Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name FFF probe3  Probe Info 
Probe concentration 20 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Compound 37  Competitor Info 
Competitor Concentration 160 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 45 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 29.4
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 19.2
 LDTP02198  Cathepsin D (CTSD) 18.9
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 16.7
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 15.7
 LDTP13702  E3 ubiquitin-protein ligase TRIM33 (TRIM33) 15.5
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 15.0
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 14.9
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 14.9
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 14.8
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 14.8
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 14.7
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 14.6
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 14.5
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 14.4
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 13.7
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 13.1
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 12.4
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 11.7
 LDTP13751  Exonuclease 1 (EXO1) 11.4
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 11.3
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 11.2
 LDTP03540  Heme oxygenase 2 (HMOX2) 11.2
 LDTP12588  Isoleucine--tRNA ligase, mitochondrial (IARS2) 11.1
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 11.0
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 10.6
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 10.4
 LDTP02837  Beta-galactosidase (GLB1) 10.4
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 10.3
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 9.7
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 9.4
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 9.3
 LDTP04183  Lanosterol synthase (LSS) 8.2
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA) 8.0
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 7.9
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 7.4
 LDTP03842  Squalene synthase (FDFT1) 7.2
 LDTP03689  Serine hydroxymethyltransferase, mitochondrial (SHMT2) 7.2
 LDTP00697  Cytochrome b5 type B (CYB5B) 7.1
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 6.4
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 5.5
 LDTP02150  ATP synthase subunit beta, mitochondrial (ATP5F1B) 5.4
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 4.2
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 4.1
 LDTP03680  DNA replication licensing factor MCM4 (MCM4) 3.8
Transporter and channel
Click to Show/Hide to Show 13 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02215  Prosaposin (PSAP) 18.5
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 14.6
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 12.8
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 12.1
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 11.4
 LDTP11213  Nucleoporin NDC1 (NDC1) 11.2
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 10.4
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 9.9
 LDTP11916  Tubulin beta-1 chain (TUBB1) 8.9
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 8.3
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 6.5
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 5.8
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 4.4
Other
Click to Show/Hide to Show 12 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12412  Reticulon-4 (RTN4) 42.6
 LDTP13630  Neudesin (NENF) 12.2
 LDTP09920  Golgi apparatus protein 1 (GLG1) 11.2
 LDTP00105  Protein unc-119 homolog B (UNC119B) 10.6
 LDTP11233  Tubulin beta-6 chain (TUBB6) 10.0
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 9.4
 LDTP05904  Tubulin beta-3 chain (TUBB3) 9.2
 LDTP02205  Tubulin beta chain (TUBB) 9.2
 LDTP11277  Tubulin beta-2B chain (TUBB2B) 9.1
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 8.4
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 6.1
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 5.7

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.