Details of the Target

General Information of Target

Target ID LDTP02675
Target Name Keratin, type I cytoskeletal 13 (KRT13)
Gene Name KRT13
Gene ID 3860
Synonyms
Keratin, type I cytoskeletal 13; Cytokeratin-13; CK-13; Keratin-13; K13
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLRLQSSSASYGGGFGGGSCQLGGGRGVSTCSTRFVSGGSAGGYGGGVSCGFGGGAGSG
FGGGYGGGLGGGYGGGLGGGFGGGFAGGFVDFGACDGGLLTGNEKITMQNLNDRLASYLE
KVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKTIEELRDKILTATIENNRVILEI
DNARLAADDFRLKYENELALRQSVEADINGLRRVLDELTLSKTDLEMQIESLNEELAYMK
KNHEEEMKEFSNQVVGQVNVEMDATPGIDLTRVLAEMREQYEAMAERNRRDAEEWFHTKS
AELNKEVSTNTAMIQTSKTEITELRRTLQGLEIELQSQLSMKAGLENTVAETECRYALQL
QQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMIGFP
SSAGSVSPRSTSVTTTSSASVTTTSNASGRRTSDVRRP
Target Bioclass
Other
Family
Intermediate filament family
Function
Type 1 keratin (Probable). Maintains postnatal tongue mucosal cell homeostasis and tissue organization in response to mechanical stress, potentially via regulation of the G1/S phase cyclins CCNE1 and CCNE2.
Uniprot ID
P13646
Ensemble ID
ENST00000246635.8
HGNC ID
HGNC:6415

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL72 SNV: p.P420S .
HCT15 SNV: p.C354R DBIA    Probe Info 
IGR1 SNV: p.N446I; p.S448Y .
MFE319 SNV: p.Y155H .
WM115 SNV: p.P154L .
WM2664 SNV: p.P154L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P2
 Probe Info  		3.71  LDD0449  [1]
P3
 Probe Info  		10.00  LDD0450  [1]
P8
 Probe Info  		2.46  LDD0451  [1]
DBIA
 Probe Info  		C383(0.92)  LDD3320  [2]
P26
 Probe Info  		1.65  LDD0409  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A204 C354(2.83); C383(1.68)  LDD2252  [2]
 LDCM0023  KB03 A204 C354(2.16)  LDD2669  [2]
 LDCM0024  KB05 RVH421 C383(0.92)  LDD3320  [2]
 LDCM0159  P28 BxPC-3 1.65  LDD0409  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Glycerate kinase (GLYCTK) Glycerate kinase type-2 family Q8IVS8
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein Hook homolog 3 (HOOK3) Hook family Q86VS8
Desmin (DES) Intermediate filament family P17661
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type II cytoskeletal 1 (KRT1) Intermediate filament family P04264
Keratin, type II cytoskeletal 2 epidermal (KRT2) Intermediate filament family P35908
Keratin, type II cytoskeletal 4 (KRT4) Intermediate filament family P19013
Keratin, type II cytoskeletal 6A (KRT6A) Intermediate filament family P02538
Keratin, type II cytoskeletal 6B (KRT6B) Intermediate filament family P04259
Keratin, type II cytoskeletal 72 (KRT72) Intermediate filament family Q14CN4
Keratin, type II cytoskeletal 74 (KRT74) Intermediate filament family Q7RTS7
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Beta-taxilin (TXLNB) Taxilin family Q8N3L3
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Integrated phenotypic screening and activity-based protein profiling to reveal potential therapy targets of pancreatic cancer. Chem Commun (Camb). 2019 Jan 31;55(11):1596-1599. doi: 10.1039/c8cc08753a.