Details of the Target

General Information of Target

Target ID LDTP09100
Target Name Cytoplasmic dynein 2 heavy chain 1 (DYNC2H1)
Gene Name DYNC2H1
Gene ID 79659
Synonyms
DHC1B; DHC2; DNCH2; DYH1B; KIAA1997; Cytoplasmic dynein 2 heavy chain 1; Cytoplasmic dynein 2 heavy chain; Dynein cytoplasmic heavy chain 2; Dynein heavy chain 11; hDHC11; Dynein heavy chain isotype 1B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MANGTADVRKLFIFTTTQNYFGLMSELWDQPLLCNCLEINNFLDDGNQMLLRVQRSDAGI
SFSNTIEFGDTKDKVLVFFKLRPEVITDENLHDNILVSSMLESPISSLYQAVRQVFAPML
LKDQEWSRNFDPKLQNLLSELEAGLGIVLRRSDTNLTKLKFKEDDTRGILTPSDEFQFWI
EQAHRGNKQISKERANYFKELFETIAREFYNLDSLSLLEVVDLVETTQDVVDDVWRQTEH
DHYPESRMLHLLDIIGGSFGRFVQKKLGTLNLWEDPYYLVKESLKAGISICEQWVIVCNH
LTGQVWQRYVPHPWKNEKYFPETLDKLGKRLEEVLAIRTIHEKFLYFLPASEEKIICLTR
VFEPFTGLNPVQYNPYTEPLWKAAVSQYEKIIAPAEQKIAGKLKNYISEIQDSPQQLLQA
FLKYKELVKRPTISKELMLERETLLARLVDSIKDFRLDFENRCRGIPGDASGPLSGKNLS
EVVNSIVWVRQLELKVDDTIKIAEALLSDLPGFRCFHQSAKDLLDQLKLYEQEQFDDWSR
DIQSGLSDSRSGLCIEASSRIMELDSNDGLLKVHYSDRLVILLREVRQLSALGFVIPAKI
QQVANIAQKFCKQAIILKQVAHFYNSIDQQMIQSQRPMMLQSALAFEQIIKNSKAGSGGK
SQITWDNPKELEGYIQKLQNAAERLATENRKLRKWHTTFCEKVVVLMNIDLLRQQQRWKD
GLQELRTGLATVEAQGFQASDMHAWKQHWNHQLYKALEHQYQMGLEALNENLPEINIDLT
YKQGRLQFRPPFEEIRAKYYREMKRFIGIPNQFKGVGEAGDESIFSIMIDRNASGFLTIF
SKAEDLFRRLSAVLHQHKEWIVIGQVDMEALVEKHLFTVHDWEKNFKALKIKGKEVERLP
SAVKVDCLNINCNPVKTVIDDLIQKLFDLLVLSLKKSIQAHLHEIDTFVTEAMEVLTIMP
QSVEEIGDANLQYSKLQERKPEILPLFQEAEDKNRLLRTVAGGGLETISNLKAKWDKFEL
MMESHQLMIKDQIEVMKGNVKSRLQIYYQELEKFKARWDQLKPGDDVIETGQHNTLDKSA
KLIKEKKIEFDDLEVTRKKLVDDCHHFRLEEPNFSLASSISKDIESCAQIWAFYEEFQQG
FQEMANEDWITFRTKTYLFEEFLMNWHDRLRKVEEHSVMTVKLQSEVDKYKIVIPILKYV
RGEHLSPDHWLDLFRLLGLPRGTSLEKLLFGDLLRVADTIVAKAADLKDLNSRAQGEVTI
REALRELDLWGVGAVFTLIDYEDSQSRTMKLIKDWKDIVNQVGDNRCLLQSLKDSPYYKG
FEDKVSIWERKLAELDEYLQNLNHIQRKWVYLEPIFGRGALPKEQTRFNRVDEDFRSIMT
DIKKDNRVTTLTTHAGIRNSLLTILDQLQRCQKSLNEFLEEKRSAFPRFYFIGDDDLLEI
LGQSTNPSVIQSHLKKLFAGINSVCFDEKSKHITAMKSLEGEVVPFKNKVPLSNNVETWL
NDLALEMKKTLEQLLKECVTTGRSSQGAVDPSLFPSQILCLAEQIKFTEDVENAIKDHSL
HQIETQLVNKLEQYTNIDTSSEDPGNTESGILELKLKALILDIIHNIDVVKQLNQIQVHT
TEDWAWKKQLRFYMKSDHTCCVQMVDSEFQYTYEYQGNASKLVYTPLTDKCYLTLTQAMK
MGLGGNPYGPAGTGKTESVKALGGLLGRQVLVFNCDEGIDVKSMGRIFVGLVKCGAWGCF
DEFNRLEESVLSAVSMQIQTIQDALKNHRTVCELLGKEVEVNSNSGIFITMNPAGKGYGG
RQKLPDNLKQLFRPVAMSHPDNELIAEVILYSEGFKDAKVLSRKLVAIFNLSRELLTPQQ
HYDWGLRALKTVLRGSGNLLRQLNKSGTTQNANESHIVVQALRLNTMSKFTFTDCTRFDA
LIKDVFPGIELKEVEYDELSAALKQVFEEANYEIIPNQIKKALELYEQLCQRMGVVIVGP
SGAGKSTLWRMLRAALCKTGKVVKQYTMNPKAMPRYQLLGHIDMDTREWSDGVLTNSARQ
VVREPQDVSSWIICDGDIDPEWIESLNSVLDDNRLLTMPSGERIQFGPNVNFVFETHDLS
CASPATISRMGMIFLSDEETDLNSLIKSWLRNQPAEYRNNLENWIGDYFEKALQWVLKQN
DYVVETSLVGTVMNGLSHLHGCRDHDEFIINLIRGLGGNLNMKSRLEFTKEVFHWARESP
PDFHKPMDTYYDSTRGRLATYVLKKPEDLTADDFSNGLTLPVIQTPDMQRGLDYFKPWLS
SDTKQPFILVGPEGCGKGMLLRYAFSQLRSTQIATVHCSAQTTSRHLLQKLSQTCMVIST
NTGRVYRPKDCERLVLYLKDINLPKLDKWGTSTLVAFLQQVLTYQGFYDENLEWVGLENI
QIVASMSAGGRLGRHKLTTRFTSIVRLCSIDYPEREQLQTIYGAYLEPVLHKNLKNHSIW
GSSSKIYLLAGSMVQVYEQVRAKFTVDDYSHYFFTPCILTQWVLGLFRYDLEGGSSNHPL
DYVLEIVAYEARRLFRDKIVGAKELHLFDIILTSVFQGDWGSDILDNMSDSFYVTWGARH
NSGARAAPGQPLPPHGKPLGKLNSTDLKDVIKKGLIHYGRDNQNLDILLFHEVLEYMSRI
DRVLSFPGGSLLLAGRSGVGRRTITSLVSHMHGAVLFSPKISRGYELKQFKNDLKHVLQL
AGIEAQQVVLLLEDYQFVHPTFLEMINSLLSSGEVPGLYTLEELEPLLLPLKDQASQDGF
FGPVFNYFTYRIQQNLHIVLIMDSANSNFMINCESNPALHKKCQVLWMEGWSNSSMKKIP
EMLFSETGGGEKYNDKKRKEEKKKNSVDPDFLKSFLLIHESCKAYGATPSRYMTFLHVYS
AISSSKKKELLKRQSHLQAGVSKLNEAKALVDELNRKAGEQSVLLKTKQDEADAALQMIT
VSMQDASEQKTELERLKHRIAEEVVKIEERKNKIDDELKEVQPLVNEAKLAVGNIKPESL
SEIRSLRMPPDVIRDILEGVLRLMGIFDTSWVSMKSFLAKRGVREDIATFDARNISKEIR
ESVEELLFKNKGSFDPKNAKRASTAAAPLAAWVKANIQYSHVLERIHPLETEQAGLESNL
KKTEDRKRKLEELLNSVGQKVSELKEKFQSRTSEAAKLEAEVSKAQETIKAAEVLINQLD
REHKRWNAQVVEITEELATLPKRAQLAAAFITYLSAAPESLRKTCLEEWTKSAGLEKFDL
RRFLCTESEQLIWKSEGLPSDDLSIENALVILQSRVCPFLIDPSSQATEWLKTHLKDSRL
EVINQQDSNFITALELAVRFGKTLIIQEMDGVEPVLYPLLRRDLVAQGPRYVVQIGDKII
DYNEEFRLFLSTRNPNPFIPPDAASIVTEVNFTTTRSGLRGQLLALTIQHEKPDLEEQKT
KLLQQEEDKKIQLAKLEESLLETLATSQGNILENKDLIESLNQTKASSALIQESLKESYK
LQISLDQERDAYLPLAESASKMYFIISDLSKINNMYRFSLAAFLRLFQRALQNKQDSENT
EQRIQSLISSLQHMVYEYICRCLFKADQLMFALHFVRGMHPELFQENEWDTFTGVVVGDM
LRKADSQQKIRDQLPSWIDQERSWAVATLKIALPSLYQTLCFEDAALWRTYYNNSMCEQE
FPSILAKKVSLFQQILVVQALRPDRLQSAMALFACKTLGLKEVSPLPLNLKRLYKETLEI
EPILIIISPGADPSQELQELANAERSGECYHQVAMGQGQADLAIQMLKECARNGDWLCLK
NLHLVVSWLPVLEKELNTLQPKDTFRLWLTAEVHPNFTPILLQSSLKITYESPPGLKKNL
MRTYESWTPEQISKKDNTHRAHALFSLAWFHAACQERRNYIPQGWTKFYEFSLSDLRAGY
NIIDRLFDGAKDVQWEFVHGLLENAIYGGRIDNYFDLRVLQSYLKQFFNSSVIDVFNQRN
KKSIFPYSVSLPQSCSILDYRAVIEKIPEDDKPSFFGLPANIARSSQRMISSQVISQLRI
LGRSITAGSKFDREIWSNELSPVLNLWKKLNQNSNLIHQKVPPPNDRQGSPILSFIILEQ
FNAIRLVQSVHQSLAALSKVIRGTTLLSSEVQKLASALLNQKCPLAWQSKWEGPEDPLQY
LRGLVARALAIQNWVDKAEKQALLSETLDLSELFHPDTFLNALRQETARAVGRSVDSLKF
VASWKGRLQEAKLQIKISGLLLEGCSFDGNQLSENQLDSPSVSSVLPCFMGWIPQDACGP
YSPDECISLPVYTSAERDRVVTNIDVPCGGNQDQWIQCGAALFLKNQ
Target Bioclass
Other
Family
Dynein heavy chain family
Subcellular location
Cytoplasm, cytoskeleton, cilium axoneme
Function
May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells.
Uniprot ID
Q8NCM8
Ensemble ID
ENST00000334267.11
HGNC ID
HGNC:2962

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BT549 SNV: p.R456Ter .
CALU1 SNV: p.L4040I .
CMK SNV: p.G1730S .
DU145 SNV: p.L3640I DBIA    Probe Info 
EFO21 SNV: p.G673S .
G415 SNV: p.T1857A .
HCT116 SNV: p.L1234V; p.Y2241H .
HCT15 SNV: p.E3173K; p.E3582V .
HS936T SNV: p.G1984E DBIA    Probe Info 
HT115 SNV: p.G4103E .
HUH7 SNV: p.D3357E .
HUPT3 SNV: p.G2370E .
IGR1 SNV: p.L2910F DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.L1234F .
JURKAT Deletion: p.T3293HfsTer3
SNV: p.V2002I		 .
KARPAS422 SNV: p.K4199Q .
KATOIII SNV: p.G3899V .
L428 SNV: p.M3570I .
LNCaP clone FGC SNV: p.P1820Q; p.V2172A; p.E2952Ter; p.W3915Ter DBIA    Probe Info 
LS180 Insertion: p.N2972KfsTer2
SNV: p.D3990G		 .
MCC13 SNV: p.E2906K DBIA    Probe Info 
MEWO Substitution: p.N3839H DBIA    Probe Info 
MFE296 SNV: p.Q3425R .
MV411 SNV: p.L2157Q .
NCIH1299 SNV: p.Y3900C .
NCIH1793 SNV: p.R796L; p.S4089I .
NCIH1975 SNV: p.Q1407H DBIA    Probe Info 
NCIH82 SNV: p.G784A DBIA    Probe Info 
NUGC3 SNV: p.H2859N .
OZ SNV: p.F1728C .
RH41 Deletion: p.F948LfsTer9 .
RKO SNV: p.I1955T DBIA    Probe Info 
SAOS2 SNV: p.S2731Y .
SHP77 SNV: p.H4175P DBIA    Probe Info 
SKMEL30 SNV: p.R3525Q DBIA    Probe Info 
SNGM Deletion: p.D1092del .
SNU1 Deletion: p.F1788LfsTer4 .
SW1271 SNV: p.S657N .
SW403 SNV: p.G764D DBIA    Probe Info 
TC71 SNV: p.Q1142H DBIA    Probe Info 
TE4 SNV: p.Q307H .
UACC62 SNV: p.S1115F DBIA    Probe Info 
WM2664 Insertion: p.I391NfsTer35 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.68  LDD0402  [1]
Jackson_1
 Probe Info  		20.00  LDD0120  [2]
AHL-Pu-1
 Probe Info  		C515(2.19)  LDD0171  [3]
DBIA
 Probe Info  		C3225(5.62); C4123(31.89)  LDD0209  [4]
N1
 Probe Info  		K1041(0.00); S1042(0.00)  LDD0245  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [6]
ENE
 Probe Info  		N.A.  LDD0006  [7]
IPM
 Probe Info  		N.A.  LDD0005  [7]
AOyne
 Probe Info  		8.40  LDD0443  [8]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C515(2.03); C554(2.94)  LDD0371  [3]
 LDCM0026  4SU-RNA+native RNA DM93 C515(2.19)  LDD0171  [3]
 LDCM0214  AC1 HEK-293T C1518(0.94); C515(1.07); C1104(1.07); C554(0.99)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C1518(1.05); C515(1.09); C1104(0.93); C554(0.92)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C1518(1.11); C1104(1.01); C554(0.99); C2428(1.03)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C1518(1.04); C515(1.14); C2318(1.08); C1104(0.96)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C1518(0.96); C1104(1.06); C554(1.02); C2428(1.01)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C1518(1.01); C2318(0.74); C1104(1.11); C554(1.05)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C1518(1.03); C515(1.02); C1104(1.07); C554(1.05)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C1518(1.01); C515(1.03); C1104(1.01); C554(0.95)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C1518(1.01); C1104(1.25); C554(0.99); C2428(1.01)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C1518(1.03); C515(1.03); C1104(0.92); C554(0.96)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C1518(0.97); C515(0.78); C2318(0.95); C1104(1.00)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C1518(1.07); C515(1.09); C2318(0.82); C1104(0.95)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C1518(1.02); C1104(1.03); C554(0.93); C2428(0.93)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C1518(0.94); C2318(0.69); C1104(1.03); C554(0.96)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C1518(0.85); C515(1.00); C2318(0.98); C1104(0.96)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C1518(0.98); C515(1.09); C1104(1.01); C554(0.97)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C1518(0.98); C515(1.02); C1104(1.00); C554(0.99)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C1518(1.02); C1104(0.98); C554(1.02); C2428(1.07)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C1518(0.96); C515(1.05); C2318(0.97); C1104(0.95)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C1518(0.99); C515(0.99); C2318(0.99); C1104(1.06)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C1518(1.04); C1104(1.01); C554(0.97); C2428(1.07)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C1518(0.92); C1104(1.03); C554(0.99); C2428(0.97)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C1518(0.97); C2318(0.90); C1104(1.11); C554(1.00)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C1518(0.94); C515(0.98); C2318(1.09); C1104(1.06)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C1518(1.01); C515(1.06); C1104(1.07); C554(0.97)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C1518(0.97); C515(1.06); C1104(1.07); C554(0.98)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C1518(0.99); C1104(0.99); C554(0.99); C2428(1.13)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C1518(0.96); C515(1.03); C2318(0.99); C1104(1.04)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C1518(1.13); C515(1.03); C2318(1.03); C1104(0.89)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C1518(0.88); C1104(1.01); C554(0.99); C2428(1.01)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C1518(0.94); C2318(0.93); C1104(1.24); C554(1.05)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C1518(1.03); C515(0.93); C2318(0.83); C1104(0.99)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C1518(0.95); C515(1.06); C2318(0.94); C1104(1.01)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C1518(1.02); C515(1.11); C1104(1.02); C554(0.99)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C1518(1.06); C515(1.18); C1104(0.96); C554(0.95)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C1518(1.00); C1104(0.94); C554(1.08); C2428(1.10)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C1518(0.97); C515(0.88); C2318(0.86); C1104(0.97)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C1518(1.10); C515(1.06); C2318(0.97); C1104(0.98)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C1518(0.92); C1104(1.05); C554(1.03); C2428(0.94)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C1518(0.99); C2318(0.91); C1104(1.03); C554(1.04)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C1518(0.97); C515(1.04); C2318(0.87); C1104(0.99)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C1518(0.94); C515(1.16); C1104(1.05); C554(1.01)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C1518(1.04); C515(0.98); C2318(1.07); C1104(0.87)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C1518(1.08); C515(1.10); C1104(0.92); C554(0.90)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C1518(0.95); C1104(0.98); C554(0.92); C2428(1.13)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C1518(1.04); C515(1.00); C2318(0.87); C1104(0.94)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C1518(1.06); C515(1.06); C2318(1.09); C1104(0.90)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C1518(0.93); C1104(1.00); C554(1.00); C2428(1.02)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C1518(0.96); C2318(0.88); C1104(1.06); C554(0.96)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C1518(0.93); C515(1.07); C2318(0.91); C1104(1.01)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C1518(1.04); C515(1.06); C1104(1.04); C554(1.05)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C1518(1.06); C515(1.07); C1104(0.97); C554(1.00)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C1518(1.01); C1104(0.95); C554(1.01); C2428(1.04)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C1518(1.02); C1104(1.04); C554(0.96); C2428(0.98)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C1518(1.04); C515(0.95); C2318(0.92); C1104(0.94)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C1518(1.06); C515(0.98); C2318(0.98); C1104(0.88)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C1518(0.96); C1104(1.14); C554(1.00); C2428(0.98)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C1518(1.00); C2318(0.79); C1104(1.05); C554(1.00)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C1518(0.92); C515(1.00); C2318(0.93); C1104(0.94)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C1518(1.02); C2318(1.05); C1104(0.97); C554(1.13)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C1518(1.04); C515(0.98); C2318(0.87); C1104(0.99)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C1518(1.06); C515(1.05); C2318(1.02); C1104(0.93)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C1518(1.01); C515(1.15); C1104(1.04); C554(1.02)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C1518(1.00); C515(1.06); C2318(0.94); C1104(0.98)  LDD1514  [10]
 LDCM0070  Cisar_cp37 MDA-MB-231 20.00  LDD0120  [2]
 LDCM0367  CL1 HEK-293T C1518(0.90); C515(1.05); C2318(0.78); C1104(0.93)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C1518(0.86); C1104(1.24); C554(1.40); C2428(1.30)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C1518(0.99); C1104(0.98); C554(0.91); C2428(1.03)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C1518(0.98); C515(1.19); C2318(0.91); C1104(0.93)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C1518(0.86); C515(1.20); C2318(0.80); C1104(0.99)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C1518(0.93); C2318(1.01); C1104(0.94); C554(0.97)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C1518(1.08); C1104(0.94); C554(0.92); C2428(0.90)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C1518(1.03); C515(1.04); C2318(0.81); C1104(0.84)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C1518(0.85); C515(1.06); C2318(1.34); C1104(1.03)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C1518(0.94); C2318(1.11); C1104(0.95); C554(0.98)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C1518(0.97); C1104(0.92); C554(0.94); C2428(1.05)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C1518(1.08); C515(1.01); C2318(0.90); C1104(0.88)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C1518(0.92); C2318(0.88); C1104(1.08); C554(1.45)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C1518(0.98); C515(1.19); C2318(1.08); C1104(1.04)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C1518(0.84); C2318(1.37); C1104(0.90); C554(1.08)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C1518(0.96); C1104(0.99); C554(0.91); C2428(1.09)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C1518(1.13); C515(1.13); C2318(0.80); C1104(0.94)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C1518(0.85); C515(1.16); C2318(0.68); C1104(0.94)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C1518(0.85); C2318(0.70); C1104(1.00); C554(1.07)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C1518(1.10); C1104(0.97); C554(0.95); C2428(0.91)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C1518(1.08); C515(1.11); C2318(0.99); C1104(0.96)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C1518(1.06); C515(1.17); C2318(1.03); C1104(1.00)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C1518(0.99); C2318(0.75); C1104(0.96); C554(1.06)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C1518(0.88); C515(1.00); C2318(0.99); C1104(1.04)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C1518(1.02); C1104(0.98); C554(0.94); C2428(0.99)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C1518(1.07); C515(1.15); C2318(0.77); C1104(0.88)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C1518(0.84); C515(1.14); C2318(0.81); C1104(0.98)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C1518(0.95); C2318(0.95); C1104(0.96); C554(1.04)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C1518(0.97); C1104(0.97); C554(0.90); C2428(0.98)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C1518(0.95); C515(0.91); C2318(0.80); C1104(0.89)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C1518(0.84); C515(1.02); C2318(1.07); C1104(0.95)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C1518(0.92); C2318(0.94); C1104(0.94); C554(0.99)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C1518(1.07); C1104(1.04); C554(0.96); C2428(0.91)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C1518(0.89); C515(1.07); C2318(0.82); C1104(1.00)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C1518(1.00); C515(1.21); C2318(0.74); C1104(1.02)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C1518(0.98); C2318(1.07); C1104(0.95); C554(0.80)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C1518(0.98); C1104(0.96); C554(0.90); C2428(0.97)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C1518(1.01); C515(1.24); C1104(1.17); C554(1.12)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C1518(1.05); C515(1.16); C1104(0.96); C554(0.87)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C1518(0.99); C1104(0.99); C554(0.94); C2428(1.28)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C1518(0.79); C515(1.07); C2318(0.66); C1104(0.94)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C1518(1.01); C515(0.98); C2318(0.95); C1104(1.18)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C1518(1.02); C515(1.18); C2318(1.22); C1104(1.06)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C1518(0.83); C1104(1.22); C554(1.21); C2428(1.38)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C1518(1.06); C2318(0.86); C1104(1.18); C554(1.39)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C1518(0.92); C515(1.10); C2318(0.99); C1104(1.07)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C1518(0.91); C515(1.02); C2318(0.97); C1104(0.97)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C1518(0.90); C515(1.08); C2318(0.94); C1104(0.97)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C1518(0.92); C2318(1.11); C1104(1.01); C554(1.06)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C1518(1.01); C1104(0.93); C554(0.96); C2428(0.97)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C1518(1.02); C515(1.12); C1104(1.02); C554(1.04)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C1518(0.89); C2318(1.07); C1104(0.91); C554(1.04)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C1518(1.07); C515(1.02); C1104(1.00); C554(1.02)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C1518(0.99); C1104(1.00); C554(1.18); C2428(1.45)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C1518(1.11); C515(1.03); C2318(1.01); C1104(1.03)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C1518(1.10); C515(1.09); C2318(0.77); C1104(1.26)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C1518(0.97); C1104(1.02); C554(1.28); C2428(1.30)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C1518(1.00); C2318(1.02); C1104(1.01); C554(1.55)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C1518(0.84); C515(1.09); C2318(1.14); C1104(1.04)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C1518(0.97); C515(0.92); C2318(0.76); C1104(0.82)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C1518(0.79); C2318(1.07); C1104(0.94); C554(1.04)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C1518(0.97); C1104(0.91); C554(1.08); C2428(1.04)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C1518(0.96); C1104(1.00); C554(0.98); C2428(1.01)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C1518(0.99); C515(1.08); C1104(1.05); C554(1.03)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C1518(0.98); C515(1.07); C1104(0.93); C554(1.01)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C1518(1.10); C1104(1.05); C554(1.05); C2428(1.20)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C1518(1.28); C515(0.91); C2318(0.92); C1104(1.04)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C1518(1.01); C515(1.28); C2318(1.15); C1104(1.08)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C1518(0.98); C1104(1.27); C554(1.21); C2428(1.25)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C1518(0.96); C2318(1.22); C1104(1.14); C554(1.53)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C1518(0.83); C515(1.04); C2318(0.97); C1104(0.94)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C1518(1.08); C515(1.03); C2318(1.05); C1104(0.80)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C1518(0.97); C515(1.04); C1104(1.04); C554(1.11)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C1518(0.93); C515(1.14); C2318(0.60); C1104(0.95)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C1518(1.10); C1104(1.01); C554(0.96); C2428(1.04)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C1518(1.06); C515(1.32); C1104(1.09); C554(1.12)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C1518(1.03); C515(1.13); C1104(1.03); C554(1.09)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C1518(0.95); C1104(1.08); C554(1.11); C2428(1.26)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C1518(1.01); C515(1.14); C2318(1.01); C1104(1.09)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C1518(1.07); C515(1.16); C2318(1.18); C1104(1.05)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C1518(0.91); C1104(1.11); C554(1.21); C2428(1.20)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C1518(1.07); C2318(1.03); C1104(1.09); C554(1.45)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C1518(1.05); C515(1.12); C1104(0.99); C554(1.11)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C1518(1.10); C515(1.10); C2318(0.91); C1104(1.10)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C1518(0.99); C515(1.00); C2318(0.90); C1104(0.80)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C1518(0.89); C515(1.13); C2318(0.58); C1104(0.99)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C1518(0.96); C2318(0.80); C1104(0.91); C554(1.03)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C1518(1.07); C1104(1.01); C554(1.01); C2428(1.07)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C1518(1.08); C515(1.19); C1104(1.04); C554(1.00)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C1518(1.08); C515(1.10); C1104(1.03); C554(1.04)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C1518(1.05); C1104(0.94); C554(1.08); C2428(1.22)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C1518(1.04); C515(1.20); C2318(1.08); C1104(1.02)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C1518(1.02); C515(1.09); C2318(0.99); C1104(1.00)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C1518(1.00); C1104(1.02); C554(1.06); C2428(1.35)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C1518(1.00); C1104(1.17); C554(1.21); C2428(1.11)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C1518(0.99); C2318(1.07); C1104(1.06); C554(1.48)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C1518(0.82); C515(1.10); C2318(0.91); C1104(1.06)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C1518(1.01); C515(1.06); C2318(0.79); C1104(0.83)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C1518(0.84); C515(1.13); C2318(0.82); C1104(0.97)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C1518(0.98); C1104(0.94); C554(1.04); C2428(0.95)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C1518(0.96); C515(1.59); C1104(1.05); C554(1.05)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C1518(1.04); C515(1.10); C1104(0.92); C554(1.05)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C1518(1.03); C1104(0.94); C554(1.09); C2428(1.04)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C1518(1.25); C515(0.90); C2318(1.29); C1104(1.30)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C1518(0.92); C515(1.11); C2318(0.99); C1104(1.08)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C1518(1.06); C515(1.09); C2318(1.47); C1104(0.93)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C1518(1.04); C1104(1.09); C554(1.09); C2428(1.13)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C1518(0.95); C2318(0.90); C1104(1.12); C554(1.38)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C1518(1.04); C515(1.07); C2318(0.94); C1104(0.98)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C1518(0.93); C515(0.90); C2318(0.80); C1104(0.85)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C1518(0.82); C515(0.97); C2318(0.63); C1104(0.95)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C1518(0.90); C2318(1.17); C1104(0.90); C554(0.91)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C1518(1.01); C1104(0.95); C554(0.94); C2428(0.92)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C1518(0.99); C515(1.06); C1104(1.06); C554(1.01)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C1518(1.02); C515(1.03); C2318(1.00); C1104(1.00)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C1518(1.07); C515(1.14); C1104(1.07); C554(1.00)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C1518(1.08); C1104(1.01); C554(1.04); C2428(1.18)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C1518(0.87); C515(1.08); C2318(0.91); C1104(1.03)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C1518(1.09); C515(1.04); C2318(1.22); C1104(1.00)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C1518(0.96); C1104(1.13); C554(1.17); C2428(1.07)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C1518(1.09); C2318(1.19); C1104(1.13); C554(1.45)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C1518(0.98); C515(0.92); C2318(0.78); C1104(1.05)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C1518(1.09); C515(1.05); C2318(1.07); C1104(0.89)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C1518(0.97); C515(1.14); C2318(0.81); C1104(0.93)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C1518(0.83); C2318(0.84); C1104(0.84); C554(0.98)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C1518(0.86); C2318(0.87); C1104(0.96); C554(1.06)  LDD1698  [10]
 LDCM0625  F8 Ramos C3874(0.73)  LDD2187  [11]
 LDCM0573  Fragment11 Ramos C3874(0.79)  LDD2190  [11]
 LDCM0576  Fragment14 Ramos C3874(3.60)  LDD2193  [11]
 LDCM0468  Fragment33 HEK-293T C1518(0.97); C2318(0.84); C1104(0.92); C554(1.06)  LDD1671  [10]
 LDCM0566  Fragment4 Ramos C3874(0.44)  LDD2184  [11]
 LDCM0427  Fragment51 HEK-293T C1518(0.84); C515(1.12); C2318(1.20); C1104(0.93)  LDD1631  [10]
 LDCM0569  Fragment7 Ramos C3874(0.89)  LDD2186  [11]
 LDCM0022  KB02 HEK-293T C515(0.93); C2318(0.88); C1104(0.96); C554(1.11)  LDD1492  [10]
 LDCM0023  KB03 Jurkat C3225(5.62); C4123(31.89)  LDD0209  [4]
 LDCM0024  KB05 COLO792 C1518(2.72)  LDD3310  [12]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840