Details of the Target

General Information of Target

Target ID LDTP19379
Target Name Mitochondrial import inner membrane translocase subunit Tim23B (TIMM23B)
Gene Name TIMM23B
Gene ID 100652748
Synonyms
Mitochondrial import inner membrane translocase subunit Tim23B; TIMM23B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPSQSACPVLSTAPGTPCDLRKHLLNMVSEEKRSPQLSAKTWRRGLRLQKRRNALFLPEG
DICVVGSTSGARALIPETSKLERSGTVIAYCNLELLASSDPPVWASQSTGMTGMSYRSQP
QLGFKSTPPAHSSVFHHSVKAPKEDQAQEAASRPLTSQDGWNPNIKK
Target Bioclass
Transporter and channel
Family
Tim17/Tim22/Tim23 family
Subcellular location
Mitochondrion inner membrane
Function May participate in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. the PAM complex.
Uniprot ID
Q5SRD1
Ensemble ID
ENST00000651259.3
HGNC ID
HGNC:23581

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.04  LDD0402  [1]
Jackson_1
 Probe Info  		20.00  LDD0120  [2]
IA-alkyne
 Probe Info  		C83(1.07); C84(1.07)  LDD2206  [3]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		20.00  LDD0472  [4]
FFF probe3
 Probe Info  		19.42  LDD0465  [4]
LD-F
 Probe Info  		S139(0.00); D154(0.00); S133(0.00); Y138(0.00)  LDD0015  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 14.20  LDD0403  [1]
 LDCM0070  Cisar_cp37 MDA-MB-231 20.00  LDD0120  [2]
 LDCM0627  NUDT7-COV-1 HEK-293T C83(1.07); C84(1.07)  LDD2206  [3]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
3 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
4 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
5 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652