Details of the Target

General Information of Target

Target ID LDTP10078
Target Name Far upstream element-binding protein 1 (FUBP1)
Gene Name FUBP1
Gene ID 8880
Synonyms
Far upstream element-binding protein 1; FBP; FUSE-binding protein 1; DNA helicase V; hDH V
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFPREKTWNISFAGCGFLGVYYVGVASCLREHAPFLVANATHIYGASAGALTATALVTGV
CLGEAGAKFIEVSKEARKRFLGPLHPSFNLVKIIRSFLLKVLPADSHEHASGRLGISLTR
VSDGENVIISHFNSKDELIQANVCSGFIPVYCGLIPPSLQGVRYVDGGISDNLPLYELKN
TITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPLVLREMCKQ
GYRDGLRFLQRNGLLNRPNPLLALPPARPHGPEDKDQAVESAQAEDYSQLPGEDHILEHL
PARLNEALLEACVEPTDLLTTLSNMLPVRLATAMMVPYTLPLESALSFTIRLLEWLPDVP
EDIRWMKEQTGSICQYLVMRAKRKLGRHLPSRLPEQVELRRVQSLPSVPLSCAAYREALP
GWMRNNLSLGDALAKWEECQRQLLLGLFCTNVAFPPEALRMRAPADPAPAPADPASPQHQ
LAGPAPLLSTPAPEARPVIGALGL
Target Bioclass
Other
Subcellular location
Nucleus
Function Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription.
Uniprot ID
Q96AE4
Ensemble ID
ENST00000294623.8
HGNC ID
HGNC:4004
ChEMBL ID
CHEMBL4295922

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.P523S DBIA    Probe Info 
IGROV1 Insertion: p.I301NfsTer4 DBIA    Probe Info 
IM95 SNV: p.Y484H DBIA    Probe Info 
JURKAT Deletion: p.S11LfsTer43 .
KYSE150 SNV: p.K527E DBIA    Probe Info 
NCIH1666 SNV: p.P553S DBIA    Probe Info 
RL SNV: p.E411Ter DBIA    Probe Info 
SHP77 SNV: p.R65K DBIA    Probe Info 
SNU1 SNV: p.K196N DBIA    Probe Info 
TCCSUP SNV: p.R284T; p.G327A DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 38 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		2.89  LDD0215  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
C-Sul
 Probe Info  		3.58  LDD0066  [3]
TH211
 Probe Info  		Y60(20.00); Y58(7.85); Y618(5.94); Y611(5.86)  LDD0257  [4]
TH216
 Probe Info  		Y618(20.00)  LDD0259  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
AZ-9
 Probe Info  		E169(0.69); E276(0.95); E587(0.92)  LDD2208  [6]
Probe 1
 Probe Info  		Y242(51.62); Y438(81.70); Y611(5.54)  LDD3495  [7]
DBIA
 Probe Info  		C148(1.51)  LDD3310  [8]
HHS-482
 Probe Info  		Y242(1.04); Y58(1.03)  LDD0285  [9]
HHS-475
 Probe Info  		Y611(0.75); Y242(0.77); Y58(0.87); Y60(0.87)  LDD0264  [10]
HHS-465
 Probe Info  		Y242(10.00); Y268(10.00); Y438(8.61); Y58(10.00)  LDD2237  [11]
5E-2FA
 Probe Info  		H334(0.00); H178(0.00); H179(0.00); H637(0.00)  LDD2235  [12]
ATP probe
 Probe Info  		K170(0.00); K394(0.00); K243(0.00); K248(0.00)  LDD0199  [13]
m-APA
 Probe Info  		H334(0.00); H179(0.00); H178(0.00); H637(0.00)  LDD2231  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C132(0.00); C332(0.00); C148(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C332(0.00); C132(0.00); C148(0.00)  LDD0036  [14]
IPIAA_L
 Probe Info  		C132(0.00); C148(0.00)  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C332(0.00); C132(0.00); C148(0.00)  LDD0037  [14]
ATP probe
 Probe Info  		K233(0.00); K218(0.00)  LDD0035  [16]
BTD
 Probe Info  		N.A.  LDD0004  [17]
TFBX
 Probe Info  		C148(0.00); C132(0.00)  LDD0027  [18]
WYneC
 Probe Info  		N.A.  LDD0014  [17]
WYneN
 Probe Info  		N.A.  LDD0021  [17]
WYneO
 Probe Info  		N.A.  LDD0022  [17]
ENE
 Probe Info  		N.A.  LDD0006  [17]
IPM
 Probe Info  		C148(0.00); C332(0.00); C132(0.00)  LDD0147  [18]
NHS
 Probe Info  		K243(0.00); K77(0.00); K425(0.00); K209(0.00)  LDD0010  [17]
SF
 Probe Info  		Y589(0.00); Y4(0.00); Y590(0.00); Y60(0.00)  LDD0028  [19]
STPyne
 Probe Info  		K400(0.00); K243(0.00); K209(0.00); K248(0.00)  LDD0009  [17]
Phosphinate-6
 Probe Info  		C132(0.00); C332(0.00)  LDD0018  [20]
1c-yne
 Probe Info  		K64(0.00); K218(0.00); K133(0.00); K248(0.00)  LDD0228  [21]
1d-yne
 Probe Info  		K203(0.00); K218(0.00)  LDD0357  [21]
Acrolein
 Probe Info  		C332(0.00); C148(0.00); H179(0.00); C132(0.00)  LDD0217  [22]
Crotonaldehyde
 Probe Info  		C132(0.00); C148(0.00)  LDD0219  [22]
Methacrolein
 Probe Info  		N.A.  LDD0218  [22]
W1
 Probe Info  		C132(0.00); C148(0.00)  LDD0236  [23]
NAIA_5
 Probe Info  		C332(0.00); C132(0.00); C148(0.00)  LDD2223  [24]
PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C165
 Probe Info  		16.68  LDD1845  [25]
C191
 Probe Info  		11.31  LDD1868  [25]
C249
 Probe Info  		12.30  LDD1922  [25]
C391
 Probe Info  		12.47  LDD2050  [25]
C407
 Probe Info  		11.47  LDD2064  [25]
FFF probe11
 Probe Info  		15.82  LDD0471  [26]
FFF probe13
 Probe Info  		20.00  LDD0475  [26]
FFF probe14
 Probe Info  		13.73  LDD0477  [26]
FFF probe15
 Probe Info  		20.00  LDD0490  [26]
FFF probe2
 Probe Info  		20.00  LDD0463  [26]
FFF probe3
 Probe Info  		9.85  LDD0464  [26]
FFF probe6
 Probe Info  		5.80  LDD0467  [26]
JN0003
 Probe Info  		17.58  LDD0469  [26]
VE-P
 Probe Info  		N.A.  LDD0396  [27]
Diazir
 Probe Info  		N.A.  LDD0011  [17]
DA-2
 Probe Info  		N.A.  LDD0071  [28]
OEA-DA
 Probe Info  		6.47  LDD0046  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C132(0.31); C148(0.42)  LDD2142  [30]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C132(0.35); C148(0.37)  LDD2112  [30]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C132(0.72); C148(0.89)  LDD2117  [30]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C132(1.26); C148(1.21)  LDD2152  [30]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C132(1.00)  LDD2103  [30]
 LDCM0545  Acetamide MDA-MB-231 C132(0.41)  LDD2138  [30]
 LDCM0520  AKOS000195272 MDA-MB-231 C132(0.69); C148(0.82)  LDD2113  [30]
 LDCM0108  Chloroacetamide HeLa C332(0.00); C148(0.00); C132(0.00); H179(0.00)  LDD0222  [22]
 LDCM0632  CL-Sc Hep-G2 C132(20.00); C148(2.09)  LDD2227  [24]
 LDCM0625  F8 Ramos C132(1.16); C332(0.53); C148(2.40)  LDD2187  [31]
 LDCM0572  Fragment10 Ramos C132(0.77); C332(0.11); C148(0.85)  LDD2189  [31]
 LDCM0573  Fragment11 Ramos C132(2.52); C332(0.27)  LDD2190  [31]
 LDCM0574  Fragment12 Ramos C132(0.78); C332(0.16); C148(0.59)  LDD2191  [31]
 LDCM0575  Fragment13 Ramos C132(1.10); C332(0.29); C148(1.24)  LDD2192  [31]
 LDCM0576  Fragment14 Ramos C132(0.99); C332(0.98); C148(1.09)  LDD2193  [31]
 LDCM0579  Fragment20 Ramos C132(0.64); C332(0.13); C148(0.71)  LDD2194  [31]
 LDCM0580  Fragment21 Ramos C132(1.17); C332(0.14); C148(1.22)  LDD2195  [31]
 LDCM0582  Fragment23 Ramos C132(1.13); C332(0.49); C148(1.27)  LDD2196  [31]
 LDCM0578  Fragment27 Ramos C132(1.28); C332(6.08); C148(1.23)  LDD2197  [31]
 LDCM0586  Fragment28 Ramos C132(0.66); C332(0.90)  LDD2198  [31]
 LDCM0588  Fragment30 Ramos C132(1.54); C332(0.16); C148(1.18)  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C132(1.12); C332(0.35); C148(1.22)  LDD2200  [31]
 LDCM0590  Fragment32 Ramos C132(0.92); C332(0.14); C148(0.78)  LDD2201  [31]
 LDCM0468  Fragment33 Ramos C132(1.28); C332(0.18); C148(1.31)  LDD2202  [31]
 LDCM0596  Fragment38 Ramos C132(1.15); C148(0.88)  LDD2203  [31]
 LDCM0566  Fragment4 Ramos C132(0.69); C332(0.65); C148(1.58)  LDD2184  [31]
 LDCM0610  Fragment52 Ramos C132(1.64); C332(0.28); C148(1.07)  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C132(1.84); C332(0.66); C148(1.79)  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C132(0.64); C332(0.48); C148(0.94)  LDD2186  [31]
 LDCM0571  Fragment9 Ramos C132(0.73); C332(0.09); C148(0.59)  LDD2188  [31]
 LDCM0116  HHS-0101 DM93 Y611(0.75); Y242(0.77); Y58(0.87); Y60(0.87)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y242(0.61); Y60(0.68); Y58(0.75); Y590(0.78)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y619(0.54); Y611(0.64); Y60(0.72); Y618(0.78)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y60(0.83); Y242(0.83); Y58(0.89); Y589(0.97)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y242(0.90); Y589(1.09); Y58(1.12); Y60(1.14)  LDD0268  [10]
 LDCM0107  IAA HeLa H178(0.00); H179(0.00); C132(0.00); C148(0.00)  LDD0221  [22]
 LDCM0123  JWB131 DM93 Y242(1.04); Y58(1.03)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y242(1.84); Y58(0.98); Y60(2.36)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y242(1.58); Y58(1.46); Y60(1.65)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y242(4.65); Y58(1.95)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y242(7.16); Y58(1.50)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y242(1.81); Y58(0.82); Y60(0.23)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y242(1.00); Y58(1.09); Y60(1.08)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y242(1.32); Y58(1.14)  LDD0292  [9]
 LDCM0022  KB02 Ramos C132(0.74); C332(0.42); C148(1.27)  LDD2182  [31]
 LDCM0023  KB03 Ramos C132(0.86); C332(0.54); C148(0.86)  LDD2183  [31]
 LDCM0024  KB05 COLO792 C148(1.51)  LDD3310  [8]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C132(1.11)  LDD2102  [30]
 LDCM0109  NEM HeLa H179(0.00); H334(0.00); H178(0.00)  LDD0223  [22]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C132(0.53)  LDD2089  [30]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C132(0.98)  LDD2090  [30]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C132(1.53)  LDD2092  [30]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C132(1.26)  LDD2093  [30]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C132(0.83); C148(0.83)  LDD2097  [30]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C132(0.56)  LDD2098  [30]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C132(1.20); C148(1.37)  LDD2099  [30]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C148(0.38)  LDD2100  [30]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C132(0.98); C148(1.04)  LDD2101  [30]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C132(0.40)  LDD2104  [30]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C132(1.85)  LDD2105  [30]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C132(0.22)  LDD2106  [30]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C132(0.83); C148(0.91)  LDD2107  [30]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C132(0.30); C148(0.53)  LDD2108  [30]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C132(0.71); C148(1.23)  LDD2109  [30]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C132(0.47)  LDD2110  [30]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C132(0.94); C148(1.11)  LDD2111  [30]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C148(0.23)  LDD2114  [30]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C132(0.43)  LDD2115  [30]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C132(0.32)  LDD2118  [30]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C132(2.70)  LDD2119  [30]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C132(0.81)  LDD2120  [30]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C132(0.05)  LDD2122  [30]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C132(0.63); C148(1.13)  LDD2123  [30]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C132(0.07)  LDD2124  [30]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C132(0.95); C148(1.41)  LDD2125  [30]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C132(0.89); C148(0.81)  LDD2127  [30]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C132(0.70)  LDD2128  [30]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C132(1.04)  LDD2129  [30]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C132(0.53); C148(0.89)  LDD2133  [30]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C132(0.40); C148(0.53)  LDD2134  [30]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C132(0.94); C148(1.38)  LDD2135  [30]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C132(0.80); C148(0.98)  LDD2136  [30]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C132(0.98); C148(1.09)  LDD2137  [30]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C148(2.70); C132(2.63)  LDD1700  [30]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C132(0.74); C148(0.94)  LDD2140  [30]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C132(0.43); C148(0.41)  LDD2141  [30]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C132(0.98)  LDD2143  [30]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C132(4.61); C148(2.48)  LDD2144  [30]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C132(1.03)  LDD2145  [30]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C132(0.90); C148(1.46)  LDD2146  [30]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C132(2.62)  LDD2147  [30]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C148(0.57)  LDD2148  [30]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C132(0.11)  LDD2149  [30]
 LDCM0131  RA190 MM1.R C148(1.29)  LDD0304  [32]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin carboxyl-terminal hydrolase 22 (USP22) Peptidase C19 family Q9UPT9
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Annexin A11 (ANXA11) Annexin family P50995
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MAPK-interacting and spindle-stabilizing protein-like (MAPK1IP1L) MISS family Q8NDC0
H/ACA ribonucleoprotein complex non-core subunit NAF1 (NAF1) NAF1 family Q96HR8
Pre-mRNA-processing factor 40 homolog B (PRPF40B) PRPF40 family Q6NWY9
U1 small nuclear ribonucleoprotein A (SNRPA) RRM U1 A/B'' family P09012
U1 small nuclear ribonucleoprotein C (SNRPC) U1 small nuclear ribonucleoprotein C family P09234
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) . Q13155
Proline-rich protein 13 (PRR13) . Q9NZ81

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sacituzumab Govitecan . DB12893
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Irofulven Small molecular drug DB05786

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD039931
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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Mass spectrometry data entry: PXD041264
25 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
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29 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
30 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.