Details of the Target

General Information of Target

Target ID LDTP09470
Target Name Pantothenate kinase 1 (PANK1)
Gene Name PANK1
Gene ID 53354
Synonyms
PANK; Pantothenate kinase 1; hPanK; hPanK1; EC 2.7.1.33; Pantothenic acid kinase 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLKLVGGGGGQDWACSVAGTSLGGEEAAFEVARPGDQGKAGGGSPGWGCAGIPDSAPGAG
VLQAGAVGPARGGQGAEEVGESAGGGEERRVRHPQAPALRLLNRKPQGGSGEIKTPENDL
QRGRLSRGPRTAPPAPGMGDRSGQQERSVPHSPGAPVGTSAAAVNGLLHNGFHPPPVQPP
HVCSRGPVGGSDAAPQRLPLLPELQPQPLLPQHDSPAKKCRLRRRMDSGRKNRPPFPWFG
MDIGGTLVKLVYFEPKDITAEEEQEEVENLKSIRKYLTSNTAYGKTGIRDVHLELKNLTM
CGRKGNLHFIRFPSCAMHRFIQMGSEKNFSSLHTTLCATGGGAFKFEEDFRMIADLQLHK
LDELDCLIQGLLYVDSVGFNGKPECYYFENPTNPELCQKKPYCLDNPYPMLLVNMGSGVS
ILAVYSKDNYKRVTGTSLGGGTFLGLCCLLTGCETFEEALEMAAKGDSTNVDKLVKDIYG
GDYERFGLQGSAVASSFGNMMSKEKRDSISKEDLARATLVTITNNIGSIARMCALNENID
RVVFVGNFLRINMVSMKLLAYAMDFWSKGQLKALFLEHEGYFGAVGALLELFKMTDDK
Target Bioclass
Enzyme
Family
Type II pantothenate kinase family
Subcellular location
Cytoplasm; Nucleus; Cytoplasm, cytosol
Function [Isoform 1]: Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis.
Uniprot ID
Q8TE04
Ensemble ID
ENST00000322191.10
HGNC ID
HGNC:8598
ChEMBL ID
CHEMBL3407326

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y483(13.77)  LDD3495  [1]
Jackson_1
 Probe Info  		20.00  LDD0120  [2]
DBIA
 Probe Info  		C315(1.08)  LDD1509  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [4]
AOyne
 Probe Info  		12.60  LDD0443  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C315(1.08)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C315(0.99)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C315(1.03)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C315(0.97)  LDD1513  [3]
 LDCM0278  AC19 HEK-293T C315(1.20)  LDD1517  [3]
 LDCM0280  AC20 HEK-293T C315(1.03)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C315(1.14)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C315(1.00)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C315(1.00)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C315(1.04)  LDD1523  [3]
 LDCM0287  AC27 HEK-293T C315(1.01)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C315(0.99)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C315(1.04)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C315(1.02)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C315(1.00)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C315(0.97)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C315(1.06)  LDD1532  [3]
 LDCM0296  AC35 HEK-293T C315(1.11)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C315(0.99)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C315(0.99)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C315(1.05)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C315(1.03)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C315(1.06)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C315(1.03)  LDD1541  [3]
 LDCM0305  AC43 HEK-293T C315(1.16)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C315(1.16)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C315(1.11)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C315(1.24)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C315(1.09)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C315(1.06)  LDD1549  [3]
 LDCM0312  AC5 HEK-293T C315(1.13)  LDD1551  [3]
 LDCM0314  AC51 HEK-293T C315(1.08)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C315(1.01)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C315(1.02)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C315(1.06)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C315(0.96)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C315(1.03)  LDD1558  [3]
 LDCM0322  AC59 HEK-293T C315(1.10)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C315(1.05)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C315(1.01)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C315(1.05)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C315(0.94)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C315(0.95)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C315(1.10)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C315(0.97)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C315(1.04)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C315(1.04)  LDD1511  [3]
 LDCM0275  AKOS034007705 HEK-293T C315(1.04)  LDD1514  [3]
 LDCM0070  Cisar_cp37 MDA-MB-231 20.00  LDD0120  [2]
 LDCM0368  CL10 HEK-293T C315(1.18)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C315(1.14)  LDD1573  [3]
 LDCM0371  CL102 HEK-293T C533(0.81)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C315(1.01)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C315(1.02)  LDD1577  [3]
 LDCM0375  CL106 HEK-293T C533(0.75)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C315(0.94)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C315(0.94)  LDD1581  [3]
 LDCM0379  CL11 HEK-293T C315(0.94)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C533(0.82)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C315(1.06)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C315(1.29)  LDD1586  [3]
 LDCM0384  CL114 HEK-293T C533(0.96)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C315(1.10)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C315(1.20)  LDD1590  [3]
 LDCM0388  CL118 HEK-293T C533(0.83)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C315(1.03)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C315(1.06)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C315(1.09)  LDD1595  [3]
 LDCM0393  CL122 HEK-293T C533(0.83)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C315(0.94)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C315(1.05)  LDD1599  [3]
 LDCM0397  CL126 HEK-293T C533(0.94)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C315(0.99)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C315(1.07)  LDD1603  [3]
 LDCM0401  CL14 HEK-293T C533(1.03)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C315(1.00)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C315(0.94)  LDD1607  [3]
 LDCM0406  CL19 HEK-293T C315(0.91)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C533(0.98)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C315(0.86)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C315(1.15)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C315(0.96)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C315(0.90)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C315(0.91)  LDD1616  [3]
 LDCM0414  CL26 HEK-293T C533(0.91)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C315(1.03)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C315(1.05)  LDD1620  [3]
 LDCM0418  CL3 HEK-293T C315(0.93)  LDD1622  [3]
 LDCM0420  CL31 HEK-293T C315(1.04)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C315(0.84)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C315(0.90)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C315(0.92)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C315(0.92)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C315(1.04)  LDD1629  [3]
 LDCM0428  CL39 HEK-293T C315(1.04)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C315(0.93)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C315(1.06)  LDD1634  [3]
 LDCM0433  CL43 HEK-293T C315(0.99)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C315(1.01)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C315(1.09)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C315(0.99)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C315(1.04)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C315(0.96)  LDD1642  [3]
 LDCM0441  CL50 HEK-293T C533(1.03)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C315(0.95)  LDD1646  [3]
 LDCM0446  CL55 HEK-293T C315(1.02)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C315(1.04)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C315(1.11)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C315(1.02)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C315(0.89)  LDD1653  [3]
 LDCM0452  CL60 HEK-293T C315(0.95)  LDD1655  [3]
 LDCM0454  CL62 HEK-293T C533(0.98)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C315(1.07)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C315(1.09)  LDD1659  [3]
 LDCM0459  CL67 HEK-293T C315(0.91)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C315(0.91)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C315(0.96)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C315(0.87)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C315(0.96)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C315(0.99)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C315(0.98)  LDD1668  [3]
 LDCM0467  CL74 HEK-293T C533(0.95)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C315(0.95)  LDD1672  [3]
 LDCM0472  CL79 HEK-293T C315(1.00)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C315(1.00)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C315(0.88)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C315(1.00)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C315(0.99)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C315(0.90)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C315(1.12)  LDD1681  [3]
 LDCM0480  CL86 HEK-293T C533(1.13)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C315(1.00)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C315(0.95)  LDD1685  [3]
 LDCM0484  CL9 HEK-293T C315(1.01)  LDD1687  [3]
 LDCM0486  CL91 HEK-293T C315(0.97)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C315(0.88)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C315(0.90)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C315(1.00)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C315(1.22)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C315(1.05)  LDD1694  [3]
 LDCM0493  CL98 HEK-293T C533(1.10)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C315(1.22)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C315(1.18)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C315(0.98)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C533(1.07)  LDD1631  [3]

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.