Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name P26  Probe Info 
Probe concentration 1 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name P28  Competitor Info 
Competitor Concentration 10 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Pancreas
Disease Model Pancreatic ductal adenocarcinoma [ICD-11:2C10]
Model Name Human pancreatic ductal adenocarcinoma cells (BxPC-3)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 12 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 4.2
 LDTP10432  ATP synthase membrane subunit K, mitochondrial (ATP5MK) 2.9
 LDTP03895  All-trans-retinol dehydrogenase [NAD(+)] ADH7 (ADH7) 2.7
 LDTP01707  Thioredoxin domain-containing protein 12 (TXNDC12) 2.0
 LDTP12538  Ras-related protein Rab-6B (RAB6B) 2.0
 LDTP02639  Xaa-Pro dipeptidase (PEPD) 2.0
 LDTP10514  Cytosolic non-specific dipeptidase (CNDP2) 1.9
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) 1.7
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) 1.6
 LDTP03965  Enoyl-CoA delta isomerase 1, mitochondrial (ECI1) 1.6
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 1.6
 LDTP02587  Alcohol dehydrogenase class-3 (ADH5) 1.5
Transporter and channel
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 1.5
Other
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05386  Dystonin (DST) 3.7
 LDTP04887  Destrin (DSTN) 3.0
 LDTP00313  Nucleolar protein 56 (NOP56) 2.3
 LDTP02205  Tubulin beta chain (TUBB) 2.2
 LDTP02975  Keratin, type II cytoskeletal 4 (KRT4) 2.2
 LDTP06809  Tubulin beta-8 chain (TUBB8) 1.8
 LDTP02305  Keratin, type II cytoskeletal 7 (KRT7) 1.8
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 1.8
 LDTP02675  Keratin, type I cytoskeletal 13 (KRT13) 1.7
 LDTP02047  Calpain small subunit 1 (CAPNS1) 1.5
 LDTP05036  Transformer-2 protein homolog beta (TRA2B) 1.3

References

1 Integrated phenotypic screening and activity-based protein profiling to reveal potential therapy targets of pancreatic cancer. Chem Commun (Camb). 2019 Jan 31;55(11):1596-1599. doi: 10.1039/c8cc08753a.