVG
Target Bioclass
Other
Family
PIGS family
Subcellular location
Endoplasmic reticulum membrane
Function Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates.
Uniprot ID
Q96S52
Ensemble ID
ENST00000308360.8
HGNC ID
HGNC:14937

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO678 SNV: p.G172R .
J82 SNV: p.P306Q .
NCIH23 SNV: p.I181F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K106(5.90)  LDD0277  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
P11
 Probe Info  		20.00  LDD0201  [3]
DBIA
 Probe Info  		C408(1.52)  LDD3312  [4]
Jackson_1
 Probe Info  		2.12  LDD0120  [5]
Acrolein
 Probe Info  		N.A.  LDD0222  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
Ox-W18
 Probe Info  		N.A.  LDD2175  [9]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C388
 Probe Info  		41.36  LDD2047  [10]
STS-2
 Probe Info  		N.A.  LDD0138  [11]
VE-P
 Probe Info  		N.A.  LDD0396  [12]
Alk-rapa
 Probe Info  		4.53  LDD0213  [13]
OEA-DA
 Probe Info  		9.37  LDD0046  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C408(0.98)  LDD1507  [15]
 LDCM0215  AC10 HEK-293T C408(1.03)  LDD0813  [16]
 LDCM0216  AC100 HEK-293T C408(1.12)  LDD0814  [16]
 LDCM0217  AC101 HEK-293T C408(0.87)  LDD0815  [16]
 LDCM0218  AC102 HEK-293T C408(1.05)  LDD0816  [16]
 LDCM0219  AC103 HEK-293T C408(1.07)  LDD0817  [16]
 LDCM0220  AC104 HEK-293T C408(1.23)  LDD0818  [16]
 LDCM0221  AC105 HEK-293T C408(0.85)  LDD0819  [16]
 LDCM0222  AC106 HEK-293T C408(0.64)  LDD0820  [16]
 LDCM0223  AC107 HEK-293T C408(0.92)  LDD0821  [16]
 LDCM0224  AC108 HEK-293T C408(0.81)  LDD0822  [16]
 LDCM0225  AC109 HEK-293T C408(0.81)  LDD0823  [16]
 LDCM0226  AC11 HEK-293T C408(0.85)  LDD0824  [16]
 LDCM0227  AC110 HEK-293T C408(1.22)  LDD0825  [16]
 LDCM0228  AC111 HEK-293T C408(1.53)  LDD0826  [16]
 LDCM0229  AC112 HEK-293T C408(1.31)  LDD0827  [16]
 LDCM0237  AC12 HEK-293T C408(0.97)  LDD0835  [16]
 LDCM0259  AC14 HEK-293T C408(0.88)  LDD0857  [16]
 LDCM0270  AC15 HEK-293T C408(1.21)  LDD0868  [16]
 LDCM0276  AC17 HEK-293T C408(1.12)  LDD1515  [15]
 LDCM0277  AC18 HEK-293T C408(1.13)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C408(0.81)  LDD1517  [15]
 LDCM0279  AC2 HEK-293T C408(1.15)  LDD1518  [15]
 LDCM0280  AC20 HEK-293T C408(1.04)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C408(1.11)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C408(1.28)  LDD1521  [15]
 LDCM0283  AC23 HEK-293T C408(0.89)  LDD1522  [15]
 LDCM0284  AC24 HEK-293T C408(1.15)  LDD1523  [15]
 LDCM0285  AC25 HEK-293T C408(1.02)  LDD1524  [15]
 LDCM0286  AC26 HEK-293T C408(0.95)  LDD1525  [15]
 LDCM0287  AC27 HEK-293T C408(0.81)  LDD1526  [15]
 LDCM0288  AC28 HEK-293T C408(1.09)  LDD1527  [15]
 LDCM0289  AC29 HEK-293T C408(0.82)  LDD1528  [15]
 LDCM0290  AC3 HEK-293T C408(0.80)  LDD1529  [15]
 LDCM0291  AC30 HEK-293T C408(1.11)  LDD1530  [15]
 LDCM0292  AC31 HEK-293T C408(0.90)  LDD1531  [15]
 LDCM0293  AC32 HEK-293T C408(1.01)  LDD1532  [15]
 LDCM0294  AC33 HEK-293T C408(1.02)  LDD1533  [15]
 LDCM0295  AC34 HEK-293T C408(1.06)  LDD1534  [15]
 LDCM0296  AC35 HEK-293T C408(0.70)  LDD0894  [16]
 LDCM0297  AC36 HEK-293T C408(1.03)  LDD0895  [16]
 LDCM0298  AC37 HEK-293T C408(1.10)  LDD0896  [16]
 LDCM0299  AC38 HEK-293T C408(0.99)  LDD0897  [16]
 LDCM0300  AC39 HEK-293T C408(0.78)  LDD0898  [16]
 LDCM0301  AC4 HEK-293T C408(1.02)  LDD1540  [15]
 LDCM0302  AC40 HEK-293T C408(1.00)  LDD0900  [16]
 LDCM0303  AC41 HEK-293T C408(0.84)  LDD0901  [16]
 LDCM0304  AC42 HEK-293T C408(0.88)  LDD0902  [16]
 LDCM0305  AC43 HEK-293T C408(0.74)  LDD0903  [16]
 LDCM0306  AC44 HEK-293T C408(1.07)  LDD0904  [16]
 LDCM0307  AC45 HEK-293T C408(0.90)  LDD0905  [16]
 LDCM0308  AC46 HEK-293T C408(1.01)  LDD0906  [16]
 LDCM0309  AC47 HEK-293T C408(1.00)  LDD0907  [16]
 LDCM0310  AC48 HEK-293T C408(1.14)  LDD0908  [16]
 LDCM0311  AC49 HEK-293T C408(1.08)  LDD0909  [16]
 LDCM0312  AC5 HEK-293T C408(0.79)  LDD1551  [15]
 LDCM0313  AC50 HEK-293T C408(1.14)  LDD0911  [16]
 LDCM0314  AC51 HEK-293T C408(1.49)  LDD0912  [16]
 LDCM0315  AC52 HEK-293T C408(1.45)  LDD0913  [16]
 LDCM0316  AC53 HEK-293T C408(1.11)  LDD0914  [16]
 LDCM0317  AC54 HEK-293T C408(1.31)  LDD0915  [16]
 LDCM0318  AC55 HEK-293T C408(1.15)  LDD0916  [16]
 LDCM0319  AC56 HEK-293T C408(1.18)  LDD0917  [16]
 LDCM0320  AC57 HEK-293T C408(1.14)  LDD1559  [15]
 LDCM0321  AC58 HEK-293T C408(1.05)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C408(0.89)  LDD1561  [15]
 LDCM0323  AC6 HEK-293T C408(0.85)  LDD0921  [16]
 LDCM0324  AC60 HEK-293T C408(1.07)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C408(0.78)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C408(1.16)  LDD1565  [15]
 LDCM0327  AC63 HEK-293T C408(0.90)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C408(0.94)  LDD1567  [15]
 LDCM0334  AC7 HEK-293T C408(1.11)  LDD0932  [16]
 LDCM0345  AC8 HEK-293T C408(1.34)  LDD0943  [16]
 LDCM0349  AC83 HEK-293T C408(0.79)  LDD0947  [16]
 LDCM0350  AC84 HEK-293T C408(1.70)  LDD0948  [16]
 LDCM0351  AC85 HEK-293T C408(1.32)  LDD0949  [16]
 LDCM0352  AC86 HEK-293T C408(0.86)  LDD0950  [16]
 LDCM0353  AC87 HEK-293T C408(1.34)  LDD0951  [16]
 LDCM0354  AC88 HEK-293T C408(1.24)  LDD0952  [16]
 LDCM0355  AC89 HEK-293T C408(0.94)  LDD0953  [16]
 LDCM0357  AC90 HEK-293T C408(2.05)  LDD0955  [16]
 LDCM0358  AC91 HEK-293T C408(0.88)  LDD0956  [16]
 LDCM0359  AC92 HEK-293T C408(1.04)  LDD0957  [16]
 LDCM0360  AC93 HEK-293T C408(1.51)  LDD0958  [16]
 LDCM0361  AC94 HEK-293T C408(2.59)  LDD0959  [16]
 LDCM0362  AC95 HEK-293T C408(1.00)  LDD0960  [16]
 LDCM0363  AC96 HEK-293T C408(1.51)  LDD0961  [16]
 LDCM0364  AC97 HEK-293T C408(2.27)  LDD0962  [16]
 LDCM0365  AC98 HEK-293T C408(0.88)  LDD0963  [16]
 LDCM0366  AC99 HEK-293T C408(1.25)  LDD0964  [16]
 LDCM0248  AKOS034007472 HEK-293T C408(1.01)  LDD0846  [16]
 LDCM0356  AKOS034007680 HEK-293T C408(0.96)  LDD0954  [16]
 LDCM0275  AKOS034007705 HEK-293T C408(1.28)  LDD0873  [16]
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0070  Cisar_cp37 MDA-MB-231 2.12  LDD0120  [5]
 LDCM0367  CL1 HEK-293T C408(1.23)  LDD1571  [15]
 LDCM0368  CL10 HEK-293T C408(1.41)  LDD1572  [15]
 LDCM0369  CL100 HEK-293T C408(1.14)  LDD1573  [15]
 LDCM0370  CL101 HEK-293T C408(1.35)  LDD0968  [16]
 LDCM0371  CL102 HEK-293T C408(1.37)  LDD0969  [16]
 LDCM0372  CL103 HEK-293T C408(1.22)  LDD0970  [16]
 LDCM0373  CL104 HEK-293T C408(0.93)  LDD0971  [16]
 LDCM0374  CL105 HEK-293T C408(0.97)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C408(0.88)  LDD1579  [15]
 LDCM0376  CL107 HEK-293T C408(1.10)  LDD1580  [15]
 LDCM0377  CL108 HEK-293T C408(1.03)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C408(1.13)  LDD1582  [15]
 LDCM0379  CL11 HEK-293T C408(1.91)  LDD1583  [15]
 LDCM0380  CL110 HEK-293T C408(0.77)  LDD1584  [15]
 LDCM0381  CL111 HEK-293T C408(1.07)  LDD1585  [15]
 LDCM0382  CL112 HEK-293T C408(1.09)  LDD1586  [15]
 LDCM0383  CL113 HEK-293T C408(0.97)  LDD1587  [15]
 LDCM0384  CL114 HEK-293T C408(0.98)  LDD1588  [15]
 LDCM0385  CL115 HEK-293T C408(1.08)  LDD1589  [15]
 LDCM0386  CL116 HEK-293T C408(1.09)  LDD1590  [15]
 LDCM0387  CL117 HEK-293T C408(1.15)  LDD0985  [16]
 LDCM0388  CL118 HEK-293T C408(0.89)  LDD0986  [16]
 LDCM0389  CL119 HEK-293T C408(0.98)  LDD0987  [16]
 LDCM0390  CL12 HEK-293T C408(1.95)  LDD1594  [15]
 LDCM0391  CL120 HEK-293T C408(0.83)  LDD0989  [16]
 LDCM0392  CL121 HEK-293T C408(1.23)  LDD0990  [16]
 LDCM0393  CL122 HEK-293T C408(1.24)  LDD0991  [16]
 LDCM0394  CL123 HEK-293T C408(1.60)  LDD0992  [16]
 LDCM0395  CL124 HEK-293T C408(1.20)  LDD0993  [16]
 LDCM0396  CL125 HEK-293T C408(0.99)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C408(0.97)  LDD1601  [15]
 LDCM0398  CL127 HEK-293T C408(1.12)  LDD1602  [15]
 LDCM0399  CL128 HEK-293T C408(1.28)  LDD1603  [15]
 LDCM0400  CL13 HEK-293T C408(0.82)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C408(1.02)  LDD1605  [15]
 LDCM0402  CL15 HEK-293T C408(1.12)  LDD1606  [15]
 LDCM0403  CL16 HEK-293T C408(1.19)  LDD1607  [15]
 LDCM0404  CL17 HEK-293T C408(1.15)  LDD1608  [15]
 LDCM0405  CL18 HEK-293T C408(1.08)  LDD1609  [15]
 LDCM0406  CL19 HEK-293T C408(1.81)  LDD1610  [15]
 LDCM0407  CL2 HEK-293T C408(1.14)  LDD1611  [15]
 LDCM0408  CL20 HEK-293T C408(1.01)  LDD1612  [15]
 LDCM0409  CL21 HEK-293T C408(2.90)  LDD1613  [15]
 LDCM0410  CL22 HEK-293T C408(1.23)  LDD1614  [15]
 LDCM0411  CL23 HEK-293T C408(1.90)  LDD1615  [15]
 LDCM0412  CL24 HEK-293T C408(2.28)  LDD1616  [15]
 LDCM0413  CL25 HEK-293T C408(1.12)  LDD1617  [15]
 LDCM0414  CL26 HEK-293T C408(0.84)  LDD1618  [15]
 LDCM0415  CL27 HEK-293T C408(1.01)  LDD1619  [15]
 LDCM0416  CL28 HEK-293T C408(1.08)  LDD1620  [15]
 LDCM0417  CL29 HEK-293T C408(1.01)  LDD1621  [15]
 LDCM0418  CL3 HEK-293T C408(1.11)  LDD1622  [15]
 LDCM0419  CL30 HEK-293T C408(1.08)  LDD1623  [15]
 LDCM0420  CL31 HEK-293T C408(1.68)  LDD1624  [15]
 LDCM0421  CL32 HEK-293T C408(1.11)  LDD1625  [15]
 LDCM0422  CL33 HEK-293T C408(4.37)  LDD1626  [15]
 LDCM0423  CL34 HEK-293T C408(1.20)  LDD1627  [15]
 LDCM0424  CL35 HEK-293T C408(1.86)  LDD1628  [15]
 LDCM0425  CL36 HEK-293T C408(2.28)  LDD1629  [15]
 LDCM0426  CL37 HEK-293T C408(0.98)  LDD1630  [15]
 LDCM0428  CL39 HEK-293T C408(1.22)  LDD1632  [15]
 LDCM0429  CL4 HEK-293T C408(1.22)  LDD1633  [15]
 LDCM0430  CL40 HEK-293T C408(1.25)  LDD1634  [15]
 LDCM0431  CL41 HEK-293T C408(1.05)  LDD1635  [15]
 LDCM0432  CL42 HEK-293T C408(1.40)  LDD1636  [15]
 LDCM0433  CL43 HEK-293T C408(1.80)  LDD1637  [15]
 LDCM0434  CL44 HEK-293T C408(1.04)  LDD1638  [15]
 LDCM0435  CL45 HEK-293T C408(2.71)  LDD1639  [15]
 LDCM0436  CL46 HEK-293T C408(1.29)  LDD1640  [15]
 LDCM0437  CL47 HEK-293T C408(1.83)  LDD1641  [15]
 LDCM0438  CL48 HEK-293T C408(2.38)  LDD1642  [15]
 LDCM0439  CL49 HEK-293T C408(1.11)  LDD1643  [15]
 LDCM0440  CL5 HEK-293T C408(1.03)  LDD1644  [15]
 LDCM0441  CL50 HEK-293T C408(1.06)  LDD1645  [15]
 LDCM0443  CL52 HEK-293T C408(1.17)  LDD1646  [15]
 LDCM0444  CL53 HEK-293T C408(1.13)  LDD1647  [15]
 LDCM0445  CL54 HEK-293T C408(1.39)  LDD1648  [15]
 LDCM0446  CL55 HEK-293T C408(1.71)  LDD1649  [15]
 LDCM0447  CL56 HEK-293T C408(1.01)  LDD1650  [15]
 LDCM0448  CL57 HEK-293T C408(4.05)  LDD1651  [15]
 LDCM0449  CL58 HEK-293T C408(1.10)  LDD1652  [15]
 LDCM0450  CL59 HEK-293T C408(1.93)  LDD1653  [15]
 LDCM0451  CL6 HEK-293T C408(1.22)  LDD1654  [15]
 LDCM0452  CL60 HEK-293T C408(2.22)  LDD1655  [15]
 LDCM0453  CL61 HEK-293T C408(1.59)  LDD1051  [16]
 LDCM0454  CL62 HEK-293T C408(1.56)  LDD1052  [16]
 LDCM0455  CL63 HEK-293T C408(1.86)  LDD1053  [16]
 LDCM0456  CL64 HEK-293T C408(1.69)  LDD1054  [16]
 LDCM0457  CL65 HEK-293T C408(1.40)  LDD1055  [16]
 LDCM0458  CL66 HEK-293T C408(1.54)  LDD1056  [16]
 LDCM0459  CL67 HEK-293T C408(1.20)  LDD1057  [16]
 LDCM0460  CL68 HEK-293T C408(1.57)  LDD1058  [16]
 LDCM0461  CL69 HEK-293T C408(1.53)  LDD1059  [16]
 LDCM0462  CL7 HEK-293T C408(1.70)  LDD1665  [15]
 LDCM0463  CL70 HEK-293T C408(1.14)  LDD1061  [16]
 LDCM0464  CL71 HEK-293T C408(1.54)  LDD1062  [16]
 LDCM0465  CL72 HEK-293T C408(1.53)  LDD1063  [16]
 LDCM0466  CL73 HEK-293T C408(1.53)  LDD1064  [16]
 LDCM0467  CL74 HEK-293T C408(2.47)  LDD1065  [16]
 LDCM0469  CL76 HEK-293T C408(0.86)  LDD1067  [16]
 LDCM0470  CL77 HEK-293T C408(1.18)  LDD1068  [16]
 LDCM0471  CL78 HEK-293T C408(0.69)  LDD1069  [16]
 LDCM0472  CL79 HEK-293T C408(1.06)  LDD1070  [16]
 LDCM0473  CL8 HEK-293T C408(1.22)  LDD1676  [15]
 LDCM0474  CL80 HEK-293T C408(0.78)  LDD1072  [16]
 LDCM0475  CL81 HEK-293T C408(1.20)  LDD1073  [16]
 LDCM0476  CL82 HEK-293T C408(1.19)  LDD1074  [16]
 LDCM0477  CL83 HEK-293T C408(1.55)  LDD1075  [16]
 LDCM0478  CL84 HEK-293T C408(1.03)  LDD1076  [16]
 LDCM0479  CL85 HEK-293T C408(0.78)  LDD1077  [16]
 LDCM0480  CL86 HEK-293T C408(0.75)  LDD1078  [16]
 LDCM0481  CL87 HEK-293T C408(1.21)  LDD1079  [16]
 LDCM0482  CL88 HEK-293T C408(1.04)  LDD1080  [16]
 LDCM0483  CL89 HEK-293T C408(0.92)  LDD1081  [16]
 LDCM0484  CL9 HEK-293T C408(3.65)  LDD1687  [15]
 LDCM0485  CL90 HEK-293T C408(1.46)  LDD1083  [16]
 LDCM0486  CL91 HEK-293T C408(1.42)  LDD1689  [15]
 LDCM0487  CL92 HEK-293T C408(1.52)  LDD1690  [15]
 LDCM0488  CL93 HEK-293T C408(2.21)  LDD1691  [15]
 LDCM0489  CL94 HEK-293T C408(1.16)  LDD1692  [15]
 LDCM0490  CL95 HEK-293T C408(1.42)  LDD1693  [15]
 LDCM0491  CL96 HEK-293T C408(1.62)  LDD1694  [15]
 LDCM0492  CL97 HEK-293T C408(1.18)  LDD1695  [15]
 LDCM0493  CL98 HEK-293T C408(0.95)  LDD1696  [15]
 LDCM0494  CL99 HEK-293T C408(1.12)  LDD1697  [15]
 LDCM0495  E2913 HEK-293T C408(1.25)  LDD1698  [15]
 LDCM0468  Fragment33 HEK-293T C408(2.23)  LDD1066  [16]
 LDCM0427  Fragment51 HEK-293T C408(0.95)  LDD1631  [15]
 LDCM0022  KB02 D283 Med C408(1.14)  LDD2312  [4]
 LDCM0023  KB03 Daoy C408(1.80)  LDD2731  [4]
 LDCM0024  KB05 HMCB C408(1.52)  LDD3312  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]
 LDCM0090  Rapamycin JHH-7 4.53  LDD0213  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 19-2 (KRTAP19-2) KRTAP type 19 family Q3LHN2
Keratin-associated protein 2-4 (KRTAP2-4) KRTAP type 2 family Q9BYR9
Keratin-associated protein 9-2 (KRTAP9-2) KRTAP type 9 family Q9BYQ4
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
GPI transamidase component PIG-T (PIGT) PIGT family Q969N2
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
12 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
13 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
14 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.