Details of the Target

General Information of Target

Target ID LDTP06612
Target Name 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (DECR1)
Gene Name DECR1
Gene ID 1666
Synonyms
DECR; SDR18C1; 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial; EC 1.3.1.124; 2,4-dienoyl-CoA reductase [NADPH]; 4-enoyl-CoA reductase [NADPH]; Short chain dehydrogenase/reductase family 18C member 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLPARVFFTLGSRLPCGLAPRRFFSYGTKILYQNTEALQSKFFSPLQKAMLPPNSFQGK
VAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRD
PDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIG
KQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQP
GPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVIKFD
GGEEVLISGEFNDLRKVTKEQWDTIEELIRKTKGS
Target Bioclass
Enzyme
Family
Short-chain dehydrogenases/reductases (SDR) family, 2,4-dienoyl-CoA reductase subfamily
Subcellular location
Mitochondrion
Function
Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.
Uniprot ID
Q16698
Ensemble ID
ENST00000220764.7
HGNC ID
HGNC:2753

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FADU SNV: p.P138A .
HEC1B SNV: p.V207A .
ICC10 SNV: p.Q115H DBIA    Probe Info 
ICC106 SNV: p.Q115H DBIA    Probe Info 
ICC108 SNV: p.Q115H DBIA    Probe Info 
KMCH1 Deletion: p.N236_T245del
SNV: p.S151P		 .
NALM6 SNV: p.Y27N DBIA    Probe Info 
NCIH146 SNV: p.I184V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
YN-4
 Probe Info  		100.00  LDD0445  [3]
STPyne
 Probe Info  		K244(7.70); K246(7.40); K260(2.48)  LDD0277  [4]
BTD
 Probe Info  		C116(0.85)  LDD2092  [5]
Jackson_1
 Probe Info  		2.83  LDD0120  [6]
DBIA
 Probe Info  		C86(7.65)  LDD0209  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C116(0.00); C86(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C116(0.00); C86(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C116(0.00); C86(0.00)  LDD0037  [9]
IPM
 Probe Info  		N.A.  LDD0025  [10]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
TFBX
 Probe Info  		C86(0.00); C268(0.00)  LDD0027  [10]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
WYneO
 Probe Info  		N.A.  LDD0022  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
Ox-W18
 Probe Info  		N.A.  LDD2175  [13]
1c-yne
 Probe Info  		N.A.  LDD0228  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [15]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
MPP-AC
 Probe Info  		N.A.  LDD0428  [17]
NAIA_5
 Probe Info  		C116(0.00); C268(0.00); C86(0.00); C285(0.00)  LDD2223  [18]
TER-AC
 Probe Info  		N.A.  LDD0426  [17]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		9.18  LDD0472  [19]
FFF probe13
 Probe Info  		20.00  LDD0475  [19]
FFF probe2
 Probe Info  		18.45  LDD0463  [19]
FFF probe3
 Probe Info  		15.59  LDD0464  [19]
FFF probe6
 Probe Info  		20.00  LDD0467  [19]
JN0003
 Probe Info  		20.00  LDD0469  [19]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [20]
OEA-DA
 Probe Info  		20.00  LDD0046  [21]
STS-1
 Probe Info  		N.A.  LDD0068  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C116(0.58)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C116(0.63)  LDD2112  [5]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C116(0.81)  LDD2095  [5]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C116(0.76)  LDD2130  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C116(1.03)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C116(1.02)  LDD2152  [5]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C116(0.91)  LDD2103  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C116(0.70)  LDD2132  [5]
 LDCM0214  AC1 HCT 116 C86(0.69)  LDD0531  [23]
 LDCM0215  AC10 HCT 116 C116(0.97)  LDD0532  [23]
 LDCM0216  AC100 HCT 116 C116(1.11)  LDD0533  [23]
 LDCM0217  AC101 HCT 116 C116(0.92)  LDD0534  [23]
 LDCM0218  AC102 HCT 116 C116(0.80)  LDD0535  [23]
 LDCM0219  AC103 HCT 116 C116(0.81)  LDD0536  [23]
 LDCM0220  AC104 HCT 116 C116(0.70)  LDD0537  [23]
 LDCM0221  AC105 HCT 116 C116(0.75)  LDD0538  [23]
 LDCM0222  AC106 HCT 116 C116(0.71)  LDD0539  [23]
 LDCM0223  AC107 HCT 116 C116(0.65)  LDD0540  [23]
 LDCM0224  AC108 HCT 116 C116(0.98)  LDD0541  [23]
 LDCM0225  AC109 HCT 116 C116(0.80)  LDD0542  [23]
 LDCM0226  AC11 HCT 116 C116(0.86)  LDD0543  [23]
 LDCM0227  AC110 HCT 116 C116(0.86)  LDD0544  [23]
 LDCM0228  AC111 HCT 116 C116(0.91)  LDD0545  [23]
 LDCM0229  AC112 HCT 116 C116(0.79)  LDD0546  [23]
 LDCM0230  AC113 HCT 116 C116(0.72)  LDD0547  [23]
 LDCM0231  AC114 HCT 116 C116(0.38)  LDD0548  [23]
 LDCM0232  AC115 HCT 116 C116(0.57)  LDD0549  [23]
 LDCM0233  AC116 HCT 116 C116(0.42)  LDD0550  [23]
 LDCM0234  AC117 HCT 116 C116(0.46)  LDD0551  [23]
 LDCM0235  AC118 HCT 116 C116(0.49)  LDD0552  [23]
 LDCM0236  AC119 HCT 116 C116(0.58)  LDD0553  [23]
 LDCM0237  AC12 HCT 116 C116(1.11)  LDD0554  [23]
 LDCM0238  AC120 HCT 116 C116(0.57)  LDD0555  [23]
 LDCM0239  AC121 HCT 116 C116(0.51)  LDD0556  [23]
 LDCM0240  AC122 HCT 116 C116(0.44)  LDD0557  [23]
 LDCM0241  AC123 HCT 116 C116(0.44)  LDD0558  [23]
 LDCM0242  AC124 HCT 116 C116(0.47)  LDD0559  [23]
 LDCM0243  AC125 HCT 116 C116(0.54)  LDD0560  [23]
 LDCM0244  AC126 HCT 116 C116(0.49)  LDD0561  [23]
 LDCM0245  AC127 HCT 116 C116(0.43)  LDD0562  [23]
 LDCM0246  AC128 HCT 116 C116(0.58)  LDD0563  [23]
 LDCM0247  AC129 HCT 116 C116(0.96)  LDD0564  [23]
 LDCM0249  AC130 HCT 116 C116(0.64)  LDD0566  [23]
 LDCM0250  AC131 HCT 116 C116(0.75)  LDD0567  [23]
 LDCM0251  AC132 HCT 116 C116(1.27)  LDD0568  [23]
 LDCM0252  AC133 HCT 116 C116(0.74)  LDD0569  [23]
 LDCM0253  AC134 HCT 116 C116(0.87)  LDD0570  [23]
 LDCM0254  AC135 HCT 116 C116(0.90)  LDD0571  [23]
 LDCM0255  AC136 HCT 116 C116(0.86)  LDD0572  [23]
 LDCM0256  AC137 HCT 116 C116(1.00)  LDD0573  [23]
 LDCM0257  AC138 HCT 116 C116(0.78)  LDD0574  [23]
 LDCM0258  AC139 HCT 116 C116(0.88)  LDD0575  [23]
 LDCM0259  AC14 HCT 116 C116(0.91)  LDD0576  [23]
 LDCM0260  AC140 HCT 116 C116(0.85)  LDD0577  [23]
 LDCM0261  AC141 HCT 116 C116(0.90)  LDD0578  [23]
 LDCM0262  AC142 HCT 116 C116(0.90)  LDD0579  [23]
 LDCM0263  AC143 HEK-293T C116(1.07); C86(1.07)  LDD0861  [23]
 LDCM0264  AC144 HEK-293T C116(1.34); C86(1.29)  LDD0862  [23]
 LDCM0265  AC145 HEK-293T C116(1.18); C86(1.31)  LDD0863  [23]
 LDCM0266  AC146 HEK-293T C116(1.18); C86(1.33)  LDD0864  [23]
 LDCM0267  AC147 HEK-293T C116(1.39); C86(1.48)  LDD0865  [23]
 LDCM0268  AC148 HEK-293T C116(1.07); C86(1.49)  LDD0866  [23]
 LDCM0269  AC149 HEK-293T C116(1.06); C86(1.14)  LDD0867  [23]
 LDCM0270  AC15 HCT 116 C116(0.94)  LDD0587  [23]
 LDCM0271  AC150 HEK-293T C116(1.12); C86(1.29)  LDD0869  [23]
 LDCM0272  AC151 HEK-293T C116(1.27); C86(1.21)  LDD0870  [23]
 LDCM0273  AC152 HEK-293T C116(1.19); C86(1.13)  LDD0871  [23]
 LDCM0274  AC153 HEK-293T C116(1.23); C86(1.23)  LDD0872  [23]
 LDCM0621  AC154 HEK-293T C116(1.04); C86(0.98)  LDD2162  [23]
 LDCM0622  AC155 HEK-293T C116(1.18); C86(1.13)  LDD2163  [23]
 LDCM0623  AC156 HEK-293T C116(1.40); C86(1.28)  LDD2164  [23]
 LDCM0624  AC157 HEK-293T C116(1.47); C86(1.63)  LDD2165  [23]
 LDCM0276  AC17 HCT 116 C116(0.81)  LDD0593  [23]
 LDCM0277  AC18 HCT 116 C116(0.55)  LDD0594  [23]
 LDCM0278  AC19 HCT 116 C116(0.84)  LDD0595  [23]
 LDCM0279  AC2 HCT 116 C86(0.96)  LDD0596  [23]
 LDCM0280  AC20 HCT 116 C116(0.77)  LDD0597  [23]
 LDCM0281  AC21 HCT 116 C116(0.70)  LDD0598  [23]
 LDCM0282  AC22 HCT 116 C116(0.75)  LDD0599  [23]
 LDCM0283  AC23 HCT 116 C116(0.78)  LDD0600  [23]
 LDCM0284  AC24 HCT 116 C116(1.07)  LDD0601  [23]
 LDCM0285  AC25 HCT 116 C116(1.06)  LDD0602  [23]
 LDCM0286  AC26 HCT 116 C116(0.90)  LDD0603  [23]
 LDCM0287  AC27 HCT 116 C116(0.84)  LDD0604  [23]
 LDCM0288  AC28 HCT 116 C116(0.83)  LDD0605  [23]
 LDCM0289  AC29 HCT 116 C116(0.90)  LDD0606  [23]
 LDCM0290  AC3 HCT 116 C86(0.76)  LDD0607  [23]
 LDCM0291  AC30 HCT 116 C116(0.74)  LDD0608  [23]
 LDCM0292  AC31 HCT 116 C116(0.76)  LDD0609  [23]
 LDCM0293  AC32 HCT 116 C116(0.63)  LDD0610  [23]
 LDCM0294  AC33 HCT 116 C116(0.65)  LDD0611  [23]
 LDCM0295  AC34 HCT 116 C116(0.60)  LDD0612  [23]
 LDCM0296  AC35 HEK-293T C86(1.20)  LDD0894  [23]
 LDCM0297  AC36 HEK-293T C86(0.93)  LDD0895  [23]
 LDCM0298  AC37 HEK-293T C86(1.22)  LDD0896  [23]
 LDCM0299  AC38 HEK-293T C86(1.06)  LDD0897  [23]
 LDCM0300  AC39 HEK-293T C86(1.04)  LDD0898  [23]
 LDCM0301  AC4 HCT 116 C86(0.74)  LDD0618  [23]
 LDCM0302  AC40 HEK-293T C86(1.19)  LDD0900  [23]
 LDCM0303  AC41 HEK-293T C86(1.14)  LDD0901  [23]
 LDCM0304  AC42 HEK-293T C86(1.12)  LDD0902  [23]
 LDCM0305  AC43 HEK-293T C86(1.14)  LDD0903  [23]
 LDCM0306  AC44 HEK-293T C86(1.17)  LDD0904  [23]
 LDCM0307  AC45 HEK-293T C86(1.01)  LDD0905  [23]
 LDCM0308  AC46 HCT 116 C116(0.98)  LDD0625  [23]
 LDCM0309  AC47 HCT 116 C116(0.90)  LDD0626  [23]
 LDCM0310  AC48 HCT 116 C116(0.89)  LDD0627  [23]
 LDCM0311  AC49 HCT 116 C116(0.54)  LDD0628  [23]
 LDCM0312  AC5 HCT 116 C86(0.74)  LDD0629  [23]
 LDCM0313  AC50 HCT 116 C116(0.54)  LDD0630  [23]
 LDCM0314  AC51 HCT 116 C116(1.37)  LDD0631  [23]
 LDCM0315  AC52 HCT 116 C116(1.02)  LDD0632  [23]
 LDCM0316  AC53 HCT 116 C116(0.69)  LDD0633  [23]
 LDCM0317  AC54 HCT 116 C116(0.70)  LDD0634  [23]
 LDCM0318  AC55 HCT 116 C116(0.48)  LDD0635  [23]
 LDCM0319  AC56 HCT 116 C116(0.34)  LDD0636  [23]
 LDCM0320  AC57 HCT 116 C116(0.59)  LDD0637  [23]
 LDCM0321  AC58 HCT 116 C116(0.49)  LDD0638  [23]
 LDCM0322  AC59 HCT 116 C116(0.61)  LDD0639  [23]
 LDCM0323  AC6 HCT 116 C116(0.77)  LDD0640  [23]
 LDCM0324  AC60 HCT 116 C116(0.56)  LDD0641  [23]
 LDCM0325  AC61 HCT 116 C116(0.45)  LDD0642  [23]
 LDCM0326  AC62 HCT 116 C116(0.44)  LDD0643  [23]
 LDCM0327  AC63 HCT 116 C116(0.55)  LDD0644  [23]
 LDCM0328  AC64 HCT 116 C116(0.53)  LDD0645  [23]
 LDCM0329  AC65 HCT 116 C116(0.72)  LDD0646  [23]
 LDCM0330  AC66 HCT 116 C116(0.73)  LDD0647  [23]
 LDCM0331  AC67 HCT 116 C116(0.32)  LDD0648  [23]
 LDCM0332  AC68 HCT 116 C116(0.69); C86(0.93)  LDD0649  [23]
 LDCM0333  AC69 HCT 116 C116(0.52); C86(1.00)  LDD0650  [23]
 LDCM0334  AC7 HCT 116 C116(0.99)  LDD0651  [23]
 LDCM0335  AC70 HCT 116 C116(0.41); C86(1.02)  LDD0652  [23]
 LDCM0336  AC71 HCT 116 C116(0.88); C86(0.98)  LDD0653  [23]
 LDCM0337  AC72 HCT 116 C116(0.63); C86(0.93)  LDD0654  [23]
 LDCM0338  AC73 HCT 116 C116(0.37); C86(1.08)  LDD0655  [23]
 LDCM0339  AC74 HCT 116 C116(0.30); C86(0.99)  LDD0656  [23]
 LDCM0340  AC75 HCT 116 C116(0.30); C86(0.99)  LDD0657  [23]
 LDCM0341  AC76 HCT 116 C116(0.60); C86(1.12)  LDD0658  [23]
 LDCM0342  AC77 HCT 116 C116(0.63); C86(0.90)  LDD0659  [23]
 LDCM0343  AC78 HCT 116 C116(0.64); C86(0.95)  LDD0660  [23]
 LDCM0344  AC79 HCT 116 C116(0.76); C86(1.17)  LDD0661  [23]
 LDCM0345  AC8 HCT 116 C116(0.82)  LDD0662  [23]
 LDCM0346  AC80 HCT 116 C116(0.63); C86(1.15)  LDD0663  [23]
 LDCM0347  AC81 HCT 116 C116(0.79); C86(0.93)  LDD0664  [23]
 LDCM0348  AC82 HCT 116 C116(0.30); C86(1.05)  LDD0665  [23]
 LDCM0349  AC83 HCT 116 C116(0.46)  LDD0666  [23]
 LDCM0350  AC84 HCT 116 C116(0.47)  LDD0667  [23]
 LDCM0351  AC85 HCT 116 C116(0.60)  LDD0668  [23]
 LDCM0352  AC86 HCT 116 C116(0.95)  LDD0669  [23]
 LDCM0353  AC87 HCT 116 C116(0.99)  LDD0670  [23]
 LDCM0354  AC88 HCT 116 C116(0.88)  LDD0671  [23]
 LDCM0355  AC89 HCT 116 C116(0.70)  LDD0672  [23]
 LDCM0357  AC90 HCT 116 C116(1.64)  LDD0674  [23]
 LDCM0358  AC91 HCT 116 C116(0.49)  LDD0675  [23]
 LDCM0359  AC92 HCT 116 C116(0.60)  LDD0676  [23]
 LDCM0360  AC93 HCT 116 C116(0.83)  LDD0677  [23]
 LDCM0361  AC94 HCT 116 C116(0.80)  LDD0678  [23]
 LDCM0362  AC95 HCT 116 C116(0.64)  LDD0679  [23]
 LDCM0363  AC96 HCT 116 C116(0.64)  LDD0680  [23]
 LDCM0364  AC97 HCT 116 C116(0.63)  LDD0681  [23]
 LDCM0365  AC98 HCT 116 C116(0.70)  LDD0682  [23]
 LDCM0366  AC99 HCT 116 C116(1.08)  LDD0683  [23]
 LDCM0520  AKOS000195272 MDA-MB-231 C116(0.78)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C116(1.09)  LDD0565  [23]
 LDCM0356  AKOS034007680 HCT 116 C116(0.94)  LDD0673  [23]
 LDCM0275  AKOS034007705 HCT 116 C116(0.59)  LDD0592  [23]
 LDCM0156  Aniline NCI-H1299 12.11  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C116(0.00); C86(0.00); H112(0.00)  LDD0222  [15]
 LDCM0071  Cisar_cp14 MDA-MB-231 5.56  LDD0121  [6]
 LDCM0070  Cisar_cp37 MDA-MB-231 2.83  LDD0120  [6]
 LDCM0632  CL-Sc Hep-G2 C86(20.00)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C86(0.94); C116(0.96)  LDD0684  [23]
 LDCM0368  CL10 HCT 116 C116(0.52); C86(0.56)  LDD0685  [23]
 LDCM0369  CL100 HCT 116 C86(0.75)  LDD0686  [23]
 LDCM0370  CL101 HCT 116 C116(0.77)  LDD0687  [23]
 LDCM0371  CL102 HCT 116 C116(1.05)  LDD0688  [23]
 LDCM0372  CL103 HCT 116 C116(0.91)  LDD0689  [23]
 LDCM0373  CL104 HCT 116 C116(0.97)  LDD0690  [23]
 LDCM0374  CL105 HCT 116 C116(0.64)  LDD0691  [23]
 LDCM0375  CL106 HCT 116 C116(0.30)  LDD0692  [23]
 LDCM0376  CL107 HCT 116 C116(0.61)  LDD0693  [23]
 LDCM0377  CL108 HCT 116 C116(0.48)  LDD0694  [23]
 LDCM0378  CL109 HCT 116 C116(0.62)  LDD0695  [23]
 LDCM0379  CL11 HCT 116 C116(0.49); C86(0.54)  LDD0696  [23]
 LDCM0380  CL110 HCT 116 C116(0.56)  LDD0697  [23]
 LDCM0381  CL111 HCT 116 C116(0.71)  LDD0698  [23]
 LDCM0382  CL112 HCT 116 C116(1.06)  LDD0699  [23]
 LDCM0383  CL113 HCT 116 C116(0.62)  LDD0700  [23]
 LDCM0384  CL114 HCT 116 C116(0.71)  LDD0701  [23]
 LDCM0385  CL115 HCT 116 C116(0.76)  LDD0702  [23]
 LDCM0386  CL116 HCT 116 C116(0.88)  LDD0703  [23]
 LDCM0387  CL117 HEK-293T C86(0.94)  LDD0985  [23]
 LDCM0388  CL118 HEK-293T C86(1.10)  LDD0986  [23]
 LDCM0389  CL119 HEK-293T C86(1.01)  LDD0987  [23]
 LDCM0390  CL12 HCT 116 C116(0.52); C86(0.60)  LDD0707  [23]
 LDCM0391  CL120 HEK-293T C86(1.08)  LDD0989  [23]
 LDCM0392  CL121 HCT 116 C116(0.95)  LDD0709  [23]
 LDCM0393  CL122 HCT 116 C116(0.65)  LDD0710  [23]
 LDCM0394  CL123 HCT 116 C116(0.44)  LDD0711  [23]
 LDCM0395  CL124 HCT 116 C116(0.56)  LDD0712  [23]
 LDCM0396  CL125 HCT 116 C116(1.07)  LDD0713  [23]
 LDCM0397  CL126 HCT 116 C116(0.95)  LDD0714  [23]
 LDCM0398  CL127 HCT 116 C116(0.85)  LDD0715  [23]
 LDCM0399  CL128 HCT 116 C116(0.70)  LDD0716  [23]
 LDCM0400  CL13 HCT 116 C116(0.45); C86(0.64)  LDD0717  [23]
 LDCM0401  CL14 HCT 116 C116(0.78); C86(0.91)  LDD0718  [23]
 LDCM0402  CL15 HCT 116 C116(0.42); C86(0.55)  LDD0719  [23]
 LDCM0403  CL16 HCT 116 C116(0.77); C86(1.26)  LDD0720  [23]
 LDCM0404  CL17 HCT 116 C116(0.58); C86(0.73)  LDD0721  [23]
 LDCM0405  CL18 HCT 116 C116(0.37); C86(0.61)  LDD0722  [23]
 LDCM0406  CL19 HCT 116 C116(0.64); C86(0.86)  LDD0723  [23]
 LDCM0407  CL2 HCT 116 C116(0.86); C86(0.95)  LDD0724  [23]
 LDCM0408  CL20 HCT 116 C116(0.60); C86(0.82)  LDD0725  [23]
 LDCM0409  CL21 HCT 116 C116(0.41); C86(0.69)  LDD0726  [23]
 LDCM0410  CL22 HCT 116 C116(0.36); C86(0.41)  LDD0727  [23]
 LDCM0411  CL23 HCT 116 C116(0.79); C86(1.39)  LDD0728  [23]
 LDCM0412  CL24 HCT 116 C116(0.56); C86(0.68)  LDD0729  [23]
 LDCM0413  CL25 HCT 116 C116(0.59); C86(0.78)  LDD0730  [23]
 LDCM0414  CL26 HCT 116 C116(0.78); C86(0.79)  LDD0731  [23]
 LDCM0415  CL27 HCT 116 C116(0.80); C86(0.76)  LDD0732  [23]
 LDCM0416  CL28 HCT 116 C116(0.59); C86(0.72)  LDD0733  [23]
 LDCM0417  CL29 HCT 116 C116(0.69); C86(0.71)  LDD0734  [23]
 LDCM0418  CL3 HCT 116 C116(0.89); C86(0.98)  LDD0735  [23]
 LDCM0419  CL30 HCT 116 C116(0.70); C86(1.14)  LDD0736  [23]
 LDCM0420  CL31 HCT 116 C86(0.76)  LDD0737  [23]
 LDCM0421  CL32 HCT 116 C86(0.51)  LDD0738  [23]
 LDCM0422  CL33 HCT 116 C86(0.91)  LDD0739  [23]
 LDCM0423  CL34 HCT 116 C86(0.54)  LDD0740  [23]
 LDCM0424  CL35 HCT 116 C86(0.65)  LDD0741  [23]
 LDCM0425  CL36 HCT 116 C86(0.79)  LDD0742  [23]
 LDCM0426  CL37 HCT 116 C86(0.69)  LDD0743  [23]
 LDCM0428  CL39 HCT 116 C86(0.61)  LDD0745  [23]
 LDCM0429  CL4 HCT 116 C116(0.78); C86(0.78)  LDD0746  [23]
 LDCM0430  CL40 HCT 116 C86(0.59)  LDD0747  [23]
 LDCM0431  CL41 HCT 116 C86(0.68)  LDD0748  [23]
 LDCM0432  CL42 HCT 116 C86(0.40)  LDD0749  [23]
 LDCM0433  CL43 HCT 116 C86(0.56)  LDD0750  [23]
 LDCM0434  CL44 HCT 116 C86(0.55)  LDD0751  [23]
 LDCM0435  CL45 HCT 116 C86(0.52)  LDD0752  [23]
 LDCM0436  CL46 HCT 116 C86(1.45)  LDD0753  [23]
 LDCM0437  CL47 HCT 116 C86(1.22)  LDD0754  [23]
 LDCM0438  CL48 HCT 116 C86(1.48)  LDD0755  [23]
 LDCM0439  CL49 HCT 116 C86(1.53)  LDD0756  [23]
 LDCM0440  CL5 HCT 116 C116(0.98); C86(1.06)  LDD0757  [23]
 LDCM0441  CL50 HCT 116 C86(1.42)  LDD0758  [23]
 LDCM0442  CL51 HCT 116 C86(1.71)  LDD0759  [23]
 LDCM0443  CL52 HCT 116 C86(1.31)  LDD0760  [23]
 LDCM0444  CL53 HCT 116 C86(1.55)  LDD0761  [23]
 LDCM0445  CL54 HCT 116 C86(1.37)  LDD0762  [23]
 LDCM0446  CL55 HCT 116 C86(1.54)  LDD0763  [23]
 LDCM0447  CL56 HCT 116 C86(1.23)  LDD0764  [23]
 LDCM0448  CL57 HCT 116 C86(1.51)  LDD0765  [23]
 LDCM0449  CL58 HCT 116 C86(1.53)  LDD0766  [23]
 LDCM0450  CL59 HCT 116 C86(1.37)  LDD0767  [23]
 LDCM0451  CL6 HCT 116 C116(0.56); C86(0.69)  LDD0768  [23]
 LDCM0452  CL60 HCT 116 C86(1.49)  LDD0769  [23]
 LDCM0453  CL61 HCT 116 C86(0.91)  LDD0770  [23]
 LDCM0454  CL62 HCT 116 C86(0.89)  LDD0771  [23]
 LDCM0455  CL63 HCT 116 C86(0.74)  LDD0772  [23]
 LDCM0456  CL64 HCT 116 C86(0.63)  LDD0773  [23]
 LDCM0457  CL65 HCT 116 C86(0.90)  LDD0774  [23]
 LDCM0458  CL66 HCT 116 C86(0.54)  LDD0775  [23]
 LDCM0459  CL67 HCT 116 C86(0.70)  LDD0776  [23]
 LDCM0460  CL68 HCT 116 C86(0.61)  LDD0777  [23]
 LDCM0461  CL69 HCT 116 C86(0.60)  LDD0778  [23]
 LDCM0462  CL7 HCT 116 C116(0.67); C86(0.60)  LDD0779  [23]
 LDCM0463  CL70 HCT 116 C86(0.65)  LDD0780  [23]
 LDCM0464  CL71 HCT 116 C86(0.73)  LDD0781  [23]
 LDCM0465  CL72 HCT 116 C86(0.95)  LDD0782  [23]
 LDCM0466  CL73 HCT 116 C86(0.70)  LDD0783  [23]
 LDCM0467  CL74 HCT 116 C86(0.75)  LDD0784  [23]
 LDCM0469  CL76 HCT 116 C116(0.73); C86(0.80)  LDD0786  [23]
 LDCM0470  CL77 HCT 116 C116(0.67); C86(0.64)  LDD0787  [23]
 LDCM0471  CL78 HCT 116 C116(0.76); C86(0.99)  LDD0788  [23]
 LDCM0472  CL79 HCT 116 C116(0.65); C86(0.77)  LDD0789  [23]
 LDCM0473  CL8 HCT 116 C116(0.39); C86(0.54)  LDD0790  [23]
 LDCM0474  CL80 HCT 116 C116(0.52); C86(0.82)  LDD0791  [23]
 LDCM0475  CL81 HCT 116 C116(0.78); C86(0.85)  LDD0792  [23]
 LDCM0476  CL82 HCT 116 C116(0.44); C86(0.55)  LDD0793  [23]
 LDCM0477  CL83 HCT 116 C116(0.48); C86(0.60)  LDD0794  [23]
 LDCM0478  CL84 HCT 116 C116(0.32); C86(0.46)  LDD0795  [23]
 LDCM0479  CL85 HCT 116 C116(0.84); C86(0.81)  LDD0796  [23]
 LDCM0480  CL86 HCT 116 C116(1.02); C86(0.84)  LDD0797  [23]
 LDCM0481  CL87 HCT 116 C116(0.87); C86(0.83)  LDD0798  [23]
 LDCM0482  CL88 HCT 116 C116(0.57); C86(0.63)  LDD0799  [23]
 LDCM0483  CL89 HCT 116 C116(0.28); C86(0.44)  LDD0800  [23]
 LDCM0484  CL9 HCT 116 C116(0.66); C86(0.94)  LDD0801  [23]
 LDCM0485  CL90 HCT 116 C116(0.62); C86(0.54)  LDD0802  [23]
 LDCM0486  CL91 HCT 116 C86(1.13)  LDD0803  [23]
 LDCM0487  CL92 HCT 116 C86(0.83)  LDD0804  [23]
 LDCM0488  CL93 HCT 116 C86(0.81)  LDD0805  [23]
 LDCM0489  CL94 HCT 116 C86(0.75)  LDD0806  [23]
 LDCM0490  CL95 HCT 116 C86(0.81)  LDD0807  [23]
 LDCM0491  CL96 HCT 116 C86(0.81)  LDD0808  [23]
 LDCM0492  CL97 HCT 116 C86(0.91)  LDD0809  [23]
 LDCM0493  CL98 HCT 116 C86(0.70)  LDD0810  [23]
 LDCM0494  CL99 HCT 116 C86(0.69)  LDD0811  [23]
 LDCM0495  E2913 HEK-293T C116(0.98)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C116(2.14)  LDD1702  [5]
 LDCM0625  F8 Ramos C116(1.98)  LDD2187  [25]
 LDCM0572  Fragment10 Ramos C116(0.95); C268(1.13)  LDD2189  [25]
 LDCM0573  Fragment11 Ramos C116(1.20); C268(3.02)  LDD2190  [25]
 LDCM0574  Fragment12 Ramos C116(0.88)  LDD2191  [25]
 LDCM0575  Fragment13 Ramos C116(1.09); C268(0.98)  LDD2192  [25]
 LDCM0576  Fragment14 Ramos C116(1.09); C268(0.80)  LDD2193  [25]
 LDCM0579  Fragment20 Ramos C116(0.80)  LDD2194  [25]
 LDCM0580  Fragment21 Ramos C116(1.07)  LDD2195  [25]
 LDCM0582  Fragment23 Ramos C116(1.34); C268(0.83)  LDD2196  [25]
 LDCM0578  Fragment27 Ramos C116(0.91)  LDD2197  [25]
 LDCM0586  Fragment28 Ramos C116(0.77); C268(8.59)  LDD2198  [25]
 LDCM0588  Fragment30 Ramos C116(0.68); C268(0.55)  LDD2199  [25]
 LDCM0589  Fragment31 Ramos C116(1.27); C268(0.64)  LDD2200  [25]
 LDCM0590  Fragment32 Ramos C116(0.73)  LDD2201  [25]
 LDCM0468  Fragment33 HCT 116 C86(0.73)  LDD0785  [23]
 LDCM0596  Fragment38 Ramos C116(2.64); C268(1.11)  LDD2203  [25]
 LDCM0566  Fragment4 Ramos C116(0.85); C268(1.06)  LDD2184  [25]
 LDCM0427  Fragment51 HCT 116 C86(0.49)  LDD0744  [23]
 LDCM0610  Fragment52 Ramos C116(1.04); C268(0.46)  LDD2204  [25]
 LDCM0614  Fragment56 Ramos C116(0.73); C268(0.37)  LDD2205  [25]
 LDCM0569  Fragment7 Ramos C116(1.08); C268(1.10)  LDD2186  [25]
 LDCM0571  Fragment9 Ramos C116(0.72); C268(0.31)  LDD2188  [25]
 LDCM0107  IAA HeLa N.A.  LDD0221  [15]
 LDCM0022  KB02 HEK-293T C116(1.03); C86(0.98)  LDD1492  [24]
 LDCM0023  KB03 Jurkat C86(7.65)  LDD0209  [7]
 LDCM0024  KB05 COLO792 C86(1.29); C116(0.88)  LDD3310  [26]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C116(0.84)  LDD2102  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [15]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C116(0.85)  LDD2092  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C116(0.83)  LDD2093  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C116(0.95)  LDD2094  [5]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C116(0.83)  LDD2096  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C116(1.00)  LDD2097  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C116(0.45)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C116(1.23)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C116(0.62)  LDD2100  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C116(0.88)  LDD2101  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C116(0.59)  LDD2104  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C116(0.92)  LDD2105  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C116(0.99)  LDD2107  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C116(0.86)  LDD2111  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C116(1.09)  LDD2114  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C116(0.56)  LDD2115  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C116(0.72)  LDD2119  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C116(0.79)  LDD2120  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C116(0.47)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C116(1.25)  LDD2123  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C116(0.71)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C116(0.96)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C116(0.85)  LDD2127  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C116(1.00)  LDD2128  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C116(0.79)  LDD2129  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C116(0.53)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C116(0.42)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C116(1.07)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C116(0.94)  LDD2136  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C116(0.79)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C116(0.61)  LDD2141  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C116(0.81)  LDD2143  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C116(1.22)  LDD2144  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C116(1.34)  LDD2145  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C116(0.84)  LDD2146  [5]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C116(2.99)  LDD2147  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C116(0.37)  LDD2148  [5]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [20]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
6-methyl-2(Propane-1-sulfonyl)-2h-thieno[32-d][123]Diazaborinin-1-ol . DB08605
Nicotinamide Adenine Dinucleotide Phosphate . DB03461

References

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2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
7 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
21 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
22 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
23 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840