Details of the Target

General Information of Target

Target ID LDTP02227
Target Name Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC)
Gene Name HNRNPC
Gene ID 3183
Synonyms
HNRPC; Heterogeneous nuclear ribonucleoproteins C1/C2; hnRNP C1/C2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASNVTNKTDPRSMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIVGCSVHKGFAFVQYVNE
RNARAAVAGEDGRMIAGQVLDINLAAEPKVNRGKAGVKRSAAEMYGSVTEHPSPSPLLSS
SFDLDYDFQRDYYDRMYSYPARVPPPPPIARAVVPSKRQRVSGNTSRRGKSGFNSKSGQR
GSSKSGKLKGDDLQAIKKELTQIKQKVDSLLENLEKIEKEQSKQAVEMKNDKSEEEQSSS
SVKKDETNVKMESEGGADDSAEEGDLLDDDDNEDRGDDQLELIKDDEKEAEEGEDDRDSA
NGEDDS
Target Bioclass
Other
Family
RRM HNRPC family, RALY subfamily
Subcellular location
Nucleus
Function
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing.
Uniprot ID
P07910
Ensemble ID
ENST00000420743.6
HGNC ID
HGNC:5035
ChEMBL ID
CHEMBL2216742

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 33 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P2
 Probe Info  		3.84  LDD0449  [1]
P3
 Probe Info  		3.62  LDD0450  [1]
P8
 Probe Info  		5.05  LDD0451  [1]
A-EBA
 Probe Info  		4.52  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
C-Sul
 Probe Info  		5.31  LDD0066  [4]
TH211
 Probe Info  		Y139(8.58)  LDD0257  [5]
TH216
 Probe Info  		Y137(5.47)  LDD0259  [5]
AZ-9
 Probe Info  		E60(1.11); E246(1.80)  LDD2208  [6]
ONAyne
 Probe Info  		K184(0.00); K189(0.00); K197(0.00); K198(0.00)  LDD0273  [7]
OPA-S-S-alkyne
 Probe Info  		K170(2.35); K176(3.10); K98(3.25); K94(3.25)  LDD3494  [8]
Probe 1
 Probe Info  		Y139(65.94)  LDD3495  [9]
BTD
 Probe Info  		C46(1.83)  LDD1700  [10]
ATP probe
 Probe Info  		K198(0.00); K189(0.00); K170(0.00); K8(0.00)  LDD0199  [11]
m-APA
 Probe Info  		N.A.  LDD2231  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [13]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [13]
ATP probe
 Probe Info  		K206(0.00); K89(0.00); K8(0.00); K29(0.00)  LDD0035  [15]
TFBX
 Probe Info  		N.A.  LDD0027  [16]
IPM
 Probe Info  		N.A.  LDD0005  [17]
NHS
 Probe Info  		K223(0.00); K189(0.00); K176(0.00); K232(0.00)  LDD0010  [17]
OSF
 Probe Info  		Y139(0.00); Y137(0.00)  LDD0029  [18]
SF
 Probe Info  		K8(0.00); Y137(0.00); Y139(0.00); K170(0.00)  LDD0028  [18]
STPyne
 Probe Info  		K30(0.00); K216(0.00); K206(0.00); K8(0.00)  LDD0009  [17]
1c-yne
 Probe Info  		K284(0.00); K50(0.00); K229(0.00); K39(0.00)  LDD0228  [19]
AOyne
 Probe Info  		7.00  LDD0443  [20]
MPP-AC
 Probe Info  		N.A.  LDD0428  [21]
NAIA_5
 Probe Info  		N.A.  LDD2223  [22]
HHS-482
 Probe Info  		Y137(0.90)  LDD2239  [23]
PAL-AfBPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C338
 Probe Info  		12.73  LDD2001  [24]
FFF probe11
 Probe Info  		10.41  LDD0471  [25]
FFF probe12
 Probe Info  		7.28  LDD0473  [25]
FFF probe13
 Probe Info  		14.38  LDD0475  [25]
FFF probe2
 Probe Info  		12.46  LDD0463  [25]
FFF probe3
 Probe Info  		7.95  LDD0464  [25]
FFF probe4
 Probe Info  		6.36  LDD0466  [25]
JN0003
 Probe Info  		11.73  LDD0469  [25]
STS-2
 Probe Info  		N.A.  LDD0138  [26]
VE-P
 Probe Info  		N.A.  LDD0396  [27]
DA-2
 Probe Info  		N.A.  LDD0070  [28]
OEA-DA
 Probe Info  		3.65  LDD0046  [29]
STS-1
 Probe Info  		N.A.  LDD0069  [30]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C46(0.44)  LDD2142  [10]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C46(0.76)  LDD2112  [10]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C46(0.45)  LDD2095  [10]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C46(0.58)  LDD2117  [10]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C46(1.18)  LDD2152  [10]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C46(1.26)  LDD2103  [10]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C46(0.42)  LDD2132  [10]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C46(0.88)  LDD2131  [10]
 LDCM0545  Acetamide MDA-MB-231 C46(0.37)  LDD2138  [10]
 LDCM0520  AKOS000195272 MDA-MB-231 C46(0.72)  LDD2113  [10]
 LDCM0498  BS-3668 MDA-MB-231 C46(0.55)  LDD2091  [10]
 LDCM0625  F8 Ramos C46(0.59)  LDD2187  [31]
 LDCM0572  Fragment10 Ramos C46(0.60)  LDD2189  [31]
 LDCM0573  Fragment11 Ramos C46(3.42)  LDD2190  [31]
 LDCM0574  Fragment12 Ramos C46(0.66)  LDD2191  [31]
 LDCM0575  Fragment13 Ramos C46(1.12)  LDD2192  [31]
 LDCM0576  Fragment14 Ramos C46(0.88)  LDD2193  [31]
 LDCM0579  Fragment20 Ramos C46(0.59)  LDD2194  [31]
 LDCM0580  Fragment21 Ramos C46(0.97)  LDD2195  [31]
 LDCM0582  Fragment23 Ramos C46(1.30)  LDD2196  [31]
 LDCM0578  Fragment27 Ramos C46(1.06)  LDD2197  [31]
 LDCM0586  Fragment28 Ramos C46(0.61)  LDD2198  [31]
 LDCM0588  Fragment30 Ramos C46(1.41)  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C46(1.32)  LDD2200  [31]
 LDCM0590  Fragment32 Ramos C46(0.77)  LDD2201  [31]
 LDCM0468  Fragment33 Ramos C46(1.21)  LDD2202  [31]
 LDCM0596  Fragment38 Ramos C46(1.31)  LDD2203  [31]
 LDCM0566  Fragment4 Ramos C46(0.72)  LDD2184  [31]
 LDCM0610  Fragment52 Ramos C46(1.61)  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C46(1.65)  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C46(0.53)  LDD2186  [31]
 LDCM0571  Fragment9 Ramos C46(0.57)  LDD2188  [31]
 LDCM0022  KB02 Ramos C46(0.54)  LDD2182  [31]
 LDCM0023  KB03 MDA-MB-231 C46(1.82)  LDD1701  [10]
 LDCM0024  KB05 Ramos C46(0.47)  LDD2185  [31]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C46(1.07)  LDD2102  [10]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C46(0.61)  LDD2121  [10]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C46(0.56)  LDD2089  [10]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C46(0.90)  LDD2090  [10]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C46(1.16)  LDD2092  [10]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C46(0.99)  LDD2093  [10]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C46(0.12)  LDD2096  [10]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C46(0.88)  LDD2097  [10]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C46(0.81)  LDD2098  [10]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C46(0.97)  LDD2099  [10]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C46(0.45)  LDD2100  [10]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C46(0.64)  LDD2101  [10]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C46(0.45)  LDD2104  [10]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C46(1.49)  LDD2105  [10]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C46(0.37)  LDD2106  [10]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C46(0.92)  LDD2107  [10]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C46(0.47)  LDD2108  [10]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C46(0.45)  LDD2109  [10]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C46(0.50)  LDD2110  [10]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C46(0.81)  LDD2111  [10]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C46(0.55)  LDD2114  [10]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C46(0.36)  LDD2115  [10]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C46(0.17)  LDD2116  [10]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C46(0.23)  LDD2118  [10]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C46(1.88)  LDD2119  [10]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C46(0.76)  LDD2120  [10]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C46(0.18)  LDD2122  [10]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C46(0.68)  LDD2123  [10]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C46(0.09)  LDD2124  [10]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C46(0.64)  LDD2125  [10]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C46(0.09)  LDD2126  [10]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C46(0.66)  LDD2127  [10]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C46(0.88)  LDD2128  [10]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C46(1.13)  LDD2129  [10]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C46(0.50)  LDD2133  [10]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C46(0.48)  LDD2134  [10]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C46(1.15)  LDD2135  [10]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C46(0.97)  LDD2136  [10]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C46(0.80)  LDD2137  [10]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C46(1.83)  LDD1700  [10]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C46(0.63)  LDD2140  [10]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C46(0.45)  LDD2141  [10]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C46(0.83)  LDD2143  [10]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C46(1.84)  LDD2144  [10]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C46(1.99)  LDD2145  [10]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C46(0.86)  LDD2146  [10]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C46(2.39)  LDD2147  [10]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C46(0.38)  LDD2148  [10]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C46(0.42)  LDD2150  [10]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C46(2.03)  LDD2153  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-lysine methyltransferase KMT5A (KMT5A) Histone-lysine methyltransferase family Q9NQR1
Nucleolar RNA helicase 2 (DDX21) DEAD box helicase family Q9NR30
SRSF protein kinase 2 (SRPK2) CMGC Ser/Thr protein kinase family P78362
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Transporter and channel
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
Huntingtin (HTT) Huntingtin family P42858
Importin subunit alpha-1 (KPNA2) Importin alpha family P52292
Importin subunit alpha-3 (KPNA4) Importin alpha family O00629
Importin subunit alpha-4 (KPNA3) Importin alpha family O00505
Importin subunit alpha-6 (KPNA5) Importin alpha family O15131
SH3 and multiple ankyrin repeat domains protein 3 (SHANK3) . Q9BYB0
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell division cycle 5-like protein (CDC5L) CEF1 family Q99459
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Epidermal growth factor receptor kinase substrate 8 (EPS8) EPS8 family Q12929
Heterogeneous nuclear ribonucleoprotein C-like 1 (HNRNPCL1) RRM HNRPC family O60812
Heterogeneous nuclear ribonucleoprotein C-like 2 (HNRNPCL2) RRM HNRPC family B2RXH8
Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC) RRM HNRPC family P07910
RNA-binding protein Raly (RALY) RRM HNRPC family Q9UKM9
RNA-binding Raly-like protein (RALYL) RRM HNRPC family Q86SE5
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165
Small ubiquitin-related modifier 5 (SUMO1P1) Ubiquitin family G2XKQ0
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) . P09651
Rhombotin-2 (LMO2) . P25791
RNA-binding protein 41 (RBM41) . Q96IZ5
RNA-binding protein with multiple splicing 2 (RBPMS2) . Q6ZRY4
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
9 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
24 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
26 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
27 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
28 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
29 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
30 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578