Details of the Target

General Information of Target

Target ID LDTP06200
Target Name Delta(14)-sterol reductase LBR (LBR)
Gene Name LBR
Gene ID 3930
Synonyms
Delta(14)-sterol reductase LBR; Delta-14-SR; EC 1.3.1.70; 3-beta-hydroxysterol Delta; 14)-reductase; C-14 sterol reductase; C14SR; Integral nuclear envelope inner membrane protein; LMN2R; Lamin-B receptor; Sterol C14-reductase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSF
RQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPL
ILKPFGNSISRYNGEPEHIERNDAPHKNTQEKFSLSQESSYIATQYSLRPRREEVKLKEI
DSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSL
LNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFY
AFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPAS
SGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAM
ILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPN
EVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWW
GFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWE
KYCQRVPYRIFPYIY
Target Bioclass
Enzyme
Family
ERG4/ERG24 family
Subcellular location
Nucleus inner membrane
Function
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation. Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation. Anchors the lamina and the heterochromatin to the inner nuclear membrane.
Uniprot ID
Q14739
Ensemble ID
ENST00000272163.9
HGNC ID
HGNC:6518

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
11RK72
 Probe Info  		2.03  LDD0327  [1]
AZ-9
 Probe Info  		5.65  LDD0393  [2]
TH211
 Probe Info  		Y132(11.71); Y187(20.00); Y366(20.00); Y589(16.78)  LDD0260  [3]
YN-4
 Probe Info  		100.00  LDD0445  [4]
STPyne
 Probe Info  		K107(1.23); K123(8.12); K5(4.17); K508(1.96)  LDD0277  [5]
ONAyne
 Probe Info  		K64(0.00); K107(0.00)  LDD0273  [5]
IPM
 Probe Info  		N.A.  LDD0241  [6]
Propranolol-CA-4PAP
 Probe Info  		4.10  LDD0271  [7]
BTD
 Probe Info  		C591(3.25)  LDD1700  [8]
HPAP
 Probe Info  		3.44  LDD0062  [9]
DBIA
 Probe Info  		C591(10.69)  LDD0209  [10]
AMP probe
 Probe Info  		N.A.  LDD0200  [11]
ATP probe
 Probe Info  		K55(0.00); K593(0.00); K594(0.00); K42(0.00)  LDD0199  [11]
m-APA
 Probe Info  		H146(0.00); H102(0.00)  LDD2231  [12]
N1
 Probe Info  		N.A.  LDD0245  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [14]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [14]
NHS
 Probe Info  		K123(0.00); K519(0.00); K594(0.00); K42(0.00)  LDD0010  [15]
SF
 Probe Info  		Y132(0.00); Y595(0.00)  LDD0028  [16]
TFBX
 Probe Info  		N.A.  LDD0148  [17]
Acrolein
 Probe Info  		N.A.  LDD0217  [18]
Crotonaldehyde
 Probe Info  		H102(0.00); H138(0.00)  LDD0219  [18]
NAIA_5
 Probe Info  		C591(0.00); C603(0.00)  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 105 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		6.32  LDD1711  [20]
C004
 Probe Info  		6.19  LDD1714  [20]
C022
 Probe Info  		9.65  LDD1728  [20]
C040
 Probe Info  		12.47  LDD1740  [20]
C041
 Probe Info  		13.55  LDD1741  [20]
C052
 Probe Info  		6.45  LDD1750  [20]
C055
 Probe Info  		12.73  LDD1752  [20]
C056
 Probe Info  		18.25  LDD1753  [20]
C063
 Probe Info  		20.25  LDD1760  [20]
C064
 Probe Info  		7.36  LDD1761  [20]
C067
 Probe Info  		6.59  LDD1763  [20]
C068
 Probe Info  		4.92  LDD1764  [20]
C070
 Probe Info  		10.78  LDD1766  [20]
C072
 Probe Info  		9.71  LDD1768  [20]
C082
 Probe Info  		7.73  LDD1774  [20]
C085
 Probe Info  		5.03  LDD1777  [20]
C091
 Probe Info  		12.30  LDD1782  [20]
C092
 Probe Info  		30.27  LDD1783  [20]
C094
 Probe Info  		24.42  LDD1785  [20]
C106
 Probe Info  		23.26  LDD1793  [20]
C107
 Probe Info  		13.93  LDD1794  [20]
C108
 Probe Info  		13.74  LDD1795  [20]
C112
 Probe Info  		20.39  LDD1799  [20]
C140
 Probe Info  		12.47  LDD1822  [20]
C143
 Probe Info  		33.13  LDD1825  [20]
C159
 Probe Info  		10.48  LDD1839  [20]
C160
 Probe Info  		11.79  LDD1840  [20]
C161
 Probe Info  		21.86  LDD1841  [20]
C163
 Probe Info  		10.27  LDD1843  [20]
C165
 Probe Info  		37.53  LDD1845  [20]
C166
 Probe Info  		8.40  LDD1846  [20]
C171
 Probe Info  		8.11  LDD1851  [20]
C182
 Probe Info  		9.38  LDD1860  [20]
C191
 Probe Info  		9.65  LDD1868  [20]
C194
 Probe Info  		23.10  LDD1870  [20]
C196
 Probe Info  		10.70  LDD1872  [20]
C201
 Probe Info  		33.36  LDD1877  [20]
C206
 Probe Info  		20.53  LDD1881  [20]
C218
 Probe Info  		14.62  LDD1892  [20]
C220
 Probe Info  		21.11  LDD1894  [20]
C225
 Probe Info  		9.65  LDD1898  [20]
C226
 Probe Info  		11.00  LDD1899  [20]
C228
 Probe Info  		28.05  LDD1901  [20]
C229
 Probe Info  		10.27  LDD1902  [20]
C231
 Probe Info  		23.92  LDD1904  [20]
C233
 Probe Info  		9.65  LDD1906  [20]
C234
 Probe Info  		5.82  LDD1907  [20]
C235
 Probe Info  		40.22  LDD1908  [20]
C246
 Probe Info  		20.97  LDD1919  [20]
C260
 Probe Info  		5.39  LDD1932  [20]
C265
 Probe Info  		15.03  LDD1936  [20]
C270
 Probe Info  		7.57  LDD1940  [20]
C273
 Probe Info  		5.13  LDD1943  [20]
C277
 Probe Info  		8.94  LDD1947  [20]
C286
 Probe Info  		7.78  LDD1956  [20]
C287
 Probe Info  		8.82  LDD1957  [20]
C288
 Probe Info  		15.24  LDD1958  [20]
C293
 Probe Info  		31.12  LDD1963  [20]
C296
 Probe Info  		12.47  LDD1966  [20]
C307
 Probe Info  		8.51  LDD1975  [20]
C310
 Probe Info  		8.34  LDD1977  [20]
C322
 Probe Info  		8.88  LDD1988  [20]
C326
 Probe Info  		7.36  LDD1990  [20]
C338
 Probe Info  		10.13  LDD2001  [20]
C339
 Probe Info  		12.55  LDD2002  [20]
C342
 Probe Info  		8.57  LDD2004  [20]
C343
 Probe Info  		12.38  LDD2005  [20]
C348
 Probe Info  		15.45  LDD2009  [20]
C349
 Probe Info  		20.53  LDD2010  [20]
C350
 Probe Info  		82.14  LDD2011  [20]
C351
 Probe Info  		5.94  LDD2012  [20]
C353
 Probe Info  		8.11  LDD2014  [20]
C355
 Probe Info  		29.45  LDD2016  [20]
C356
 Probe Info  		9.32  LDD2017  [20]
C357
 Probe Info  		6.82  LDD2018  [20]
C362
 Probe Info  		30.91  LDD2023  [20]
C364
 Probe Info  		18.13  LDD2025  [20]
C367
 Probe Info  		5.31  LDD2028  [20]
C376
 Probe Info  		9.00  LDD2036  [20]
C380
 Probe Info  		5.66  LDD2039  [20]
C382
 Probe Info  		8.88  LDD2041  [20]
C403
 Probe Info  		14.22  LDD2061  [20]
C407
 Probe Info  		14.62  LDD2064  [20]
C408
 Probe Info  		7.46  LDD2065  [20]
C413
 Probe Info  		17.51  LDD2069  [20]
C420
 Probe Info  		12.30  LDD2075  [20]
C423
 Probe Info  		9.06  LDD2078  [20]
C431
 Probe Info  		14.93  LDD2086  [20]
FFF probe11
 Probe Info  		20.00  LDD0471  [21]
FFF probe13
 Probe Info  		20.00  LDD0475  [21]
FFF probe14
 Probe Info  		15.10  LDD0477  [21]
FFF probe15
 Probe Info  		11.41  LDD0478  [21]
FFF probe2
 Probe Info  		20.00  LDD0463  [21]
FFF probe3
 Probe Info  		20.00  LDD0464  [21]
FFF probe4
 Probe Info  		17.88  LDD0466  [21]
FFF probe6
 Probe Info  		5.16  LDD0467  [21]
FFF probe9
 Probe Info  		6.01  LDD0470  [21]
JN0003
 Probe Info  		20.00  LDD0469  [21]
STS-1
 Probe Info  		N.A.  LDD0137  [22]
STS-2
 Probe Info  		N.A.  LDD0138  [22]
VE-P
 Probe Info  		N.A.  LDD0396  [23]
A-DA
 Probe Info  		2.10  LDD0143  [24]
Staurosporine capture compound
 Probe Info  		2.00  LDD0083  [25]
DA-2
 Probe Info  		N.A.  LDD0073  [26]
OEA-DA
 Probe Info  		13.74  LDD0046  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C591(0.96)  LDD2142  [8]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C591(1.05)  LDD2112  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C591(1.14)  LDD2117  [8]
 LDCM0237  AC12 HEK-293T C496(0.87)  LDD1510  [28]
 LDCM0280  AC20 HEK-293T C496(0.93)  LDD1519  [28]
 LDCM0288  AC28 HEK-293T C496(1.05)  LDD1527  [28]
 LDCM0297  AC36 HEK-293T C496(0.84)  LDD1536  [28]
 LDCM0301  AC4 HEK-293T C496(0.84)  LDD1540  [28]
 LDCM0306  AC44 HEK-293T C496(0.86)  LDD1545  [28]
 LDCM0315  AC52 HEK-293T C496(0.98)  LDD1554  [28]
 LDCM0324  AC60 HEK-293T C496(1.54)  LDD1563  [28]
 LDCM0545  Acetamide MDA-MB-231 C591(0.35)  LDD2138  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C591(0.89)  LDD2113  [8]
 LDCM0083  Avasimibe A-549 2.10  LDD0143  [24]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [18]
 LDCM0408  CL20 HEK-293T C496(0.84)  LDD1612  [28]
 LDCM0421  CL32 HEK-293T C496(1.58)  LDD1625  [28]
 LDCM0434  CL44 HEK-293T C496(1.02)  LDD1638  [28]
 LDCM0447  CL56 HEK-293T C496(1.01)  LDD1650  [28]
 LDCM0460  CL68 HEK-293T C496(2.06)  LDD1663  [28]
 LDCM0473  CL8 HEK-293T C496(1.03)  LDD1676  [28]
 LDCM0474  CL80 HEK-293T C496(1.37)  LDD1677  [28]
 LDCM0487  CL92 HEK-293T C496(0.99)  LDD1690  [28]
 LDCM0625  F8 Ramos C603(1.38); C591(1.71)  LDD2187  [29]
 LDCM0572  Fragment10 Ramos C603(0.67); C591(1.46)  LDD2189  [29]
 LDCM0573  Fragment11 Ramos C603(0.49); C591(0.70)  LDD2190  [29]
 LDCM0574  Fragment12 Ramos C603(1.22); C591(1.19)  LDD2191  [29]
 LDCM0575  Fragment13 Ramos C603(0.88); C591(0.65)  LDD2192  [29]
 LDCM0576  Fragment14 Ramos C603(2.47); C591(2.91)  LDD2193  [29]
 LDCM0579  Fragment20 Ramos C603(2.91)  LDD2194  [29]
 LDCM0580  Fragment21 Ramos C603(1.02)  LDD2195  [29]
 LDCM0582  Fragment23 Ramos C603(1.58)  LDD2196  [29]
 LDCM0578  Fragment27 Ramos C603(0.75)  LDD2197  [29]
 LDCM0586  Fragment28 Ramos C603(0.70); C591(0.52)  LDD2198  [29]
 LDCM0588  Fragment30 Ramos C603(0.94); C591(1.25)  LDD2199  [29]
 LDCM0589  Fragment31 Ramos C603(1.30); C591(1.40)  LDD2200  [29]
 LDCM0590  Fragment32 Ramos C603(0.81); C591(2.11)  LDD2201  [29]
 LDCM0468  Fragment33 Ramos C603(0.76); C591(1.34)  LDD2202  [29]
 LDCM0596  Fragment38 Ramos C603(2.29)  LDD2203  [29]
 LDCM0566  Fragment4 Ramos C603(0.95)  LDD2184  [29]
 LDCM0610  Fragment52 Ramos C603(0.63)  LDD2204  [29]
 LDCM0614  Fragment56 Ramos C603(1.01); C591(0.60)  LDD2205  [29]
 LDCM0569  Fragment7 Ramos C603(0.84); C591(0.93)  LDD2186  [29]
 LDCM0571  Fragment9 Ramos C603(1.49)  LDD2188  [29]
 LDCM0107  IAA HeLa N.A.  LDD0221  [18]
 LDCM0022  KB02 Ramos C603(1.08); C591(1.15)  LDD2182  [29]
 LDCM0023  KB03 Jurkat C591(10.69)  LDD0209  [10]
 LDCM0024  KB05 MOLM-13 C496(2.75)  LDD3333  [30]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C591(1.20)  LDD2102  [8]
 LDCM0109  NEM HeLa N.A.  LDD0224  [18]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C591(0.72)  LDD2092  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C591(0.85)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C591(0.84)  LDD2094  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C591(1.08)  LDD2098  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C591(1.05)  LDD2100  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C591(1.10)  LDD2101  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C591(1.48)  LDD2105  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C591(0.98)  LDD2107  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C591(1.08)  LDD2109  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C591(1.36)  LDD2111  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C591(0.77)  LDD2114  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C591(0.40)  LDD2115  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C591(1.86)  LDD2119  [8]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C591(0.52)  LDD2122  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C591(1.06)  LDD2123  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C591(1.06)  LDD2125  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C591(1.26)  LDD2127  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C591(1.02)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C591(0.38)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C591(0.39)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C591(1.11)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C591(1.66)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C591(1.15)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C591(3.25)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C591(1.08)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C591(1.03)  LDD2141  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C591(2.86)  LDD2144  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C591(1.01)  LDD2146  [8]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C591(1.71)  LDD2153  [8]
 LDCM0014  Panhematin HEK-293T 3.44  LDD0062  [9]
 LDCM0098  Propranolol K562 4.10  LDD0271  [7]
 LDCM0084  Ro 48-8071 A-549 2.30  LDD0144  [24]
 LDCM0019  Staurosporine Hep-G2 2.00  LDD0083  [25]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CD81 antigen (CD81) Tetraspanin (TM4SF) family P60033
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chromobox protein homolog 3 (CBX3) . Q13185
Chromobox protein homolog 5 (CBX5) . P45973

References

1 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
7 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
10 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD007570
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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Mass spectrometry data entry: PXD047840