Details of the Target

General Information of Target

Target ID LDTP03519
Target Name UMP-CMP kinase (CMPK1)
Gene Name CMPK1
Gene ID 51727
Synonyms
CMK; CMPK; UCK; UMK; UMPK; UMP-CMP kinase; EC 2.7.4.14; Deoxycytidylate kinase; CK; dCMP kinase; Nucleoside-diphosphate kinase; EC 2.7.4.6; Uridine monophosphate/cytidine monophosphate kinase; UMP/CMP kinase; UMP/CMPK
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKPLVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNPDSQYGELIEKYIKEG
KIVPVEITISLLKREMDQTMAANAQKNKFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFF
DCNNEICIERCLERGKSSGRSDDNRESLEKRIQTYLQSTKPIIDLYEEMGKVKKIDASKS
VDEVFDEVVQIFDKEG
Target Bioclass
Enzyme
Family
Adenylate kinase family, UMP-CMP kinase subfamily
Subcellular location
Nucleus
Function
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. {|HAMAP-Rule:MF_03172}.
Uniprot ID
P30085
Ensemble ID
ENST00000371873.10
HGNC ID
HGNC:18170
ChEMBL ID
CHEMBL5681

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AZ-9
 Probe Info  		4.29  LDD0393  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K106(1.15); K2(9.22); K43(6.08); K55(7.01)  LDD0277  [4]
Probe 1
 Probe Info  		Y27(7.19); Y49(13.37)  LDD3495  [5]
BTD
 Probe Info  		C20(1.01)  LDD1700  [6]
Jackson_1
 Probe Info  		10.56  LDD0120  [7]
DBIA
 Probe Info  		C20(332.45)  LDD0209  [8]
HHS-482
 Probe Info  		Y49(0.91)  LDD0285  [9]
HHS-475
 Probe Info  		Y49(0.87); Y155(0.99)  LDD0264  [10]
HHS-465
 Probe Info  		Y49(5.18)  LDD2237  [11]
Acrolein
 Probe Info  		N.A.  LDD0226  [12]
5E-2FA
 Probe Info  		N.A.  LDD2235  [13]
ATP probe
 Probe Info  		K16(0.00); K43(0.00)  LDD0199  [14]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [15]
ATP probe
 Probe Info  		K16(0.00); K2(0.00)  LDD0035  [16]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [17]
TFBX
 Probe Info  		N.A.  LDD0027  [17]
IPM
 Probe Info  		N.A.  LDD0005  [18]
SF
 Probe Info  		N.A.  LDD0028  [19]
AOyne
 Probe Info  		15.00  LDD0443  [20]
NAIA_5
 Probe Info  		N.A.  LDD2223  [21]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe14
 Probe Info  		15.57  LDD0477  [22]
JN0003
 Probe Info  		20.00  LDD0469  [22]
STS-1
 Probe Info  		N.A.  LDD0137  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C20(0.67)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C20(0.89)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C20(0.52)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C20(0.87)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C20(0.60)  LDD2117  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C20(1.21)  LDD2131  [6]
 LDCM0214  AC1 PaTu 8988t C122(1.77); C127(1.77)  LDD1093  [24]
 LDCM0215  AC10 PaTu 8988t C122(1.47); C127(1.47)  LDD1094  [24]
 LDCM0216  AC100 PaTu 8988t C122(1.44); C127(1.44)  LDD1095  [24]
 LDCM0217  AC101 PaTu 8988t C122(1.60); C127(1.60)  LDD1096  [24]
 LDCM0218  AC102 PaTu 8988t C122(1.03); C127(1.03)  LDD1097  [24]
 LDCM0219  AC103 PaTu 8988t C122(1.83); C127(1.83)  LDD1098  [24]
 LDCM0220  AC104 PaTu 8988t C122(0.92); C127(0.92)  LDD1099  [24]
 LDCM0221  AC105 PaTu 8988t C122(1.18); C127(1.18)  LDD1100  [24]
 LDCM0222  AC106 PaTu 8988t C122(1.48); C127(1.48)  LDD1101  [24]
 LDCM0223  AC107 PaTu 8988t C122(2.10); C127(2.10)  LDD1102  [24]
 LDCM0224  AC108 PaTu 8988t C122(1.20); C127(1.20)  LDD1103  [24]
 LDCM0225  AC109 PaTu 8988t C122(1.13); C127(1.13)  LDD1104  [24]
 LDCM0226  AC11 PaTu 8988t C122(1.34); C127(1.34)  LDD1105  [24]
 LDCM0227  AC110 PaTu 8988t C122(1.90); C127(1.90)  LDD1106  [24]
 LDCM0228  AC111 PaTu 8988t C122(1.42); C127(1.42)  LDD1107  [24]
 LDCM0229  AC112 PaTu 8988t C122(1.27); C127(1.27)  LDD1108  [24]
 LDCM0230  AC113 PaTu 8988t C122(0.70); C127(0.70)  LDD1109  [24]
 LDCM0231  AC114 PaTu 8988t C122(0.67); C127(0.67)  LDD1110  [24]
 LDCM0232  AC115 PaTu 8988t C122(0.81); C127(0.81)  LDD1111  [24]
 LDCM0233  AC116 PaTu 8988t C122(0.85); C127(0.85)  LDD1112  [24]
 LDCM0234  AC117 PaTu 8988t C122(0.65); C127(0.65)  LDD1113  [24]
 LDCM0235  AC118 PaTu 8988t C122(0.92); C127(0.92)  LDD1114  [24]
 LDCM0236  AC119 PaTu 8988t C122(0.82); C127(0.82)  LDD1115  [24]
 LDCM0237  AC12 PaTu 8988t C122(1.36); C127(1.36)  LDD1116  [24]
 LDCM0238  AC120 PaTu 8988t C122(0.67); C127(0.67)  LDD1117  [24]
 LDCM0239  AC121 PaTu 8988t C122(0.70); C127(0.70)  LDD1118  [24]
 LDCM0240  AC122 PaTu 8988t C122(1.03); C127(1.03)  LDD1119  [24]
 LDCM0241  AC123 PaTu 8988t C122(1.28); C127(1.28)  LDD1120  [24]
 LDCM0242  AC124 PaTu 8988t C122(1.72); C127(1.72)  LDD1121  [24]
 LDCM0243  AC125 PaTu 8988t C122(1.65); C127(1.65)  LDD1122  [24]
 LDCM0244  AC126 PaTu 8988t C122(1.11); C127(1.11)  LDD1123  [24]
 LDCM0245  AC127 PaTu 8988t C122(1.09); C127(1.09)  LDD1124  [24]
 LDCM0246  AC128 PaTu 8988t C122(0.41); C127(0.41)  LDD1125  [24]
 LDCM0247  AC129 PaTu 8988t C122(0.63); C127(0.63)  LDD1126  [24]
 LDCM0249  AC130 PaTu 8988t C122(0.58); C127(0.58)  LDD1128  [24]
 LDCM0250  AC131 PaTu 8988t C122(0.61); C127(0.61)  LDD1129  [24]
 LDCM0251  AC132 PaTu 8988t C122(0.62); C127(0.62)  LDD1130  [24]
 LDCM0252  AC133 PaTu 8988t C122(0.61); C127(0.61)  LDD1131  [24]
 LDCM0253  AC134 PaTu 8988t C122(0.60); C127(0.60)  LDD1132  [24]
 LDCM0254  AC135 PaTu 8988t C122(0.56); C127(0.56)  LDD1133  [24]
 LDCM0255  AC136 PaTu 8988t C122(0.42); C127(0.42)  LDD1134  [24]
 LDCM0256  AC137 PaTu 8988t C122(0.71); C127(0.71)  LDD1135  [24]
 LDCM0257  AC138 PaTu 8988t C122(0.69); C127(0.69)  LDD1136  [24]
 LDCM0258  AC139 PaTu 8988t C122(0.49); C127(0.49)  LDD1137  [24]
 LDCM0259  AC14 PaTu 8988t C122(1.20); C127(1.20)  LDD1138  [24]
 LDCM0260  AC140 PaTu 8988t C122(0.77); C127(0.77)  LDD1139  [24]
 LDCM0261  AC141 PaTu 8988t C122(0.77); C127(0.77)  LDD1140  [24]
 LDCM0262  AC142 PaTu 8988t C122(0.73); C127(0.73)  LDD1141  [24]
 LDCM0263  AC143 PaTu 8988t C122(1.00); C127(1.00)  LDD1142  [24]
 LDCM0264  AC144 PaTu 8988t C122(1.09); C127(1.09)  LDD1143  [24]
 LDCM0265  AC145 PaTu 8988t C122(1.30); C127(1.30)  LDD1144  [24]
 LDCM0266  AC146 PaTu 8988t C122(1.40); C127(1.40)  LDD1145  [24]
 LDCM0267  AC147 PaTu 8988t C122(1.22); C127(1.22)  LDD1146  [24]
 LDCM0268  AC148 PaTu 8988t C122(1.37); C127(1.37)  LDD1147  [24]
 LDCM0269  AC149 PaTu 8988t C122(1.33); C127(1.33)  LDD1148  [24]
 LDCM0270  AC15 PaTu 8988t C122(1.14); C127(1.14)  LDD1149  [24]
 LDCM0271  AC150 PaTu 8988t C122(1.53); C127(1.53)  LDD1150  [24]
 LDCM0272  AC151 PaTu 8988t C122(2.17); C127(2.17)  LDD1151  [24]
 LDCM0273  AC152 PaTu 8988t C122(1.36); C127(1.36)  LDD1152  [24]
 LDCM0274  AC153 PaTu 8988t C122(1.35); C127(1.35)  LDD1153  [24]
 LDCM0621  AC154 PaTu 8988t C122(1.91); C127(1.91)  LDD2166  [24]
 LDCM0622  AC155 PaTu 8988t C122(1.64); C127(1.64)  LDD2167  [24]
 LDCM0623  AC156 PaTu 8988t C122(1.42); C127(1.42)  LDD2168  [24]
 LDCM0624  AC157 PaTu 8988t C122(1.69); C127(1.69)  LDD2169  [24]
 LDCM0278  AC19 HEK-293T C122(0.99)  LDD1517  [25]
 LDCM0279  AC2 PaTu 8988t C122(1.52); C127(1.52)  LDD1158  [24]
 LDCM0283  AC23 HEK-293T C122(0.80)  LDD1522  [25]
 LDCM0287  AC27 HEK-293T C122(0.92)  LDD1526  [25]
 LDCM0290  AC3 PaTu 8988t C122(1.25); C127(1.25)  LDD1169  [24]
 LDCM0292  AC31 HEK-293T C122(1.07)  LDD1531  [25]
 LDCM0296  AC35 PaTu 8988t C122(1.24); C127(1.24)  LDD1175  [24]
 LDCM0297  AC36 PaTu 8988t C122(1.37); C127(1.37)  LDD1176  [24]
 LDCM0298  AC37 PaTu 8988t C122(1.36); C127(1.36)  LDD1177  [24]
 LDCM0299  AC38 PaTu 8988t C122(1.44); C127(1.44)  LDD1178  [24]
 LDCM0300  AC39 PaTu 8988t C122(1.91); C127(1.91)  LDD1179  [24]
 LDCM0301  AC4 PaTu 8988t C122(1.26); C127(1.26)  LDD1180  [24]
 LDCM0302  AC40 PaTu 8988t C122(2.12); C127(2.12)  LDD1181  [24]
 LDCM0303  AC41 PaTu 8988t C122(1.60); C127(1.60)  LDD1182  [24]
 LDCM0304  AC42 PaTu 8988t C122(1.45); C127(1.45)  LDD1183  [24]
 LDCM0305  AC43 PaTu 8988t C122(1.59); C127(1.59)  LDD1184  [24]
 LDCM0306  AC44 PaTu 8988t C122(2.43); C127(2.43)  LDD1185  [24]
 LDCM0307  AC45 PaTu 8988t C122(1.59); C127(1.59)  LDD1186  [24]
 LDCM0309  AC47 HEK-293T C122(0.86)  LDD1548  [25]
 LDCM0312  AC5 PaTu 8988t C122(2.12); C127(2.12)  LDD1191  [24]
 LDCM0314  AC51 HEK-293T C122(0.98)  LDD1553  [25]
 LDCM0318  AC55 HEK-293T C122(0.77)  LDD1557  [25]
 LDCM0320  AC57 PaTu 8988t C122(0.81); C127(0.81)  LDD1199  [24]
 LDCM0321  AC58 PaTu 8988t C122(0.90); C127(0.90)  LDD1200  [24]
 LDCM0322  AC59 PaTu 8988t C122(1.10); C127(1.10)  LDD1201  [24]
 LDCM0323  AC6 PaTu 8988t C122(1.17); C127(1.17)  LDD1202  [24]
 LDCM0324  AC60 PaTu 8988t C122(0.80); C127(0.80)  LDD1203  [24]
 LDCM0325  AC61 PaTu 8988t C122(0.85); C127(0.85)  LDD1204  [24]
 LDCM0326  AC62 PaTu 8988t C122(1.02); C127(1.02)  LDD1205  [24]
 LDCM0327  AC63 PaTu 8988t C122(0.82); C127(0.82)  LDD1206  [24]
 LDCM0328  AC64 PaTu 8988t C122(0.57); C127(0.57)  LDD1207  [24]
 LDCM0329  AC65 PaTu 8988t C122(1.15); C127(1.15)  LDD1208  [24]
 LDCM0330  AC66 PaTu 8988t C122(0.80); C127(0.80)  LDD1209  [24]
 LDCM0331  AC67 PaTu 8988t C122(0.74); C127(0.74)  LDD1210  [24]
 LDCM0332  AC68 PaTu 8988t C122(0.91); C127(0.91)  LDD1211  [24]
 LDCM0333  AC69 PaTu 8988t C122(0.96); C127(0.96)  LDD1212  [24]
 LDCM0334  AC7 PaTu 8988t C122(1.11); C127(1.11)  LDD1213  [24]
 LDCM0335  AC70 PaTu 8988t C122(1.65); C127(1.65)  LDD1214  [24]
 LDCM0336  AC71 PaTu 8988t C122(1.02); C127(1.02)  LDD1215  [24]
 LDCM0337  AC72 PaTu 8988t C122(0.90); C127(0.90)  LDD1216  [24]
 LDCM0338  AC73 PaTu 8988t C122(0.83); C127(0.83)  LDD1217  [24]
 LDCM0339  AC74 PaTu 8988t C122(0.94); C127(0.94)  LDD1218  [24]
 LDCM0340  AC75 PaTu 8988t C122(1.02); C127(1.02)  LDD1219  [24]
 LDCM0341  AC76 PaTu 8988t C122(0.78); C127(0.78)  LDD1220  [24]
 LDCM0342  AC77 PaTu 8988t C122(1.10); C127(1.10)  LDD1221  [24]
 LDCM0343  AC78 PaTu 8988t C122(0.90); C127(0.90)  LDD1222  [24]
 LDCM0344  AC79 PaTu 8988t C122(0.84); C127(0.84)  LDD1223  [24]
 LDCM0345  AC8 PaTu 8988t C122(1.18); C127(1.18)  LDD1224  [24]
 LDCM0346  AC80 PaTu 8988t C122(0.87); C127(0.87)  LDD1225  [24]
 LDCM0347  AC81 PaTu 8988t C122(0.88); C127(0.88)  LDD1226  [24]
 LDCM0348  AC82 PaTu 8988t C122(1.01); C127(1.01)  LDD1227  [24]
 LDCM0365  AC98 PaTu 8988t C122(1.25); C127(1.25)  LDD1244  [24]
 LDCM0366  AC99 PaTu 8988t C122(0.89); C127(0.89)  LDD1245  [24]
 LDCM0545  Acetamide MDA-MB-231 C20(0.26)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C20(0.71)  LDD2113  [6]
 LDCM0248  AKOS034007472 PaTu 8988t C122(1.40); C127(1.40)  LDD1127  [24]
 LDCM0356  AKOS034007680 PaTu 8988t C122(1.34); C127(1.34)  LDD1235  [24]
 LDCM0275  AKOS034007705 PaTu 8988t C122(1.25); C127(1.25)  LDD1154  [24]
 LDCM0156  Aniline NCI-H1299 13.26  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C20(0.33)  LDD2091  [6]
 LDCM0070  Cisar_cp37 MDA-MB-231 10.56  LDD0120  [7]
 LDCM0632  CL-Sc Hep-G2 C20(0.91); C20(0.72)  LDD2227  [21]
 LDCM0369  CL100 PaTu 8988t C122(1.23); C127(1.23)  LDD1248  [24]
 LDCM0370  CL101 PaTu 8988t C122(1.14); C127(1.14)  LDD1249  [24]
 LDCM0371  CL102 PaTu 8988t C122(1.39); C127(1.39)  LDD1250  [24]
 LDCM0372  CL103 PaTu 8988t C122(1.88); C127(1.88)  LDD1251  [24]
 LDCM0373  CL104 PaTu 8988t C122(1.50); C127(1.50)  LDD1252  [24]
 LDCM0379  CL11 HEK-293T C122(0.92)  LDD1583  [25]
 LDCM0387  CL117 PaTu 8988t C122(1.30); C127(1.30)  LDD1266  [24]
 LDCM0388  CL118 PaTu 8988t C122(1.52); C127(1.52)  LDD1267  [24]
 LDCM0389  CL119 PaTu 8988t C122(1.51); C127(1.51)  LDD1268  [24]
 LDCM0391  CL120 PaTu 8988t C122(1.52); C127(1.52)  LDD1270  [24]
 LDCM0396  CL125 PaTu 8988t C122(0.89); C127(0.89)  LDD1275  [24]
 LDCM0397  CL126 PaTu 8988t C122(0.82); C127(0.82)  LDD1276  [24]
 LDCM0398  CL127 PaTu 8988t C122(1.06); C127(1.06)  LDD1277  [24]
 LDCM0399  CL128 PaTu 8988t C122(0.75); C127(0.75)  LDD1278  [24]
 LDCM0403  CL16 PaTu 8988t C122(1.35); C127(1.35)  LDD1282  [24]
 LDCM0404  CL17 PaTu 8988t C122(1.39); C127(1.39)  LDD1283  [24]
 LDCM0405  CL18 PaTu 8988t C122(1.24); C127(1.24)  LDD1284  [24]
 LDCM0406  CL19 PaTu 8988t C122(1.72); C127(1.72)  LDD1285  [24]
 LDCM0408  CL20 PaTu 8988t C122(2.67); C127(2.67)  LDD1287  [24]
 LDCM0409  CL21 PaTu 8988t C122(2.02); C127(2.02)  LDD1288  [24]
 LDCM0410  CL22 PaTu 8988t C122(2.05); C127(2.05)  LDD1289  [24]
 LDCM0411  CL23 PaTu 8988t C122(1.67); C127(1.67)  LDD1290  [24]
 LDCM0412  CL24 PaTu 8988t C122(1.02); C127(1.02)  LDD1291  [24]
 LDCM0413  CL25 PaTu 8988t C122(0.99); C127(0.99)  LDD1292  [24]
 LDCM0414  CL26 PaTu 8988t C122(1.58); C127(1.58)  LDD1293  [24]
 LDCM0415  CL27 PaTu 8988t C122(1.21); C127(1.21)  LDD1294  [24]
 LDCM0416  CL28 PaTu 8988t C122(2.45); C127(2.45)  LDD1295  [24]
 LDCM0417  CL29 PaTu 8988t C122(2.45); C127(2.45)  LDD1296  [24]
 LDCM0419  CL30 PaTu 8988t C122(1.35); C127(1.35)  LDD1298  [24]
 LDCM0420  CL31 PaTu 8988t C122(0.78); C127(0.78)  LDD1299  [24]
 LDCM0421  CL32 PaTu 8988t C122(0.79); C127(0.79)  LDD1300  [24]
 LDCM0422  CL33 PaTu 8988t C122(1.15); C127(1.15)  LDD1301  [24]
 LDCM0423  CL34 PaTu 8988t C122(1.02); C127(1.02)  LDD1302  [24]
 LDCM0424  CL35 PaTu 8988t C122(0.99); C127(0.99)  LDD1303  [24]
 LDCM0425  CL36 PaTu 8988t C122(1.66); C127(1.66)  LDD1304  [24]
 LDCM0426  CL37 PaTu 8988t C122(1.40); C127(1.40)  LDD1305  [24]
 LDCM0428  CL39 PaTu 8988t C122(0.79); C127(0.79)  LDD1307  [24]
 LDCM0430  CL40 PaTu 8988t C122(0.83); C127(0.83)  LDD1309  [24]
 LDCM0431  CL41 PaTu 8988t C122(0.92); C127(0.92)  LDD1310  [24]
 LDCM0432  CL42 PaTu 8988t C122(1.66); C127(1.66)  LDD1311  [24]
 LDCM0433  CL43 PaTu 8988t C122(1.83); C127(1.83)  LDD1312  [24]
 LDCM0434  CL44 PaTu 8988t C122(0.91); C127(0.91)  LDD1313  [24]
 LDCM0435  CL45 PaTu 8988t C122(1.65); C127(1.65)  LDD1314  [24]
 LDCM0436  CL46 PaTu 8988t C122(0.85); C127(0.85)  LDD1315  [24]
 LDCM0437  CL47 PaTu 8988t C122(0.86); C127(0.86)  LDD1316  [24]
 LDCM0438  CL48 PaTu 8988t C122(0.98); C127(0.98)  LDD1317  [24]
 LDCM0439  CL49 PaTu 8988t C122(0.90); C127(0.90)  LDD1318  [24]
 LDCM0441  CL50 PaTu 8988t C122(1.02); C127(1.02)  LDD1320  [24]
 LDCM0442  CL51 PaTu 8988t C122(0.83); C127(0.83)  LDD1321  [24]
 LDCM0443  CL52 PaTu 8988t C122(1.14); C127(1.14)  LDD1322  [24]
 LDCM0444  CL53 PaTu 8988t C122(1.69); C127(1.69)  LDD1323  [24]
 LDCM0445  CL54 PaTu 8988t C122(1.14); C127(1.14)  LDD1324  [24]
 LDCM0446  CL55 PaTu 8988t C122(1.00); C127(1.00)  LDD1325  [24]
 LDCM0447  CL56 PaTu 8988t C122(0.71); C127(0.71)  LDD1326  [24]
 LDCM0448  CL57 PaTu 8988t C122(2.09); C127(2.09)  LDD1327  [24]
 LDCM0449  CL58 PaTu 8988t C122(1.37); C127(1.37)  LDD1328  [24]
 LDCM0450  CL59 PaTu 8988t C122(2.53); C127(2.53)  LDD1329  [24]
 LDCM0452  CL60 PaTu 8988t C122(1.46); C127(1.46)  LDD1331  [24]
 LDCM0459  CL67 HEK-293T C122(1.35)  LDD1662  [25]
 LDCM0462  CL7 HEK-293T C122(0.77)  LDD1665  [25]
 LDCM0464  CL71 HEK-293T C122(1.04)  LDD1667  [25]
 LDCM0469  CL76 PaTu 8988t C122(1.22); C127(1.22)  LDD1348  [24]
 LDCM0470  CL77 PaTu 8988t C122(0.88); C127(0.88)  LDD1349  [24]
 LDCM0471  CL78 PaTu 8988t C122(1.34); C127(1.34)  LDD1350  [24]
 LDCM0472  CL79 PaTu 8988t C122(0.96); C127(0.96)  LDD1351  [24]
 LDCM0474  CL80 PaTu 8988t C122(0.86); C127(0.86)  LDD1353  [24]
 LDCM0475  CL81 PaTu 8988t C122(1.25); C127(1.25)  LDD1354  [24]
 LDCM0476  CL82 PaTu 8988t C122(1.30); C127(1.30)  LDD1355  [24]
 LDCM0477  CL83 PaTu 8988t C122(1.16); C127(1.16)  LDD1356  [24]
 LDCM0478  CL84 PaTu 8988t C122(1.36); C127(1.36)  LDD1357  [24]
 LDCM0479  CL85 PaTu 8988t C122(0.96); C127(0.96)  LDD1358  [24]
 LDCM0480  CL86 PaTu 8988t C122(1.07); C127(1.07)  LDD1359  [24]
 LDCM0481  CL87 PaTu 8988t C122(1.32); C127(1.32)  LDD1360  [24]
 LDCM0482  CL88 PaTu 8988t C122(1.75); C127(1.75)  LDD1361  [24]
 LDCM0483  CL89 PaTu 8988t C122(1.35); C127(1.35)  LDD1362  [24]
 LDCM0485  CL90 PaTu 8988t C122(1.19); C127(1.19)  LDD1364  [24]
 LDCM0486  CL91 PaTu 8988t C122(1.32); C127(1.32)  LDD1365  [24]
 LDCM0487  CL92 PaTu 8988t C122(1.51); C127(1.51)  LDD1366  [24]
 LDCM0488  CL93 PaTu 8988t C122(1.59); C127(1.59)  LDD1367  [24]
 LDCM0489  CL94 PaTu 8988t C122(2.28); C127(2.28)  LDD1368  [24]
 LDCM0490  CL95 PaTu 8988t C122(2.02); C127(2.02)  LDD1369  [24]
 LDCM0491  CL96 PaTu 8988t C122(1.31); C127(1.31)  LDD1370  [24]
 LDCM0492  CL97 PaTu 8988t C122(1.23); C127(1.23)  LDD1371  [24]
 LDCM0493  CL98 PaTu 8988t C122(1.80); C127(1.80)  LDD1372  [24]
 LDCM0494  CL99 PaTu 8988t C122(1.38); C127(1.38)  LDD1373  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C20(1.36)  LDD1702  [6]
 LDCM0625  F8 Ramos C20(5.14)  LDD2187  [26]
 LDCM0576  Fragment14 Ramos C20(0.23)  LDD2193  [26]
 LDCM0586  Fragment28 Ramos C20(0.70)  LDD2198  [26]
 LDCM0566  Fragment4 Ramos C20(1.15)  LDD2184  [26]
 LDCM0427  Fragment51 PaTu 8988t C122(1.82); C127(1.82)  LDD1306  [24]
 LDCM0569  Fragment7 Ramos C20(1.04)  LDD2186  [26]
 LDCM0116  HHS-0101 DM93 Y49(0.87); Y155(0.99)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y49(0.72)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y49(0.79); Y155(1.22)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y49(0.82); Y155(0.83)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y49(0.99)  LDD0268  [10]
 LDCM0123  JWB131 DM93 Y49(0.91)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y49(0.60)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y49(0.90)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y49(1.28)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y49(0.89)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y49(0.56)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y49(0.73)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y49(1.01)  LDD0292  [9]
 LDCM0022  KB02 Ramos C20(1.69)  LDD2182  [26]
 LDCM0023  KB03 Jurkat C20(332.45)  LDD0209  [8]
 LDCM0024  KB05 MKN45 C52(4.00)  LDD3332  [27]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C20(1.13)  LDD2102  [6]
 LDCM0109  NEM HeLa N.A.  LDD0226  [12]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C20(1.35)  LDD2090  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C20(0.78)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C20(0.96)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C20(0.54)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C20(0.78)  LDD2097  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C20(0.60)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C20(0.50)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C20(1.03)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C20(0.63)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C20(1.61)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C20(0.60)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C20(0.83)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C20(0.71)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C20(0.44)  LDD2109  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C20(0.51)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C20(0.98)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C20(0.87)  LDD2118  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C20(0.90)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C20(1.04)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C20(0.53)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C20(1.00)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C20(0.50)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C20(1.76)  LDD2126  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C20(0.86)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C20(0.70)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C20(0.62)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C20(0.51)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C20(0.83)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C20(0.69)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C20(0.83)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C20(1.01)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C20(0.65)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C20(0.52)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C20(1.36)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C20(4.31)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C20(0.59)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C20(4.13)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C20(0.78)  LDD2148  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C20(1.00)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C20(0.29)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C20(1.76)  LDD2151  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C20(2.07)  LDD2153  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calpain-1 catalytic subunit (CAPN1) Peptidase C2 family P07384
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipid transferase CIDEB (CIDEB) CIDE family Q9UHD4
Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB) SGT family Q96EQ0

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Decitabine Small molecular drug DB01262
Gemcitabine Small molecular drug DB00441
Lamivudine Small molecular drug DB00709
Sofosbuvir Small molecular drug DB08934
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cytidine-5'-monophosphate Small molecular drug DB03403
Uridine-5'-diphosphate Small molecular drug DB03435
Tetrafluoroaluminate Ion . DB04444

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
8 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
24 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
27 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840