Details of the Target

General Information of Target

Target ID LDTP05076
Target Name Tubulin beta-4B chain (TUBB4B)
Gene Name TUBB4B
Gene ID 10383
Synonyms
TUBB2C; Tubulin beta-4B chain; Tubulin beta-2 chain; Tubulin beta-2C chain
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYV
PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEGEFEEEAEEEVA
Target Bioclass
Other
Family
Tubulin family
Subcellular location
Cytoplasm, cytoskeleton
Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Uniprot ID
P68371
Ensemble ID
ENST00000340384.5
HGNC ID
HGNC:20771
ChEMBL ID
CHEMBL1848

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 49 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P1
 Probe Info  		10.00  LDD0452  [2]
P2
 Probe Info  		10.00  LDD0449  [2]
P3
 Probe Info  		10.00  LDD0450  [2]
P8
 Probe Info  		4.00  LDD0451  [2]
AZ-5
 Probe Info  		2.33  LDD0394  [3]
CHEMBL5175495
 Probe Info  		6.26  LDD0196  [4]
CY-1
 Probe Info  		2.55  LDD0243  [5]
CY4
 Probe Info  		2.06  LDD0244  [5]
N1
 Probe Info  		4.66  LDD0242  [5]
TH211
 Probe Info  		Y51(20.00); Y50(13.44); Y36(7.84)  LDD0257  [6]
TH214
 Probe Info  		Y51(20.00); Y59(20.00); Y36(6.09)  LDD0258  [6]
TH216
 Probe Info  		Y59(20.00); Y36(14.39); Y50(12.12)  LDD0259  [6]
YN-4
 Probe Info  		100.00  LDD0445  [7]
AZ-9
 Probe Info  		E53(0.88); E383(0.90)  LDD2208  [3]
ONAyne
 Probe Info  		N.A.  LDD0273  [8]
OPA-S-S-alkyne
 Probe Info  		K58(2.53)  LDD3494  [9]
Probe 1
 Probe Info  		Y50(255.14); Y51(125.97)  LDD3495  [10]
P26
 Probe Info  		1.76  LDD0409  [11]
JZ128-DTB
 Probe Info  		C239(0.00); C354(0.00); C303(0.00); C201(0.00)  LDD0462  [12]
AHL-Pu-1
 Probe Info  		C129(2.47); C303(2.15)  LDD0168  [13]
HHS-482
 Probe Info  		Y36(0.51); Y50(0.94); Y51(0.89); Y59(0.94)  LDD0285  [14]
HHS-475
 Probe Info  		Y222(0.69); Y310(0.76); Y106(0.78); Y281(0.79)  LDD0264  [15]
HHS-465
 Probe Info  		Y106(10.00); Y159(9.41); Y183(10.00); Y200(3.29)  LDD2237  [16]
DBIA
 Probe Info  		C239(1.19); C12(1.07); C127(1.05); C129(1.05)  LDD0078  [17]
AMP probe
 Probe Info  		N.A.  LDD0200  [18]
ATP probe
 Probe Info  		N.A.  LDD0199  [18]
IA-alkyne
 Probe Info  		C127(0.00); C239(0.00); C201(0.00); C354(0.00)  LDD0032  [19]
IPIAA_H
 Probe Info  		C239(0.00); C127(0.00); C303(0.00)  LDD0030  [20]
IPIAA_L
 Probe Info  		C129(0.00); C303(0.00); C239(0.00); C354(0.00)  LDD0031  [20]
ATP probe
 Probe Info  		K58(0.00); K252(0.00); K103(0.00); K216(0.00)  LDD0035  [21]
IPM
 Probe Info  		C129(0.00); C303(0.00); C239(0.00); C127(0.00)  LDD0025  [22]
JW-RF-010
 Probe Info  		C129(0.00); C201(0.00); C354(0.00); C127(0.00)  LDD0026  [22]
NAIA_4
 Probe Info  		C211(0.00); C201(0.00); C12(0.00); C303(0.00)  LDD2226  [23]
NAIA_5
 Probe Info  		C354(0.00); C303(0.00); C239(0.00)  LDD2224  [23]
TFBX
 Probe Info  		C239(0.00); C129(0.00); C303(0.00); C127(0.00)  LDD0027  [22]
WYneC
 Probe Info  		N.A.  LDD0014  [24]
WYneO
 Probe Info  		C303(0.00); C354(0.00)  LDD0022  [24]
1d-yne
 Probe Info  		K216(0.00); K362(0.00); K252(0.00); K103(0.00)  LDD0356  [25]
Compound 10
 Probe Info  		C12(0.00); C127(0.00); C129(0.00); C239(0.00)  LDD2216  [26]
Compound 11
 Probe Info  		C239(0.00); C303(0.00); C354(0.00)  LDD2213  [26]
NHS
 Probe Info  		K324(0.00); K58(0.00); K336(0.00)  LDD0010  [24]
OSF
 Probe Info  		Y159(0.00); H105(0.00); H264(0.00); Y310(0.00)  LDD0029  [27]
SF
 Probe Info  		Y106(0.00); K252(0.00); Y310(0.00); Y51(0.00)  LDD0028  [27]
STPyne
 Probe Info  		K58(0.00); K252(0.00); K324(0.00)  LDD0009  [24]
VSF
 Probe Info  		C129(0.00); C127(0.00); C239(0.00)  LDD0007  [24]
Ox-W18
 Probe Info  		W21(0.00); W344(0.00); W101(0.00)  LDD2175  [28]
1c-yne
 Probe Info  		K58(0.00); K362(0.00); K19(0.00); K297(0.00)  LDD0228  [25]
AOyne
 Probe Info  		15.00  LDD0443  [29]
PAL-AfBPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C049
 Probe Info  		6.59  LDD1747  [30]
C198
 Probe Info  		52.71  LDD1874  [30]
C218
 Probe Info  		13.18  LDD1892  [30]
C255
 Probe Info  		7.06  LDD1928  [30]
C264
 Probe Info  		86.22  LDD1935  [30]
C270
 Probe Info  		9.65  LDD1940  [30]
C287
 Probe Info  		21.41  LDD1957  [30]
C363
 Probe Info  		17.15  LDD2024  [30]
C378
 Probe Info  		6.45  LDD2037  [30]
C382
 Probe Info  		22.16  LDD2041  [30]
C390
 Probe Info  		28.44  LDD2049  [30]
C413
 Probe Info  		18.77  LDD2069  [30]
C420
 Probe Info  		10.63  LDD2075  [30]
C424
 Probe Info  		13.55  LDD2079  [30]
FFF probe11
 Probe Info  		17.88  LDD0472  [31]
FFF probe12
 Probe Info  		7.86  LDD0473  [31]
FFF probe13
 Probe Info  		8.76  LDD0475  [31]
FFF probe3
 Probe Info  		10.41  LDD0464  [31]
FFF probe6
 Probe Info  		8.98  LDD0467  [31]
JN0003
 Probe Info  		8.18  LDD0469  [31]
VE-P
 Probe Info  		N.A.  LDD0396  [32]
A-DA
 Probe Info  		2.35  LDD0143  [33]
Kambe_55
 Probe Info  		3.10  LDD0129  [34]
OEA-DA
 Probe Info  		5.43  LDD0046  [35]
STS-1
 Probe Info  		N.A.  LDD0068  [36]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C129(2.47); C303(2.15)  LDD0168  [13]
 LDCM0214  AC1 HCT 116 C127(1.52); C129(1.52)  LDD0531  [17]
 LDCM0215  AC10 HCT 116 C127(0.99); C129(0.96)  LDD0532  [17]
 LDCM0216  AC100 HCT 116 C127(0.78); C129(0.78)  LDD0533  [17]
 LDCM0217  AC101 HCT 116 C127(0.84); C129(0.82)  LDD0534  [17]
 LDCM0218  AC102 HCT 116 C127(1.04); C129(1.07)  LDD0535  [17]
 LDCM0219  AC103 HCT 116 C127(0.95); C129(0.91)  LDD0536  [17]
 LDCM0220  AC104 HCT 116 C127(0.99); C129(1.02)  LDD0537  [17]
 LDCM0221  AC105 HCT 116 C127(1.02); C129(1.02)  LDD0538  [17]
 LDCM0222  AC106 HCT 116 C127(0.91); C129(0.91)  LDD0539  [17]
 LDCM0223  AC107 HCT 116 C127(1.03); C129(1.09)  LDD0540  [17]
 LDCM0224  AC108 HCT 116 C127(0.76); C129(0.77)  LDD0541  [17]
 LDCM0225  AC109 HCT 116 C127(0.90); C129(0.93)  LDD0542  [17]
 LDCM0226  AC11 HCT 116 C127(1.11); C129(1.07)  LDD0543  [17]
 LDCM0227  AC110 HCT 116 C127(0.97); C129(1.00)  LDD0544  [17]
 LDCM0228  AC111 HCT 116 C127(1.01); C129(1.04)  LDD0545  [17]
 LDCM0229  AC112 HCT 116 C127(0.99); C129(1.10)  LDD0546  [17]
 LDCM0230  AC113 HCT 116 C127(1.16); C129(1.20)  LDD0547  [17]
 LDCM0231  AC114 HCT 116 C127(1.07); C129(1.17)  LDD0548  [17]
 LDCM0232  AC115 HCT 116 C127(1.37); C129(1.47)  LDD0549  [17]
 LDCM0233  AC116 HCT 116 C127(0.86); C129(0.96)  LDD0550  [17]
 LDCM0234  AC117 HCT 116 C127(0.84); C129(0.95)  LDD0551  [17]
 LDCM0235  AC118 HCT 116 C127(0.74); C129(0.85)  LDD0552  [17]
 LDCM0236  AC119 HCT 116 C127(0.73); C129(0.82)  LDD0553  [17]
 LDCM0237  AC12 HCT 116 C127(0.99); C129(0.94)  LDD0554  [17]
 LDCM0238  AC120 HCT 116 C127(1.16); C129(1.19)  LDD0555  [17]
 LDCM0239  AC121 HCT 116 C127(0.70); C129(0.84)  LDD0556  [17]
 LDCM0240  AC122 HCT 116 C127(0.87); C129(1.02)  LDD0557  [17]
 LDCM0241  AC123 HCT 116 C127(0.98); C129(1.05)  LDD0558  [17]
 LDCM0242  AC124 HCT 116 C127(1.01); C129(1.14)  LDD0559  [17]
 LDCM0243  AC125 HCT 116 C127(0.71); C129(0.81)  LDD0560  [17]
 LDCM0244  AC126 HCT 116 C127(0.89); C129(0.95)  LDD0561  [17]
 LDCM0245  AC127 HCT 116 C127(0.72); C129(0.83)  LDD0562  [17]
 LDCM0246  AC128 HCT 116 C127(0.90); C129(0.91)  LDD0563  [17]
 LDCM0247  AC129 HCT 116 C127(1.04); C129(0.95)  LDD0564  [17]
 LDCM0249  AC130 HCT 116 C127(1.04); C129(0.95)  LDD0566  [17]
 LDCM0250  AC131 HCT 116 C127(1.08); C129(1.03)  LDD0567  [17]
 LDCM0251  AC132 HCT 116 C127(1.37); C129(1.17)  LDD0568  [17]
 LDCM0252  AC133 HCT 116 C127(0.93); C129(0.94)  LDD0569  [17]
 LDCM0253  AC134 HCT 116 C127(1.43); C129(1.29)  LDD0570  [17]
 LDCM0254  AC135 HCT 116 C127(0.83); C129(0.82)  LDD0571  [17]
 LDCM0255  AC136 HCT 116 C127(1.08); C129(1.05)  LDD0572  [17]
 LDCM0256  AC137 HCT 116 C127(1.88); C129(1.41)  LDD0573  [17]
 LDCM0257  AC138 HCT 116 C127(1.24); C129(1.24)  LDD0574  [17]
 LDCM0258  AC139 HCT 116 C127(1.07); C129(1.05)  LDD0575  [17]
 LDCM0259  AC14 HCT 116 C127(1.94); C129(1.92)  LDD0576  [17]
 LDCM0260  AC140 HCT 116 C127(1.20); C129(1.16)  LDD0577  [17]
 LDCM0261  AC141 HCT 116 C127(1.13); C129(1.10)  LDD0578  [17]
 LDCM0262  AC142 HCT 116 C127(0.85); C129(0.82)  LDD0579  [17]
 LDCM0263  AC143 HCT 116 C129(0.85); C127(0.87)  LDD0580  [17]
 LDCM0264  AC144 HCT 116 C127(1.16); C129(1.19)  LDD0581  [17]
 LDCM0265  AC145 HCT 116 C127(0.98); C129(1.01)  LDD0582  [17]
 LDCM0266  AC146 HCT 116 C129(1.23); C127(1.31)  LDD0583  [17]
 LDCM0267  AC147 HCT 116 C127(1.45); C129(1.48)  LDD0584  [17]
 LDCM0268  AC148 HCT 116 C127(1.63); C129(1.71)  LDD0585  [17]
 LDCM0269  AC149 HCT 116 C129(1.26); C127(1.28)  LDD0586  [17]
 LDCM0270  AC15 HCT 116 C129(1.17); C127(1.19)  LDD0587  [17]
 LDCM0271  AC150 HCT 116 C129(0.99); C127(1.04)  LDD0588  [17]
 LDCM0272  AC151 HCT 116 C129(0.90); C127(0.97)  LDD0589  [17]
 LDCM0273  AC152 HCT 116 C129(1.34); C127(1.49)  LDD0590  [17]
 LDCM0274  AC153 HCT 116 C127(1.33); C129(1.34)  LDD0591  [17]
 LDCM0621  AC154 HCT 116 C127(1.63); C129(1.58)  LDD2158  [17]
 LDCM0622  AC155 HCT 116 C127(1.23); C129(1.23)  LDD2159  [17]
 LDCM0623  AC156 HCT 116 C127(1.06); C129(1.09)  LDD2160  [17]
 LDCM0624  AC157 HCT 116 C127(1.22); C129(1.13)  LDD2161  [17]
 LDCM0276  AC17 HCT 116 C127(0.67); C129(0.74)  LDD0593  [17]
 LDCM0277  AC18 HCT 116 C127(1.49); C129(1.72)  LDD0594  [17]
 LDCM0278  AC19 HCT 116 C127(0.81); C129(0.83)  LDD0595  [17]
 LDCM0279  AC2 HCT 116 C129(1.34); C127(1.35)  LDD0596  [17]
 LDCM0280  AC20 HCT 116 C129(0.87); C127(0.89)  LDD0597  [17]
 LDCM0281  AC21 HCT 116 C127(0.79); C129(0.82)  LDD0598  [17]
 LDCM0282  AC22 HCT 116 C127(0.72); C129(0.74)  LDD0599  [17]
 LDCM0283  AC23 HCT 116 C127(0.75); C129(0.76)  LDD0600  [17]
 LDCM0284  AC24 HCT 116 C129(0.98); C127(1.02)  LDD0601  [17]
 LDCM0285  AC25 HCT 116 C129(0.76); C127(0.83)  LDD0602  [17]
 LDCM0286  AC26 HCT 116 C129(0.71); C127(0.74)  LDD0603  [17]
 LDCM0287  AC27 HCT 116 C129(0.87); C127(0.93)  LDD0604  [17]
 LDCM0288  AC28 HCT 116 C129(1.16); C127(1.25)  LDD0605  [17]
 LDCM0289  AC29 HCT 116 C129(1.06); C127(1.18)  LDD0606  [17]
 LDCM0290  AC3 HCT 116 C129(1.56); C127(1.57)  LDD0607  [17]
 LDCM0291  AC30 HCT 116 C129(1.05); C127(1.12)  LDD0608  [17]
 LDCM0292  AC31 HCT 116 C129(1.10); C127(1.32)  LDD0609  [17]
 LDCM0293  AC32 HCT 116 C129(1.49); C127(1.76)  LDD0610  [17]
 LDCM0294  AC33 HCT 116 C129(1.20); C127(1.33)  LDD0611  [17]
 LDCM0295  AC34 HCT 116 C129(1.36); C127(1.41)  LDD0612  [17]
 LDCM0296  AC35 HCT 116 C129(1.00); C127(1.01)  LDD0613  [17]
 LDCM0297  AC36 HCT 116 C129(0.89); C127(0.91)  LDD0614  [17]
 LDCM0298  AC37 HCT 116 C129(0.76); C127(0.76)  LDD0615  [17]
 LDCM0299  AC38 HCT 116 C129(0.83); C127(0.84)  LDD0616  [17]
 LDCM0300  AC39 HCT 116 C129(0.72); C127(0.76)  LDD0617  [17]
 LDCM0301  AC4 HCT 116 C129(1.85); C127(1.85)  LDD0618  [17]
 LDCM0302  AC40 HCT 116 C127(0.92); C129(0.96)  LDD0619  [17]
 LDCM0303  AC41 HCT 116 C127(0.83); C129(0.88)  LDD0620  [17]
 LDCM0304  AC42 HCT 116 C129(1.03); C127(1.06)  LDD0621  [17]
 LDCM0305  AC43 HCT 116 C129(0.82); C127(0.89)  LDD0622  [17]
 LDCM0306  AC44 HCT 116 C129(0.95); C127(1.01)  LDD0623  [17]
 LDCM0307  AC45 HCT 116 C129(0.87); C127(0.93)  LDD0624  [17]
 LDCM0308  AC46 HCT 116 C129(0.94); C127(1.00)  LDD0625  [17]
 LDCM0309  AC47 HCT 116 C129(0.82); C127(0.88)  LDD0626  [17]
 LDCM0310  AC48 HCT 116 C127(0.83); C129(0.86)  LDD0627  [17]
 LDCM0311  AC49 HCT 116 C129(1.21); C127(1.32)  LDD0628  [17]
 LDCM0312  AC5 HCT 116 C129(2.13); C127(2.14)  LDD0629  [17]
 LDCM0313  AC50 HCT 116 C129(1.20); C127(1.21)  LDD0630  [17]
 LDCM0314  AC51 HCT 116 C127(0.96); C129(1.16)  LDD0631  [17]
 LDCM0315  AC52 HCT 116 C127(1.00); C129(1.02)  LDD0632  [17]
 LDCM0316  AC53 HCT 116 C127(1.18); C129(1.24)  LDD0633  [17]
 LDCM0317  AC54 HCT 116 C127(1.13); C129(1.19)  LDD0634  [17]
 LDCM0318  AC55 HCT 116 C127(1.03); C129(1.19)  LDD0635  [17]
 LDCM0319  AC56 HCT 116 C127(1.15); C129(1.41)  LDD0636  [17]
 LDCM0320  AC57 HCT 116 C127(1.15); C129(1.17)  LDD0637  [17]
 LDCM0321  AC58 HCT 116 C129(1.36); C127(1.37)  LDD0638  [17]
 LDCM0322  AC59 HCT 116 C129(1.16); C127(1.17)  LDD0639  [17]
 LDCM0323  AC6 HCT 116 C129(1.04); C127(1.06)  LDD0640  [17]
 LDCM0324  AC60 HCT 116 C127(1.16); C129(1.19)  LDD0641  [17]
 LDCM0325  AC61 HCT 116 C127(1.07); C129(1.07)  LDD0642  [17]
 LDCM0326  AC62 HCT 116 C127(1.37); C129(1.39)  LDD0643  [17]
 LDCM0327  AC63 HCT 116 C127(1.01); C129(1.03)  LDD0644  [17]
 LDCM0328  AC64 HCT 116 C127(1.22); C129(1.25)  LDD0645  [17]
 LDCM0329  AC65 HCT 116 C127(0.97); C129(0.99)  LDD0646  [17]
 LDCM0330  AC66 HCT 116 C127(0.76); C129(0.77)  LDD0647  [17]
 LDCM0331  AC67 HCT 116 C127(1.03); C129(1.05)  LDD0648  [17]
 LDCM0332  AC68 HCT 116 C129(1.05); C127(1.16)  LDD0649  [17]
 LDCM0333  AC69 HCT 116 C129(0.90); C127(0.95)  LDD0650  [17]
 LDCM0334  AC7 HCT 116 C129(0.98); C127(1.01)  LDD0651  [17]
 LDCM0335  AC70 HCT 116 C129(1.06); C127(1.17)  LDD0652  [17]
 LDCM0336  AC71 HCT 116 C129(1.11); C127(1.17)  LDD0653  [17]
 LDCM0337  AC72 HCT 116 C129(1.10); C127(1.17)  LDD0654  [17]
 LDCM0338  AC73 HCT 116 C129(1.04); C127(1.07)  LDD0655  [17]
 LDCM0339  AC74 HCT 116 C129(1.10); C127(1.14)  LDD0656  [17]
 LDCM0340  AC75 HCT 116 C129(0.79); C127(0.82)  LDD0657  [17]
 LDCM0341  AC76 HCT 116 C129(1.02); C127(1.03)  LDD0658  [17]
 LDCM0342  AC77 HCT 116 C127(0.89); C129(0.89)  LDD0659  [17]
 LDCM0343  AC78 HCT 116 C127(0.64); C129(0.67)  LDD0660  [17]
 LDCM0344  AC79 HCT 116 C129(0.91); C127(0.97)  LDD0661  [17]
 LDCM0345  AC8 HCT 116 C129(1.61); C127(1.63)  LDD0662  [17]
 LDCM0346  AC80 HCT 116 C127(1.04); C129(1.07)  LDD0663  [17]
 LDCM0347  AC81 HCT 116 C129(1.68); C127(1.75)  LDD0664  [17]
 LDCM0348  AC82 HCT 116 C129(0.87); C127(0.96)  LDD0665  [17]
 LDCM0349  AC83 HCT 116 C129(1.53); C127(1.54)  LDD0666  [17]
 LDCM0350  AC84 HCT 116 C129(1.93); C127(1.97)  LDD0667  [17]
 LDCM0351  AC85 HCT 116 C129(1.33); C127(1.35)  LDD0668  [17]
 LDCM0352  AC86 HCT 116 C129(1.09); C127(1.13)  LDD0669  [17]
 LDCM0353  AC87 HCT 116 C129(1.18); C127(1.19)  LDD0670  [17]
 LDCM0354  AC88 HCT 116 C127(1.62); C129(1.65)  LDD0671  [17]
 LDCM0355  AC89 HCT 116 C129(1.52); C127(1.54)  LDD0672  [17]
 LDCM0357  AC90 HCT 116 C129(0.79); C127(0.82)  LDD0674  [17]
 LDCM0358  AC91 HCT 116 C129(1.68); C127(1.71)  LDD0675  [17]
 LDCM0359  AC92 HCT 116 C129(1.45); C127(1.50)  LDD0676  [17]
 LDCM0360  AC93 HCT 116 C127(1.31); C129(1.33)  LDD0677  [17]
 LDCM0361  AC94 HCT 116 C127(1.67); C129(1.68)  LDD0678  [17]
 LDCM0362  AC95 HCT 116 C129(1.15); C127(1.18)  LDD0679  [17]
 LDCM0363  AC96 HCT 116 C129(1.55); C127(1.59)  LDD0680  [17]
 LDCM0364  AC97 HCT 116 C129(1.44); C127(1.45)  LDD0681  [17]
 LDCM0365  AC98 HCT 116 C129(0.71); C127(0.73)  LDD0682  [17]
 LDCM0366  AC99 HCT 116 C129(0.91); C127(0.91)  LDD0683  [17]
 LDCM0248  AKOS034007472 HCT 116 C127(0.92); C129(0.91)  LDD0565  [17]
 LDCM0356  AKOS034007680 HCT 116 C129(0.77); C127(0.80)  LDD0673  [17]
 LDCM0275  AKOS034007705 HCT 116 C129(1.19); C127(1.23)  LDD0592  [17]
 LDCM0156  Aniline NCI-H1299 11.72  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C239(1.19); C12(1.07); C127(1.05); C129(1.05)  LDD0078  [17]
 LDCM0083  Avasimibe A-549 2.35  LDD0143  [33]
 LDCM0632  CL-Sc Hep-G2 C239(3.60); C303(1.07); C354(1.06); C354(0.89)  LDD2227  [23]
 LDCM0367  CL1 HCT 116 C127(0.70); C129(0.72)  LDD0684  [17]
 LDCM0368  CL10 HCT 116 C129(0.84); C127(0.85)  LDD0685  [17]
 LDCM0369  CL100 HCT 116 C129(1.57); C127(1.58)  LDD0686  [17]
 LDCM0370  CL101 HCT 116 C129(1.47); C127(1.50)  LDD0687  [17]
 LDCM0371  CL102 HCT 116 C129(0.91); C127(0.93)  LDD0688  [17]
 LDCM0372  CL103 HCT 116 C129(0.97); C127(1.00)  LDD0689  [17]
 LDCM0373  CL104 HCT 116 C129(1.19); C127(1.20)  LDD0690  [17]
 LDCM0374  CL105 HCT 116 C129(0.85); C127(0.87)  LDD0691  [17]
 LDCM0375  CL106 HCT 116 C129(1.16); C127(1.17)  LDD0692  [17]
 LDCM0376  CL107 HCT 116 C127(1.03); C129(1.04)  LDD0693  [17]
 LDCM0377  CL108 HCT 116 C127(1.12); C129(1.17)  LDD0694  [17]
 LDCM0378  CL109 HCT 116 C127(0.90); C129(0.92)  LDD0695  [17]
 LDCM0379  CL11 HCT 116 C129(1.00); C127(1.04)  LDD0696  [17]
 LDCM0380  CL110 HCT 116 C127(0.97); C129(0.99)  LDD0697  [17]
 LDCM0381  CL111 HCT 116 C127(1.09); C129(1.12)  LDD0698  [17]
 LDCM0382  CL112 HCT 116 C129(1.10); C127(1.20)  LDD0699  [17]
 LDCM0383  CL113 HCT 116 C129(1.61); C127(1.90)  LDD0700  [17]
 LDCM0384  CL114 HCT 116 C129(1.24); C127(1.35)  LDD0701  [17]
 LDCM0385  CL115 HCT 116 C129(1.16); C127(1.22)  LDD0702  [17]
 LDCM0386  CL116 HCT 116 C129(1.08); C127(1.19)  LDD0703  [17]
 LDCM0387  CL117 HCT 116 C129(0.96); C127(1.03)  LDD0704  [17]
 LDCM0388  CL118 HCT 116 C129(0.85); C127(0.89)  LDD0705  [17]
 LDCM0389  CL119 HCT 116 C129(0.77); C127(0.87)  LDD0706  [17]
 LDCM0390  CL12 HCT 116 C129(1.03); C127(1.03)  LDD0707  [17]
 LDCM0391  CL120 HCT 116 C129(0.65); C127(0.68)  LDD0708  [17]
 LDCM0392  CL121 HCT 116 C127(1.38); C129(1.91)  LDD0709  [17]
 LDCM0393  CL122 HCT 116 C127(1.13); C129(1.28)  LDD0710  [17]
 LDCM0394  CL123 HCT 116 C129(0.98); C127(1.02)  LDD0711  [17]
 LDCM0395  CL124 HCT 116 C127(0.99); C129(1.07)  LDD0712  [17]
 LDCM0396  CL125 HCT 116 C127(0.83); C129(0.83)  LDD0713  [17]
 LDCM0397  CL126 HCT 116 C127(1.06); C129(1.08)  LDD0714  [17]
 LDCM0398  CL127 HCT 116 C127(1.14); C129(1.17)  LDD0715  [17]
 LDCM0399  CL128 HCT 116 C127(1.08); C129(1.10)  LDD0716  [17]
 LDCM0400  CL13 HCT 116 C127(1.01); C129(1.02)  LDD0717  [17]
 LDCM0401  CL14 HCT 116 C129(0.95); C127(0.96)  LDD0718  [17]
 LDCM0402  CL15 HCT 116 C129(0.88); C127(0.94)  LDD0719  [17]
 LDCM0403  CL16 HCT 116 C129(1.27); C127(1.32)  LDD0720  [17]
 LDCM0404  CL17 HCT 116 C127(1.22); C129(1.25)  LDD0721  [17]
 LDCM0405  CL18 HCT 116 C127(1.58); C129(1.59)  LDD0722  [17]
 LDCM0406  CL19 HCT 116 C127(1.19); C129(1.20)  LDD0723  [17]
 LDCM0407  CL2 HCT 116 C129(0.96); C127(0.97)  LDD0724  [17]
 LDCM0408  CL20 HCT 116 C127(1.14); C129(1.17)  LDD0725  [17]
 LDCM0409  CL21 HCT 116 C127(1.22); C129(1.24)  LDD0726  [17]
 LDCM0410  CL22 HCT 116 C127(1.30); C129(1.30)  LDD0727  [17]
 LDCM0411  CL23 HCT 116 C129(1.28); C127(1.30)  LDD0728  [17]
 LDCM0412  CL24 HCT 116 C127(1.48); C129(1.48)  LDD0729  [17]
 LDCM0413  CL25 HCT 116 C127(1.16); C129(1.18)  LDD0730  [17]
 LDCM0414  CL26 HCT 116 C127(1.33); C129(1.34)  LDD0731  [17]
 LDCM0415  CL27 HCT 116 C127(0.92); C129(0.94)  LDD0732  [17]
 LDCM0416  CL28 HCT 116 C127(1.09); C129(1.09)  LDD0733  [17]
 LDCM0417  CL29 HCT 116 C127(1.13); C129(1.12)  LDD0734  [17]
 LDCM0418  CL3 HCT 116 C127(0.96); C129(0.92)  LDD0735  [17]
 LDCM0419  CL30 HCT 116 C127(1.02); C129(1.02)  LDD0736  [17]
 LDCM0420  CL31 HCT 116 C127(1.45); C129(1.43)  LDD0737  [17]
 LDCM0421  CL32 HCT 116 C127(1.72); C129(1.64)  LDD0738  [17]
 LDCM0422  CL33 HCT 116 C127(2.10); C129(2.00)  LDD0739  [17]
 LDCM0423  CL34 HCT 116 C127(2.07); C129(1.98)  LDD0740  [17]
 LDCM0424  CL35 HCT 116 C127(2.50); C129(2.33)  LDD0741  [17]
 LDCM0425  CL36 HCT 116 C127(2.10); C129(2.00)  LDD0742  [17]
 LDCM0426  CL37 HCT 116 C127(1.80); C129(1.71)  LDD0743  [17]
 LDCM0428  CL39 HCT 116 C127(1.49); C129(1.48)  LDD0745  [17]
 LDCM0429  CL4 HCT 116 C127(0.89); C129(0.90)  LDD0746  [17]
 LDCM0430  CL40 HCT 116 C127(1.93); C129(1.81)  LDD0747  [17]
 LDCM0431  CL41 HCT 116 C127(2.29); C129(2.19)  LDD0748  [17]
 LDCM0432  CL42 HCT 116 C127(2.19); C129(2.08)  LDD0749  [17]
 LDCM0433  CL43 HCT 116 C127(2.75); C129(2.66)  LDD0750  [17]
 LDCM0434  CL44 HCT 116 C127(1.94); C129(1.90)  LDD0751  [17]
 LDCM0435  CL45 HCT 116 C127(1.87); C129(1.79)  LDD0752  [17]
 LDCM0436  CL46 HCT 116 C127(0.59); C129(0.57)  LDD0753  [17]
 LDCM0437  CL47 HCT 116 C127(0.69); C129(0.70)  LDD0754  [17]
 LDCM0438  CL48 HCT 116 C127(0.89); C129(0.84)  LDD0755  [17]
 LDCM0439  CL49 HCT 116 C127(0.74); C129(0.73)  LDD0756  [17]
 LDCM0440  CL5 HCT 116 C127(0.83); C129(0.85)  LDD0757  [17]
 LDCM0441  CL50 HCT 116 C127(0.88); C129(0.86)  LDD0758  [17]
 LDCM0442  CL51 HCT 116 C127(0.64); C129(0.63)  LDD0759  [17]
 LDCM0443  CL52 HCT 116 C127(0.69); C129(0.68)  LDD0760  [17]
 LDCM0444  CL53 HCT 116 C127(0.96); C129(0.95)  LDD0761  [17]
 LDCM0445  CL54 HCT 116 C127(0.85); C129(0.84)  LDD0762  [17]
 LDCM0446  CL55 HCT 116 C127(0.81); C129(0.82)  LDD0763  [17]
 LDCM0447  CL56 HCT 116 C127(0.86); C129(0.92)  LDD0764  [17]
 LDCM0448  CL57 HCT 116 C127(0.88); C129(0.87)  LDD0765  [17]
 LDCM0449  CL58 HCT 116 C127(0.81); C129(0.79)  LDD0766  [17]
 LDCM0450  CL59 HCT 116 C127(1.05); C129(1.04)  LDD0767  [17]
 LDCM0451  CL6 HCT 116 C127(0.85); C129(0.85)  LDD0768  [17]
 LDCM0452  CL60 HCT 116 C127(1.01); C129(0.98)  LDD0769  [17]
 LDCM0453  CL61 HCT 116 C127(0.96); C129(0.98)  LDD0770  [17]
 LDCM0454  CL62 HCT 116 C127(1.12); C129(1.11)  LDD0771  [17]
 LDCM0455  CL63 HCT 116 C127(1.17); C129(1.20)  LDD0772  [17]
 LDCM0456  CL64 HCT 116 C127(1.04); C129(1.06)  LDD0773  [17]
 LDCM0457  CL65 HCT 116 C127(1.11); C129(1.12)  LDD0774  [17]
 LDCM0458  CL66 HCT 116 C127(1.16); C129(1.17)  LDD0775  [17]
 LDCM0459  CL67 HCT 116 C127(1.53); C129(1.50)  LDD0776  [17]
 LDCM0460  CL68 HCT 116 C127(1.74); C129(1.87)  LDD0777  [17]
 LDCM0461  CL69 HCT 116 C127(1.08); C129(1.08)  LDD0778  [17]
 LDCM0462  CL7 HCT 116 C127(0.87); C129(0.86)  LDD0779  [17]
 LDCM0463  CL70 HCT 116 C127(1.38); C129(1.42)  LDD0780  [17]
 LDCM0464  CL71 HCT 116 C127(1.30); C129(1.30)  LDD0781  [17]
 LDCM0465  CL72 HCT 116 C127(1.14); C129(1.15)  LDD0782  [17]
 LDCM0466  CL73 HCT 116 C127(1.20); C129(1.21)  LDD0783  [17]
 LDCM0467  CL74 HCT 116 C127(1.50); C129(1.53)  LDD0784  [17]
 LDCM0469  CL76 HCT 116 C127(1.03); C129(1.21)  LDD0786  [17]
 LDCM0470  CL77 HCT 116 C127(1.05); C129(1.34)  LDD0787  [17]
 LDCM0471  CL78 HCT 116 C127(0.88); C129(0.93)  LDD0788  [17]
 LDCM0472  CL79 HCT 116 C127(1.21); C129(1.24)  LDD0789  [17]
 LDCM0473  CL8 HCT 116 C127(1.07); C129(1.07)  LDD0790  [17]
 LDCM0474  CL80 HCT 116 C127(0.90); C129(0.96)  LDD0791  [17]
 LDCM0475  CL81 HCT 116 C127(0.93); C129(0.89)  LDD0792  [17]
 LDCM0476  CL82 HCT 116 C127(1.09); C129(1.08)  LDD0793  [17]
 LDCM0477  CL83 HCT 116 C127(0.99); C129(0.97)  LDD0794  [17]
 LDCM0478  CL84 HCT 116 C127(0.87); C129(0.88)  LDD0795  [17]
 LDCM0479  CL85 HCT 116 C127(0.99); C129(1.03)  LDD0796  [17]
 LDCM0480  CL86 HCT 116 C127(0.80); C129(0.96)  LDD0797  [17]
 LDCM0481  CL87 HCT 116 C127(0.86); C129(0.98)  LDD0798  [17]
 LDCM0482  CL88 HCT 116 C127(1.17); C129(1.34)  LDD0799  [17]
 LDCM0483  CL89 HCT 116 C127(1.15); C129(1.14)  LDD0800  [17]
 LDCM0484  CL9 HCT 116 C127(0.76); C129(0.78)  LDD0801  [17]
 LDCM0485  CL90 HCT 116 C127(0.71); C129(0.74)  LDD0802  [17]
 LDCM0486  CL91 HCT 116 C127(1.17); C129(1.16)  LDD0803  [17]
 LDCM0487  CL92 HCT 116 C127(1.21); C129(1.21)  LDD0804  [17]
 LDCM0488  CL93 HCT 116 C127(1.01); C129(1.00)  LDD0805  [17]
 LDCM0489  CL94 HCT 116 C127(1.50); C129(1.50)  LDD0806  [17]
 LDCM0490  CL95 HCT 116 C127(1.30); C129(1.29)  LDD0807  [17]
 LDCM0491  CL96 HCT 116 C127(1.04); C129(1.04)  LDD0808  [17]
 LDCM0492  CL97 HCT 116 C127(1.40); C129(1.39)  LDD0809  [17]
 LDCM0493  CL98 HCT 116 C127(1.61); C129(1.59)  LDD0810  [17]
 LDCM0494  CL99 HCT 116 C127(1.64); C129(1.64)  LDD0811  [17]
 LDCM0189  Compound 16 HEK-293T 11.51  LDD0492  [31]
 LDCM0182  Compound 18 HEK-293T 7.05  LDD0501  [31]
 LDCM0191  Compound 21 HEK-293T 7.92  LDD0493  [31]
 LDCM0190  Compound 34 HEK-293T 12.43  LDD0497  [31]
 LDCM0192  Compound 35 HEK-293T 6.94  LDD0491  [31]
 LDCM0193  Compound 36 HEK-293T 5.45  LDD0494  [31]
 LDCM0194  Compound 37 HEK-293T 9.42  LDD0498  [31]
 LDCM0195  Compound 38 HEK-293T 7.27  LDD0499  [31]
 LDCM0196  Compound 39 HEK-293T 6.98  LDD0496  [31]
 LDCM0197  Compound 40 HEK-293T 6.44  LDD0495  [31]
 LDCM0181  Compound 41 HEK-293T 8.15  LDD0502  [31]
 LDCM0183  Compound 42 HEK-293T 4.76  LDD0500  [31]
 LDCM0634  CY-0357 Hep-G2 C354(1.57); C303(1.06); C239(0.85); C12(0.80)  LDD2228  [23]
 LDCM0495  E2913 HEK-293T C354(1.01); C12(0.86); C239(1.00); C127(1.01)  LDD1698  [37]
 LDCM0625  F8 Ramos C303(1.46); C354(1.66); C239(1.23); 20.00  LDD2187  [38]
 LDCM0572  Fragment10 Ramos C303(1.54); C354(1.65); C239(0.39)  LDD2189  [38]
 LDCM0573  Fragment11 Ramos C303(0.00); C354(0.18); C239(0.00); 4.46  LDD2190  [38]
 LDCM0574  Fragment12 Ramos C303(1.73); C354(0.90); C239(0.57)  LDD2191  [38]
 LDCM0575  Fragment13 Ramos C303(1.21); C354(0.50); C239(0.70)  LDD2192  [38]
 LDCM0576  Fragment14 Ramos C303(0.64); C354(0.48); C239(0.75); 1.05  LDD2193  [38]
 LDCM0579  Fragment20 Ramos C303(2.05); C354(1.41); C239(0.68)  LDD2194  [38]
 LDCM0580  Fragment21 Ramos C303(1.03); C354(0.57); C239(0.78)  LDD2195  [38]
 LDCM0582  Fragment23 Ramos C303(1.11); C354(0.46); C239(0.74)  LDD2196  [38]
 LDCM0578  Fragment27 Ramos C303(1.31); C354(0.40); C239(0.60)  LDD2197  [38]
 LDCM0586  Fragment28 Ramos C303(0.76); C354(1.16); C239(0.93); 0.21  LDD2198  [38]
 LDCM0588  Fragment30 Ramos C303(1.73); C354(0.70); C239(0.51)  LDD2199  [38]
 LDCM0589  Fragment31 Ramos C303(1.21); C354(0.50); C239(0.64)  LDD2200  [38]
 LDCM0590  Fragment32 Ramos C303(1.45); C354(1.12); C239(0.45)  LDD2201  [38]
 LDCM0468  Fragment33 HCT 116 C127(1.42); C129(1.43)  LDD0785  [17]
 LDCM0596  Fragment38 Ramos C303(0.89); C354(0.51); C239(0.58)  LDD2203  [38]
 LDCM0566  Fragment4 Ramos C303(1.06); C354(1.07); C239(0.94)  LDD2184  [38]
 LDCM0427  Fragment51 HCT 116 C127(1.80); C129(1.74)  LDD0744  [17]
 LDCM0610  Fragment52 Ramos C303(1.48); C354(0.68); C239(0.47)  LDD2204  [38]
 LDCM0614  Fragment56 Ramos C303(1.34); C354(1.33); C239(0.41)  LDD2205  [38]
 LDCM0569  Fragment7 Ramos C303(1.13); C354(0.84); C239(0.73)  LDD2186  [38]
 LDCM0571  Fragment9 Ramos C303(2.53); C354(1.71); C239(0.79)  LDD2188  [38]
 LDCM0116  HHS-0101 DM93 Y222(0.69); Y310(0.76); Y106(0.78); Y281(0.79)  LDD0264  [15]
 LDCM0117  HHS-0201 DM93 Y50(0.44); Y222(0.59); Y106(0.68); Y310(0.74)  LDD0265  [15]
 LDCM0118  HHS-0301 DM93 Y222(0.62); Y106(0.66); Y310(0.75); Y281(0.85)  LDD0266  [15]
 LDCM0119  HHS-0401 DM93 Y50(0.58); Y222(0.63); Y106(0.63); Y310(0.74)  LDD0267  [15]
 LDCM0120  HHS-0701 DM93 Y106(0.62); Y222(0.63); Y36(0.74); Y281(0.76)  LDD0268  [15]
 LDCM0123  JWB131 DM93 Y36(0.51); Y50(0.94); Y51(0.89); Y59(0.94)  LDD0285  [14]
 LDCM0124  JWB142 DM93 Y36(0.85); Y50(0.65); Y51(0.59); Y59(0.60)  LDD0286  [14]
 LDCM0125  JWB146 DM93 Y36(0.80); Y50(1.14); Y51(1.06); Y59(1.07)  LDD0287  [14]
 LDCM0126  JWB150 DM93 Y36(1.36); Y50(2.40); Y51(2.29); Y59(3.09)  LDD0288  [14]
 LDCM0127  JWB152 DM93 Y36(1.13); Y50(1.70); Y51(1.58); Y59(2.19)  LDD0289  [14]
 LDCM0128  JWB198 DM93 Y36(0.55); Y50(1.09); Y51(0.63); Y59(0.73)  LDD0290  [14]
 LDCM0129  JWB202 DM93 Y36(0.95); Y50(0.43); Y51(0.42); Y59(0.64)  LDD0291  [14]
 LDCM0130  JWB211 DM93 Y36(0.62); Y50(0.94); Y51(0.89); Y59(0.91)  LDD0292  [14]
 LDCM0179  JZ128 PC-3 C239(0.00); C354(0.00); C303(0.00); C201(0.00)  LDD0462  [12]
 LDCM0073  Kambe_cp3 PC-3 3.10  LDD0129  [34]
 LDCM0022  KB02 MDA-MB-231 C213(5.31)  LDD1374  [39]
 LDCM0023  KB03 MDA-MB-231 C213(11.89)  LDD1376  [39]
 LDCM0024  KB05 RVH-421 C12(5.64)  LDD3413  [40]
 LDCM0628  OTUB2-COV-1 HEK-293T C129(1.07)  LDD2207  [41]
 LDCM0159  P28 BxPC-3 1.76  LDD0409  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Albendazole Small molecular drug DB00518
Mebendazole Small molecular drug DB00643
Investigative
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Epothilone D Small molecular drug DB01873
Oxibendazole Small molecular drug DB04910
Patupilone Small molecular drug DB03010
Phenethyl Isothiocyanate Small molecular drug DB12695
Cyt997 . DB05147

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD022279
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Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD001377 , PXD005252
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD007570
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