Details of the Target

General Information of Target

Target ID LDTP01768
Target Name Glutamate dehydrogenase 1, mitochondrial (GLUD1)
Gene Name GLUD1
Gene ID 2746
Synonyms
GLUD; Glutamate dehydrogenase 1, mitochondrial; GDH 1; EC 1.4.1.3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYRYLGEALLLSRAGPAALGSASADSAALLGWARGQPAAAPQPGLALAARRHYSEAVADR
EDDPNFFKMVEGFFDRGASIVEDKLVEDLRTRESEEQKRNRVRGILRIIKPCNHVLSLSF
PIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFG
GAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTY
ASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFG
DKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILG
FPKAKPYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLER
NIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGK
HGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYV
NAIEKVFKVYNEAGVTFT
Target Bioclass
Enzyme
Family
Glu/Leu/Phe/Val dehydrogenases family
Subcellular location
Mitochondrion
Function
Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. Plays a role in insulin homeostasis. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate.
Uniprot ID
P00367
Ensemble ID
ENST00000277865.5
HGNC ID
HGNC:4335

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL23 SNV: p.A237T .
MOLT4 SNV: p.V131F IA-alkyne    Probe Info 
NCIH1650 SNV: p.H278Y DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P2
 Probe Info  		10.00  LDD0449  [1]
P8
 Probe Info  		1.66  LDD0451  [1]
CY4
 Probe Info  		100.00  LDD0244  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y193(20.00)  LDD0260  [3]
YN-4
 Probe Info  		100.00  LDD0445  [4]
ONAyne
 Probe Info  		K503(9.09)  LDD0274  [5]
BTD
 Probe Info  		C376(1.08)  LDD2098  [6]
AHL-Pu-1
 Probe Info  		C376(2.30)  LDD0169  [7]
DBIA
 Probe Info  		C327(1.20)  LDD0531  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
AMP probe
 Probe Info  		N.A.  LDD0200  [10]
ATP probe
 Probe Info  		K503(0.00); K480(0.00); K191(0.00); K84(0.00)  LDD0199  [10]
m-APA
 Probe Info  		H465(0.00); H481(0.00)  LDD2231  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C376(0.00); C172(0.00); C327(0.00); C112(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C376(0.00); C172(0.00)  LDD0032  [12]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [13]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [13]
Lodoacetamide azide
 Probe Info  		C376(0.00); C172(0.00); C327(0.00); C254(0.00)  LDD0037  [11]
ATP probe
 Probe Info  		K110(0.00); K390(0.00); K527(0.00)  LDD0035  [14]
JW-RF-010
 Probe Info  		C172(0.00); C376(0.00)  LDD0026  [15]
NAIA_4
 Probe Info  		C172(0.00); C327(0.00); C376(0.00)  LDD2226  [16]
TFBX
 Probe Info  		C172(0.00); C376(0.00)  LDD0027  [15]
WYneC
 Probe Info  		N.A.  LDD0014  [17]
WYneO
 Probe Info  		N.A.  LDD0022  [17]
1d-yne
 Probe Info  		K399(0.00); K480(0.00)  LDD0356  [18]
IPM
 Probe Info  		N.A.  LDD0005  [17]
NHS
 Probe Info  		K162(0.00); K415(0.00); K191(0.00); K480(0.00)  LDD0010  [17]
STPyne
 Probe Info  		K183(0.00); K480(0.00)  LDD0009  [17]
Phosphinate-6
 Probe Info  		C376(0.00); C146(0.00); C327(0.00); C112(0.00)  LDD0018  [19]
Ox-W18
 Probe Info  		W338(0.00); W442(0.00)  LDD2175  [20]
1c-yne
 Probe Info  		K352(0.00); K365(0.00); K162(0.00)  LDD0228  [18]
Acrolein
 Probe Info  		H481(0.00); C376(0.00)  LDD0217  [21]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [21]
W1
 Probe Info  		C112(0.00); K183(0.00); K187(0.00); Q354(0.00)  LDD0236  [22]
NAIA_5
 Probe Info  		N.A.  LDD2223  [16]
TER-AC
 Probe Info  		N.A.  LDD0426  [23]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IMP2070
 Probe Info  		2.46  LDD0367  [24]
C166
 Probe Info  		11.24  LDD1846  [25]
C249
 Probe Info  		14.03  LDD1922  [25]
C338
 Probe Info  		12.13  LDD2001  [25]
FFF probe11
 Probe Info  		14.05  LDD0471  [26]
FFF probe13
 Probe Info  		13.97  LDD0475  [26]
FFF probe15
 Probe Info  		7.88  LDD0478  [26]
FFF probe2
 Probe Info  		19.69  LDD0463  [26]
FFF probe3
 Probe Info  		18.79  LDD0464  [26]
FFF probe6
 Probe Info  		15.05  LDD0467  [26]
JN0003
 Probe Info  		20.00  LDD0469  [26]
STS-1
 Probe Info  		N.A.  LDD0136  [27]
STS-2
 Probe Info  		N.A.  LDD0138  [27]
VE-P
 Probe Info  		N.A.  LDD0396  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C376(0.37)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C376(0.66)  LDD2112  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C376(0.98)  LDD2117  [6]
 LDCM0025  4SU-RNA HEK-293T C327(2.12)  LDD0172  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C376(2.30)  LDD0169  [7]
 LDCM0214  AC1 HCT 116 C327(1.20)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C172(1.09); C327(1.01)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C112(1.23)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C112(1.12)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C112(1.05)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C112(1.18)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C112(1.07)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C112(1.05)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C112(1.21)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C112(1.17)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C112(1.09)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C112(1.02)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C172(1.07); C327(1.07)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C112(1.25)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C112(1.20)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C112(1.21)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C112(1.10)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C112(0.96)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C112(1.01)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C112(1.01)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C112(1.03)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C112(1.10)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C112(1.11)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C172(0.99); C327(0.97)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C112(1.45)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C112(0.89)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C112(1.17)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C112(0.97)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C112(0.86)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C112(1.11)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C112(1.00)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C112(0.93)  LDD0562  [8]
 LDCM0246  AC128 HEK-293T C112(0.88)  LDD0844  [8]
 LDCM0247  AC129 HEK-293T C112(0.90)  LDD0845  [8]
 LDCM0249  AC130 HEK-293T C112(0.63)  LDD0847  [8]
 LDCM0250  AC131 HEK-293T C112(0.97)  LDD0848  [8]
 LDCM0251  AC132 HEK-293T C112(0.70)  LDD0849  [8]
 LDCM0252  AC133 HEK-293T C112(0.83)  LDD0850  [8]
 LDCM0253  AC134 HEK-293T C112(0.95)  LDD0851  [8]
 LDCM0254  AC135 HEK-293T C112(0.95)  LDD0852  [8]
 LDCM0255  AC136 HEK-293T C112(0.72)  LDD0853  [8]
 LDCM0256  AC137 HEK-293T C112(0.71)  LDD0854  [8]
 LDCM0257  AC138 HEK-293T C112(0.82)  LDD0855  [8]
 LDCM0258  AC139 HEK-293T C112(0.74)  LDD0856  [8]
 LDCM0259  AC14 HCT 116 C172(1.14); C327(0.99)  LDD0576  [8]
 LDCM0260  AC140 HEK-293T C112(1.12)  LDD0858  [8]
 LDCM0261  AC141 HEK-293T C112(0.71)  LDD0859  [8]
 LDCM0262  AC142 HEK-293T C112(0.88)  LDD0860  [8]
 LDCM0263  AC143 HCT 116 C327(1.03)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C327(1.25)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C327(1.16)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C327(1.01)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C327(1.22)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C327(1.07)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C327(1.17)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C327(1.20); C172(1.35)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C327(1.53)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C327(1.32)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C327(1.39)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C327(1.70)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C327(1.31)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C327(1.51)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C327(1.42)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C327(1.45)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C172(1.19)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C172(1.33)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C172(1.25)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C327(1.06)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C172(1.18)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C172(1.36)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C172(1.20)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C172(1.19)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C172(1.06)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C172(1.18)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C172(1.19)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C172(1.34)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C172(1.29)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C172(1.23)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C327(1.08)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C172(1.14)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C172(1.33)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C172(1.41)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C172(1.45)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C172(1.29)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C172(0.86); C327(0.89)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C172(0.94); C327(0.98)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C172(0.94); C327(1.08)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C172(0.84); C327(0.98)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C327(0.90); C172(1.08)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C327(1.04)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C172(0.99); C327(1.14)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C172(0.94); C327(1.03)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C172(1.00); C327(1.06)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C172(1.03); C327(1.14)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C172(1.04); C327(1.37)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C172(1.02); C327(1.15)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C172(1.01); C327(1.05); C112(1.19)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C327(0.93); C112(1.03); C172(1.12)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C327(0.78); C112(0.94); C172(1.28)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C172(0.86); C327(0.97); C112(1.11)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C327(1.56)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C327(0.78); C112(1.01); C172(1.16)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C327(0.76); C112(1.04); C172(1.11)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C327(0.95); C112(1.07); C172(1.11)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C327(0.91); C172(1.01); C112(1.02)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C112(0.84); C327(0.94); C172(1.13)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C172(0.92); C327(1.08); C112(1.27)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C172(0.32); C327(0.88); C112(0.99)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C327(1.02); C112(1.23)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C112(0.89); C327(1.23)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C112(1.04); C327(1.15)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C172(1.19); C327(1.26)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C112(1.05); C327(1.34)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C112(1.06); C327(1.10)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C112(1.17); C327(1.19)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C327(0.84); C112(0.99)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C327(1.10); C112(1.13)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C112(1.07); C327(1.21)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C112(0.85); C327(1.29)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C327(0.56); C112(1.14)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C112(1.09)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C112(1.23)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C327(0.90); C172(1.02)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C112(1.13)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C112(1.03)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C112(1.06)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C112(1.03)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C112(1.15)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C112(1.12)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C112(1.18)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C112(1.34)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C112(1.01)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C112(1.24)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C327(0.98); C172(1.02)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C112(1.25)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C112(1.19)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C112(1.19)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C327(1.47)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C327(1.16)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C327(1.27)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C327(1.53)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C327(1.48)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C327(1.55)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C327(1.35)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C327(1.85)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C327(1.21)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C327(1.35)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C327(1.22)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C327(1.16)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C327(1.31)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C327(1.14)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C327(1.43)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C112(1.18)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C112(1.16)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C172(0.95); C327(1.02)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C172(1.09); C327(1.13)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C327(1.13); C172(1.42)  LDD0592  [8]
 LDCM0108  Chloroacetamide HeLa H481(0.00); C376(0.00)  LDD0222  [21]
 LDCM0367  CL1 HEK-293T C112(1.33)  LDD0965  [8]
 LDCM0368  CL10 HEK-293T C112(0.96)  LDD0966  [8]
 LDCM0369  CL100 HCT 116 C327(0.88)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C327(1.03); C172(1.22)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C327(1.07); C172(1.16)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C327(0.90); C172(1.13)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C327(0.95); C172(1.22)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C172(1.24)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C172(1.49)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C172(1.49)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C172(1.53)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C172(1.14)  LDD0695  [8]
 LDCM0379  CL11 HEK-293T C112(0.79)  LDD0977  [8]
 LDCM0380  CL110 HCT 116 C172(1.16)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C172(1.11)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C172(0.86)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C172(1.27)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C172(0.88)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C172(1.13)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C172(1.17)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C172(0.52); C327(0.73)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C172(0.96); C327(0.98)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C172(1.09); C327(1.16)  LDD0706  [8]
 LDCM0390  CL12 HEK-293T C112(0.80)  LDD0988  [8]
 LDCM0391  CL120 HCT 116 C172(0.97); C327(1.10)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C327(0.84); C172(1.04); C112(1.08)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C327(0.70); C112(1.02); C172(1.23)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C327(0.73); C172(1.06); C112(1.07)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C327(0.97); C172(1.04); C112(1.19)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C327(0.76); C112(1.16)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C327(0.88); C112(0.95)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C327(0.80); C112(1.05)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C327(1.01); C112(1.06)  LDD0716  [8]
 LDCM0400  CL13 HEK-293T C112(0.77)  LDD0998  [8]
 LDCM0401  CL14 HEK-293T C112(0.88)  LDD0999  [8]
 LDCM0402  CL15 HEK-293T C112(0.60)  LDD1000  [8]
 LDCM0403  CL16 HCT 116 C327(0.94); C172(1.04)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C172(0.81); C327(0.95); C112(1.15)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C112(0.92); C327(1.05); C172(1.06)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C172(0.89); C327(1.04); C112(1.18)  LDD0723  [8]
 LDCM0407  CL2 HEK-293T C112(0.63)  LDD1005  [8]
 LDCM0408  CL20 HCT 116 C172(0.98); C327(1.08); C112(1.17)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C172(0.78); C327(0.95); C112(1.00)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C327(0.24); C172(1.09); C112(1.14)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C112(1.01); C172(1.08); C327(1.14)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C112(0.94); C327(0.98); C172(1.01)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C112(1.15); C172(0.91); C327(1.11)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C112(0.99); C172(1.01); C327(0.89)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C112(0.91); C172(0.93); C327(1.14)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C112(1.08); C172(1.06); C327(0.92)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C112(1.30); C172(1.12); C327(1.19)  LDD0734  [8]
 LDCM0418  CL3 HEK-293T C112(0.85)  LDD1016  [8]
 LDCM0419  CL30 HCT 116 C112(1.67); C172(1.12); C327(1.22)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C112(1.01)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C327(1.05)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C327(0.86)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C327(0.87)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C327(1.28)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C327(0.82)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C327(0.85)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C327(0.85)  LDD0745  [8]
 LDCM0429  CL4 HEK-293T C112(0.97)  LDD1027  [8]
 LDCM0430  CL40 HCT 116 C327(0.91)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C327(1.26)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C327(0.74)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C327(1.17)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C327(0.85)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C327(0.76)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C172(0.75); C327(1.47)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C172(0.72); C327(0.93)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C172(0.70); C327(1.11)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C172(0.90); C327(1.23)  LDD0756  [8]
 LDCM0440  CL5 HEK-293T C112(1.00)  LDD1038  [8]
 LDCM0441  CL50 HCT 116 C172(0.78); C327(1.09)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C172(0.97); C327(0.98)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C172(1.11); C327(1.19)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C172(0.96); C327(0.90)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C172(0.77); C327(1.13)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C172(0.75); C327(0.96)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C172(0.92); C327(1.03)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C172(0.86); C327(1.00)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C172(1.02); C327(1.39)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C172(0.92); C327(1.17)  LDD0767  [8]
 LDCM0451  CL6 HEK-293T C112(0.75)  LDD1049  [8]
 LDCM0452  CL60 HCT 116 C172(0.85); C327(1.43)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C112(1.37)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C112(1.56)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C112(1.12)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C112(1.23)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C112(1.16)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C112(1.21)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C112(1.16)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C112(1.50)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C112(1.23)  LDD0778  [8]
 LDCM0462  CL7 HEK-293T C112(0.99)  LDD1060  [8]
 LDCM0463  CL70 HCT 116 C112(1.19)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C112(1.24)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C112(1.28)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C112(1.26)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C112(1.16)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C172(0.90)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C172(0.89)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C172(0.89)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C172(0.97)  LDD0789  [8]
 LDCM0473  CL8 HEK-293T C112(0.80)  LDD1071  [8]
 LDCM0474  CL80 HCT 116 C172(1.14)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C172(1.00)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C172(0.97)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C172(0.81)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C172(0.85)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C172(0.88)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C172(0.91)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C172(0.95)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C172(0.97)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C172(1.00)  LDD0800  [8]
 LDCM0484  CL9 HEK-293T C112(0.88)  LDD1082  [8]
 LDCM0485  CL90 HCT 116 C172(0.78)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C327(1.14)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C327(0.79)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C327(1.01)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C327(1.08)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C327(0.84)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C327(0.91)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C327(0.74)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C327(0.99)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C327(0.70)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C112(1.00); C172(1.04); C327(1.04); C376(1.07)  LDD1698  [29]
 LDCM0625  F8 Ramos C172(0.77); C112(0.49); C327(1.73); C376(0.75)  LDD2187  [30]
 LDCM0572  Fragment10 Ramos C172(0.85); C376(0.36)  LDD2189  [30]
 LDCM0573  Fragment11 Ramos C172(0.06); C146(20.00); C112(4.50); C376(0.12)  LDD2190  [30]
 LDCM0574  Fragment12 Ramos C172(1.43); C376(0.47)  LDD2191  [30]
 LDCM0575  Fragment13 Ramos C172(1.35)  LDD2192  [30]
 LDCM0576  Fragment14 Ramos C172(1.09); C146(0.44); C112(1.29); C376(1.02)  LDD2193  [30]
 LDCM0579  Fragment20 Ramos C172(1.35); C376(0.36)  LDD2194  [30]
 LDCM0580  Fragment21 Ramos C172(1.06); C376(0.57)  LDD2195  [30]
 LDCM0582  Fragment23 Ramos C172(1.13); C376(0.84)  LDD2196  [30]
 LDCM0578  Fragment27 Ramos C172(0.92); C376(1.02)  LDD2197  [30]
 LDCM0586  Fragment28 Ramos C172(0.89); C146(1.00); C112(1.85); C376(0.87)  LDD2198  [30]
 LDCM0588  Fragment30 Ramos C172(1.53); C376(0.30)  LDD2199  [30]
 LDCM0589  Fragment31 Ramos C172(1.30)  LDD2200  [30]
 LDCM0590  Fragment32 Ramos C172(0.87); C376(0.35)  LDD2201  [30]
 LDCM0468  Fragment33 HCT 116 C112(1.20)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C172(1.33); C376(0.42)  LDD2203  [30]
 LDCM0566  Fragment4 Ramos C172(0.95); C112(0.53); C327(1.22); C376(0.58)  LDD2184  [30]
 LDCM0427  Fragment51 HCT 116 C327(1.11)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C172(2.35); C376(0.39)  LDD2204  [30]
 LDCM0614  Fragment56 Ramos C172(1.83); C376(0.48)  LDD2205  [30]
 LDCM0569  Fragment7 Ramos C172(0.72); C112(0.35); C327(1.38); C376(0.60)  LDD2186  [30]
 LDCM0571  Fragment9 Ramos C172(0.85); C376(0.27)  LDD2188  [30]
 LDCM0107  IAA HeLa H481(0.00); C376(0.00)  LDD0221  [21]
 LDCM0022  KB02 HEK-293T C112(0.91); C376(0.88); C172(1.04); C327(1.04)  LDD1492  [29]
 LDCM0023  KB03 HEK-293T C112(1.02); C376(0.97); C172(1.08); C327(0.94)  LDD1497  [29]
 LDCM0024  KB05 HMCB C376(1.75)  LDD3312  [31]
 LDCM0109  NEM HeLa N.A.  LDD0223  [21]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C376(1.08)  LDD2098  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C376(0.52)  LDD2100  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C376(0.48)  LDD2104  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C376(0.41)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C376(0.93)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C376(0.56)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C376(0.70)  LDD2109  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C376(0.44)  LDD2110  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C376(0.50)  LDD2114  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C376(1.00)  LDD2123  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C376(0.93)  LDD2127  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C376(0.79)  LDD2137  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C376(0.46)  LDD2141  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C376(0.13)  LDD2145  [6]
 LDCM0131  RA190 MM1.R C376(1.58)  LDD0304  [32]
 LDCM0110  W12 Hep-G2 K110(0.82); N113(0.90)  LDD0237  [22]
 LDCM0111  W14 Hep-G2 K110(0.87); H114(0.94)  LDD0238  [22]
 LDCM0112  W16 Hep-G2 K110(0.95); N113(0.95); H114(1.03)  LDD0239  [22]
 LDCM0113  W17 Hep-G2 K110(0.94)  LDD0240  [22]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Glutamic Acid Small molecular drug DB00142
Hexachlorophene Small molecular drug DB00756
Nadh Small molecular drug DB00157
Aluminum Chloride . DB11081
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Guanosine-5'-triphosphate Small molecular drug DB04137

References

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2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
14 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
23 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
24 A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target. ACS Chem Biol. 2021 Jun 18;16(6):982-990. doi: 10.1021/acschembio.1c00218. Epub 2021 May 18.
Mass spectrometry data entry: PXD024915 , PXD024913
25 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
28 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
30 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
31 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
32 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.