General Information of Experiment

Probe Name DA-2  Probe Info 
Probe concentration 10 uM
Criteria Other data
In Vivo Experiment Model Model Type Living cell
Derived Tissue Liver
Disease Model Hepatoblastoma [ICD-11:DB91]
Model Name Human hepatoblastoma cells (Hep-G2)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 140 Protein Related to This Bioclass
Target ID Target Name
 LDTP10869  26S proteasome non-ATPase regulatory subunit 1 (PSMD1)
 LDTP13667  26S proteasome non-ATPase regulatory subunit 13 (PSMD13)
 LDTP05782  26S proteasome non-ATPase regulatory subunit 2 (PSMD2)
 LDTP06532  26S proteasome non-ATPase regulatory subunit 5 (PSMD5)
 LDTP04196  26S proteasome non-ATPase regulatory subunit 8 (PSMD8)
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6)
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)
 LDTP06905  Acylglycerol kinase, mitochondrial (AGK)
 LDTP02220  Adenine phosphoribosyltransferase (APRT)
 LDTP04689  Adenosine kinase (ADK)
 LDTP04636  Adenylate kinase 2, mitochondrial (AK2)
 LDTP12682  ADP-ribosylation factor-like protein 8B (ARL8B)
 LDTP04262  Alanine--tRNA ligase, cytoplasmic (AARS1)
 LDTP15371  Aldehyde dehydrogenase family 16 member A1 (ALDH16A1)
 LDTP05436  Aldo-keto reductase family 1 member C1 (AKR1C1)
 LDTP02902  Aldo-keto reductase family 1 member C4 (AKR1C4)
 LDTP02514  Alkaline phosphatase, germ cell type (ALPG)
 LDTP02100  Alkaline phosphatase, placental type (ALPP)
 LDTP15993  Aminopeptidase B (RNPEP)
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1)
 LDTP07684  Arylsulfatase K (ARSK)
 LDTP02264  Asparagine synthetase [glutamine-hydrolyzing] (ASNS)
 LDTP00866  Asparagine--tRNA ligase, cytoplasmic (NARS1)
 LDTP01783  Aspartate aminotransferase, mitochondrial (GOT2)
 LDTP02752  Aspartate--tRNA ligase, cytoplasmic (DARS1)
 LDTP04561  ATP-citrate synthase (ACLY)
 LDTP02925  ATP-dependent 6-phosphofructokinase, liver type (PFKL)
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP)
 LDTP05550  ATP-dependent RNA helicase A (DHX9)
 LDTP00192  ATP-dependent RNA helicase DDX39A (DDX39A)
 LDTP00314  ATP-dependent RNA helicase DDX3X (DDX3X)
 LDTP00684  ATP-dependent RNA helicase DHX15 (DHX15)
 LDTP12681  ATPase family AAA domain-containing protein 3A (ATAD3A)
 LDTP02222  Bifunctional glutamate/proline--tRNA ligase (EPRS1)
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)
 LDTP04552  Biliverdin reductase A (BLVRA)
 LDTP02204  Calpain-1 catalytic subunit (CAPN1)
 LDTP02909  cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)
 LDTP10215  Carboxymethylenebutenolidase homolog (CMBL)
 LDTP03145  Catechol O-methyltransferase (COMT)
 LDTP01205  Citrate synthase, mitochondrial (CS)
 LDTP02616  Creatine kinase B-type (CKB)
 LDTP05946  Cullin-1 (CUL1)
 LDTP08296  Cullin-associated NEDD8-dissociated protein 1 (CAND1)
 LDTP03753  Cystathionine beta-synthase (CBS)
 LDTP04263  Cysteine--tRNA ligase, cytoplasmic (CARS1)
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2)
 LDTP06200  Delta(14)-sterol reductase LBR (LBR)
 LDTP02497  Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (DLAT)
 LDTP03316  DNA replication licensing factor MCM3 (MCM3)
 LDTP03680  DNA replication licensing factor MCM4 (MCM4)
 LDTP03681  DNA replication licensing factor MCM5 (MCM5)
 LDTP06150  DNA replication licensing factor MCM6 (MCM6)
 LDTP03682  DNA replication licensing factor MCM7 (MCM7)
 LDTP02567  DNA topoisomerase 1 (TOP1)
 LDTP02568  DNA topoisomerase 2-alpha (TOP2A)
 LDTP05379  DNA topoisomerase 2-beta (TOP2B)
 LDTP05136  DNA-dependent protein kinase catalytic subunit (PRKDC)
 LDTP04374  Dynamin-2 (DNM2)
 LDTP02694  Electron transfer flavoprotein subunit alpha, mitochondrial (ETFA)
 LDTP03849  Electron transfer flavoprotein subunit beta (ETFB)
 LDTP05071  Elongation factor 1-alpha 1 (EEF1A1)
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM)
 LDTP03965  Enoyl-CoA delta isomerase 1, mitochondrial (ECI1)
 LDTP03518  Enoyl-CoA hydratase, mitochondrial (ECHS1)
 LDTP03511  Flavin reductase (NADPH) (BLVRB)
 LDTP02386  Fructose-bisphosphate aldolase C (ALDOC)
 LDTP02235  Fumarate hydratase, mitochondrial (FH)
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1)
 LDTP03946  Glycine--tRNA ligase (GARS1)
 LDTP04333  GMP synthase [glutamine-hydrolyzing] (GMPS)
 LDTP06645  Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH)
 LDTP01782  Hypoxanthine-guanine phosphoribosyltransferase (HPRT1)
 LDTP11842  Inorganic pyrophosphatase 2, mitochondrial (PPA2)
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)
 LDTP03409  Inositol-trisphosphate 3-kinase B (ITPKB)
 LDTP04345  Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (IDH3A)
 LDTP03947  Isoleucine--tRNA ligase, cytoplasmic (IARS1)
 LDTP12588  Isoleucine--tRNA ligase, mitochondrial (IARS2)
 LDTP11509  L-lactate dehydrogenase A-like 6B (LDHAL6B)
 LDTP05434  Lactoylglutathione lyase (GLO1)
 LDTP13056  Leucine--tRNA ligase, cytoplasmic (LARS1)
 LDTP03817  Lon protease homolog, mitochondrial (LONP1)
 LDTP06294  Lysine--tRNA ligase (KARS1)
 LDTP03907  Malate dehydrogenase, cytoplasmic (MDH1)
 LDTP04730  Methionine--tRNA ligase, cytoplasmic (MARS1)
 LDTP10776  Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCC1)
 LDTP06192  Neutral alpha-glucosidase AB (GANAB)
 LDTP12469  Nucleolar RNA helicase 2 (DDX21)
 LDTP12610  Obg-like ATPase 1 (OLA1)
 LDTP10878  Parkinson disease protein 7 (PARK7)
 LDTP03216  Peptidyl-prolyl cis-trans isomerase B (PPIB)
 LDTP04440  Peroxisomal multifunctional enzyme type 2 (HSD17B4)
 LDTP01787  Phosphoglycerate kinase 1 (PGK1)
 LDTP02375  Poly [ADP-ribose] polymerase 1 (PARP1)
 LDTP09899  Probable ATP-dependent RNA helicase DDX17 (DDX17)
 LDTP02924  Probable ATP-dependent RNA helicase DDX5 (DDX5)
 LDTP15391  Probable phosphoglycerate mutase 4 (PGAM4)
 LDTP13750  Proliferation-associated protein 2G4 (PA2G4)
 LDTP06338  Prostaglandin E synthase 3 (PTGES3)
 LDTP03413  Proteasome subunit alpha type-5 (PSMA5)
 LDTP00449  Proteasome subunit alpha type-7 (PSMA7)
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1)
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3)
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6)
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2)
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS)
 LDTP00343  Pyridoxal kinase (PDXK)
 LDTP03644  Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1)
 LDTP10159  Pyrroline-5-carboxylate reductase 2 (PYCR2)
 LDTP02733  Pyruvate kinase PKM (PKM)
 LDTP04895  Ras-related protein Rab-10 (RAB10)
 LDTP04399  Ras-related protein Rab-7a (RAB7A)
 LDTP04910  Ras-related protein Rap-1b (RAP1B)
 LDTP03097  Ribose-phosphate pyrophosphokinase 3 (PRPS1L1)
 LDTP13816  RuvB-like 1 (RUVBL1)
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2)
 LDTP03689  Serine hydroxymethyltransferase, mitochondrial (SHMT2)
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1)
 LDTP08275  Serine/threonine-protein kinase pim-3 (PIM3)
 LDTP03819  Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PPP1CC)
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3)
 LDTP05991  Spliceosome RNA helicase DDX39B (DDX39B)
 LDTP07929  Staphylococcal nuclease domain-containing protein 1 (SND1)
 LDTP00101  Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1)
 LDTP03572  Succinate dehydrogenase flavoprotein subunit, mitochondrial (SDHA)
 LDTP03365  Threonine--tRNA ligase 1, cytoplasmic (TARS1)
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA)
 LDTP03156  Trifunctional purine biosynthetic protein adenosine-3 (GART)
 LDTP04851  Triosephosphate isomerase (TPI1)
 LDTP03222  Tryptophan--tRNA ligase, cytoplasmic (WARS1)
 LDTP06639  Tyrosine-protein phosphatase non-receptor type 21 (PTPN21)
 LDTP01283  U5 small nuclear ribonucleoprotein 200 kDa helicase (SNRNP200)
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3)
 LDTP12851  UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1)
 LDTP03366  Valine--tRNA ligase (VARS1)
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR)
 LDTP02642  X-ray repair cross-complementing protein 5 (XRCC5)
 LDTP02640  X-ray repair cross-complementing protein 6 (XRCC6)
Transporter and channel
Click to Show/Hide to Show 44 Protein Related to This Bioclass
Target ID Target Name
 LDTP04969  14-3-3 protein epsilon (YWHAE)
 LDTP04953  14-3-3 protein gamma (YWHAG)
 LDTP02087  ADP/ATP translocase 2 (SLC25A5)
 LDTP02609  ADP/ATP translocase 3 (SLC25A6)
 LDTP05038  AP-2 complex subunit beta (AP2B1)
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB)
 LDTP03810  ATP synthase subunit gamma, mitochondrial (ATP5F1C)
 LDTP03405  Calnexin (CANX)
 LDTP03402  Calreticulin (CALR)
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1)
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4)
 LDTP05252  Clathrin heavy chain 1 (CLTC)
 LDTP04578  Clathrin heavy chain 2 (CLTCL1)
 LDTP05510  Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP)
 LDTP02057  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1)
 LDTP02058  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (RPN2)
 LDTP01301  Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (SLC25A12)
 LDTP00501  Exportin-1 (XPO1)
 LDTP04662  Exportin-2 (CSE1L)
 LDTP12142  Exportin-5 (XPO5)
 LDTP11161  Extended synaptotagmin-1 (ESYT1)
 LDTP06103  Filamin-C (FLNC)
 LDTP00328  Importin subunit alpha-3 (KPNA4)
 LDTP06242  Importin subunit beta-1 (KPNB1)
 LDTP10663  Importin-9 (IPO9)
 LDTP06660  MICOS complex subunit MIC60 (IMMT)
 LDTP05384  Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11)
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2)
 LDTP06462  Neutral amino acid transporter B(0) (SLC1A5)
 LDTP01295  Nuclear pore complex protein Nup155 (NUP155)
 LDTP05642  Nuclear pore complex protein Nup160 (NUP160)
 LDTP04707  Protein SEC13 homolog (SEC13)
 LDTP12090  Sideroflexin-1 (SFXN1)
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1)
 LDTP05238  Solute carrier family 25 member 3 (SLC25A3)
 LDTP05273  Spectrin beta chain, non-erythrocytic 1 (SPTBN1)
 LDTP00592  Surfeit locus protein 4 (SURF4)
 LDTP01969  Transferrin receptor protein 1 (TFRC)
 LDTP04787  Transmembrane protein 33 (TMEM33)
 LDTP04553  Tricarboxylate transport protein, mitochondrial (SLC25A1)
 LDTP10741  Vacuolar protein sorting-associated protein 35 (VPS35)
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1)
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2)
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3)
Transcription factor
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name
 LDTP03363  High mobility group protein B2 (HMGB2)
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO)
 LDTP16723  Putative high mobility group protein B1-like 1 (HMGB1P1)
 LDTP03903  Signal transducer and activator of transcription 3 (STAT3)
 LDTP03971  Signal transducer and activator of transcription 5A (STAT5A)
 LDTP04454  Signal transducer and activator of transcription 5B (STAT5B)
Other
Click to Show/Hide to Show 88 Protein Related to This Bioclass
Target ID Target Name
 LDTP03617  14-3-3 protein beta/alpha (YWHAB)
 LDTP05442  14-3-3 protein eta (YWHAH)
 LDTP03871  Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A)
 LDTP05294  Adenylyl cyclase-associated protein 1 (CAP1)
 LDTP08760  Cell cycle and apoptosis regulator protein 2 (CCAR2)
 LDTP06584  Cleavage and polyadenylation specificity factor subunit 6 (CPSF6)
 LDTP04571  Coatomer subunit alpha (COPA)
 LDTP04570  Coatomer subunit beta (COPB1)
 LDTP04092  Crk-like protein (CRKL)
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB)
 LDTP06083  Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1)
 LDTP06543  DNA damage-binding protein 1 (DDB1)
 LDTP04518  DNA mismatch repair protein Msh6 (MSH6)
 LDTP06450  ELAV-like protein 1 (ELAVL1)
 LDTP03283  Elongation factor 1-beta (EEF1B2)
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2)
 LDTP02101  Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)
 LDTP02779  Ezrin (EZR)
 LDTP10078  Far upstream element-binding protein 1 (FUBP1)
 LDTP09938  Far upstream element-binding protein 2 (KHSRP)
 LDTP08263  Fermitin family homolog 3 (FERMT3)
 LDTP02710  Glial fibrillary acidic protein (GFAP)
 LDTP01922  Hemoglobin subunit epsilon (HBE1)
 LDTP04495  Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3)
 LDTP06032  Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD)
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF)
 LDTP02750  Heterogeneous nuclear ribonucleoprotein L (HNRNPL)
 LDTP04500  Heterogeneous nuclear ribonucleoprotein M (HNRNPM)
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP)
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR)
 LDTP03182  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)
 LDTP02227  Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC)
 LDTP07384  Histone H2A type 2-A (H2AC18; H2AC19)
 LDTP06628  Histone H2B type 2-E (H2BC21)
 LDTP12904  Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
 LDTP00272  Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
 LDTP05688  Interleukin enhancer-binding factor 2 (ILF2)
 LDTP05689  Interleukin enhancer-binding factor 3 (ILF3)
 LDTP02975  Keratin, type II cytoskeletal 4 (KRT4)
 LDTP01931  Keratin, type II cytoskeletal 6A (KRT6A)
 LDTP04205  Keratin, type II cytoskeletal 6C (KRT6C)
 LDTP03065  Lamin-B1 (LMNB1)
 LDTP04094  Large proline-rich protein BAG6 (BAG6)
 LDTP04389  Large ribosomal subunit protein eL14 (RPL14)
 LDTP05509  Large ribosomal subunit protein eL18 (RPL18)
 LDTP05196  Large ribosomal subunit protein eL19 (RPL19)
 LDTP05360  Large ribosomal subunit protein eL20 (RPL18A)
 LDTP05378  Large ribosomal subunit protein eL6 (RPL6)
 LDTP02109  Large ribosomal subunit protein uL10 (RPLP0)
 LDTP03517  Large ribosomal subunit protein uL11 (RPL12)
 LDTP04106  Large ribosomal subunit protein uL18 (RPL5)
 LDTP03997  Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC)
 LDTP12764  MICOS complex subunit MIC19 (CHCHD3)
 LDTP01432  Mitochondrial import receptor subunit TOM70 (TOMM70)
 LDTP05977  Nascent polypeptide-associated complex subunit alpha (NACA)
 LDTP02164  Nucleophosmin (NPM1)
 LDTP05895  Phosphatidylinositol-binding clathrin assembly protein (PICALM)
 LDTP06367  Poly(rC)-binding protein 2 (PCBP2)
 LDTP02595  Polyadenylate-binding protein 1 (PABPC1)
 LDTP03364  Polypyrimidine tract-binding protein 1 (PTBP1)
 LDTP07526  Pre-mRNA-processing-splicing factor 8 (PRPF8)
 LDTP01932  Prelamin-A/C (LMNA)
 LDTP13519  Proteasome activator complex subunit 2 (PSME2)
 LDTP04917  Proteasome activator complex subunit 3 (PSME3)
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1)
 LDTP14957  Putative heat shock protein HSP 90-alpha A4 (HSP90AA4P)
 LDTP13956  Putative RNA-binding protein Luc7-like 2 (LUC7L2)
 LDTP04355  Rab GDP dissociation inhibitor beta (GDI2)
 LDTP04117  Ras GTPase-activating-like protein IQGAP1 (IQGAP1)
 LDTP02964  Regulator of chromosome condensation (RCC1)
 LDTP01379  Ribosomal L1 domain-containing protein 1 (RSL1D1)
 LDTP06583  Serine/arginine-rich splicing factor 7 (SRSF7)
 LDTP09081  SERPINE1 mRNA-binding protein 1 (SERBP1)
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X)
 LDTP05002  Small ribosomal subunit protein eS6 (RPS6)
 LDTP04964  Small ribosomal subunit protein eS8 (RPS8)
 LDTP06376  Splicing factor 3B subunit 3 (SF3B3)
 LDTP06280  Squamous cell carcinoma antigen recognized by T-cells 3 (SART3)
 LDTP06094  Src substrate cortactin (CTTN)
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1)
 LDTP03619  Stress-induced-phosphoprotein 1 (STIP1)
 LDTP00875  Striatin (STRN)
 LDTP02934  T-complex protein 1 subunit alpha (TCP1)
 LDTP05113  T-complex protein 1 subunit beta (CCT2)
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5)
 LDTP04249  T-complex protein 1 subunit gamma (CCT3)
 LDTP03888  T-complex protein 1 subunit zeta (CCT6A)
 LDTP02297  Vimentin (VIM)

References

1 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.