Details of the Target

General Information of Target

Target ID LDTP10514
Target Name Cytosolic non-specific dipeptidase (CNDP2)
Gene Name CNDP2
Gene ID 55748
Synonyms
CN2; CPGL; HEL-S-13; PEPA; Cytosolic non-specific dipeptidase; EC 3.4.13.18; CNDP dipeptidase 2; Glutamate carboxypeptidase-like protein 1; Peptidase A; Threonyl dipeptidase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRSRQPPLVTGISPNEGIPWTKVTIRGENLGTGPTDLIGLTICGHNCLLTAEWMSASKI
VCRVGQAKNDKGDIIVTTKSGGRGTSTVSFKLLKPEKIGILDQSAVWVDEMNYYDMRTDR
NKGIPPLSLRPANPLGIEIEKSKFSQKDLEMLFHGMSADFTSENFSAAWYLIENHSNTSF
EQLKMAVTNLKRQANKKSEGSLAYVKGGLSTFFEAQDALSAIHQKLEADGTEKVEGSMTQ
KLENVLNRASNTADTLFQEVLGRKDKADSTRNALNVLQRFKFLFNLPLNIERNIQKGDYD
VVINDYEKAKSLFGKTEVQVFKKYYAEVETRIEALRELLLDKLLETPSTLHDQKRYIRYL
SDLHASGDPAWQCIGAQHKWILQLMHSCKEGYVKDLKGNPGLHSPMLDLDNDTRPSVLGH
LSQTASLKRGSSFQSGRDDTWRYKTPHRVAFVEKLTKLVLSQLPNFWKLWISYVNGSLFS
ETAEKSGQIERSKNVRQRQNDFKKMIQEVMHSLVKLTRGALLPLSIRDGEAKQYGGWEVK
CELSGQWLAHAIQTVRLTHESLTALEIPNDLLQTIQDLILDLRVRCVMATLQHTAEEIKR
LAEKEDWIVDNEGLTSLPCQFEQCIVCSLQSLKGVLECKPGEASVFQQPKTQEEVCQLSI
NIMQVFIYCLEQLSTKPDADIDTTHLSVDVSSPDLFGSIHEDFSLTSEQRLLIVLSNCCY
LERHTFLNIAEHFEKHNFQGIEKITQVSMASLKELDQRLFENYIELKADPIVGSLEPGIY
AGYFDWKDCLPPTGVRNYLKEALVNIIAVHAEVFTISKELVPRVLSKVIEAVSEELSRLM
QCVSSFSKNGALQARLEICALRDTVAVYLTPESKSSFKQALEALPQLSSGADKKLLEELL
NKFKSSMHLQLTCFQAASSTMMKT
Target Bioclass
Enzyme
Family
Peptidase M20A family
Subcellular location
Cytoplasm
Function
Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides. Mediates threonyl dipeptide catabolism in a tissue-specific way. Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism. Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis. Plays a role in the regulation of cell cycle arrest and apoptosis.
Uniprot ID
Q96KP4
Ensemble ID
ENST00000324262.9
HGNC ID
HGNC:24437

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LS180 SNV: p.R310W .
NCIH446 SNV: p.V251M .
TOV21G SNV: p.E219Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		5.46  LDD0393  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
ONAyne
 Probe Info  		K364(1.06)  LDD0274  [3]
STPyne
 Probe Info  		K20(6.35); K24(5.28); K302(6.02); K363(5.63)  LDD0277  [3]
Probe 1
 Probe Info  		Y208(35.49)  LDD3495  [4]
m-APA
 Probe Info  		11.77  LDD0403  [5]
P26
 Probe Info  		1.86  LDD0409  [6]
BTD
 Probe Info  		C205(1.07)  LDD1700  [7]
Jackson_14
 Probe Info  		2.13  LDD0123  [8]
HHS-475
 Probe Info  		Y18(2.65)  LDD0266  [9]
DBIA
 Probe Info  		C192(1.62)  LDD0613  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C192(0.00); C161(0.00); C205(0.00); C95(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C192(0.00); C161(0.00); C205(0.00); C95(0.00)  LDD0036  [11]
IPIAA_L
 Probe Info  		C192(0.00); C95(0.00)  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		C192(0.00); C161(0.00); C205(0.00); C95(0.00)  LDD0037  [11]
IPM
 Probe Info  		N.A.  LDD2156  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [14]
NAIA_5
 Probe Info  		C161(0.00); C192(0.00); C205(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Staurosporine capture compound
 Probe Info  		2.00  LDD0083  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C205(0.84)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C205(0.61)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C205(0.37)  LDD2095  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C205(1.01)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C205(1.17)  LDD2152  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C205(0.93)  LDD2103  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C205(3.76)  LDD0372  [17]
 LDCM0214  AC1 HEK-293T C205(1.50); C161(0.99); C222(0.99)  LDD1507  [18]
 LDCM0215  AC10 PaTu 8988t C214(0.68); C222(0.68)  LDD1094  [10]
 LDCM0226  AC11 PaTu 8988t C214(0.58); C222(0.58)  LDD1105  [10]
 LDCM0237  AC12 PaTu 8988t C214(0.53); C222(0.53)  LDD1116  [10]
 LDCM0259  AC14 PaTu 8988t C214(0.93); C222(0.93)  LDD1138  [10]
 LDCM0270  AC15 PaTu 8988t C214(1.13); C222(1.13)  LDD1149  [10]
 LDCM0276  AC17 PaTu 8988t C214(1.28); C222(1.28)  LDD1155  [10]
 LDCM0277  AC18 PaTu 8988t C214(0.93); C222(0.93)  LDD1156  [10]
 LDCM0278  AC19 PaTu 8988t C214(1.06); C222(1.06)  LDD1157  [10]
 LDCM0279  AC2 HEK-293T C205(1.26); C95(0.77); C222(0.91)  LDD1518  [18]
 LDCM0280  AC20 PaTu 8988t C214(0.84); C222(0.84)  LDD1159  [10]
 LDCM0281  AC21 PaTu 8988t C214(0.57); C222(0.57)  LDD1160  [10]
 LDCM0282  AC22 PaTu 8988t C214(0.40); C222(0.40)  LDD1161  [10]
 LDCM0283  AC23 PaTu 8988t C214(0.52); C222(0.52)  LDD1162  [10]
 LDCM0284  AC24 PaTu 8988t C214(0.86); C222(0.86)  LDD1163  [10]
 LDCM0285  AC25 HEK-293T C205(1.44); C161(1.09); C222(0.98)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C205(1.06); C95(1.11); C222(0.93)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C205(1.05); C222(1.03)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C205(1.66); C161(1.15); C222(0.81)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C205(1.43); C95(1.19); C161(1.02); C222(0.97)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C205(1.05); C222(1.00)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C95(1.10); C161(0.91); C222(0.97)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C205(2.02); C95(0.94); C161(0.96); C222(1.01)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C205(2.06); C95(1.25); C161(0.80); C222(1.01)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C205(1.37); C161(0.86); C222(0.88)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C205(1.16); C95(1.06); C222(1.01)  LDD1534  [18]
 LDCM0296  AC35 HCT 116 C192(1.62)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C192(1.35)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C192(1.57)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C192(1.82)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C192(1.23)  LDD0617  [10]
 LDCM0301  AC4 HEK-293T C205(1.73); C161(1.12); C222(0.80)  LDD1540  [18]
 LDCM0302  AC40 HCT 116 C192(0.48)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C192(0.98)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C192(0.84)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C192(1.44)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C192(0.77)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C192(0.43)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C192(1.10)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C192(0.76)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C192(0.99)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C192(0.10)  LDD0628  [10]
 LDCM0312  AC5 HEK-293T C205(1.71); C95(1.53); C161(1.01); C222(0.86)  LDD1551  [18]
 LDCM0313  AC50 HCT 116 C192(0.15)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C192(1.83)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C192(0.88)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C192(0.32)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C192(0.32)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C192(0.10)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C192(0.05)  LDD0636  [10]
 LDCM0320  AC57 HEK-293T C205(1.00); C161(1.18); C222(1.09)  LDD1559  [18]
 LDCM0321  AC58 HEK-293T C205(0.98); C95(0.77); C222(0.87)  LDD1560  [18]
 LDCM0322  AC59 HEK-293T C205(1.04); C222(0.97)  LDD1561  [18]
 LDCM0323  AC6 PaTu 8988t C214(1.05); C222(1.05)  LDD1202  [10]
 LDCM0324  AC60 HEK-293T C205(0.85); C161(1.26); C222(0.78)  LDD1563  [18]
 LDCM0325  AC61 HEK-293T C205(1.09); C95(0.83); C161(1.10); C222(0.93)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C95(0.91); C161(0.95); C222(0.96)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C205(1.12); C95(1.02); C161(1.20); C222(0.99)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C205(1.18); C95(1.19); C161(0.93); C222(0.97)  LDD1567  [18]
 LDCM0332  AC68 HCT 116 C192(0.91)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C192(0.63)  LDD0650  [10]
 LDCM0334  AC7 PaTu 8988t C214(0.89); C222(0.89)  LDD1213  [10]
 LDCM0335  AC70 HCT 116 C192(0.21)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C192(1.06)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C192(0.69)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C192(0.10)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C192(0.11)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C192(0.07)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C192(0.39)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C192(0.47)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C192(0.87)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C192(0.81)  LDD0661  [10]
 LDCM0345  AC8 PaTu 8988t C214(1.10); C222(1.10)  LDD1224  [10]
 LDCM0346  AC80 HCT 116 C192(0.63)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C192(0.68)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C192(0.05)  LDD0665  [10]
 LDCM0520  AKOS000195272 MDA-MB-231 C205(0.78)  LDD2113  [7]
 LDCM0248  AKOS034007472 PaTu 8988t C214(1.26); C222(1.26)  LDD1127  [10]
 LDCM0356  AKOS034007680 PaTu 8988t C214(0.27); C222(0.27)  LDD1235  [10]
 LDCM0275  AKOS034007705 PaTu 8988t C214(0.48); C222(0.48)  LDD1154  [10]
 LDCM0156  Aniline NCI-H1299 11.77  LDD0403  [5]
 LDCM0367  CL1 PaTu 8988t C214(1.17); C222(1.00)  LDD1246  [10]
 LDCM0368  CL10 PaTu 8988t C214(0.98); C222(0.61)  LDD1247  [10]
 LDCM0369  CL100 HEK-293T C205(1.70); C161(0.75); C222(0.88)  LDD1573  [18]
 LDCM0370  CL101 PaTu 8988t C214(0.98); C222(0.98)  LDD1249  [10]
 LDCM0371  CL102 PaTu 8988t C214(0.86); C222(0.86)  LDD1250  [10]
 LDCM0372  CL103 PaTu 8988t C214(0.60); C222(0.60)  LDD1251  [10]
 LDCM0373  CL104 PaTu 8988t C214(0.96); C222(0.96)  LDD1252  [10]
 LDCM0374  CL105 PaTu 8988t C214(1.09); C222(1.09)  LDD1253  [10]
 LDCM0375  CL106 PaTu 8988t C214(0.92); C222(0.92)  LDD1254  [10]
 LDCM0376  CL107 PaTu 8988t C214(1.04); C222(1.04)  LDD1255  [10]
 LDCM0377  CL108 PaTu 8988t C214(1.26); C222(1.26)  LDD1256  [10]
 LDCM0378  CL109 PaTu 8988t C214(1.09); C222(1.09)  LDD1257  [10]
 LDCM0379  CL11 PaTu 8988t C214(1.16); C222(1.03)  LDD1258  [10]
 LDCM0380  CL110 PaTu 8988t C214(1.04); C222(1.04)  LDD1259  [10]
 LDCM0381  CL111 PaTu 8988t C214(0.37); C222(0.37)  LDD1260  [10]
 LDCM0382  CL112 HEK-293T C205(1.30); C161(0.83); C222(0.95)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C205(1.10); C95(1.08); C192(1.10); C161(1.01)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C95(1.24); C222(0.87)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C205(1.44); C161(1.20); C222(0.92)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C205(1.48); C161(0.77); C222(1.04)  LDD1590  [18]
 LDCM0387  CL117 HCT 116 C192(0.11)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C192(0.79)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C192(0.74)  LDD0706  [10]
 LDCM0390  CL12 PaTu 8988t C214(1.08); C222(1.03)  LDD1269  [10]
 LDCM0391  CL120 HCT 116 C192(1.13)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C192(0.69)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C192(0.76)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C192(0.50)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C192(0.16)  LDD0712  [10]
 LDCM0396  CL125 HEK-293T C205(0.89); C95(0.94); C192(0.98); C161(1.42)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C95(0.89); C222(0.98)  LDD1601  [18]
 LDCM0398  CL127 HEK-293T C205(0.95); C161(0.98); C222(0.84)  LDD1602  [18]
 LDCM0399  CL128 HEK-293T C205(1.14); C161(1.09); C222(0.96)  LDD1603  [18]
 LDCM0400  CL13 PaTu 8988t C214(0.40); C222(0.36)  LDD1279  [10]
 LDCM0401  CL14 PaTu 8988t C214(0.34); C222(0.33)  LDD1280  [10]
 LDCM0402  CL15 PaTu 8988t C214(1.05); C222(0.77)  LDD1281  [10]
 LDCM0403  CL16 PaTu 8988t C214(0.64); C222(0.64)  LDD1282  [10]
 LDCM0404  CL17 PaTu 8988t C214(0.66); C222(0.66)  LDD1283  [10]
 LDCM0405  CL18 PaTu 8988t C214(0.39); C222(0.39)  LDD1284  [10]
 LDCM0406  CL19 PaTu 8988t C214(0.27); C222(0.27)  LDD1285  [10]
 LDCM0407  CL2 PaTu 8988t C214(1.12); C222(1.06)  LDD1286  [10]
 LDCM0408  CL20 PaTu 8988t C214(0.13); C222(0.13)  LDD1287  [10]
 LDCM0409  CL21 PaTu 8988t C214(0.12); C222(0.12)  LDD1288  [10]
 LDCM0410  CL22 PaTu 8988t C214(0.22); C222(0.22)  LDD1289  [10]
 LDCM0411  CL23 PaTu 8988t C214(0.20); C222(0.20)  LDD1290  [10]
 LDCM0412  CL24 PaTu 8988t C214(0.79); C222(0.79)  LDD1291  [10]
 LDCM0413  CL25 PaTu 8988t C214(0.89); C222(0.89)  LDD1292  [10]
 LDCM0414  CL26 PaTu 8988t C214(0.24); C222(0.24)  LDD1293  [10]
 LDCM0415  CL27 PaTu 8988t C214(0.60); C222(0.60)  LDD1294  [10]
 LDCM0416  CL28 PaTu 8988t C214(0.14); C222(0.14)  LDD1295  [10]
 LDCM0417  CL29 PaTu 8988t C214(0.12); C222(0.12)  LDD1296  [10]
 LDCM0418  CL3 PaTu 8988t C214(1.33); C222(0.85)  LDD1297  [10]
 LDCM0419  CL30 PaTu 8988t C214(0.43); C222(0.43)  LDD1298  [10]
 LDCM0420  CL31 HCT 116 C192(20.00)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C192(1.42)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C192(0.67)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C192(0.30)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C192(0.17)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C192(0.38)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C192(0.12)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C192(0.23)  LDD0745  [10]
 LDCM0429  CL4 PaTu 8988t C214(1.44); C222(1.05)  LDD1308  [10]
 LDCM0430  CL40 HCT 116 C192(0.43)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C192(0.46)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C192(0.06)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C192(0.09)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C192(0.56)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C192(0.23)  LDD0752  [10]
 LDCM0436  CL46 PaTu 8988t C214(1.27); C222(1.27)  LDD1315  [10]
 LDCM0437  CL47 PaTu 8988t C214(1.26); C222(1.26)  LDD1316  [10]
 LDCM0438  CL48 PaTu 8988t C214(1.01); C222(1.01)  LDD1317  [10]
 LDCM0439  CL49 PaTu 8988t C214(0.95); C222(0.95)  LDD1318  [10]
 LDCM0440  CL5 PaTu 8988t C214(0.57); C222(0.42)  LDD1319  [10]
 LDCM0441  CL50 PaTu 8988t C214(0.93); C222(0.93)  LDD1320  [10]
 LDCM0442  CL51 PaTu 8988t C214(0.76); C222(0.76)  LDD1321  [10]
 LDCM0443  CL52 PaTu 8988t C214(1.00); C222(1.00)  LDD1322  [10]
 LDCM0444  CL53 PaTu 8988t C214(0.91); C222(0.91)  LDD1323  [10]
 LDCM0445  CL54 PaTu 8988t C214(1.36); C222(1.36)  LDD1324  [10]
 LDCM0446  CL55 PaTu 8988t C214(1.04); C222(1.04)  LDD1325  [10]
 LDCM0447  CL56 PaTu 8988t C214(0.14); C222(0.14)  LDD1326  [10]
 LDCM0448  CL57 PaTu 8988t C214(0.17); C222(0.17)  LDD1327  [10]
 LDCM0449  CL58 PaTu 8988t C214(0.93); C222(0.93)  LDD1328  [10]
 LDCM0450  CL59 PaTu 8988t C214(0.18); C222(0.18)  LDD1329  [10]
 LDCM0451  CL6 PaTu 8988t C214(0.99); C222(0.88)  LDD1330  [10]
 LDCM0452  CL60 PaTu 8988t C214(0.34); C222(0.34)  LDD1331  [10]
 LDCM0453  CL61 PaTu 8988t C214(0.91); C222(0.91)  LDD1332  [10]
 LDCM0454  CL62 PaTu 8988t C214(0.99); C222(0.99)  LDD1333  [10]
 LDCM0455  CL63 PaTu 8988t C214(0.97); C222(0.97)  LDD1334  [10]
 LDCM0456  CL64 PaTu 8988t C214(0.74); C222(0.74)  LDD1335  [10]
 LDCM0457  CL65 PaTu 8988t C214(1.05); C222(1.05)  LDD1336  [10]
 LDCM0458  CL66 PaTu 8988t C214(0.94); C222(0.94)  LDD1337  [10]
 LDCM0459  CL67 PaTu 8988t C214(0.57); C222(0.57)  LDD1338  [10]
 LDCM0460  CL68 PaTu 8988t C214(0.29); C222(0.29)  LDD1339  [10]
 LDCM0461  CL69 PaTu 8988t C214(0.42); C222(0.42)  LDD1340  [10]
 LDCM0462  CL7 PaTu 8988t C214(0.71); C222(0.42)  LDD1341  [10]
 LDCM0463  CL70 PaTu 8988t C214(0.52); C222(0.52)  LDD1342  [10]
 LDCM0464  CL71 PaTu 8988t C214(0.83); C222(0.83)  LDD1343  [10]
 LDCM0465  CL72 PaTu 8988t C214(0.86); C222(0.86)  LDD1344  [10]
 LDCM0466  CL73 PaTu 8988t C214(0.52); C222(0.52)  LDD1345  [10]
 LDCM0467  CL74 PaTu 8988t C214(0.77); C222(0.77)  LDD1346  [10]
 LDCM0469  CL76 PaTu 8988t C214(0.85); C222(0.85)  LDD1348  [10]
 LDCM0470  CL77 PaTu 8988t C214(0.75); C222(0.75)  LDD1349  [10]
 LDCM0471  CL78 PaTu 8988t C214(0.74); C222(0.74)  LDD1350  [10]
 LDCM0472  CL79 PaTu 8988t C214(0.81); C222(0.81)  LDD1351  [10]
 LDCM0473  CL8 PaTu 8988t C214(1.34); C222(1.29)  LDD1352  [10]
 LDCM0474  CL80 PaTu 8988t C214(0.80); C222(0.80)  LDD1353  [10]
 LDCM0475  CL81 PaTu 8988t C214(0.58); C222(0.58)  LDD1354  [10]
 LDCM0476  CL82 PaTu 8988t C214(1.15); C222(1.15)  LDD1355  [10]
 LDCM0477  CL83 PaTu 8988t C214(0.71); C222(0.71)  LDD1356  [10]
 LDCM0478  CL84 PaTu 8988t C214(0.40); C222(0.40)  LDD1357  [10]
 LDCM0479  CL85 PaTu 8988t C214(0.90); C222(0.90)  LDD1358  [10]
 LDCM0480  CL86 PaTu 8988t C214(0.90); C222(0.90)  LDD1359  [10]
 LDCM0481  CL87 PaTu 8988t C214(0.34); C222(0.34)  LDD1360  [10]
 LDCM0482  CL88 PaTu 8988t C214(0.60); C222(0.60)  LDD1361  [10]
 LDCM0483  CL89 PaTu 8988t C214(0.48); C222(0.48)  LDD1362  [10]
 LDCM0484  CL9 PaTu 8988t C214(0.88); C222(0.59)  LDD1363  [10]
 LDCM0485  CL90 PaTu 8988t C214(0.53); C222(0.53)  LDD1364  [10]
 LDCM0486  CL91 HEK-293T C205(1.39); C222(1.00)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C205(1.48); C161(1.37); C222(0.94)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C205(2.05); C95(0.89); C161(0.97); C222(1.05)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C95(1.12); C161(1.04); C222(1.09)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C205(2.40); C95(1.01); C161(0.83); C222(0.70)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C205(1.44); C95(0.86); C161(1.03); C222(0.87)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C205(1.02); C95(0.88); C192(1.07); C161(1.05)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C95(1.28); C222(1.03)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C205(1.80); C161(1.10); C222(0.82)  LDD1697  [18]
 LDCM0495  E2913 HEK-293T C205(2.57); C161(1.06); C222(0.84)  LDD1698  [18]
 LDCM0468  Fragment33 PaTu 8988t C214(0.93); C222(0.93)  LDD1347  [10]
 LDCM0427  Fragment51 HCT 116 C192(0.08)  LDD0744  [10]
 LDCM0118  HHS-0301 DM93 Y18(2.65)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y18(0.62)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y18(0.81)  LDD0268  [9]
 LDCM0022  KB02 HEK-293T C205(0.89); C161(1.04)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C205(1.03); C161(0.96)  LDD1497  [18]
 LDCM0024  KB05 UACC257 C205(0.92)  LDD3325  [19]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C205(0.82)  LDD2102  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C205(1.30)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C205(0.92)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C205(1.10)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C205(0.96)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C205(0.69)  LDD2096  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C205(0.60)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C205(0.91)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C205(0.82)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C205(0.44)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C205(0.52)  LDD2101  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C205(1.17)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C205(0.59)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C205(0.77)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C205(0.56)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C205(0.62)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C205(1.36)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C205(0.93)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C205(0.62)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C205(0.61)  LDD2115  [7]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C205(1.26)  LDD2116  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C205(1.18)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C205(1.28)  LDD2119  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C205(1.08)  LDD2122  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C205(0.93)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C205(0.71)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C205(0.89)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C205(1.04)  LDD2127  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C205(0.84)  LDD2129  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C205(0.80)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C205(1.11)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C205(1.02)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C205(0.71)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C205(1.07)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C205(0.66)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C205(0.51)  LDD2141  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C205(1.34)  LDD2144  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C205(0.71)  LDD2148  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C205(1.08)  LDD2149  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C205(0.25)  LDD2150  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C205(0.98)  LDD2151  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C205(2.39)  LDD2153  [7]
 LDCM0159  P28 BxPC-3 1.86  LDD0409  [6]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.13  LDD0123  [8]
 LDCM0019  Staurosporine Hep-G2 2.00  LDD0083  [16]

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
6 Integrated phenotypic screening and activity-based protein profiling to reveal potential therapy targets of pancreatic cancer. Chem Commun (Camb). 2019 Jan 31;55(11):1596-1599. doi: 10.1039/c8cc08753a.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
17 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840