Details of the Target

General Information of Target

Target ID LDTP05386
Target Name Dystonin (DST)
Gene Name DST
Gene ID 667
Synonyms
BP230; BP240; BPAG1; DMH; DT; KIAA0728; Dystonin; 230 kDa bullous pemphigoid antigen; 230/240 kDa bullous pemphigoid antigen; Bullous pemphigoid antigen 1; BPA; Bullous pemphigoid antigen; Dystonia musculorum protein; Hemidesmosomal plaque protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGYLSPAAYLYVEEQEYLQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLY
EDLRDGHNLISLLEVLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITD
GNPKLTLGLIWTIILHFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCW
RDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDE
KSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFP
NNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEK
EWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLES
GVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNEC
SSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLS
SGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTE
EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI
SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE
EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR
AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI
HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ
IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ
NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL
EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE
NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS
SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA
VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH
KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ
PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ
KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK
EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLA
KHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTID
QTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQI
LCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQL
TLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPV
RPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAV
REGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVG
LIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIID
NNTASILKNITLPDKMPDLGDLEACKNARRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTT
QTSEETKKLFLSYLMINSYMDANTGQRLLLYDGDLDEAVGMLLEGCHAEFDGNTAIKECL
DVLSSSGVFLNNASGREKDECTATPSSFNKCHCGEPEHEETPENRKCAIDEEFNEMRNTV
INSEFSQSGKLASTISIDPKVNSSPSVCVPSLISYLTQTELADISMLRSDSENILTNYEN
QSRVETNERANECSHSKNIQNFPSDLIENPIMKSKMSKFCGVNETENEDNTNRDSPIFDY
SPRLSALLSHDKLMHSQGSFNDTHTPESNGNKCEAPALSFSDKTMLSGQRIGEKFQDQFL
GIAAINISLPGEQYGQKSLNMISSNPQVQYHNDKYISNTSGEDEKTHPGFQQMPEDKEDE
SEIEEYSCAVTPGGDTDNAIVSLTCATPLLDETISASDYETSLLNDQQNNTGTDTDSDDD
FYDTPLFEDDDHDSLLLDGDDRDCLHPEDYDTLQEENDETASPADVFYDVSKENENSMVP
QGAPVGSLSVKNKAHCLQDFLMDVEKDELDSGEKIHLNPVGSDKVNGQSLETGSERECTN
ILEGDESDSLTDYDIVGGKESFTASLKFDDSGSWRGRKEEYVTGQEFHSDTDHLDSMQSE
ESYGDYIYDSNDQDDDDDDGIDEEGGGIRDENGKPRCQNVAEDMDIQLCASILNENSDEN
ENINTMILLDKMHSCSSLEKQQRVNVVQLASPSENNLVTEKSNLPEYTTEIAGKSKENLL
NHEMVLKDVLPPIIKDTESEKTFGPASISHDNNNISSTSELGTDLANTKVKLIQGSELPE
LTDSVKGKDEYFKNMTPKVDSSLDHIICTEPDLIGKPAEESHLSLIASVTDKDPQGNGSD
LIKGRDGKSDILIEDETSIQKMYLGEGEVLVEGLVEEENRHLKLLPGKNTRDSFKLINSQ
FPFPQITNNEELNQKGSLKKATVTLKDEPNNLQIIVSKSPVQFENLEEIFDTSVSKEISD
DITSDITSWEGNTHFEESFTDGPEKELDLFTYLKHCAKNIKAKDVAKPNEDVPSHVLITA
PPMKEHLQLGVNNTKEKSTSTQKDSPLNDMIQSNDLCSKESISGGGTEISQFTPESIEAT
LSILSRKHVEDVGKNDFLQSERCANGLGNDNSSNTLNTDYSFLEINNKKERIEQQLPKEQ
ALSPRSQEKEVQIPELSQVFVEDVKDILKSRLKEGHMNPQEVEEPSACADTKILIQNLIK
RITTSQLVNEASTVPSDSQMSDSSGVSPMTNSSELKPESRDDPFCIGNLKSELLLNILKQ
DQHSQKITGVFELMRELTHMEYDLEKRGITSKVLPLQLENIFYKLLADGYSEKIEHVGDF
NQKACSTSEMMEEKPHILGDIKSKEGNYYSPNLETVKEIGLESSTVWASTLPRDEKLKDL
CNDFPSHLECTSGSKEMASGDSSTEQFSSELQQCLQHTEKMHEYLTLLQDMKPPLDNQES
LDNNLEALKNQLRQLETFELGLAPIAVILRKDMKLAEEFLKSLPSDFPRGHVEELSISHQ
SLKTAFSSLSNVSSERTKQIMLAIDSEMSKLAVSHEEFLHKLKSFSDWVSEKSKSVKDIE
IVNVQDSEYVKKRLEFLKNVLKDLGHTKMQLETTAFDVQFFISEYAQDLSPNQSKQLLRL
LNTTQKCFLDVQESVTTQVERLETQLHLEQDLDDQKIVAERQQEYKEKLQGICDLLTQTE
NRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQ
EDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIE
NLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVG
TTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKEL
KVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLM
TKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDH
ATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPK
NLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYED
LSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKN
IMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAK
MEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL
EVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVL
VKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN
LISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLL
LKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKS
FEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKL
EESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKP
QYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQ
YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALC
EDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQA
WLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGS
EKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEE
IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLI
QKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKY
LTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD
EKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKK
LEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTI
KRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQ
DVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDA
LESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA
TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTI
EKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMV
QSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQD
YSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARY
KDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQM
RPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKV
EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR
HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN
QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT
GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES
LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD
KDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDF
IRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKS
IDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDL
ETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDS
LEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKH
HVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQ
LDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKE
ETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEF
HNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGT
HLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWL
EESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADD
NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAED
QPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELS
TRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT
LIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAK
QHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFM
EEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIET
KNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKS
RVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVA
ALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLR
LVRILRSTVMVRVGGGWMALDEFLVKNDPCRVHHHGSKMLRSESNSSITTTQPTIAKGRT
NMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAASPQVPATTT
PKGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKA
GSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPTPQRKSP
ASKLDKSSKR
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton
Function
Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1.; [Isoform 3]: Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; [Isoform 6]: Required for bundling actin filaments around the nucleus.; [Isoform 7]: Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.
Uniprot ID
Q03001
Ensemble ID
ENST00000244364.10
HGNC ID
HGNC:1090

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.66  LDD0402  [1]
ONAyne
 Probe Info  		K3729(0.99)  LDD0274  [2]
STPyne
 Probe Info  		K1120(1.15); K1179(10.00); K1484(1.10); K184(1.06)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K3977(1.83); K109(10.06)  LDD3494  [3]
Probe 1
 Probe Info  		Y725(3.17)  LDD3495  [4]
P26
 Probe Info  		3.68  LDD0409  [5]
BTD
 Probe Info  		C3737(0.51)  LDD2089  [6]
AHL-Pu-1
 Probe Info  		C5610(4.51)  LDD0168  [7]
HHS-475
 Probe Info  		Y5096(0.87); Y251(1.69)  LDD0264  [8]
DBIA
 Probe Info  		C179(1.31); C884(1.39); C6799(1.11)  LDD0080  [9]
5E-2FA
 Probe Info  		H3864(0.00); H1275(0.00)  LDD2235  [10]
CY4
 Probe Info  		N.A.  LDD0247  [11]
IA-alkyne
 Probe Info  		C4800(0.00); C834(0.00); C5922(0.00); C5610(0.00)  LDD0165  [12]
NAIA_4
 Probe Info  		C1622(0.00); C2976(0.00); C3168(0.00); C4370(0.00)  LDD2226  [13]
NAIA_5
 Probe Info  		N.A.  LDD2225  [13]
TFBX
 Probe Info  		N.A.  LDD0027  [14]
IPM
 Probe Info  		C1604(0.00); C5394(0.00); C6799(0.00)  LDD0005  [15]
YN-1
 Probe Info  		N.A.  LDD0446  [16]
Acrolein
 Probe Info  		C5394(0.00); C3653(0.00); H354(0.00); C5922(0.00)  LDD0217  [17]
Methacrolein
 Probe Info  		C5527(0.00); C5922(0.00)  LDD0218  [17]
W1
 Probe Info  		N.A.  LDD0236  [18]
AOyne
 Probe Info  		9.20  LDD0443  [19]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C264
 Probe Info  		42.52  LDD1935  [20]
C350
 Probe Info  		26.91  LDD2011  [20]
C382
 Probe Info  		34.78  LDD2041  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C3737(1.07); C5610(1.14)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C3737(1.20)  LDD2152  [6]
 LDCM0025  4SU-RNA HEK-293T C5610(4.51)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C5610(2.13); C1604(3.37)  LDD0169  [7]
 LDCM0214  AC1 HCT 116 C173(0.92); C179(1.18); C3653(0.82); C5394(1.09)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C173(1.17); C179(1.43); C480(0.49); C5056(1.09)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C179(0.97); C6799(1.06); C911(0.78)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C179(1.53); C6799(1.17); C911(0.92)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C179(1.05); C6799(1.10); C911(0.79)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C179(1.30); C6799(1.44); C911(0.92)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C179(1.23); C6799(1.26); C911(0.86)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C179(1.28); C6799(1.37); C911(1.13)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C179(1.55); C6799(1.37); C911(1.16)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C179(1.56); C6799(1.05); C911(1.27)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C179(0.97); C6799(0.85); C911(0.90)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C179(0.92); C6799(0.83); C911(0.86)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C173(0.97); C179(0.99); C480(0.48); C5056(1.01)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C179(0.91); C6799(0.84); C911(0.93)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C179(1.10); C6799(0.78); C911(1.05)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C179(1.34); C6799(1.01); C911(0.96)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C1130(1.31); C173(0.92); C179(1.10); C5056(1.13)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C1130(1.12); C173(0.71); C179(0.72); C5056(1.44)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C1130(1.35); C173(0.84); C179(0.88); C5056(1.40)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C1130(1.29); C173(0.93); C179(0.94); C5056(1.51)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C1130(1.11); C173(0.73); C179(0.72); C5056(1.34)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C1130(0.96); C173(0.79); C179(0.91); C5056(1.27)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C1130(1.29); C173(0.72); C179(0.76); C5056(1.22)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C173(1.00); C179(0.99); C480(0.73); C5056(0.89)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C1130(1.77); C173(0.69); C179(0.82); C5056(1.20)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C1130(0.95); C173(0.66); C179(0.72); C5056(1.24)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C1130(1.00); C173(0.73); C179(0.71); C5056(1.17)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C1130(0.98); C173(0.71); C179(0.69); C5056(1.11)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C1130(0.99); C173(0.86); C179(0.77); C5056(1.16)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C1130(1.13); C173(0.83); C179(0.96); C5056(1.22)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C1130(1.41); C173(0.75); C179(0.89); C5056(1.60)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C1130(1.25); C173(0.82); C179(0.96); C5056(1.48)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C173(1.68); C179(1.68); C6799(1.63); C911(1.69)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C173(1.67); C179(1.67); C6799(0.97); C911(1.47)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C173(1.60); C179(1.60); C6799(1.41); C911(1.57)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C173(1.45); C179(1.45); C6799(1.05); C911(1.05)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C173(1.50); C179(1.50); C6799(1.12); C911(1.22)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C173(1.50); C179(1.50); C6799(1.21); C911(1.72)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C173(1.76); C179(1.76); C6799(1.61); C911(1.64)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C173(1.85); C179(1.85); C6799(1.56); C911(1.47)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C173(1.26); C179(1.26); C6799(1.32); C911(1.06)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C173(1.08); C179(1.08); C6799(1.36); C911(1.20)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C173(1.60); C179(1.60); C6799(1.36); C911(1.51)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C173(1.75); C179(1.75); C6799(1.24); C911(1.41)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C173(1.24); C179(1.13); C480(0.50); C5056(1.07)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C173(2.04); C179(2.04); C6799(1.40); C911(1.82)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C173(1.71); C179(1.71); C6799(1.51); C911(1.60)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C173(1.43); C179(1.43); C6799(1.04); C911(1.51)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C179(0.99); C3653(1.28); C5056(1.19); C5922(1.13)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C3653(0.87); C5922(1.15); C179(1.18); C911(1.19)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C3653(0.95); C911(1.03); C5056(1.20); C6799(1.33)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C3653(0.97); C911(1.27); C179(1.31); C5922(1.31)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C3653(1.02); C5922(1.13); C911(1.17); C179(1.27)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C3653(1.06); C911(1.81); C5922(1.82); C179(1.94)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C3653(0.99); C5922(1.42); C911(1.48); C5056(1.65)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C480(0.57); C6907(0.99); C5922(1.01); C173(1.06)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C3653(0.93); C911(1.00); C5922(1.09); C5056(1.18)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C3653(0.89); C911(1.00); C5056(1.15); C6799(1.27)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C3653(0.93); C911(1.02); C5922(1.33); C5056(1.45)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C3653(0.82); C179(1.68); C5056(1.80); C911(1.80)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C179(1.41); C3653(0.98); C5056(1.37); C5922(1.15)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C179(1.39); C3653(0.90); C5056(1.35); C5922(1.37)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C179(1.18); C3653(0.89); C5056(1.10); C5922(1.59)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C179(1.13); C3653(0.93); C5056(0.96); C5922(1.30)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C1130(0.73); C480(0.76); C5394(0.99); C3653(1.00)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C1130(0.28); C3653(0.83); C5394(0.88); C5056(0.93)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C480(0.63); C5394(0.93); C1130(0.96); C3653(0.96)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C3653(0.91); C173(0.98); C6907(1.04); C911(1.05)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C1130(0.62); C480(0.68); C5056(0.96); C6907(1.01)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C1130(0.63); C480(0.63); C5394(0.91); C3653(0.92)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C1130(0.60); C3653(0.94); C5394(0.96); C6907(0.96)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C480(0.67); C5394(0.82); C1130(0.83); C6907(0.90)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C1130(0.78); C911(0.95); C5394(0.96); C6799(0.98)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C480(0.63); C5922(0.83); C3653(0.85); C5056(0.91)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C480(0.76); C3653(0.91); C5922(1.02); C911(1.05)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C480(0.37); C5922(1.00); C911(1.02); C5056(1.03)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C480(0.43); C911(0.95); C5394(1.05); C6907(1.08)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C480(0.46); C5394(1.01); C3653(1.08); C911(1.11)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C3653(0.86); C173(0.99); C5394(1.02); C6907(1.16)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C480(0.37); C911(0.93); C5394(1.06); C6907(1.07)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C480(0.34); C5056(1.02); C911(1.03); C5394(1.03)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C480(0.29); C911(1.10); C5394(1.14); C5056(1.18)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C480(0.30); C5056(0.98); C911(1.03); C5922(1.03)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C480(0.37); C3653(0.83); C5922(0.84); C5056(1.01)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C179(0.73); C5394(0.83); C5922(0.84); C173(0.85)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C6907(0.88); C179(0.88); C884(0.93); C5394(0.93)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C5394(0.81); C5922(0.83); C6907(0.91); C179(0.94)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C173(0.88); C6907(0.89); C179(0.89); C884(0.99)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C179(0.88); C173(0.88); C884(0.90); C6907(0.90)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C3653(0.94); C5394(1.07); C911(1.21); C5922(1.35)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C5922(0.86); C5394(0.89); C6907(0.99); C480(1.00)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C5394(0.78); C5922(0.92); C6907(0.97); C173(1.01)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C173(0.80); C6907(0.89); C5394(0.93); C5056(1.00)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C173(0.85); C6907(0.92); C5394(0.97); C5056(1.02)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C5922(0.81); C480(0.83); C5394(0.85); C173(0.90)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C173(0.74); C5394(0.80); C5922(0.80); C884(0.87)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C5056(1.02); C884(1.03); C6799(1.05); C173(1.07)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C5056(0.88); C173(0.90); C480(0.91); C911(1.10)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C5056(0.88); C6799(0.92); C173(1.02); C5922(1.15)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C1130(0.95); C5056(1.00); C173(1.06); C884(1.16)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C3653(0.84); C5394(1.09); C911(1.23); C6907(1.29)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C5056(0.87); C480(0.91); C173(0.97); C5922(1.26)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C6799(0.88); C173(0.91); C5056(0.94); C5922(0.98)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C5056(0.85); C480(0.94); C6799(1.03); C5922(1.04)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C173(0.87); C5056(0.90); C480(0.93); C5922(1.06)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C5056(0.78); C1130(1.02); C173(1.02); C911(1.06)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C480(0.85); C173(1.01); C884(1.14); C5922(1.18)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C173(0.97); C5056(1.02); C480(1.11); C5922(1.29)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C480(0.29); C173(0.83); C5922(0.89); C3653(0.99)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C480(0.68); C173(0.90); C5922(0.90); C5394(1.05)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C480(0.45); C173(0.97); C5922(1.04); C5394(1.07)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C480(0.45); C6907(0.97); C5056(0.99); C5394(1.10)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C480(0.49); C173(0.88); C5922(1.03); C5394(1.15)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C173(0.70); C480(0.74); C5922(1.05); C5394(1.08)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C480(0.38); C173(0.79); C5922(1.01); C5394(1.18)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C480(0.44); C173(0.57); C5922(0.88); C3653(1.09)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C480(0.42); C5922(1.12); C173(1.15); C5394(1.19)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C480(0.49); C173(0.99); C5922(1.03); C5394(1.22)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C480(0.49); C5922(0.86); C173(1.11); C5394(1.18)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C480(0.41); C173(0.78); C5922(1.05); C5394(1.25)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C173(0.72); C884(0.83); C5922(0.91); C179(0.99)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C884(0.85); C5922(0.87); C173(0.91); C6907(1.07)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C480(0.69); C5056(0.82); C6907(0.96); C5394(0.99)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C173(0.71); C6907(0.94); C5922(1.07); C911(1.29)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C173(0.74); C5922(0.78); C884(0.86); C6799(1.12)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C173(0.85); C884(1.01); C6907(1.02); C179(1.03)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C173(0.81); C6907(0.91); C884(1.02); C5922(1.41)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C5922(0.88); C884(0.98); C173(1.20); C6907(1.34)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C173(0.87); C884(1.05); C6907(1.11); C5922(1.14)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C173(0.82); C884(0.91); C5922(1.01); C6907(1.04)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C173(0.68); C5922(0.93); C884(0.96); C6907(1.02)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C5922(0.98); C6907(0.98); C884(0.98); C173(1.00)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C173(0.83); C179(1.03); C6907(1.06); C5922(1.07)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C480(0.47); C911(0.88); C173(0.91); C6907(0.95)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C173(0.84); C6907(0.97); C179(1.03); C6799(1.06)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C911(0.78); C173(0.94); C884(0.99); C5922(1.00)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C5922(1.03); C6907(1.09); C884(1.16); C173(1.32)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C5922(1.04); C6907(1.08); C179(1.11); C5394(1.14)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C179(0.92); C6907(0.95); C173(0.96); C5922(1.04)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C6907(0.85); C173(1.00); C179(1.01); C5394(1.05)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C6907(0.93); C5394(0.97); C5056(1.04); C6799(1.08)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C6799(0.78); C6907(0.91); C179(0.91); C173(0.94)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C6907(0.89); C5394(0.90); C6799(0.93); C5056(1.04)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C6799(0.76); C6907(0.97); C5394(1.08); C5922(1.10)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C6799(0.64); C5394(0.84); C6907(0.90); C179(0.93)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C6799(0.71); C5922(0.97); C6907(1.08); C5394(1.10)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C6799(0.76); C6907(0.91); C5394(0.97); C5922(1.06)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C6799(0.65); C179(0.79); C5394(0.84); C6907(0.92)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C6799(0.74); C179(0.79); C5394(0.93); C6907(0.94)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C6799(0.58); C6907(0.89); C5394(0.93); C179(1.03)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C6799(0.59); C5394(0.91); C6907(0.98); C179(1.02)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C6799(0.69); C6907(0.99); C173(1.03); C5394(1.03)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C911(1.33); C6799(1.70); C179(1.95)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C911(0.69); C179(0.97); C6799(0.97)  LDD0683  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C3737(0.86)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C173(1.24); C179(1.48); C480(0.64); C5056(1.19)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C5056(0.92); C5394(0.94); C480(0.97); C6907(0.98)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C480(0.40); C5056(1.05); C5922(1.18); C6907(1.20)  LDD0592  [9]
 LDCM0020  ARS-1620 HCC44 C6799(1.06); C5610(1.08); C5922(1.19); C5394(1.30)  LDD2171  [9]
 LDCM0108  Chloroacetamide HeLa C4800(0.00); C5922(0.00); C5899(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C4984(0.79); C5610(0.53)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C6907(0.62); C5394(0.95); C5922(0.96); C1130(0.97)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C6907(0.63); C1130(0.76); C911(1.04); C173(1.07)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C3653(0.95); C5394(1.02); C6907(1.05); C5922(1.07)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C480(0.48); C5394(1.00); C5922(1.03); C6907(1.08)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C480(0.53); C5922(0.85); C5394(0.91); C6907(0.96)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C480(0.59); C5394(0.82); C6907(0.85); C5922(0.94)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C480(0.72); C6907(0.95); C173(0.96); C5394(1.02)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C480(0.57); C1130(0.69); C5056(0.90); C5394(0.90)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C480(0.49); C1130(0.54); C5394(0.82); C3653(0.84)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C480(0.47); C1130(0.52); C5056(0.89); C5394(0.91)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C1130(0.41); C480(0.46); C5056(0.89); C3653(0.90)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C1130(0.52); C480(0.54); C3653(0.95); C5394(0.95)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C6907(0.56); C173(0.67); C1130(0.76); C911(0.99)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C480(0.43); C1130(0.58); C5394(0.98); C911(1.02)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C1130(0.47); C480(0.69); C911(0.94); C3653(0.99)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C480(0.72); C911(0.89); C5922(0.90); C6907(0.93)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C480(0.37); C911(0.86); C3653(0.97); C5394(1.08)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C480(0.33); C911(0.87); C3653(0.94); C6907(1.04)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C480(0.54); C911(0.88); C3653(0.95); C5922(1.04)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C480(0.38); C3653(1.00); C911(1.02); C5056(1.03)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C173(0.94); C5056(0.97); C884(0.97); C5394(1.08)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C5394(0.90); C480(0.92); C179(0.92); C6907(0.92)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C179(0.82); C5394(0.82); C480(0.90); C6907(0.97)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C6907(0.70); C173(0.73); C179(1.07); C1130(1.10)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C6907(0.88); C5394(0.88); C173(0.94); C480(0.98)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C179(0.62); C911(0.80); C480(0.89); C5056(0.90)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C5056(0.85); C173(1.00); C884(1.15); C5922(1.15)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C5056(0.85); C5922(1.01); C173(1.02); C884(1.03)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C5056(0.90); C173(1.03); C1130(1.16); C480(1.16)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C173(0.73); C3653(0.94); C5056(0.95); C6799(0.98)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C480(0.54); C173(0.66); C3653(0.95); C5922(0.97)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C480(0.74); C173(0.79); C5056(0.93); C911(0.95)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C480(0.38); C173(0.86); C5922(1.01); C5394(1.14)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C6907(0.59); C1130(0.73); C173(0.76); C3653(1.05)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C6907(0.70); C1130(0.92); C911(0.95); C3653(0.99)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C6907(0.62); C173(0.81); C5056(0.86); C3653(0.93)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C179(0.85); C173(0.91); C911(0.92); C5922(0.95)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C6799(0.74); C884(0.93); C5922(1.00); C5394(1.09)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C6799(0.74); C884(1.12); C5922(1.14); C5394(1.20)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C6799(0.90); C5922(0.94); C911(0.98); C884(1.07)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C173(0.65); C6907(0.73); C911(0.74); C1130(0.81)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C6799(0.76); C179(1.06); C173(1.08); C5394(1.17)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C6799(0.56); C173(1.08); C884(1.08); C5394(1.23)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C6799(0.76); C884(1.02); C173(1.08); C5394(1.34)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C6799(0.76); C173(1.03); C5922(1.04); C179(1.09)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C6799(0.57); C911(1.14); C173(1.17); C5922(1.25)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C173(1.49); C179(1.17); C5394(1.12); C5922(1.11)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C173(1.14); C179(1.01); C5394(1.27); C5922(1.00)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C173(1.30); C179(1.22); C5394(1.22); C5922(0.97)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C173(0.99); C179(1.16); C5394(1.19); C5922(1.26)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C173(1.08); C179(1.44); C5394(1.22); C5922(1.30)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C1130(0.76); C173(0.75); C179(1.16); C3653(0.95)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C173(0.87); C179(1.24); C5394(1.13); C5922(0.94)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C173(1.25); C179(1.19); C3653(0.96); C480(0.51)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C173(1.07); C179(0.94); C3653(1.13); C480(0.89)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C173(1.47); C179(1.25); C3653(1.27); C480(0.61)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C173(1.31); C179(1.28); C3653(1.17); C480(0.48)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C173(1.27); C179(1.17); C3653(1.17); C480(0.56)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C173(1.16); C179(1.09); C3653(1.18); C480(0.50)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C173(1.51); C179(1.27); C3653(1.26); C480(0.33)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C173(1.15); C179(0.95); C3653(1.26); C480(0.42)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C1130(0.97); C173(0.71); C179(1.25); C3653(0.98)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C173(1.43); C179(1.16); C3653(1.05); C480(0.38)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C173(1.26); C179(1.13); C3653(0.94); C480(0.43)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C173(1.34); C179(1.15); C3653(1.13); C480(0.57)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C173(1.09); C179(0.94); C3653(1.07); C480(0.48)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C173(1.72); C179(1.32); C3653(1.19); C480(0.47)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C173(1.25); C179(1.25); C3653(1.05); C480(0.59)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C173(0.88); C179(0.88); C3653(1.22); C5394(0.95)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C173(0.85); C179(0.85); C3653(1.19); C5394(0.96)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C173(0.84); C179(0.84); C3653(1.08); C5394(0.92)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C173(1.09); C179(1.09); C3653(1.05); C5394(0.99)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C1130(0.78); C173(0.66); C179(1.24); C3653(0.92)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C173(0.90); C179(0.90); C3653(1.07); C5394(0.92)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C173(1.13); C179(1.13); C3653(1.18); C5394(1.00)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C173(1.26); C179(1.26); C3653(1.30); C5394(0.96)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C173(1.01); C179(1.01); C3653(1.04); C5394(0.88)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C173(0.88); C179(0.88); C3653(1.09); C5394(0.85)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C173(0.95); C179(0.95); C3653(1.08); C5394(0.80)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C173(0.85); C179(0.85); C3653(1.02); C5394(0.84)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C173(0.98); C179(0.98); C3653(1.08); C5394(0.91)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C173(0.84); C179(0.84); C3653(1.22); C5394(0.94)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C173(1.00); C179(1.00); C3653(1.11); C5394(0.89)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C1130(1.01); C173(0.73); C179(1.51); C3653(1.03)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C173(0.86); C179(0.86); C3653(1.17); C5394(0.96)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C1130(1.45); C173(1.18); C179(1.00); C5394(0.96)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C1130(0.73); C173(0.96); C179(1.11); C5394(1.16)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C1130(0.86); C173(1.05); C179(1.26); C5394(1.06)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C1130(0.90); C173(1.03); C179(1.07); C5394(1.16)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C1130(1.01); C173(1.22); C179(0.97); C5394(1.15)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C1130(0.98); C173(1.03); C179(1.24); C5394(1.38)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C1130(0.74); C173(0.88); C179(1.03); C5394(1.28)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C1130(1.04); C173(1.22); C179(1.33); C5394(1.16)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C1130(1.25); C173(1.10); C179(1.12); C5394(1.11)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C1130(0.84); C173(0.70); C179(1.03); C3653(0.97)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C1130(1.14); C173(1.04); C179(1.03); C5394(1.07)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C1130(0.60); C173(1.05); C179(1.10); C5394(1.11)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C1130(1.26); C173(0.95); C179(1.10); C5394(1.13)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C1130(1.12); C173(1.46); C179(1.54); C5394(1.47)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C1130(1.38); C173(1.11); C179(1.10); C5394(1.21)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C1130(1.58); C173(0.98); C179(0.95); C3653(1.00)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C1130(1.01); C173(0.91); C179(0.83); C3653(0.95)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C1130(1.11); C173(0.89); C179(0.89); C3653(0.91)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C1130(0.87); C173(1.26); C179(1.06); C3653(0.94)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C1130(0.74); C173(0.91); C179(1.14); C3653(1.01)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C1130(0.95); C173(1.16); C179(1.07); C3653(0.88)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C1130(0.81); C173(1.08); C179(1.08); C3653(0.79)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C1130(1.07); C173(1.17); C179(1.08); C3653(0.92)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C1130(0.91); C173(1.28); C179(1.01); C3653(0.92)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C1130(1.09); C173(1.08); C179(1.03); C3653(0.95)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C1130(1.18); C173(1.20); C179(0.94); C3653(1.03)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C1130(0.83); C173(1.28); C179(0.91); C3653(0.97)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C1130(0.86); C173(1.29); C179(1.01); C3653(0.98)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C1130(0.76); C173(1.09); C179(0.90); C3653(1.03)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C1130(1.02); C173(1.09); C179(0.91); C3653(0.90)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C1130(0.86); C173(0.63); C179(1.20); C3653(0.92)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C1130(0.95); C173(1.02); C179(0.95); C3653(0.68)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C173(1.50); C179(1.36); C3653(1.08); C5394(1.11)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C173(1.00); C179(1.08); C3653(1.13); C5394(1.06)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C173(0.77); C179(1.07); C3653(1.06); C5394(1.04)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C173(0.97); C179(1.65); C3653(1.05); C5394(1.06)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C173(1.93); C179(1.41); C3653(1.28); C5394(1.11)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C173(1.06); C179(1.25); C3653(1.01); C5394(1.09)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C173(1.06); C179(1.29); C3653(1.01); C5394(0.98)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C173(1.15); C179(1.41); C3653(0.79); C5394(1.11)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C173(1.32); C179(1.15); C3653(0.84); C5394(1.02)  LDD0811  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C5056(1.30); C5080(1.20); C5610(1.02); C6799(0.82)  LDD1702  [6]
 LDCM0625  F8 Ramos C5610(1.35)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C5610(1.16)  LDD2189  [21]
 LDCM0575  Fragment13 Ramos C5610(0.78)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C5610(1.22)  LDD2193  [21]
 LDCM0580  Fragment21 Ramos C5610(0.82)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C5610(0.83)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C5610(0.75)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C5610(0.76)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C5610(1.16)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C5610(0.80)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C5610(0.91)  LDD2201  [21]
 LDCM0468  Fragment33 HCT 116 C1130(0.79); C173(0.93); C179(1.07); C5394(1.23)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C5610(0.66)  LDD2203  [21]
 LDCM0427  Fragment51 HCT 116 C173(1.24); C179(1.10); C3653(0.89); C480(0.38)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C5610(0.88)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C5610(0.67)  LDD2205  [21]
 LDCM0116  HHS-0101 DM93 Y5096(0.87); Y251(1.69)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y1354(0.45); Y251(1.04)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y5096(0.72); Y1354(1.12); Y251(1.71)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y5096(0.57); Y251(1.28)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y1354(0.36); Y5096(1.00); Y251(1.03)  LDD0268  [8]
 LDCM0022  KB02 HCT 116 C179(1.31); C884(1.39); C6799(1.11)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C179(1.32); C884(1.68); C6799(1.09)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C179(1.99); C884(1.49); C6799(1.03)  LDD0082  [9]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C5056(1.26); C5610(1.09)  LDD2102  [6]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C3737(0.51)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C5610(1.11)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C5056(1.02)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C5056(1.19); C3737(1.04); C5394(1.22)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C5056(1.28); C3737(1.83)  LDD2094  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C3737(0.84)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C3737(0.97); C5610(0.68)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C5610(1.18)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C3737(0.61)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C3737(0.32)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C5610(1.26)  LDD2105  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C3737(0.88); C5394(1.06)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C3737(0.35); C5610(0.78)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C5899(0.72); C480(0.99)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C3737(1.08)  LDD2111  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C5056(2.62)  LDD2119  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C1044(0.95)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C5056(1.08); C5610(0.56)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C1044(1.11)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C3737(0.76); C5394(1.10); C5610(0.70); C5899(0.97)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C3737(1.01); C5610(0.79); C5899(1.38)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C5056(1.20); C3737(0.96)  LDD2129  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C3737(0.37)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C5610(1.02)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C3737(1.18); C5394(1.49); C5610(0.91)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C3737(1.08); C5394(1.14); C5610(0.73)  LDD2137  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C3737(1.08); C5610(0.66)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C5610(0.71)  LDD2141  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C5056(1.55); C3737(2.57)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C5610(1.47)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C5056(1.37); C3737(0.86)  LDD2146  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C3737(0.40)  LDD2148  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C3737(0.41)  LDD2150  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C5610(2.47)  LDD2153  [6]
 LDCM0159  P28 BxPC-3 3.68  LDD0409  [5]
 LDCM0021  THZ1 HCT 116 C6799(1.06); C5610(1.08); C5922(1.19); C5394(1.30)  LDD2173  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Microtubule-associated protein RP/EB family member 1 (MAPRE1) MAPRE family Q15691
DCC-interacting protein 13-alpha (APPL1) . Q9UKG1
Disrupted in schizophrenia 1 protein (DISC1) . Q9NRI5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Integrated phenotypic screening and activity-based protein profiling to reveal potential therapy targets of pancreatic cancer. Chem Commun (Camb). 2019 Jan 31;55(11):1596-1599. doi: 10.1039/c8cc08753a.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578