Details of the Target

General Information of Target

Target ID LDTP02622
Target Name Creatine kinase U-type, mitochondrial (CKMT1A; CKMT1B)
Gene Name CKMT1A; CKMT1B
Gene ID 1159
Synonyms
CKMT; CKMT; Creatine kinase U-type, mitochondrial; EC 2.7.3.2; Acidic-type mitochondrial creatine kinase; Mia-CK; Ubiquitous mitochondrial creatine kinase; U-MtCK
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGPFSRLLSARPGLRLLALAGAGSLAAGFLLRPEPVRAASERRRLYPPSAEYPDLRKHN
NCMASHLTPAVYARLCDKTTPTGWTLDQCIQTGVDNPGHPFIKTVGMVAGDEETYEVFAD
LFDPVIQERHNGYDPRTMKHTTDLDASKIRSGYFDERYVLSSRVRTGRSIRGLSLPPACT
RAERREVERVVVDALSGLKGDLAGRYYRLSEMTEAEQQQLIDDHFLFDKPVSPLLTAAGM
ARDWPDARGIWHNNEKSFLIWVNEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQER
GWEFMWNERLGYILTCPSNLGTGLRAGVHIKLPLLSKDSRFPKILENLRLQKRGTGGVDT
AATGGVFDISNLDRLGKSEVELVQLVIDGVNYLIDCERRLERGQDIRIPTPVIHTKH
Target Bioclass
Enzyme
Family
ATP:guanido phosphotransferase family
Subcellular location
Mitochondrion inner membrane
Function
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Uniprot ID
P12532
Ensemble ID
ENST00000300283.10
HGNC ID
HGNC:31736

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
Probe 1
 Probe Info  		Y153(18.39); Y158(61.79)  LDD3495  [2]
AF-1
 Probe Info  		1.57  LDD0421  [3]
DBIA
 Probe Info  		C89(1.14)  LDD3310  [4]
Johansson_61
 Probe Info  		_(20.00)  LDD1485  [5]
AHL-Pu-1
 Probe Info  		C316(3.33)  LDD0169  [6]
HHS-475
 Probe Info  		Y153(0.65)  LDD0264  [7]
ATP probe
 Probe Info  		K416(0.00); K275(0.00)  LDD0199  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [9]
1d-yne
 Probe Info  		N.A.  LDD0356  [10]
NHS
 Probe Info  		K337(0.00); K343(0.00)  LDD0010  [11]
SF
 Probe Info  		K337(0.00); K331(0.00)  LDD0028  [12]
TFBX
 Probe Info  		C316(0.00); C62(0.00)  LDD0148  [13]
Phosphinate-6
 Probe Info  		C89(0.00); C62(0.00); C316(0.00); C179(0.00)  LDD0018  [14]
Ox-W18
 Probe Info  		N.A.  LDD2175  [15]
1c-yne
 Probe Info  		K256(0.00); K229(0.00)  LDD0228  [10]
W1
 Probe Info  		N.A.  LDD0236  [1]
AOyne
 Probe Info  		15.00  LDD0443  [16]
NAIA_5
 Probe Info  		C287(0.00); C62(0.00); C76(0.00); C396(0.00)  LDD2223  [17]
HHS-465
 Probe Info  		N.A.  LDD2240  [18]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info  		12.13  LDD1713  [19]
FFF probe11
 Probe Info  		11.46  LDD0471  [20]
FFF probe13
 Probe Info  		12.29  LDD0475  [20]
FFF probe14
 Probe Info  		20.00  LDD0477  [20]
FFF probe2
 Probe Info  		7.12  LDD0463  [20]
FFF probe3
 Probe Info  		20.00  LDD0464  [20]
FFF probe9
 Probe Info  		6.57  LDD0470  [20]
DA-2
 Probe Info  		N.A.  LDD0070  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C316(3.33)  LDD0169  [6]
 LDCM0214  AC1 HEK-293T C62(1.14); C179(1.00); C316(0.86)  LDD1507  [22]
 LDCM0215  AC10 HEK-293T C62(0.99); C179(0.98); C89(0.85); C316(0.90)  LDD1508  [22]
 LDCM0226  AC11 HEK-293T C62(0.97); C179(1.00); C89(0.97); C316(0.86)  LDD1509  [22]
 LDCM0237  AC12 HEK-293T C62(0.92); C179(1.11); C89(1.03); C316(1.01)  LDD1510  [22]
 LDCM0259  AC14 HEK-293T C62(1.01); C179(1.08); C89(1.06); C316(0.87)  LDD1512  [22]
 LDCM0270  AC15 HEK-293T C62(1.03); C179(0.93); C89(0.90); C316(0.84)  LDD1513  [22]
 LDCM0276  AC17 HEK-293T C62(1.12); C179(0.94); C316(0.95)  LDD1515  [22]
 LDCM0277  AC18 HEK-293T C62(1.08); C179(1.03); C89(1.46); C316(0.90)  LDD1516  [22]
 LDCM0278  AC19 HEK-293T C62(0.89); C179(1.07); C89(1.01); C316(0.80)  LDD1517  [22]
 LDCM0279  AC2 HEK-293T C62(1.20); C179(1.01); C89(1.23); C316(0.85)  LDD1518  [22]
 LDCM0280  AC20 HEK-293T C62(0.96); C179(1.13); C89(0.94); C316(0.95)  LDD1519  [22]
 LDCM0281  AC21 HEK-293T C62(1.13); C179(1.00); C89(1.04); C316(0.92)  LDD1520  [22]
 LDCM0282  AC22 HEK-293T C62(1.07); C179(0.96); C89(1.06); C316(1.01)  LDD1521  [22]
 LDCM0283  AC23 HEK-293T C62(1.00); C179(1.04); C89(0.95); C316(0.92)  LDD1522  [22]
 LDCM0284  AC24 HEK-293T C62(1.18); C179(1.00); C89(1.04); C316(0.96)  LDD1523  [22]
 LDCM0285  AC25 HEK-293T C62(1.08); C179(0.94); C316(0.95)  LDD1524  [22]
 LDCM0286  AC26 HEK-293T C62(1.04); C179(1.09); C89(1.21); C316(0.95)  LDD1525  [22]
 LDCM0287  AC27 HEK-293T C62(1.07); C179(0.99); C89(0.88); C316(0.84)  LDD1526  [22]
 LDCM0288  AC28 HEK-293T C62(0.99); C179(1.15); C89(0.98); C316(0.94)  LDD1527  [22]
 LDCM0289  AC29 HEK-293T C62(1.08); C179(1.02); C89(1.04); C316(0.95)  LDD1528  [22]
 LDCM0290  AC3 HEK-293T C62(1.04); C179(1.01); C89(1.26); C316(0.85)  LDD1529  [22]
 LDCM0291  AC30 HEK-293T C62(1.11); C179(1.05); C89(1.03); C316(0.86)  LDD1530  [22]
 LDCM0292  AC31 HEK-293T C62(1.02); C179(1.00); C89(0.92); C316(0.85)  LDD1531  [22]
 LDCM0293  AC32 HEK-293T C62(1.05); C179(0.94); C89(0.86); C316(0.86)  LDD1532  [22]
 LDCM0294  AC33 HEK-293T C62(1.17); C179(0.93); C316(0.99)  LDD1533  [22]
 LDCM0295  AC34 HEK-293T C62(1.10); C179(1.07); C89(1.52); C316(0.93)  LDD1534  [22]
 LDCM0296  AC35 HEK-293T C62(1.10); C179(1.00); C89(0.88); C316(0.88)  LDD1535  [22]
 LDCM0297  AC36 HEK-293T C62(1.11); C179(1.18); C89(1.02); C316(0.93)  LDD1536  [22]
 LDCM0298  AC37 HEK-293T C62(1.29); C179(1.03); C89(1.02); C316(0.94)  LDD1537  [22]
 LDCM0299  AC38 HEK-293T C62(1.03); C179(1.08); C89(1.14); C316(0.95)  LDD1538  [22]
 LDCM0300  AC39 HEK-293T C62(1.18); C179(1.09); C89(0.97); C316(0.93)  LDD1539  [22]
 LDCM0301  AC4 HEK-293T C62(1.13); C179(1.13); C89(1.02); C316(0.89)  LDD1540  [22]
 LDCM0302  AC40 HEK-293T C62(1.01); C179(0.92); C89(1.02); C316(0.92)  LDD1541  [22]
 LDCM0303  AC41 HEK-293T C62(1.08); C179(0.93); C316(0.91)  LDD1542  [22]
 LDCM0304  AC42 HEK-293T C62(1.13); C179(1.03); C89(1.15); C316(0.96)  LDD1543  [22]
 LDCM0305  AC43 HEK-293T C62(1.02); C179(1.00); C89(0.85); C316(0.91)  LDD1544  [22]
 LDCM0306  AC44 HEK-293T C62(1.02); C179(1.05); C89(1.02); C316(0.95)  LDD1545  [22]
 LDCM0307  AC45 HEK-293T C62(1.13); C179(1.02); C89(1.05); C316(0.91)  LDD1546  [22]
 LDCM0308  AC46 HEK-293T C62(1.10); C179(1.09); C89(1.05); C316(0.84)  LDD1547  [22]
 LDCM0309  AC47 HEK-293T C62(0.97); C179(0.95); C89(0.96); C316(0.80)  LDD1548  [22]
 LDCM0310  AC48 HEK-293T C62(1.03); C179(0.98); C89(1.00); C316(0.87)  LDD1549  [22]
 LDCM0311  AC49 HEK-293T C62(1.09); C179(0.97); C316(1.01)  LDD1550  [22]
 LDCM0312  AC5 HEK-293T C62(1.11); C179(0.99); C89(0.86); C316(0.91)  LDD1551  [22]
 LDCM0313  AC50 HEK-293T C62(1.09); C179(1.02); C89(1.22); C316(0.85)  LDD1552  [22]
 LDCM0314  AC51 HEK-293T C62(1.01); C179(1.01); C89(1.01); C316(0.90)  LDD1553  [22]
 LDCM0315  AC52 HEK-293T C62(0.94); C179(1.08); C89(1.06); C316(1.00)  LDD1554  [22]
 LDCM0316  AC53 HEK-293T C62(1.20); C179(1.03); C89(0.97); C316(0.91)  LDD1555  [22]
 LDCM0317  AC54 HEK-293T C62(0.95); C179(1.12); C89(1.06); C316(0.90)  LDD1556  [22]
 LDCM0318  AC55 HEK-293T C62(0.98); C179(0.90); C89(0.98); C316(0.92)  LDD1557  [22]
 LDCM0319  AC56 HEK-293T C62(0.97); C179(1.01); C89(1.03); C316(0.91)  LDD1558  [22]
 LDCM0320  AC57 HEK-293T C62(0.98); C179(0.90); C316(1.08)  LDD1559  [22]
 LDCM0321  AC58 HEK-293T C62(1.00); C179(1.04); C89(1.09); C316(0.93)  LDD1560  [22]
 LDCM0322  AC59 HEK-293T C62(0.97); C179(0.96); C89(0.88); C316(0.86)  LDD1561  [22]
 LDCM0323  AC6 HEK-293T C62(1.08); C179(1.07); C89(1.10); C316(0.77)  LDD1562  [22]
 LDCM0324  AC60 HEK-293T C62(1.01); C179(1.05); C89(0.97); C316(1.06)  LDD1563  [22]
 LDCM0325  AC61 HEK-293T C62(1.11); C179(1.02); C89(1.02); C316(0.95)  LDD1564  [22]
 LDCM0326  AC62 HEK-293T C62(0.91); C179(1.10); C89(1.09); C316(0.94)  LDD1565  [22]
 LDCM0327  AC63 HEK-293T C62(0.89); C179(1.05); C89(0.92); C316(0.91)  LDD1566  [22]
 LDCM0328  AC64 HEK-293T C62(0.86); C179(1.04); C89(1.04); C316(0.88)  LDD1567  [22]
 LDCM0334  AC7 HEK-293T C62(1.08); C179(1.08); C89(0.89); C316(0.84)  LDD1568  [22]
 LDCM0345  AC8 HEK-293T C62(0.98); C179(0.95); C89(1.06); C316(0.87)  LDD1569  [22]
 LDCM0166  Afatinib A431 1.57  LDD0421  [3]
 LDCM0248  AKOS034007472 HEK-293T C62(1.16); C179(0.93); C89(1.03); C316(0.86)  LDD1511  [22]
 LDCM0356  AKOS034007680 HEK-293T C62(1.09); C179(0.98); C316(0.98)  LDD1570  [22]
 LDCM0275  AKOS034007705 HEK-293T C62(1.00); C179(0.98); C89(1.04); C316(0.83)  LDD1514  [22]
 LDCM0632  CL-Sc Hep-G2 C316(1.51); C62(0.91); C62(0.71)  LDD2227  [17]
 LDCM0367  CL1 HEK-293T C62(0.74); C179(0.69); C89(0.68); C316(1.35)  LDD1571  [22]
 LDCM0368  CL10 HEK-293T C62(0.44); C179(0.35); C89(0.38); C316(2.51)  LDD1572  [22]
 LDCM0369  CL100 HEK-293T C62(0.81); C179(0.83); C89(0.67); C316(1.36)  LDD1573  [22]
 LDCM0370  CL101 HEK-293T C62(0.78); C179(0.87); C89(0.82); C316(1.37)  LDD1574  [22]
 LDCM0371  CL102 HEK-293T C62(0.87); C179(0.83); C89(0.75); C316(1.03)  LDD1575  [22]
 LDCM0372  CL103 HEK-293T C62(1.05); C179(0.90); C89(1.03); C316(1.00)  LDD1576  [22]
 LDCM0373  CL104 HEK-293T C62(0.86); C179(0.92); C89(0.80); C316(0.94)  LDD1577  [22]
 LDCM0374  CL105 HEK-293T C62(0.85); C179(0.88); C89(0.81); C316(1.07)  LDD1578  [22]
 LDCM0375  CL106 HEK-293T C62(0.76); C179(0.78); C89(0.61); C316(1.36)  LDD1579  [22]
 LDCM0376  CL107 HEK-293T C62(0.99); C179(0.91); C89(0.90); C316(0.97)  LDD1580  [22]
 LDCM0377  CL108 HEK-293T C62(0.94); C179(0.89); C89(0.87); C316(1.28)  LDD1581  [22]
 LDCM0378  CL109 HEK-293T C62(0.84); C179(0.77); C89(0.79); C316(1.29)  LDD1582  [22]
 LDCM0379  CL11 HEK-293T C62(0.52); C179(0.60); C89(0.49); C316(3.45)  LDD1583  [22]
 LDCM0380  CL110 HEK-293T C62(0.88); C179(0.85); C89(0.73); C316(1.41)  LDD1584  [22]
 LDCM0381  CL111 HEK-293T C62(1.07); C179(0.80); C89(0.85); C316(1.24)  LDD1585  [22]
 LDCM0382  CL112 HEK-293T C62(0.85); C179(0.78); C89(0.82); C316(1.56)  LDD1586  [22]
 LDCM0383  CL113 HEK-293T C62(1.17); C179(1.03); C89(1.00); C316(1.01)  LDD1587  [22]
 LDCM0384  CL114 HEK-293T C62(0.99); C179(0.83); C89(0.73); C316(1.24)  LDD1588  [22]
 LDCM0385  CL115 HEK-293T C62(1.09); C179(0.89); C89(0.84); C316(1.32)  LDD1589  [22]
 LDCM0386  CL116 HEK-293T C62(1.00); C179(0.99); C89(1.04); C316(1.02)  LDD1590  [22]
 LDCM0387  CL117 HEK-293T C62(1.00); C179(0.93); C89(0.86); C316(0.98)  LDD1591  [22]
 LDCM0388  CL118 HEK-293T C62(0.97); C179(0.97); C89(0.88); C316(0.92)  LDD1592  [22]
 LDCM0389  CL119 HEK-293T C62(0.97); C179(1.14); C89(1.07); C316(1.06)  LDD1593  [22]
 LDCM0390  CL12 HEK-293T C62(0.90); C179(1.12); C89(0.78); C316(1.18)  LDD1594  [22]
 LDCM0391  CL120 HEK-293T C62(1.05); C179(1.06); C89(0.96); C316(0.98)  LDD1595  [22]
 LDCM0392  CL121 HEK-293T C62(0.74); C179(0.87); C89(0.85); C316(1.43)  LDD1596  [22]
 LDCM0393  CL122 HEK-293T C62(0.89); C179(1.00); C89(0.93); C316(0.97)  LDD1597  [22]
 LDCM0394  CL123 HEK-293T C62(0.89); C179(0.78); C89(0.76); C316(1.38)  LDD1598  [22]
 LDCM0395  CL124 HEK-293T C62(0.79); C179(0.89); C89(0.73); C316(1.06)  LDD1599  [22]
 LDCM0396  CL125 HEK-293T C62(0.62); C179(0.97); C89(0.91); C316(1.07)  LDD1600  [22]
 LDCM0397  CL126 HEK-293T C62(0.65); C179(0.88); C89(0.73); C316(1.09)  LDD1601  [22]
 LDCM0398  CL127 HEK-293T C62(0.86); C179(1.04); C89(0.98); C316(1.05)  LDD1602  [22]
 LDCM0399  CL128 HEK-293T C62(0.87); C179(1.10); C89(0.97); C316(1.01)  LDD1603  [22]
 LDCM0400  CL13 HEK-293T C62(0.73); C179(0.79); C89(0.92); C316(2.79)  LDD1604  [22]
 LDCM0401  CL14 HEK-293T C62(1.01); C179(0.97); C89(0.73); C316(1.56)  LDD1605  [22]
 LDCM0402  CL15 HEK-293T C62(0.90); C179(0.97); C89(0.70); C316(1.40)  LDD1606  [22]
 LDCM0403  CL16 HEK-293T C62(0.92); C179(0.89); C89(0.83); C316(1.18)  LDD1607  [22]
 LDCM0404  CL17 HEK-293T C62(0.86); C179(0.78); C316(1.06)  LDD1608  [22]
 LDCM0405  CL18 HEK-293T C62(1.03); C179(0.97); C89(1.29); C316(0.93)  LDD1609  [22]
 LDCM0406  CL19 HEK-293T C62(0.99); C179(1.07); C89(0.97); C316(0.97)  LDD1610  [22]
 LDCM0407  CL2 HEK-293T C62(0.91); C179(0.90); C89(0.80); C316(1.63)  LDD1611  [22]
 LDCM0408  CL20 HEK-293T C62(0.90); C179(1.00); C89(1.02); C316(1.09)  LDD1612  [22]
 LDCM0409  CL21 HEK-293T C62(0.70); C179(0.39); C89(0.46); C316(2.34)  LDD1613  [22]
 LDCM0410  CL22 HEK-293T C62(0.84); C179(1.02); C89(0.97); C316(1.10)  LDD1614  [22]
 LDCM0411  CL23 HEK-293T C62(0.97); C179(1.09); C89(0.87); C316(1.09)  LDD1615  [22]
 LDCM0412  CL24 HEK-293T C62(0.93); C179(1.18); C89(0.90); C316(1.07)  LDD1616  [22]
 LDCM0413  CL25 HEK-293T C62(0.71); C179(0.83); C89(0.77); C316(1.74)  LDD1617  [22]
 LDCM0414  CL26 HEK-293T C62(1.12); C179(1.05); C89(0.99); C316(0.93)  LDD1618  [22]
 LDCM0415  CL27 HEK-293T C62(1.20); C179(1.09); C89(0.94); C316(0.93)  LDD1619  [22]
 LDCM0416  CL28 HEK-293T C62(0.83); C179(0.96); C89(0.73); C316(1.04)  LDD1620  [22]
 LDCM0417  CL29 HEK-293T C62(1.09); C179(0.92); C316(1.01)  LDD1621  [22]
 LDCM0418  CL3 HEK-293T C62(0.87); C179(0.91); C89(0.95); C316(1.39)  LDD1622  [22]
 LDCM0419  CL30 HEK-293T C62(1.11); C179(1.13); C89(1.51); C316(1.04)  LDD1623  [22]
 LDCM0420  CL31 HEK-293T C62(0.96); C179(0.80); C89(0.82); C316(1.53)  LDD1624  [22]
 LDCM0421  CL32 HEK-293T C62(0.70); C179(0.90); C89(0.77); C316(1.14)  LDD1625  [22]
 LDCM0422  CL33 HEK-293T C62(0.63); C179(0.37); C89(0.43); C316(1.81)  LDD1626  [22]
 LDCM0423  CL34 HEK-293T C62(0.73); C179(0.98); C89(0.81); C316(1.12)  LDD1627  [22]
 LDCM0424  CL35 HEK-293T C62(0.95); C179(0.97); C89(0.87); C316(1.34)  LDD1628  [22]
 LDCM0425  CL36 HEK-293T C62(0.79); C179(0.87); C89(0.80); C316(1.29)  LDD1629  [22]
 LDCM0426  CL37 HEK-293T C62(0.87); C179(0.84); C89(0.88); C316(1.02)  LDD1630  [22]
 LDCM0428  CL39 HEK-293T C62(0.91); C179(0.68); C89(0.89); C316(1.87)  LDD1632  [22]
 LDCM0429  CL4 HEK-293T C62(0.79); C179(0.92); C89(0.79); C316(1.48)  LDD1633  [22]
 LDCM0430  CL40 HEK-293T C62(1.06); C179(1.09); C89(0.86); C316(0.87)  LDD1634  [22]
 LDCM0431  CL41 HEK-293T C62(0.91); C179(0.65); C316(2.22)  LDD1635  [22]
 LDCM0432  CL42 HEK-293T C62(0.92); C179(0.90); C89(1.24); C316(1.20)  LDD1636  [22]
 LDCM0433  CL43 HEK-293T C62(0.77); C179(0.74); C89(0.84); C316(1.49)  LDD1637  [22]
 LDCM0434  CL44 HEK-293T C62(1.06); C179(1.21); C89(0.98); C316(1.08)  LDD1638  [22]
 LDCM0435  CL45 HEK-293T C62(0.78); C179(0.52); C89(0.54); C316(2.24)  LDD1639  [22]
 LDCM0436  CL46 HEK-293T C62(0.71); C179(0.85); C89(0.91); C316(1.41)  LDD1640  [22]
 LDCM0437  CL47 HEK-293T C62(0.86); C179(0.82); C89(0.78); C316(1.71)  LDD1641  [22]
 LDCM0438  CL48 HEK-293T C62(0.77); C179(0.89); C89(0.80); C316(1.07)  LDD1642  [22]
 LDCM0439  CL49 HEK-293T C62(0.80); C179(0.93); C89(1.02); C316(0.94)  LDD1643  [22]
 LDCM0440  CL5 HEK-293T C62(1.08); C179(1.02); C316(0.99)  LDD1644  [22]
 LDCM0441  CL50 HEK-293T C62(0.87); C179(0.91); C89(0.78); C316(1.31)  LDD1645  [22]
 LDCM0443  CL52 HEK-293T C62(1.01); C179(1.04); C89(0.94); C316(1.04)  LDD1646  [22]
 LDCM0444  CL53 HEK-293T C62(0.94); C179(0.63); C316(1.68)  LDD1647  [22]
 LDCM0445  CL54 HEK-293T C62(0.78); C179(0.70); C89(1.71); C316(1.29)  LDD1648  [22]
 LDCM0446  CL55 HEK-293T C62(0.99); C179(1.04); C89(1.03); C316(1.03)  LDD1649  [22]
 LDCM0447  CL56 HEK-293T C62(0.83); C179(0.85); C89(0.83); C316(1.99)  LDD1650  [22]
 LDCM0448  CL57 HEK-293T C62(1.01); C179(0.67); C89(0.71); C316(1.55)  LDD1651  [22]
 LDCM0449  CL58 HEK-293T C62(0.67); C179(0.73); C89(0.76); C316(3.69)  LDD1652  [22]
 LDCM0450  CL59 HEK-293T C62(0.79); C179(0.86); C89(0.79); C316(1.24)  LDD1653  [22]
 LDCM0451  CL6 HEK-293T C62(0.81); C179(0.75); C89(0.96); C316(0.89)  LDD1654  [22]
 LDCM0452  CL60 HEK-293T C62(0.71); C179(1.14); C89(0.77); C316(1.31)  LDD1655  [22]
 LDCM0453  CL61 HEK-293T C62(1.07); C179(1.02); C89(1.05); C316(0.92)  LDD1656  [22]
 LDCM0454  CL62 HEK-293T C62(1.07); C179(0.93); C89(0.85); C316(1.24)  LDD1657  [22]
 LDCM0455  CL63 HEK-293T C62(0.95); C179(0.96); C89(0.88); C316(1.14)  LDD1658  [22]
 LDCM0456  CL64 HEK-293T C62(0.75); C179(0.67); C89(0.61); C316(2.67)  LDD1659  [22]
 LDCM0457  CL65 HEK-293T C62(1.17); C179(0.88); C316(0.91)  LDD1660  [22]
 LDCM0458  CL66 HEK-293T C62(0.77); C179(0.67); C89(1.06); C316(2.05)  LDD1661  [22]
 LDCM0459  CL67 HEK-293T C62(1.05); C179(1.06); C89(0.92); C316(0.92)  LDD1662  [22]
 LDCM0460  CL68 HEK-293T C62(0.65); C179(0.71); C89(0.73); C316(1.31)  LDD1663  [22]
 LDCM0461  CL69 HEK-293T C62(0.98); C179(0.81); C89(0.79); C316(1.28)  LDD1664  [22]
 LDCM0462  CL7 HEK-293T C62(0.86); C179(1.03); C89(0.95); C316(1.04)  LDD1665  [22]
 LDCM0463  CL70 HEK-293T C62(0.96); C179(1.15); C89(0.98); C316(1.01)  LDD1666  [22]
 LDCM0464  CL71 HEK-293T C62(0.70); C179(0.63); C89(0.65); C316(2.21)  LDD1667  [22]
 LDCM0465  CL72 HEK-293T C62(0.94); C179(1.03); C89(0.96); C316(1.16)  LDD1668  [22]
 LDCM0466  CL73 HEK-293T C62(0.69); C179(0.67); C89(0.76); C316(1.34)  LDD1669  [22]
 LDCM0467  CL74 HEK-293T C62(0.94); C179(0.92); C89(0.95); C316(1.20)  LDD1670  [22]
 LDCM0469  CL76 HEK-293T C62(0.93); C179(0.98); C89(0.86); C316(1.12)  LDD1672  [22]
 LDCM0470  CL77 HEK-293T C62(0.96); C179(0.75); C316(2.25)  LDD1673  [22]
 LDCM0471  CL78 HEK-293T C62(1.00); C179(1.00); C89(1.12); C316(0.87)  LDD1674  [22]
 LDCM0472  CL79 HEK-293T C62(0.96); C179(1.02); C89(0.88); C316(0.92)  LDD1675  [22]
 LDCM0473  CL8 HEK-293T C62(0.38); C179(0.34); C89(0.39); C316(2.18)  LDD1676  [22]
 LDCM0474  CL80 HEK-293T C62(0.98); C179(1.11); C89(1.04); C316(1.05)  LDD1677  [22]
 LDCM0475  CL81 HEK-293T C62(1.06); C179(1.03); C89(0.98); C316(1.02)  LDD1678  [22]
 LDCM0476  CL82 HEK-293T C62(0.89); C179(1.18); C89(0.97); C316(1.05)  LDD1679  [22]
 LDCM0477  CL83 HEK-293T C62(0.87); C179(0.97); C89(0.82); C316(1.13)  LDD1680  [22]
 LDCM0478  CL84 HEK-293T C62(0.62); C179(0.70); C89(0.60); C316(1.14)  LDD1681  [22]
 LDCM0479  CL85 HEK-293T C62(0.85); C179(1.06); C89(0.97); C316(1.02)  LDD1682  [22]
 LDCM0480  CL86 HEK-293T C62(0.65); C179(0.79); C89(0.80); C316(1.46)  LDD1683  [22]
 LDCM0481  CL87 HEK-293T C62(0.83); C179(0.85); C89(0.84); C316(1.00)  LDD1684  [22]
 LDCM0482  CL88 HEK-293T C62(0.88); C179(1.08); C89(0.91); C316(0.95)  LDD1685  [22]
 LDCM0483  CL89 HEK-293T C62(1.06); C179(1.09); C316(0.87)  LDD1686  [22]
 LDCM0484  CL9 HEK-293T C62(1.01); C179(0.78); C89(0.81); C316(1.23)  LDD1687  [22]
 LDCM0485  CL90 HEK-293T C62(0.33); C179(0.32); C89(0.53); C316(2.38)  LDD1688  [22]
 LDCM0486  CL91 HEK-293T C62(0.63); C179(0.93); C89(0.80); C316(0.96)  LDD1689  [22]
 LDCM0487  CL92 HEK-293T C62(0.57); C179(0.61); C89(0.60); C316(1.68)  LDD1690  [22]
 LDCM0488  CL93 HEK-293T C62(1.00); C179(0.80); C89(0.86); C316(0.95)  LDD1691  [22]
 LDCM0489  CL94 HEK-293T C62(0.67); C179(0.72); C89(0.74); C316(1.45)  LDD1692  [22]
 LDCM0490  CL95 HEK-293T C62(0.46); C179(0.49); C89(0.52); C316(4.12)  LDD1693  [22]
 LDCM0491  CL96 HEK-293T C62(0.60); C179(0.85); C89(0.71); C316(1.31)  LDD1694  [22]
 LDCM0492  CL97 HEK-293T C62(0.51); C179(0.55); C89(0.50); C316(1.47)  LDD1695  [22]
 LDCM0493  CL98 HEK-293T C62(0.87); C179(0.93); C89(0.76); C316(2.03)  LDD1696  [22]
 LDCM0494  CL99 HEK-293T C62(0.81); C179(0.81); C89(0.80); C316(1.99)  LDD1697  [22]
 LDCM0495  E2913 HEK-293T C62(1.02); C179(0.77); C89(0.78); C316(4.24)  LDD1698  [22]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C316(0.76)  LDD1702  [23]
 LDCM0625  F8 Ramos C316(1.45); C89(0.84)  LDD2187  [24]
 LDCM0572  Fragment10 Ramos C316(20.00); C89(0.46)  LDD2189  [24]
 LDCM0573  Fragment11 Ramos C316(0.95); C62(15.85)  LDD2190  [24]
 LDCM0574  Fragment12 Ramos C316(1.07); C89(0.49)  LDD2191  [24]
 LDCM0575  Fragment13 Ramos C316(1.74)  LDD2192  [24]
 LDCM0576  Fragment14 Ramos C316(0.45); C62(1.24)  LDD2193  [24]
 LDCM0579  Fragment20 Ramos C316(0.90); C89(0.44)  LDD2194  [24]
 LDCM0580  Fragment21 Ramos C316(2.11); C89(0.91)  LDD2195  [24]
 LDCM0582  Fragment23 Ramos C316(0.66); C89(1.05)  LDD2196  [24]
 LDCM0578  Fragment27 Ramos C316(0.89)  LDD2197  [24]
 LDCM0586  Fragment28 Ramos C316(1.19); C62(1.37); C89(1.02)  LDD2198  [24]
 LDCM0588  Fragment30 Ramos C316(8.42); C89(0.55)  LDD2199  [24]
 LDCM0589  Fragment31 Ramos C316(0.90)  LDD2200  [24]
 LDCM0590  Fragment32 Ramos C316(20.00); C89(0.49)  LDD2201  [24]
 LDCM0468  Fragment33 HEK-293T C62(0.92); C179(0.90); C89(0.89); C316(1.19)  LDD1671  [22]
 LDCM0596  Fragment38 Ramos C316(0.64); C89(0.55)  LDD2203  [24]
 LDCM0566  Fragment4 Ramos C316(2.78); C62(1.11); C89(0.43)  LDD2184  [24]
 LDCM0427  Fragment51 HEK-293T C62(1.13); C179(1.04); C89(1.11); C316(0.96)  LDD1631  [22]
 LDCM0610  Fragment52 Ramos C316(1.40)  LDD2204  [24]
 LDCM0614  Fragment56 Ramos C316(0.91); C89(0.65)  LDD2205  [24]
 LDCM0616  Fragment61 Jurkat _(4.59)  LDD1489  [5]
 LDCM0615  Fragment63-R Jurkat _(20.00)  LDD1487  [5]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [5]
 LDCM0569  Fragment7 Jurkat _(20.00)  LDD1485  [5]
 LDCM0571  Fragment9 Ramos C316(20.00); C89(0.43)  LDD2188  [24]
 LDCM0116  HHS-0101 DM93 Y153(0.65)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y153(0.80)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y153(0.96)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y153(1.40)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y153(1.26)  LDD0268  [7]
 LDCM0022  KB02 HEK-293T C62(1.73); C179(1.55); C89(2.29); C316(0.61)  LDD1492  [22]
 LDCM0023  KB03 HEK-293T C62(0.95); C179(1.04); C89(1.07); C316(1.00)  LDD1497  [22]
 LDCM0024  KB05 COLO792 C89(1.14)  LDD3310  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
26S proteasome regulatory subunit 6A (PSMC3) AAA ATPase family P17980
Creatine kinase M-type (CKM) ATP:guanido phosphotransferase family P06732
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Neuron-specific calcium-binding protein hippocalcin (HPCA) Recoverin family P84074
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Retinoic acid receptor RXR-gamma (RXRG) Nuclear hormone receptor family P48443
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ankyrin repeat and SOCS box protein 9 (ASB9) Ankyrin SOCS box (ASB) family Q96DX5
Oncomodulin-1 (OCM) Parvalbumin family P0CE72
Nuclear transport factor 2 (NUTF2) . P61970
Protein phosphatase 1 regulatory subunit 16A (PPP1R16A) . Q96I34

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acyclovir Small molecular drug DB00787
Creatine Small molecular drug DB00148
Tenofovir Disoproxil Small molecular drug DB00300
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phosphocreatine . DB13191

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening. Chem Commun (Camb). 2019 Jan 15;55(6):834-837. doi: 10.1039/c8cc08685k.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578