Details of the Target

General Information of Target

Target ID LDTP12475
Target Name Histone-lysine N-methyltransferase ASH1L (ASH1L)
Gene Name ASH1L
Gene ID 55870
Synonyms
KIAA1420; KMT2H; Histone-lysine N-methyltransferase ASH1L; EC 2.1.1.359; EC 2.1.1.367; ASH1-like protein; huASH1; Absent small and homeotic disks protein 1 homolog; Lysine N-methyltransferase 2H
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDFNMKKLASDAGIFFTRAVQFTEEKFGQAEKTELDAHFENLLARADSTKNWTEKILRQT
EVLLQPNPSARVEEFLYEKLDRKVPSRVTNGELLAQYMADAASELGPTTPYGKTLIKVAE
AEKQLGAAERDFIHTASISFLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAK
AAEAKATTVPDFQETRPRNYILSASASALWNDEVDKAEQELRVAQTEFDRQAEVTRLLLE
GISSTHVNHLRCLHEFVKSQTTYYAQCYRHMLDLQKQLGRFPGTFVGTTEPASPPLSSTS
PTTAAATMPVVPSVASLAPPGEASLCLEEVAPPASGTRKARVLYDYEAADSSELALLADE
LITVYSLPGMDPDWLIGERGNKKGKVPVTYLELLS
Target Bioclass
Enzyme
Family
Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SET2 subfamily
Subcellular location
Nucleus
Function
Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The physiological significance of the H3K9me1 activity is unclear.
Uniprot ID
Q9NR48
Ensemble ID
ENST00000368346.7
HGNC ID
HGNC:19088
ChEMBL ID
CHEMBL3588739

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Jackson_1
 Probe Info  		20.00  LDD0120  [1]
DBIA
 Probe Info  		C2225(0.90); C2229(0.90)  LDD0078  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
IPM
 Probe Info  		C747(0.00); C626(0.00)  LDD0147  [4]
Phosphinate-6
 Probe Info  		C227(0.00); C157(0.00); C626(0.00)  LDD0018  [5]
W1
 Probe Info  		N.A.  LDD0236  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C2225(1.25); C2229(1.25)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C2113(1.17); C2225(0.92)  LDD0813  [2]
 LDCM0216  AC100 HCT 116 C2225(0.85); C2229(0.85)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C2225(0.84); C2229(0.84)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C2225(0.88); C2229(0.88)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C2225(0.96); C2229(0.96)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C2225(0.92); C2229(0.92)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C2225(1.05); C2229(1.05)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C2225(1.12); C2229(1.12)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C2225(0.76); C2229(1.02)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C2225(1.09); C2229(0.91)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C2225(1.41); C2229(0.77)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C2113(0.98); C2225(0.86)  LDD0824  [2]
 LDCM0227  AC110 HCT 116 C2225(1.41); C2229(0.76)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C2225(1.10); C2229(0.69)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C2225(0.73); C2229(1.10)  LDD0546  [2]
 LDCM0237  AC12 HEK-293T C2113(0.84); C2225(0.82)  LDD0835  [2]
 LDCM0246  AC128 HCT 116 C2225(1.14); C2229(1.14)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C2225(1.09); C2229(1.09)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C2225(0.97); C2229(0.97)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C2225(0.92); C2229(0.92)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C2225(0.94); C2229(0.94)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C2225(1.02); C2229(1.02)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C2225(1.09); C2229(1.09)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C2225(1.01); C2229(1.01)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C2225(1.06); C2229(1.06)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C2225(1.03); C2229(1.03)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C2225(1.12); C2229(1.12)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C2225(1.11); C2229(1.11)  LDD0575  [2]
 LDCM0259  AC14 HEK-293T C2113(0.82); C2225(0.82)  LDD0857  [2]
 LDCM0260  AC140 HCT 116 C2225(1.01); C2229(1.01)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C2225(1.09); C2229(1.09)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C2225(1.16); C2229(1.16)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C2109(1.07); C2113(1.07)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C2109(1.03); C2113(1.03)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C2109(1.02); C2113(1.02)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C2109(1.12); C2113(1.12)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C2109(1.12); C2113(1.12)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C2109(1.38); C2113(1.38)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C2109(1.19); C2113(1.19)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C2113(0.67); C2225(1.77)  LDD0868  [2]
 LDCM0271  AC150 HCT 116 C2109(1.08); C2113(1.08)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C2109(0.96); C2113(0.96)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C2109(1.16); C2113(1.16)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C2109(1.28); C2113(1.28)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C2109(0.98); C2113(0.98)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C2109(1.19); C2113(1.19)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C2109(1.14); C2113(1.14)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C2109(1.17); C2113(1.17)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C2225(0.88); C2229(0.88)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C2225(0.95); C2229(0.95)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C2225(0.97); C2229(0.97)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C2225(0.90); C2229(0.90)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C2225(0.82); C2229(0.82)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C2225(0.98); C2229(0.98)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C2225(1.01); C2229(1.01)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C2225(0.96); C2229(0.96)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C2225(0.83); C2229(0.83)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C2225(0.86); C2229(0.86)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C2225(0.76); C2229(0.76)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C2225(0.80); C2229(0.80)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C2225(0.88); C2229(0.88)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C2225(0.89); C2229(0.89)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C2225(0.91); C2229(0.91)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C2225(0.76); C2229(0.76)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C2225(0.91); C2229(0.91)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C2225(0.73); C2229(0.73)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C2225(0.83); C2229(0.83)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C2225(0.82); C2229(0.82)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C2225(0.96); C2229(0.96)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C2225(0.97); C2229(0.97)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C2225(1.00); C2229(1.00)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C2225(1.27); C2229(1.27)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C2225(1.25); C2229(1.25)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C2225(0.91); C2229(0.91)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C2225(1.14); C2229(1.14)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C2225(1.13); C2229(1.13)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C2225(1.03); C2229(1.03)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C2225(1.23); C2229(1.23)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C2225(1.26); C2229(1.26)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C2225(1.08); C2229(1.08)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C2225(0.98); C2229(0.98)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C2225(0.92); C2229(0.92)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C2225(1.25); C2229(1.25)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C2225(1.14); C2229(1.14)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C2225(1.10); C2229(1.10)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C2225(0.94); C2229(0.94)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C2225(1.10); C2229(1.10)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C2225(1.00); C2229(1.00)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C2225(0.96); C2229(0.96)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C2225(1.03); C2229(1.03)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C2225(1.04); C2229(1.04)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C2225(1.24); C2229(1.24)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C2109(0.93); C2113(0.93)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C2109(0.78); C2113(0.78)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C2109(0.88); C2113(0.88)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C2113(0.94); C2225(0.79)  LDD0921  [2]
 LDCM0324  AC60 HCT 116 C2109(1.38); C2113(1.38)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C2109(1.00); C2113(1.00)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C2109(0.69); C2113(0.69)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C2109(0.80); C2113(0.80)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C2109(1.11); C2113(1.11)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C2109(0.75); C2113(0.75)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C2109(0.81); C2113(0.81)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C2109(0.69); C2113(0.69)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C2109(1.21); C2113(1.21)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C2109(1.43); C2113(1.43)  LDD0650  [2]
 LDCM0334  AC7 HEK-293T C2113(0.66); C2225(0.90)  LDD0932  [2]
 LDCM0335  AC70 HCT 116 C2109(2.08); C2113(2.08)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C2109(1.10); C2113(1.10)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C2109(1.07); C2113(1.07)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C2109(1.21); C2113(1.21)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C2109(1.47); C2113(1.47)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C2109(1.36); C2113(1.36)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C2109(1.22); C2113(1.22)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C2109(1.13); C2113(1.13)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C2109(1.32); C2113(1.32)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C2109(1.16); C2113(1.16)  LDD0661  [2]
 LDCM0345  AC8 HEK-293T C2113(1.39); C2225(0.91)  LDD0943  [2]
 LDCM0346  AC80 HCT 116 C2109(1.20); C2113(1.20)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C2109(1.55); C2113(1.55)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C2109(1.80); C2113(1.80)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C2109(1.20); C2113(1.20)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C2109(1.00); C2113(1.00)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C2109(1.06); C2113(1.06)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C2109(1.20); C2113(1.20)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C2109(1.06); C2113(1.06)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C2109(1.22); C2113(1.22)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C2109(1.21); C2113(1.21)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C2109(1.23); C2113(1.23)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C2109(0.95); C2113(0.95)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C2109(1.02); C2113(1.02)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C2109(0.82); C2113(0.82)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C2109(0.89); C2113(0.89)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C2109(1.12); C2113(1.12)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C2109(0.92); C2113(0.92)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C2109(1.14); C2113(1.14)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C2225(1.17); C2229(1.17)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C2225(0.79); C2229(0.79)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C2113(0.60); C2225(1.01)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C2113(0.88); C2225(1.04)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C2113(1.19); C2225(1.36)  LDD0873  [2]
 LDCM0020  ARS-1620 HCC44 C2225(0.90); C2229(0.90)  LDD0078  [2]
 LDCM0070  Cisar_cp37 MDA-MB-231 20.00  LDD0120  [1]
 LDCM0367  CL1 HCT 116 C2109(0.70); C2113(0.70); C2225(1.35); C2229(1.35)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C2109(0.69); C2113(0.69); C2225(1.32); C2229(1.32)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C2225(1.03); C2229(1.03)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C2113(1.02); C2225(1.04)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C2113(1.22); C2225(0.96)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C2113(0.76); C2225(0.79)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C2113(0.89); C2225(1.20)  LDD0971  [2]
 LDCM0374  CL105 HCT 116 C2225(1.15); C2229(1.15)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C2225(1.22); C2229(1.22)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C2225(0.88); C2229(0.88)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C2225(1.02); C2229(1.02)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C2225(0.94); C2229(0.94)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C2109(0.84); C2113(0.84); C2225(1.08); C2229(1.08)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C2225(1.05); C2229(1.05)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C2225(0.93); C2229(0.93)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C2225(0.77); C2229(0.77)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C2225(0.75); C2229(0.75)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C2225(0.69); C2229(0.69)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C2225(0.80); C2229(0.80)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C2225(0.81); C2229(0.81)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C2225(1.32); C2229(1.32)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C2225(1.17); C2229(1.17)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C2225(1.08); C2229(1.08)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C2109(0.67); C2113(0.67); C2225(1.08); C2229(1.08)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C2225(1.06); C2229(1.06)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C2225(1.49); C2229(1.49)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C2225(1.02); C2229(1.02)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C2225(1.05); C2229(1.05)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C2225(1.04); C2229(1.04)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C2109(0.79); C2113(0.79)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C2109(1.16); C2113(1.16)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C2109(0.87); C2113(0.87)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C2109(0.68); C2113(0.68)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C2109(0.76); C2113(0.76); C2225(1.32); C2229(1.32)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C2109(0.89); C2113(0.89); C2225(1.51); C2229(1.51)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C2109(1.33); C2113(1.33); C2225(1.61); C2229(1.61)  LDD0719  [2]
 LDCM0407  CL2 HCT 116 C2109(0.79); C2113(0.79); C2225(1.28); C2229(1.28)  LDD0724  [2]
 LDCM0409  CL21 HEK-293T C2805(0.90)  LDD1613  [7]
 LDCM0415  CL27 HEK-293T C2805(0.92)  LDD1619  [7]
 LDCM0418  CL3 HCT 116 C2109(0.72); C2113(0.72); C2225(1.13); C2229(1.13)  LDD0735  [2]
 LDCM0420  CL31 HEK-293T C2113(0.91); C2225(1.00)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C2113(1.44); C2225(0.93)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C2113(1.25); C2225(0.93)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C2113(0.92); C2225(0.95)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C2113(1.08); C2225(0.95)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C2113(1.11); C2225(0.89)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C2113(1.04); C2225(1.00)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C2113(1.22); C2225(1.20)  LDD1026  [2]
 LDCM0429  CL4 HCT 116 C2109(0.86); C2113(0.86); C2225(1.26); C2229(1.26)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C2113(1.08); C2225(0.97)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C2113(1.28); C2225(1.20)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C2113(1.66); C2225(1.17)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C2113(1.05); C2225(1.10)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C2113(1.23); C2225(0.97)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C2113(1.84); C2225(1.07)  LDD1033  [2]
 LDCM0436  CL46 PaTu 8988t C2225(1.06); C2229(1.06)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C2225(1.03); C2229(1.03)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C2225(1.05); C2229(1.05)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C2225(1.08); C2229(1.08)  LDD1318  [2]
 LDCM0440  CL5 HCT 116 C2109(0.69); C2113(0.69); C2225(1.66); C2229(1.66)  LDD0757  [2]
 LDCM0441  CL50 PaTu 8988t C2225(1.18); C2229(1.18)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C2225(1.01); C2229(1.01)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C2225(1.06); C2229(1.06)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C2225(1.78); C2229(1.78)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C2225(0.94); C2229(0.94)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C2225(0.89); C2229(0.89)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C2225(1.09); C2229(1.09)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C2225(0.93); C2229(0.93)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C2225(1.05); C2229(1.05)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C2225(1.10); C2229(1.10)  LDD1329  [2]
 LDCM0451  CL6 HCT 116 C2109(1.28); C2113(1.28); C2225(1.39); C2229(1.39)  LDD0768  [2]
 LDCM0452  CL60 PaTu 8988t C2225(1.02); C2229(1.02)  LDD1331  [2]
 LDCM0453  CL61 HCT 116 C2109(1.29); C2113(1.29)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C2109(1.32); C2113(1.32)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C2109(1.74); C2113(1.74)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C2109(1.54); C2113(1.54)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C2109(1.39); C2113(1.39)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C2109(1.58); C2113(1.58)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C2109(1.67); C2113(1.67)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C2109(1.86); C2113(1.86)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C2109(2.75); C2113(2.75)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C2109(0.70); C2113(0.70); C2225(1.30); C2229(1.30)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C2109(1.71); C2113(1.71)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C2109(1.40); C2113(1.40)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C2109(1.57); C2113(1.57)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C2109(1.47); C2113(1.47)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C2109(1.83); C2113(1.83)  LDD0784  [2]
 LDCM0469  CL76 PaTu 8988t C2225(1.31); C2229(1.31)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C2225(0.99); C2229(0.99)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C2225(0.91); C2229(0.91)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C2225(1.08); C2229(1.08)  LDD1351  [2]
 LDCM0473  CL8 HCT 116 C2109(0.74); C2113(0.74); C2225(2.17); C2229(2.17)  LDD0790  [2]
 LDCM0474  CL80 PaTu 8988t C2225(1.45); C2229(1.45)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C2225(1.08); C2229(1.08)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C2225(1.06); C2229(1.06)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C2225(1.10); C2229(1.10)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C2225(0.90); C2229(0.90)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C2225(0.86); C2229(0.86)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C2225(1.03); C2229(1.03)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C2225(1.06); C2229(1.06)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C2225(0.98); C2229(0.98)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C2225(1.09); C2229(1.09)  LDD1362  [2]
 LDCM0484  CL9 HCT 116 C2109(0.59); C2113(0.59); C2225(1.00); C2229(1.00)  LDD0801  [2]
 LDCM0485  CL90 PaTu 8988t C2225(0.95); C2229(0.95)  LDD1364  [2]
 LDCM0486  CL91 HCT 116 C2225(0.82); C2229(0.82)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C2225(1.02); C2229(1.02)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C2225(0.83); C2229(0.83)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C2225(1.33); C2229(1.33)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C2225(1.15); C2229(1.15)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C2225(0.84); C2229(0.84)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C2225(0.89); C2229(0.89)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C2225(0.92); C2229(0.92)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C2225(1.04); C2229(1.04)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C2805(1.12)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C2109(1.29); C2113(1.29)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C2113(0.97); C2225(0.91)  LDD1025  [2]
 LDCM0022  KB02 HEK-293T C2911(1.00); C2146(0.90)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C2911(0.98); C2146(0.99)  LDD1497  [7]
 LDCM0024  KB05 OE33 C2911(1.71)  LDD3375  [8]

References

1 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840