Details of the Target

General Information of Target

Target ID LDTP03965
Target Name Enoyl-CoA delta isomerase 1, mitochondrial (ECI1)
Gene Name ECI1
Gene ID 1632
Synonyms
DCI; Enoyl-CoA delta isomerase 1, mitochondrial; EC 5.3.3.8; 3,2-trans-enoyl-CoA isomerase; Delta(3),Delta(2)-enoyl-CoA isomerase; D3,D2-enoyl-CoA isomerase; Dodecenoyl-CoA isomerase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALVASVRVPARVLLRAGARLPGAALGRTERAAGGGDGARRFGSQRVLVEPDAGAGVAVM
KFKNPPVNSLSLEFLTELVISLEKLENDKSFRGVILTSDRPGVFSAGLDLTEMCGRSPAH
YAGYWKAVQELWLRLYQSNLVLVSAINGACPAGGCLVALTCDYRILADNPRYCIGLNETQ
LGIIAPFWLKDTLENTIGHRAAERALQLGLLFPPAEALQVGIVDQVVPEEQVQSTALSAI
AQWMAIPDHARQLTKAMMRKATASRLVTQRDADVQNFVSFISKDSIQKSLQMYLERLKEE
KG
Target Bioclass
Enzyme
Family
Enoyl-CoA hydratase/isomerase family
Subcellular location
Mitochondrion matrix
Function
Key enzyme of fatty acid beta-oxidation (Probable). Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length.
Uniprot ID
P42126
Ensemble ID
ENST00000301729.9
HGNC ID
HGNC:2703

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.V227I DBIA    Probe Info 
ICC8 Insertion: p.A119GfsTer44 .
MFE319 SNV: p.L15F DBIA    Probe Info 
NCIH1155 SNV: p.S234N DBIA    Probe Info 
TOV21G SNV: p.A119S DBIA    Probe Info 
TYKNU SNV: p.E300K DBIA    Probe Info 
U2OS SNV: p.P247S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.35  LDD0402  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
AZ-9
 Probe Info  		E295(10.00)  LDD2209  [4]
IPM
 Probe Info  		C114(0.00); C173(0.00)  LDD0241  [5]
Probe 1
 Probe Info  		Y293(19.23)  LDD3495  [6]
P26
 Probe Info  		1.59  LDD0409  [7]
AHL-Pu-1
 Probe Info  		C114(2.46)  LDD0171  [8]
DBIA
 Probe Info  		C114(0.89)  LDD0078  [9]
5E-2FA
 Probe Info  		N.A.  LDD2235  [10]
ATP probe
 Probe Info  		K283(0.00); K288(0.00)  LDD0199  [11]
IA-alkyne
 Probe Info  		C114(0.00); C173(0.00)  LDD0162  [12]
NHS
 Probe Info  		N.A.  LDD0010  [13]
SF
 Probe Info  		N.A.  LDD0028  [14]
STPyne
 Probe Info  		N.A.  LDD0009  [13]
TFBX
 Probe Info  		N.A.  LDD0148  [15]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [16]
Ox-W18
 Probe Info  		N.A.  LDD2175  [17]
1c-yne
 Probe Info  		N.A.  LDD0228  [18]
Acrolein
 Probe Info  		N.A.  LDD0217  [19]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [19]
W1
 Probe Info  		N.A.  LDD0236  [5]
AOyne
 Probe Info  		6.50  LDD0443  [20]
MPP-AC
 Probe Info  		N.A.  LDD0428  [21]
NAIA_5
 Probe Info  		C114(0.00); C173(0.00)  LDD2223  [22]
TER-AC
 Probe Info  		N.A.  LDD0426  [21]
TPP-AC
 Probe Info  		N.A.  LDD0427  [21]
HHS-465
 Probe Info  		N.A.  LDD2240  [23]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		7.06  LDD1733  [24]
C158
 Probe Info  		18.51  LDD1838  [24]
C362
 Probe Info  		25.28  LDD2023  [24]
C428
 Probe Info  		11.08  LDD2083  [24]
FFF probe13
 Probe Info  		16.55  LDD0475  [25]
FFF probe14
 Probe Info  		13.13  LDD0477  [25]
FFF probe2
 Probe Info  		14.25  LDD0463  [25]
FFF probe3
 Probe Info  		12.56  LDD0464  [25]
JN0003
 Probe Info  		20.00  LDD0469  [25]
DA-2
 Probe Info  		N.A.  LDD0070  [26]
OEA-DA
 Probe Info  		4.83  LDD0046  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C114(2.46)  LDD0171  [8]
 LDCM0214  AC1 PaTu 8988t C173(1.28)  LDD1093  [9]
 LDCM0215  AC10 HCT 116 C114(1.09)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C173(0.78)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C173(0.96)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C173(0.69)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C173(0.80)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C173(0.83)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C173(0.81)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C173(0.76)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C173(0.96)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C173(0.57)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C173(0.56)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C114(0.96)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C173(0.59)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C173(0.73)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C173(0.95)  LDD0546  [9]
 LDCM0230  AC113 PaTu 8988t C173(0.83)  LDD1109  [9]
 LDCM0231  AC114 PaTu 8988t C173(0.73)  LDD1110  [9]
 LDCM0232  AC115 PaTu 8988t C173(0.85)  LDD1111  [9]
 LDCM0233  AC116 PaTu 8988t C173(0.91)  LDD1112  [9]
 LDCM0234  AC117 PaTu 8988t C173(0.83)  LDD1113  [9]
 LDCM0235  AC118 PaTu 8988t C173(0.93)  LDD1114  [9]
 LDCM0236  AC119 PaTu 8988t C173(1.21)  LDD1115  [9]
 LDCM0237  AC12 HCT 116 C114(0.81)  LDD0554  [9]
 LDCM0238  AC120 PaTu 8988t C173(1.09)  LDD1117  [9]
 LDCM0239  AC121 PaTu 8988t C173(0.95)  LDD1118  [9]
 LDCM0240  AC122 PaTu 8988t C173(0.96)  LDD1119  [9]
 LDCM0241  AC123 PaTu 8988t C173(0.87)  LDD1120  [9]
 LDCM0242  AC124 PaTu 8988t C173(1.06)  LDD1121  [9]
 LDCM0243  AC125 PaTu 8988t C173(1.04)  LDD1122  [9]
 LDCM0244  AC126 PaTu 8988t C173(0.74)  LDD1123  [9]
 LDCM0245  AC127 PaTu 8988t C173(0.97)  LDD1124  [9]
 LDCM0259  AC14 HCT 116 C114(0.98)  LDD0576  [9]
 LDCM0263  AC143 HCT 116 C114(1.21)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C114(1.26)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C114(1.18)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C114(1.14)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C114(1.42)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C114(1.56)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C114(1.13)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C114(1.02)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C114(1.10)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C114(1.04)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C114(1.70)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C114(1.58)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C114(1.31)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C114(1.42)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C114(1.07)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C114(1.18)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C173(1.32)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C173(2.02)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C173(1.26)  LDD0595  [9]
 LDCM0279  AC2 PaTu 8988t C173(1.17)  LDD1158  [9]
 LDCM0280  AC20 HCT 116 C173(1.56)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C173(1.09)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C173(1.03)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C173(1.41)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C173(1.62)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C173(0.86)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C173(1.01)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C173(1.23)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C173(1.24)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C173(1.08)  LDD0606  [9]
 LDCM0290  AC3 PaTu 8988t C173(1.17)  LDD1169  [9]
 LDCM0291  AC30 HCT 116 C173(1.34)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C173(1.38)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C173(1.63)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C173(1.20)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C173(0.99)  LDD0612  [9]
 LDCM0296  AC35 PaTu 8988t C173(1.18)  LDD1175  [9]
 LDCM0297  AC36 PaTu 8988t C173(1.18)  LDD1176  [9]
 LDCM0298  AC37 PaTu 8988t C173(1.13)  LDD1177  [9]
 LDCM0299  AC38 PaTu 8988t C173(1.11)  LDD1178  [9]
 LDCM0300  AC39 PaTu 8988t C173(1.24)  LDD1179  [9]
 LDCM0301  AC4 PaTu 8988t C173(1.17)  LDD1180  [9]
 LDCM0302  AC40 PaTu 8988t C173(1.23)  LDD1181  [9]
 LDCM0303  AC41 PaTu 8988t C173(1.06)  LDD1182  [9]
 LDCM0304  AC42 PaTu 8988t C173(1.12)  LDD1183  [9]
 LDCM0305  AC43 PaTu 8988t C173(1.11)  LDD1184  [9]
 LDCM0306  AC44 PaTu 8988t C173(1.19)  LDD1185  [9]
 LDCM0307  AC45 PaTu 8988t C173(1.16)  LDD1186  [9]
 LDCM0308  AC46 HCT 116 C114(1.01)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C114(1.37)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C114(0.99)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C114(1.15)  LDD0628  [9]
 LDCM0312  AC5 PaTu 8988t C173(1.37)  LDD1191  [9]
 LDCM0313  AC50 HCT 116 C114(1.03)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C114(1.02)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C114(1.31)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C114(1.19)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C114(1.11)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C114(0.99)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C114(0.94)  LDD0636  [9]
 LDCM0320  AC57 PaTu 8988t C173(0.93)  LDD1199  [9]
 LDCM0321  AC58 PaTu 8988t C173(1.11)  LDD1200  [9]
 LDCM0322  AC59 PaTu 8988t C173(0.72)  LDD1201  [9]
 LDCM0323  AC6 HCT 116 C114(1.05)  LDD0640  [9]
 LDCM0324  AC60 PaTu 8988t C173(0.90)  LDD1203  [9]
 LDCM0325  AC61 PaTu 8988t C173(1.44)  LDD1204  [9]
 LDCM0326  AC62 PaTu 8988t C173(0.96)  LDD1205  [9]
 LDCM0327  AC63 PaTu 8988t C173(1.10)  LDD1206  [9]
 LDCM0328  AC64 PaTu 8988t C173(0.90)  LDD1207  [9]
 LDCM0329  AC65 PaTu 8988t C173(0.88)  LDD1208  [9]
 LDCM0330  AC66 PaTu 8988t C173(1.36)  LDD1209  [9]
 LDCM0331  AC67 PaTu 8988t C173(0.91)  LDD1210  [9]
 LDCM0332  AC68 HCT 116 C114(1.06)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C114(0.84)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C114(1.04)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C114(0.71)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C114(1.09)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C114(1.17)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C114(0.87)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C114(0.65)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C114(0.74)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C114(1.01)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C114(1.04)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C114(0.94)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C114(1.21)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C114(0.83)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C114(0.94)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C114(0.68)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C114(0.31)  LDD0665  [9]
 LDCM0365  AC98 HCT 116 C173(0.66)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C173(0.62)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C114(0.97)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C114(1.00)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C114(0.94)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 11.80  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C114(0.89)  LDD0078  [9]
 LDCM0108  Chloroacetamide HeLa C114(0.00); H199(0.00)  LDD0222  [19]
 LDCM0367  CL1 HCT 116 C173(0.62); C114(0.80)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C173(0.67); C114(0.71)  LDD0685  [9]
 LDCM0369  CL100 PaTu 8988t C173(0.98)  LDD1248  [9]
 LDCM0370  CL101 HCT 116 C114(1.10)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C114(1.08)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C114(0.95)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C114(1.19)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C173(1.42)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C173(1.28)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C173(1.10)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C173(1.41)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C173(1.42)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C173(0.58); C114(0.88)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C173(0.81)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C173(1.09)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C173(1.07)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C173(0.76)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C173(0.85)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C173(1.33)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C173(1.48)  LDD0703  [9]
 LDCM0387  CL117 PaTu 8988t C173(0.89)  LDD1266  [9]
 LDCM0388  CL118 PaTu 8988t C173(0.93)  LDD1267  [9]
 LDCM0389  CL119 PaTu 8988t C173(1.10)  LDD1268  [9]
 LDCM0390  CL12 HCT 116 C173(0.81); C114(1.09)  LDD0707  [9]
 LDCM0391  CL120 PaTu 8988t C173(1.21)  LDD1270  [9]
 LDCM0392  CL121 HCT 116 C114(1.18)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C114(0.94)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C114(1.13)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C114(1.12)  LDD0712  [9]
 LDCM0396  CL125 PaTu 8988t C173(1.56)  LDD1275  [9]
 LDCM0397  CL126 PaTu 8988t C173(1.06)  LDD1276  [9]
 LDCM0398  CL127 PaTu 8988t C173(1.09)  LDD1277  [9]
 LDCM0399  CL128 PaTu 8988t C173(1.02)  LDD1278  [9]
 LDCM0400  CL13 HCT 116 C173(0.88); C114(0.92)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C173(0.91); C114(1.16)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C114(0.67); C173(0.98)  LDD0719  [9]
 LDCM0403  CL16 HEK-293T C114(1.02); C173(1.10)  LDD1607  [28]
 LDCM0404  CL17 HEK-293T C114(1.04); C173(0.92)  LDD1608  [28]
 LDCM0405  CL18 HEK-293T C114(0.95); C173(0.91)  LDD1609  [28]
 LDCM0406  CL19 HEK-293T C114(0.91); C173(1.04)  LDD1610  [28]
 LDCM0407  CL2 HCT 116 C173(0.64); C114(0.89)  LDD0724  [9]
 LDCM0408  CL20 HEK-293T C114(1.02); C173(1.03)  LDD1612  [28]
 LDCM0409  CL21 HEK-293T C114(1.07); C173(0.99)  LDD1613  [28]
 LDCM0410  CL22 HEK-293T C114(1.04); C173(1.06); C150(1.12)  LDD1614  [28]
 LDCM0411  CL23 HEK-293T C114(0.95); C173(1.08); C150(0.97)  LDD1615  [28]
 LDCM0412  CL24 HEK-293T C114(1.01); C173(1.07)  LDD1616  [28]
 LDCM0413  CL25 HEK-293T C114(0.98); C173(1.22)  LDD1617  [28]
 LDCM0414  CL26 HEK-293T C114(0.92); C173(1.01)  LDD1618  [28]
 LDCM0415  CL27 HEK-293T C114(1.06); C173(0.99)  LDD1619  [28]
 LDCM0416  CL28 HEK-293T C114(1.06); C173(0.99)  LDD1620  [28]
 LDCM0417  CL29 HEK-293T C114(1.02); C173(0.90)  LDD1621  [28]
 LDCM0418  CL3 HCT 116 C114(0.91); C173(0.70)  LDD0735  [9]
 LDCM0419  CL30 HEK-293T C114(0.96); C173(0.98)  LDD1623  [28]
 LDCM0420  CL31 HEK-293T C114(0.89); C173(0.84)  LDD1624  [28]
 LDCM0421  CL32 HEK-293T C114(1.02); C173(0.98)  LDD1625  [28]
 LDCM0422  CL33 HEK-293T C114(1.12); C173(0.79)  LDD1626  [28]
 LDCM0423  CL34 HEK-293T C114(1.10); C173(0.90); C150(1.18)  LDD1627  [28]
 LDCM0424  CL35 HEK-293T C114(0.97); C173(1.00); C150(0.75)  LDD1628  [28]
 LDCM0425  CL36 HEK-293T C114(1.07); C173(1.00)  LDD1629  [28]
 LDCM0426  CL37 HEK-293T C114(1.14); C173(1.15)  LDD1630  [28]
 LDCM0428  CL39 HEK-293T C114(0.96); C173(1.00)  LDD1632  [28]
 LDCM0429  CL4 HCT 116 C114(0.95); C173(0.80)  LDD0746  [9]
 LDCM0430  CL40 HEK-293T C114(1.03); C173(1.01)  LDD1634  [28]
 LDCM0431  CL41 HEK-293T C114(1.05); C173(0.95)  LDD1635  [28]
 LDCM0432  CL42 HEK-293T C114(1.01); C173(0.98)  LDD1636  [28]
 LDCM0433  CL43 HEK-293T C114(0.96); C173(0.99)  LDD1637  [28]
 LDCM0434  CL44 HEK-293T C114(1.01); C173(0.91)  LDD1638  [28]
 LDCM0435  CL45 HEK-293T C114(1.03); C173(0.90)  LDD1639  [28]
 LDCM0436  CL46 PaTu 8988t C173(1.34)  LDD1315  [9]
 LDCM0437  CL47 PaTu 8988t C173(1.21)  LDD1316  [9]
 LDCM0438  CL48 PaTu 8988t C173(1.28)  LDD1317  [9]
 LDCM0439  CL49 PaTu 8988t C173(0.93)  LDD1318  [9]
 LDCM0440  CL5 HCT 116 C114(1.08); C173(0.62)  LDD0757  [9]
 LDCM0441  CL50 PaTu 8988t C173(1.28)  LDD1320  [9]
 LDCM0442  CL51 PaTu 8988t C173(0.68)  LDD1321  [9]
 LDCM0443  CL52 PaTu 8988t C173(1.11)  LDD1322  [9]
 LDCM0444  CL53 PaTu 8988t C173(0.98)  LDD1323  [9]
 LDCM0445  CL54 PaTu 8988t C173(1.02)  LDD1324  [9]
 LDCM0446  CL55 PaTu 8988t C173(1.18)  LDD1325  [9]
 LDCM0447  CL56 PaTu 8988t C173(1.00)  LDD1326  [9]
 LDCM0448  CL57 PaTu 8988t C173(1.12)  LDD1327  [9]
 LDCM0449  CL58 PaTu 8988t C173(1.27)  LDD1328  [9]
 LDCM0450  CL59 PaTu 8988t C173(1.19)  LDD1329  [9]
 LDCM0451  CL6 HCT 116 C114(0.69); C173(0.96)  LDD0768  [9]
 LDCM0452  CL60 PaTu 8988t C173(1.04)  LDD1331  [9]
 LDCM0453  CL61 PaTu 8988t C173(0.92)  LDD1332  [9]
 LDCM0454  CL62 PaTu 8988t C173(0.92)  LDD1333  [9]
 LDCM0455  CL63 PaTu 8988t C173(0.97)  LDD1334  [9]
 LDCM0456  CL64 PaTu 8988t C173(0.93)  LDD1335  [9]
 LDCM0457  CL65 PaTu 8988t C173(0.97)  LDD1336  [9]
 LDCM0458  CL66 PaTu 8988t C173(1.09)  LDD1337  [9]
 LDCM0459  CL67 PaTu 8988t C173(1.01)  LDD1338  [9]
 LDCM0460  CL68 PaTu 8988t C173(0.85)  LDD1339  [9]
 LDCM0461  CL69 PaTu 8988t C173(1.02)  LDD1340  [9]
 LDCM0462  CL7 HCT 116 C114(0.85); C173(0.83)  LDD0779  [9]
 LDCM0463  CL70 PaTu 8988t C173(0.74)  LDD1342  [9]
 LDCM0464  CL71 PaTu 8988t C173(0.91)  LDD1343  [9]
 LDCM0465  CL72 PaTu 8988t C173(0.78)  LDD1344  [9]
 LDCM0466  CL73 PaTu 8988t C173(1.04)  LDD1345  [9]
 LDCM0467  CL74 PaTu 8988t C173(1.02)  LDD1346  [9]
 LDCM0469  CL76 PaTu 8988t C173(0.92)  LDD1348  [9]
 LDCM0470  CL77 PaTu 8988t C173(1.08)  LDD1349  [9]
 LDCM0471  CL78 PaTu 8988t C173(1.15)  LDD1350  [9]
 LDCM0472  CL79 PaTu 8988t C173(1.04)  LDD1351  [9]
 LDCM0473  CL8 HCT 116 C114(1.15); C173(0.64)  LDD0790  [9]
 LDCM0474  CL80 PaTu 8988t C173(1.22)  LDD1353  [9]
 LDCM0475  CL81 PaTu 8988t C173(1.29)  LDD1354  [9]
 LDCM0476  CL82 PaTu 8988t C173(1.05)  LDD1355  [9]
 LDCM0477  CL83 PaTu 8988t C173(1.09)  LDD1356  [9]
 LDCM0478  CL84 PaTu 8988t C173(1.31)  LDD1357  [9]
 LDCM0479  CL85 PaTu 8988t C173(1.19)  LDD1358  [9]
 LDCM0480  CL86 PaTu 8988t C173(1.07)  LDD1359  [9]
 LDCM0481  CL87 PaTu 8988t C173(1.17)  LDD1360  [9]
 LDCM0482  CL88 PaTu 8988t C173(1.33)  LDD1361  [9]
 LDCM0483  CL89 PaTu 8988t C173(1.30)  LDD1362  [9]
 LDCM0484  CL9 HCT 116 C114(1.20); C173(1.18)  LDD0801  [9]
 LDCM0485  CL90 PaTu 8988t C173(1.11)  LDD1364  [9]
 LDCM0486  CL91 PaTu 8988t C173(1.05)  LDD1365  [9]
 LDCM0487  CL92 PaTu 8988t C173(1.11)  LDD1366  [9]
 LDCM0488  CL93 PaTu 8988t C173(1.19)  LDD1367  [9]
 LDCM0489  CL94 PaTu 8988t C173(1.22)  LDD1368  [9]
 LDCM0490  CL95 PaTu 8988t C173(1.16)  LDD1369  [9]
 LDCM0491  CL96 PaTu 8988t C173(1.12)  LDD1370  [9]
 LDCM0492  CL97 PaTu 8988t C173(0.98)  LDD1371  [9]
 LDCM0493  CL98 PaTu 8988t C173(1.25)  LDD1372  [9]
 LDCM0494  CL99 PaTu 8988t C173(1.23)  LDD1373  [9]
 LDCM0495  E2913 HEK-293T C114(1.05); C173(1.08)  LDD1698  [28]
 LDCM0625  F8 Ramos C114(0.90)  LDD2187  [29]
 LDCM0572  Fragment10 Ramos C114(0.63)  LDD2189  [29]
 LDCM0573  Fragment11 Ramos C114(0.12)  LDD2190  [29]
 LDCM0576  Fragment14 Ramos C114(0.84)  LDD2193  [29]
 LDCM0579  Fragment20 Ramos C114(1.04)  LDD2194  [29]
 LDCM0580  Fragment21 Ramos C114(1.00)  LDD2195  [29]
 LDCM0586  Fragment28 Ramos C114(0.71)  LDD2198  [29]
 LDCM0588  Fragment30 Ramos C114(1.13)  LDD2199  [29]
 LDCM0589  Fragment31 Ramos C114(1.11)  LDD2200  [29]
 LDCM0590  Fragment32 Ramos C114(1.79)  LDD2201  [29]
 LDCM0468  Fragment33 PaTu 8988t C173(1.07)  LDD1347  [9]
 LDCM0596  Fragment38 Ramos C114(1.66)  LDD2203  [29]
 LDCM0566  Fragment4 Ramos C114(0.30)  LDD2184  [29]
 LDCM0427  Fragment51 HEK-293T C114(1.14); C173(0.98)  LDD1631  [28]
 LDCM0614  Fragment56 Ramos C114(0.43)  LDD2205  [29]
 LDCM0569  Fragment7 Ramos C114(0.54)  LDD2186  [29]
 LDCM0571  Fragment9 Ramos C114(1.22)  LDD2188  [29]
 LDCM0107  IAA HeLa N.A.  LDD0221  [19]
 LDCM0022  KB02 HEK-293T C114(0.95); C173(1.12)  LDD1492  [28]
 LDCM0023  KB03 HEK-293T C114(1.11); C173(1.12)  LDD1497  [28]
 LDCM0024  KB05 HMCB C114(1.47)  LDD3312  [30]
 LDCM0109  NEM HeLa H199(0.00); H120(0.00)  LDD0223  [19]
 LDCM0159  P28 BxPC-3 1.59  LDD0409  [7]
 LDCM0131  RA190 MM1.R C114(1.29)  LDD0304  [31]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Benzamidine Small molecular drug DB03127
Octanoyl-coenzyme A . DB02910

References

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5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Integrated phenotypic screening and activity-based protein profiling to reveal potential therapy targets of pancreatic cancer. Chem Commun (Camb). 2019 Jan 31;55(11):1596-1599. doi: 10.1039/c8cc08753a.
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
18 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
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21 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
24 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
26 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
27 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
28 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
29 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
30 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
31 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.