Details of the Target

General Information of Target

Target ID LDTP06177
Target Name Clathrin interactor 1 (CLINT1)
Gene Name CLINT1
Gene ID 9685
Synonyms
ENTH; EPN4; EPNR; KIAA0171; Clathrin interactor 1; Clathrin-interacting protein localized in the trans-Golgi region; Clint; Enthoprotin; Epsin-4; Epsin-related protein; EpsinR
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPEL
MNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEH
GKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFRYSERYDPEP
KSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISKFRRKDREDSPERCSDSDEEKKA
RRGRSPKGEFKDEEETVTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHYTGDKASP
DQNASTHTPQSSVKTSVPSSKSSGDLVDLFDGTSQSTGGSADLFGGFADFGSAAASGSFP
SQVTATSGNGDFGDWSAFNQAPSGPVASSGEFFGSASQPAVELVSGSQSALGPPPAASNS
SDLFDLMGSSQATMTSSQSMNFSMMSTNTVGLGLPMSRSQNTDMVQKSVSKTLPSTWSDP
SVNISLDNLLPGMQPSKPQQPSLNTMIQQQNMQQPMNVMTQSFGAVNLSSPSNMLPVRPQ
TNALIGGPMPMSMPNVMTGTMGMAPLGNTPMMNQSMMGMNMNIGMSAAGMGLTGTMGMGM
PNIAMTSGTVQPKQDAFANFANFSK
Target Bioclass
Transporter and channel
Family
Epsin family
Subcellular location
Cytoplasm
Function
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly.
Uniprot ID
Q14677
Ensemble ID
ENST00000411809.7
HGNC ID
HGNC:23186

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL33 SNV: p.M445V .
COLO792 SNV: p.P281S .
COLO800 SNV: p.K6R .
HCT15 SNV: p.P474H .
IM95 SNV: p.S323P .
KMRC3 SNV: p.K238R .
L428 SNV: p.M596K .
MEWO SNV: p.S334N .
SW756 SNV: p.R458T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y106(5.52)  LDD0257  [2]
YN-4
 Probe Info  		100.00  LDD0445  [3]
STPyne
 Probe Info  		K156(2.24); K200(5.26); K207(5.00); K218(6.65)  LDD0277  [4]
Probe 1
 Probe Info  		Y21(14.37); Y106(3.04); Y159(13.51); Y176(21.19)  LDD3495  [5]
Jackson_1
 Probe Info  		2.46  LDD0120  [6]
HHS-475
 Probe Info  		Y106(0.81)  LDD0264  [7]
DBIA
 Probe Info  		C231(0.91)  LDD1492  [8]
5E-2FA
 Probe Info  		H307(0.00); H292(0.00)  LDD2235  [9]
ATP probe
 Probe Info  		K218(0.00); K158(0.00)  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [11]
NAIA_5
 Probe Info  		N.A.  LDD2224  [12]
NHS
 Probe Info  		N.A.  LDD0010  [13]
OSF
 Probe Info  		N.A.  LDD0029  [14]
SF
 Probe Info  		Y106(0.00); Y293(0.00); Y159(0.00)  LDD0028  [14]
Ox-W18
 Probe Info  		N.A.  LDD2175  [15]
1c-yne
 Probe Info  		K158(0.00); K207(0.00)  LDD0228  [16]
Acrolein
 Probe Info  		H292(0.00); H261(0.00)  LDD0217  [17]
W1
 Probe Info  		N.A.  LDD0236  [18]
AOyne
 Probe Info  		5.60  LDD0443  [19]
HHS-465
 Probe Info  		Y106(0.00); Y176(0.00)  LDD2240  [20]
HHS-482
 Probe Info  		Y159(0.71)  LDD2239  [21]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C231(0.95)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C231(1.27)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C231(1.20)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C231(1.16)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C231(1.44)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C231(1.52)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C231(1.12)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C231(1.03)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C231(1.21)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C231(1.21)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C231(1.11)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C231(0.95)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C231(1.14)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C231(1.21)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C231(1.01)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C231(1.08)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C231(1.10)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C231(1.22)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C231(1.05)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C231(1.04)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C231(1.11)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C231(1.18)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C231(1.33)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C231(1.06)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C231(1.08)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C231(1.30)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C231(1.25)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C231(1.07)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C231(1.05)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C231(1.33)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C231(1.33)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C231(1.02)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C231(1.02)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C231(1.09)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C231(1.31)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C231(1.23)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C231(1.08)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C231(1.07)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C231(1.28)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C231(1.40)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C231(1.10)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C231(1.22)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C231(0.90)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C231(1.27)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C231(1.19)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C231(1.05)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C231(1.14)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C231(1.37)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C231(1.39)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C231(1.06)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C231(0.98)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C231(1.09)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C231(1.06)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C231(1.05)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C231(0.89)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C231(0.84)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C231(1.15)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C231(1.16)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C231(1.01)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C231(1.17)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C231(1.05)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C231(1.00)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C231(1.10)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C231(1.10)  LDD1514  [8]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa H263(0.00); H261(0.00); H307(0.00); H292(0.00)  LDD0222  [17]
 LDCM0071  Cisar_cp14 MDA-MB-231 20.00  LDD0121  [6]
 LDCM0070  Cisar_cp37 MDA-MB-231 2.46  LDD0120  [6]
 LDCM0632  CL-Sc Hep-G2 C231(20.00); C231(1.06); C231(1.05); C231(0.74)  LDD2227  [12]
 LDCM0367  CL1 HEK-293T C231(0.92)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C231(1.09)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C231(0.94)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C231(1.00)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C231(0.93)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C231(1.17)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C231(1.02)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C231(0.99)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C231(1.13)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C231(1.05)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C231(1.04)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C231(0.95)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C231(0.96)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C231(1.02)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C231(1.02)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C231(1.03)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C231(1.00)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C231(0.92)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C231(1.15)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C231(0.98)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C231(1.00)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C231(1.06)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C231(1.01)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C231(0.88)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C231(0.98)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C231(1.07)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C231(1.14)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C231(0.97)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C231(1.18)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C231(1.14)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C231(0.91)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C231(1.00)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C231(0.87)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C231(0.94)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C231(0.93)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C231(0.90)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C231(0.94)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C231(0.99)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C231(1.25)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C231(1.17)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C231(0.83)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C231(1.22)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C231(1.16)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C231(1.23)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C231(1.25)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C231(1.02)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C231(0.85)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C231(0.99)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C231(0.98)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C231(1.02)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C231(1.10)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C231(0.93)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C231(1.10)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C231(1.19)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C231(1.33)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C231(1.18)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C231(1.27)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C231(1.19)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C231(0.95)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C231(0.81)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C231(0.92)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C231(0.75)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C231(0.96)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C231(1.03)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C231(0.89)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C231(0.94)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C231(1.11)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C231(1.23)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C231(1.40)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C231(1.17)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C231(0.87)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C231(0.87)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C231(0.94)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C231(0.91)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C231(0.97)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C231(1.00)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C231(1.20)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C231(1.08)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C231(1.19)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C231(1.16)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C231(1.31)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C231(1.15)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C231(0.97)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C231(0.94)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C231(0.86)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C231(0.97)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C231(1.02)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C231(0.92)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C231(1.03)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C231(1.04)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C231(1.17)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C231(1.11)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C231(1.20)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C231(0.89)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C231(1.30)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C231(1.43)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C231(0.90)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C231(0.80)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C231(0.93)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C231(0.99)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C231(0.99)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C231(1.17)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C231(1.12)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C231(0.78)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C231(1.11)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C231(1.38)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C231(1.28)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C231(1.12)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C231(0.90)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C231(0.86)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C231(0.72)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C231(1.06)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C231(0.80)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C231(0.96)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C231(1.04)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C231(0.97)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C231(1.07)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C231(1.01)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C231(1.13)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C231(1.33)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C231(1.20)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C231(1.17)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C231(0.93)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C231(0.87)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C231(0.85)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C231(1.00)  LDD1698  [8]
 LDCM0625  F8 Ramos C231(2.16)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C231(0.59)  LDD2189  [23]
 LDCM0573  Fragment11 Ramos C231(4.75)  LDD2190  [23]
 LDCM0574  Fragment12 Ramos C231(0.39)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C231(0.53)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C231(0.55)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C231(0.64)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C231(0.70)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C231(3.40)  LDD2196  [23]
 LDCM0586  Fragment28 Ramos C231(0.32)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C231(0.73)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C231(0.90)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C231(0.98)  LDD2201  [23]
 LDCM0468  Fragment33 HEK-293T C231(0.98)  LDD1671  [8]
 LDCM0596  Fragment38 Ramos C231(1.01)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C231(0.64)  LDD2184  [23]
 LDCM0427  Fragment51 HEK-293T C231(0.90)  LDD1631  [8]
 LDCM0610  Fragment52 Ramos C231(0.68)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C231(0.53)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C231(0.59)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C231(0.34)  LDD2188  [23]
 LDCM0116  HHS-0101 DM93 Y106(0.81)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y106(0.72)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y106(0.48)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y106(0.99)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y106(0.53)  LDD0268  [7]
 LDCM0107  IAA HeLa H292(0.00); H261(0.00); H307(0.00); H263(0.00)  LDD0221  [17]
 LDCM0022  KB02 HEK-293T C231(0.91)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C231(1.03)  LDD1497  [8]
 LDCM0024  KB05 HEK-293T C231(0.86)  LDD1502  [8]
 LDCM0109  NEM HeLa H292(0.00); H261(0.00); H120(0.00); H263(0.00)  LDD0223  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-2 complex subunit beta (AP2B1) Adaptor complexes large subunit family P63010
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) ATG8 family Q9H0R8
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) ATG8 family Q9GZQ8

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
21 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
22 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578