Details of the Target

General Information of Target

Target ID LDTP05724
Target Name Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1)
Gene Name ECH1
Gene ID 1891
Synonyms
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial; EC 5.3.3.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAGIVASRRLRDLLTRRLTGSNYPGLSISLRLTGSSAQEEASGVALGEAPDHSYESLRV
TSAQKHVLHVQLNRPNKRNAMNKVFWREMVECFNKISRDADCRAVVISGAGKMFTAGIDL
MDMASDILQPKGDDVARISWYLRDIITRYQETFNVIERCPKPVIAAVHGGCIGGGVDLVT
ACDIRYCAQDAFFQVKEVDVGLAADVGTLQRLPKVIGNQSLVNELAFTARKMMADEALGS
GLVSRVFPDKEVMLDAALALAAEISSKSPVAVQSTKVNLLYSRDHSVAESLNYVASWNMS
MLQTQDLVKSVQATTENKELKTVTFSKL
Target Bioclass
Enzyme
Family
Enoyl-CoA hydratase/isomerase family
Subcellular location
Mitochondrion
Function Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA.
Uniprot ID
Q13011
Ensemble ID
ENST00000221418.9
HGNC ID
HGNC:3149
ChEMBL ID
CHEMBL4523284

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ILS-1
 Probe Info  		9.39  LDD0415  [2]
FBPP2
 Probe Info  		25.72  LDD0318  [3]
TH211
 Probe Info  		Y149(20.00)  LDD0260  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
YN-4
 Probe Info  		100.00  LDD0445  [5]
STPyne
 Probe Info  		K231(10.00)  LDD0277  [6]
IPM
 Probe Info  		C187(0.00); C92(0.00)  LDD0241  [7]
OPA-S-S-alkyne
 Probe Info  		K83(1.59); K231(1.70)  LDD3494  [8]
Probe 1
 Probe Info  		Y149(43.25); Y281(5.39)  LDD3495  [9]
P11
 Probe Info  		20.00  LDD0201  [10]
m-APA
 Probe Info  		5.58  LDD0403  [11]
Alkylaryl probe 3
 Probe Info  		4.38  LDD0282  [12]
BTD
 Probe Info  		C92(1.44)  LDD2093  [13]
HHS-475
 Probe Info  		Y149(0.77)  LDD0264  [14]
HHS-465
 Probe Info  		Y149(7.27)  LDD2237  [15]
DBIA
 Probe Info  		C187(0.96)  LDD0580  [16]
ATP probe
 Probe Info  		K231(0.00); K318(0.00); K321(0.00)  LDD0199  [17]
4-Iodoacetamidophenylacetylene
 Probe Info  		C92(0.00); C187(0.00)  LDD0038  [18]
IA-alkyne
 Probe Info  		C187(0.00); C92(0.00)  LDD0032  [19]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [20]
Lodoacetamide azide
 Probe Info  		C92(0.00); C187(0.00)  LDD0037  [18]
ATP probe
 Probe Info  		K83(0.00); K65(0.00); K276(0.00)  LDD0035  [21]
WYneN
 Probe Info  		N.A.  LDD0021  [22]
NHS
 Probe Info  		N.A.  LDD0010  [22]
SF
 Probe Info  		N.A.  LDD0028  [23]
1d-yne
 Probe Info  		N.A.  LDD0357  [24]
Acrolein
 Probe Info  		H53(0.00); C92(0.00); C187(0.00)  LDD0217  [25]
Crotonaldehyde
 Probe Info  		C187(0.00); H53(0.00); C92(0.00)  LDD0219  [25]
Methacrolein
 Probe Info  		C187(0.00); C92(0.00)  LDD0218  [25]
NAIA_5
 Probe Info  		C102(0.00); C92(0.00); C187(0.00)  LDD2223  [26]
TER-AC
 Probe Info  		N.A.  LDD0426  [27]
HHS-482
 Probe Info  		Y149(0.68)  LDD2239  [15]
PAL-AfBPP Probe
Click To Hide/Show 51 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
PARPYnD
 Probe Info  		1.44  LDD0374  [28]
C041
 Probe Info  		10.56  LDD1741  [29]
C055
 Probe Info  		12.04  LDD1752  [29]
C087
 Probe Info  		7.84  LDD1779  [29]
C131
 Probe Info  		4.92  LDD1813  [29]
C140
 Probe Info  		8.69  LDD1822  [29]
C142
 Probe Info  		10.78  LDD1824  [29]
C143
 Probe Info  		18.00  LDD1825  [29]
C145
 Probe Info  		13.83  LDD1827  [29]
C158
 Probe Info  		9.51  LDD1838  [29]
C163
 Probe Info  		6.36  LDD1843  [29]
C166
 Probe Info  		8.00  LDD1846  [29]
C174
 Probe Info  		5.39  LDD1854  [29]
C176
 Probe Info  		5.10  LDD1855  [29]
C177
 Probe Info  		9.78  LDD1856  [29]
C212
 Probe Info  		6.11  LDD1886  [29]
C215
 Probe Info  		6.96  LDD1889  [29]
C229
 Probe Info  		10.34  LDD1902  [29]
C233
 Probe Info  		11.39  LDD1906  [29]
C234
 Probe Info  		5.90  LDD1907  [29]
C258
 Probe Info  		6.11  LDD1931  [29]
C326
 Probe Info  		10.48  LDD1990  [29]
C339
 Probe Info  		8.82  LDD2002  [29]
C346
 Probe Info  		10.70  LDD2007  [29]
C355
 Probe Info  		31.56  LDD2016  [29]
C356
 Probe Info  		11.47  LDD2017  [29]
C361
 Probe Info  		20.82  LDD2022  [29]
C378
 Probe Info  		10.20  LDD2037  [29]
C390
 Probe Info  		28.05  LDD2049  [29]
C391
 Probe Info  		34.30  LDD2050  [29]
C413
 Probe Info  		11.63  LDD2069  [29]
C429
 Probe Info  		15.56  LDD2084  [29]
C430
 Probe Info  		6.50  LDD2085  [29]
C431
 Probe Info  		19.97  LDD2086  [29]
C433
 Probe Info  		11.00  LDD2088  [29]
FFF probe11
 Probe Info  		10.87  LDD0486  [30]
FFF probe13
 Probe Info  		10.97  LDD0475  [30]
FFF probe14
 Probe Info  		13.59  LDD0477  [30]
FFF probe15
 Probe Info  		12.80  LDD0478  [30]
FFF probe3
 Probe Info  		13.27  LDD0464  [30]
FFF probe4
 Probe Info  		13.14  LDD0466  [30]
FFF probe6
 Probe Info  		8.68  LDD0467  [30]
FFF probe7
 Probe Info  		13.65  LDD0483  [30]
JN0003
 Probe Info  		13.09  LDD0469  [30]
VE-P
 Probe Info  		N.A.  LDD0396  [31]
A-DA
 Probe Info  		5.13  LDD0145  [32]
Kambe_31
 Probe Info  		3.27  LDD0135  [33]
Alk-rapa
 Probe Info  		3.38  LDD0213  [34]
Diazir
 Probe Info  		N.A.  LDD0011  [22]
DA-2
 Probe Info  		N.A.  LDD0072  [35]
OEA-DA
 Probe Info  		20.00  LDD0046  [36]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C159(0.27)  LDD2142  [13]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C159(0.47)  LDD2117  [13]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C92(1.58)  LDD2152  [13]
 LDCM0214  AC1 PaTu 8988t C92(0.23); C187(0.14)  LDD1093  [16]
 LDCM0215  AC10 HEK-293T C187(0.65); C171(0.85)  LDD0813  [16]
 LDCM0216  AC100 HEK-293T C187(0.94); C182(1.18)  LDD0814  [16]
 LDCM0217  AC101 HEK-293T C187(1.01); C182(1.08)  LDD0815  [16]
 LDCM0218  AC102 HEK-293T C187(0.69); C182(1.27)  LDD0816  [16]
 LDCM0219  AC103 HEK-293T C187(0.94); C182(1.25)  LDD0817  [16]
 LDCM0220  AC104 HEK-293T C187(0.87); C182(1.19)  LDD0818  [16]
 LDCM0221  AC105 HEK-293T C187(0.93); C182(1.02)  LDD0819  [16]
 LDCM0222  AC106 HEK-293T C187(1.01); C182(0.84)  LDD0820  [16]
 LDCM0223  AC107 HEK-293T C187(0.99); C182(1.23)  LDD0821  [16]
 LDCM0224  AC108 HEK-293T C187(0.93); C182(0.89)  LDD0822  [16]
 LDCM0225  AC109 HEK-293T C187(1.22); C182(0.92)  LDD0823  [16]
 LDCM0226  AC11 HEK-293T C187(0.80); C171(1.02)  LDD0824  [16]
 LDCM0227  AC110 HEK-293T C187(1.00); C182(1.49)  LDD0825  [16]
 LDCM0228  AC111 HEK-293T C187(0.85); C182(1.91)  LDD0826  [16]
 LDCM0229  AC112 HEK-293T C187(0.96); C182(1.76)  LDD0827  [16]
 LDCM0230  AC113 HEK-293T C187(0.97); C182(0.87)  LDD0828  [16]
 LDCM0231  AC114 HEK-293T C187(0.92); C182(1.23)  LDD0829  [16]
 LDCM0232  AC115 HEK-293T C187(0.89); C182(0.94)  LDD0830  [16]
 LDCM0233  AC116 HEK-293T C187(0.88); C182(1.08)  LDD0831  [16]
 LDCM0234  AC117 HEK-293T C187(0.93); C182(1.14)  LDD0832  [16]
 LDCM0235  AC118 HEK-293T C187(0.92); C182(1.13)  LDD0833  [16]
 LDCM0236  AC119 HEK-293T C187(0.89); C182(1.45)  LDD0834  [16]
 LDCM0237  AC12 HEK-293T C187(0.99); C171(0.97)  LDD0835  [16]
 LDCM0238  AC120 HEK-293T C187(0.93); C182(1.26)  LDD0836  [16]
 LDCM0239  AC121 HEK-293T C187(0.79); C182(1.28)  LDD0837  [16]
 LDCM0240  AC122 HEK-293T C187(0.86); C182(1.34)  LDD0838  [16]
 LDCM0241  AC123 HEK-293T C187(0.89); C182(1.41)  LDD0839  [16]
 LDCM0242  AC124 HEK-293T C187(0.78); C182(1.36)  LDD0840  [16]
 LDCM0243  AC125 HEK-293T C187(0.86); C182(1.55)  LDD0841  [16]
 LDCM0244  AC126 HEK-293T C187(0.93); C182(1.72)  LDD0842  [16]
 LDCM0245  AC127 HEK-293T C187(0.92); C182(2.17)  LDD0843  [16]
 LDCM0246  AC128 HEK-293T C187(1.17); C182(0.80)  LDD0844  [16]
 LDCM0247  AC129 HEK-293T C187(1.01); C182(1.15)  LDD0845  [16]
 LDCM0249  AC130 HEK-293T C187(1.02); C182(1.17)  LDD0847  [16]
 LDCM0250  AC131 HEK-293T C187(1.07); C182(1.26)  LDD0848  [16]
 LDCM0251  AC132 HEK-293T C187(1.07); C182(1.19)  LDD0849  [16]
 LDCM0252  AC133 HEK-293T C187(1.09); C182(1.50)  LDD0850  [16]
 LDCM0253  AC134 HEK-293T C187(1.05); C182(1.71)  LDD0851  [16]
 LDCM0254  AC135 HEK-293T C187(1.05); C182(1.14)  LDD0852  [16]
 LDCM0255  AC136 HEK-293T C187(0.73); C182(1.26)  LDD0853  [16]
 LDCM0256  AC137 HEK-293T C187(1.16); C182(1.56)  LDD0854  [16]
 LDCM0257  AC138 HEK-293T C187(1.16); C182(1.57)  LDD0855  [16]
 LDCM0258  AC139 HEK-293T C187(1.11); C182(1.57)  LDD0856  [16]
 LDCM0259  AC14 HEK-293T C187(0.97); C171(0.95)  LDD0857  [16]
 LDCM0260  AC140 HEK-293T C187(1.11); C182(1.41)  LDD0858  [16]
 LDCM0261  AC141 HEK-293T C187(1.10); C182(1.62)  LDD0859  [16]
 LDCM0262  AC142 HEK-293T C187(0.94); C182(1.68)  LDD0860  [16]
 LDCM0263  AC143 HCT 116 C187(0.96)  LDD0580  [16]
 LDCM0264  AC144 HCT 116 C187(0.71)  LDD0581  [16]
 LDCM0265  AC145 HCT 116 C187(0.81)  LDD0582  [16]
 LDCM0266  AC146 HCT 116 C187(0.71)  LDD0583  [16]
 LDCM0267  AC147 HCT 116 C187(0.64)  LDD0584  [16]
 LDCM0268  AC148 HCT 116 C187(0.09)  LDD0585  [16]
 LDCM0269  AC149 HCT 116 C187(0.56)  LDD0586  [16]
 LDCM0270  AC15 HEK-293T C187(0.82); C171(0.92)  LDD0868  [16]
 LDCM0271  AC150 HCT 116 C187(2.24)  LDD0588  [16]
 LDCM0272  AC151 HCT 116 C187(0.77)  LDD0589  [16]
 LDCM0273  AC152 HCT 116 C187(0.50)  LDD0590  [16]
 LDCM0274  AC153 HCT 116 C187(0.08)  LDD0591  [16]
 LDCM0621  AC154 HCT 116 C187(0.58)  LDD2158  [16]
 LDCM0622  AC155 HCT 116 C187(0.93)  LDD2159  [16]
 LDCM0623  AC156 HCT 116 C187(0.82)  LDD2160  [16]
 LDCM0624  AC157 HCT 116 C187(0.95)  LDD2161  [16]
 LDCM0276  AC17 HEK-293T C171(1.66); C182(1.67)  LDD0874  [16]
 LDCM0277  AC18 HEK-293T C171(1.76); C182(1.68)  LDD0875  [16]
 LDCM0278  AC19 HEK-293T C171(1.71); C182(1.69)  LDD0876  [16]
 LDCM0279  AC2 PaTu 8988t C92(0.62); C187(0.42)  LDD1158  [16]
 LDCM0280  AC20 HEK-293T C171(1.79); C182(1.42)  LDD0878  [16]
 LDCM0281  AC21 HEK-293T C171(1.46); C182(1.42)  LDD0879  [16]
 LDCM0282  AC22 HEK-293T C171(1.64); C182(1.66)  LDD0880  [16]
 LDCM0283  AC23 HEK-293T C171(1.50); C182(1.66)  LDD0881  [16]
 LDCM0284  AC24 HEK-293T C171(1.82); C182(1.76)  LDD0882  [16]
 LDCM0285  AC25 PaTu 8988t C187(1.81)  LDD1164  [16]
 LDCM0286  AC26 PaTu 8988t C187(0.80)  LDD1165  [16]
 LDCM0287  AC27 PaTu 8988t C187(0.94)  LDD1166  [16]
 LDCM0288  AC28 PaTu 8988t C187(0.54)  LDD1167  [16]
 LDCM0289  AC29 PaTu 8988t C187(0.73)  LDD1168  [16]
 LDCM0290  AC3 PaTu 8988t C92(0.94); C187(0.12)  LDD1169  [16]
 LDCM0291  AC30 PaTu 8988t C187(0.74)  LDD1170  [16]
 LDCM0292  AC31 PaTu 8988t C187(0.91)  LDD1171  [16]
 LDCM0293  AC32 PaTu 8988t C187(0.95)  LDD1172  [16]
 LDCM0294  AC33 PaTu 8988t C187(0.46)  LDD1173  [16]
 LDCM0295  AC34 PaTu 8988t C187(0.56)  LDD1174  [16]
 LDCM0296  AC35 HEK-293T C187(1.63)  LDD0894  [16]
 LDCM0297  AC36 HEK-293T C187(4.91)  LDD0895  [16]
 LDCM0298  AC37 HEK-293T C187(3.20)  LDD0896  [16]
 LDCM0299  AC38 HEK-293T C187(2.56)  LDD0897  [16]
 LDCM0300  AC39 HEK-293T C187(1.20)  LDD0898  [16]
 LDCM0301  AC4 PaTu 8988t C92(0.98); C187(0.27)  LDD1180  [16]
 LDCM0302  AC40 HEK-293T C187(2.17)  LDD0900  [16]
 LDCM0303  AC41 HEK-293T C187(1.40)  LDD0901  [16]
 LDCM0304  AC42 HEK-293T C187(1.55)  LDD0902  [16]
 LDCM0305  AC43 HEK-293T C187(1.24)  LDD0903  [16]
 LDCM0306  AC44 HEK-293T C187(2.81)  LDD0904  [16]
 LDCM0307  AC45 HEK-293T C187(4.18)  LDD0905  [16]
 LDCM0308  AC46 HCT 116 C187(0.97)  LDD0625  [16]
 LDCM0309  AC47 HCT 116 C187(0.91)  LDD0626  [16]
 LDCM0310  AC48 HCT 116 C187(1.04)  LDD0627  [16]
 LDCM0311  AC49 HCT 116 C187(0.11)  LDD0628  [16]
 LDCM0312  AC5 PaTu 8988t C92(0.36); C187(0.16)  LDD1191  [16]
 LDCM0313  AC50 HCT 116 C187(0.17)  LDD0630  [16]
 LDCM0314  AC51 HCT 116 C187(1.80)  LDD0631  [16]
 LDCM0315  AC52 HCT 116 C187(1.15)  LDD0632  [16]
 LDCM0316  AC53 HCT 116 C187(0.51)  LDD0633  [16]
 LDCM0317  AC54 HCT 116 C187(0.44)  LDD0634  [16]
 LDCM0318  AC55 HCT 116 C187(0.11)  LDD0635  [16]
 LDCM0319  AC56 HCT 116 C187(0.08)  LDD0636  [16]
 LDCM0320  AC57 HEK-293T C187(1.35); C171(0.78); C182(1.13)  LDD0918  [16]
 LDCM0321  AC58 HEK-293T C187(1.21); C171(0.96); C182(1.18)  LDD0919  [16]
 LDCM0322  AC59 HEK-293T C187(1.02); C171(1.10); C182(1.18)  LDD0920  [16]
 LDCM0323  AC6 HEK-293T C187(0.65); C171(1.34)  LDD0921  [16]
 LDCM0324  AC60 HEK-293T C187(1.22); C171(0.81); C182(1.39)  LDD0922  [16]
 LDCM0325  AC61 HEK-293T C187(0.80); C171(0.94); C182(1.23)  LDD0923  [16]
 LDCM0326  AC62 HEK-293T C187(1.04); C171(0.80); C182(0.88)  LDD0924  [16]
 LDCM0327  AC63 HEK-293T C187(1.03); C171(0.97); C182(1.23)  LDD0925  [16]
 LDCM0328  AC64 HEK-293T C187(1.09); C171(1.06); C182(1.05)  LDD0926  [16]
 LDCM0329  AC65 HEK-293T C187(1.02); C171(0.88); C182(1.35)  LDD0927  [16]
 LDCM0330  AC66 HEK-293T C187(1.16); C171(0.88); C182(0.99)  LDD0928  [16]
 LDCM0331  AC67 HEK-293T C187(1.09); C171(1.06); C182(1.21)  LDD0929  [16]
 LDCM0332  AC68 HCT 116 C187(1.34)  LDD0649  [16]
 LDCM0333  AC69 HCT 116 C187(0.84)  LDD0650  [16]
 LDCM0334  AC7 HEK-293T C187(0.90); C171(1.35)  LDD0932  [16]
 LDCM0335  AC70 HCT 116 C187(0.67)  LDD0652  [16]
 LDCM0336  AC71 HCT 116 C187(3.85)  LDD0653  [16]
 LDCM0337  AC72 HCT 116 C187(1.71)  LDD0654  [16]
 LDCM0338  AC73 HCT 116 C187(0.45)  LDD0655  [16]
 LDCM0339  AC74 HCT 116 C187(0.50)  LDD0656  [16]
 LDCM0340  AC75 HCT 116 C187(0.76)  LDD0657  [16]
 LDCM0341  AC76 HCT 116 C187(0.85)  LDD0658  [16]
 LDCM0342  AC77 HCT 116 C187(0.60)  LDD0659  [16]
 LDCM0343  AC78 HCT 116 C187(1.53)  LDD0660  [16]
 LDCM0344  AC79 HCT 116 C187(1.36)  LDD0661  [16]
 LDCM0345  AC8 HEK-293T C187(0.83); C171(1.37)  LDD0943  [16]
 LDCM0346  AC80 HCT 116 C187(0.85)  LDD0663  [16]
 LDCM0347  AC81 HCT 116 C187(1.13)  LDD0664  [16]
 LDCM0348  AC82 HCT 116 C187(0.64)  LDD0665  [16]
 LDCM0349  AC83 HEK-293T C187(1.04); C182(1.08)  LDD0947  [16]
 LDCM0350  AC84 HEK-293T C187(0.59); C182(1.17)  LDD0948  [16]
 LDCM0351  AC85 HEK-293T C187(0.66); C182(1.24)  LDD0949  [16]
 LDCM0352  AC86 HEK-293T C187(0.88); C182(1.04)  LDD0950  [16]
 LDCM0353  AC87 HEK-293T C187(0.71); C182(1.18)  LDD0951  [16]
 LDCM0354  AC88 HEK-293T C187(0.85); C182(1.17)  LDD0952  [16]
 LDCM0355  AC89 HEK-293T C187(0.70); C182(1.25)  LDD0953  [16]
 LDCM0357  AC90 HEK-293T C187(0.67); C182(1.46)  LDD0955  [16]
 LDCM0358  AC91 HEK-293T C187(0.74); C182(1.12)  LDD0956  [16]
 LDCM0359  AC92 HEK-293T C187(0.66); C182(1.38)  LDD0957  [16]
 LDCM0360  AC93 HEK-293T C187(0.94); C182(1.14)  LDD0958  [16]
 LDCM0361  AC94 HEK-293T C187(0.79); C182(1.10)  LDD0959  [16]
 LDCM0362  AC95 HEK-293T C187(0.68); C182(1.33)  LDD0960  [16]
 LDCM0363  AC96 HEK-293T C187(0.51); C182(1.40)  LDD0961  [16]
 LDCM0364  AC97 HEK-293T C187(0.86); C182(1.91)  LDD0962  [16]
 LDCM0365  AC98 HEK-293T C187(1.05); C182(0.91)  LDD0963  [16]
 LDCM0366  AC99 HEK-293T C187(1.07); C182(0.97)  LDD0964  [16]
 LDCM0248  AKOS034007472 HEK-293T C187(0.98); C171(1.07)  LDD0846  [16]
 LDCM0356  AKOS034007680 HEK-293T C187(0.89); C171(1.02)  LDD0954  [16]
 LDCM0275  AKOS034007705 HEK-293T C187(1.13); C171(1.31)  LDD0873  [16]
 LDCM0156  Aniline NCI-H1299 5.58  LDD0403  [11]
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [10]
 LDCM0108  Chloroacetamide HeLa C92(0.00); H53(0.00)  LDD0222  [25]
 LDCM0367  CL1 HCT 116 C187(1.35)  LDD0684  [16]
 LDCM0368  CL10 HCT 116 C187(0.43)  LDD0685  [16]
 LDCM0369  CL100 PaTu 8988t C92(0.83); C187(0.34)  LDD1248  [16]
 LDCM0370  CL101 HEK-293T C187(1.06); C171(1.51)  LDD0968  [16]
 LDCM0371  CL102 HEK-293T C187(1.24); C171(1.30)  LDD0969  [16]
 LDCM0372  CL103 HEK-293T C187(1.25); C171(1.42)  LDD0970  [16]
 LDCM0373  CL104 HEK-293T C187(0.98); C171(1.44)  LDD0971  [16]
 LDCM0374  CL105 HEK-293T C171(1.49); C182(1.37)  LDD0972  [16]
 LDCM0375  CL106 HEK-293T C171(1.20); C182(1.20)  LDD0973  [16]
 LDCM0376  CL107 HEK-293T C171(1.50); C182(1.40)  LDD0974  [16]
 LDCM0377  CL108 HEK-293T C171(1.20); C182(1.40)  LDD0975  [16]
 LDCM0378  CL109 HEK-293T C171(1.62); C182(1.31)  LDD0976  [16]
 LDCM0379  CL11 HCT 116 C187(0.15)  LDD0696  [16]
 LDCM0380  CL110 HEK-293T C171(1.72); C182(1.63)  LDD0978  [16]
 LDCM0381  CL111 HEK-293T C171(1.56); C182(1.48)  LDD0979  [16]
 LDCM0382  CL112 PaTu 8988t C187(0.96)  LDD1261  [16]
 LDCM0383  CL113 PaTu 8988t C187(1.28)  LDD1262  [16]
 LDCM0384  CL114 PaTu 8988t C187(0.71)  LDD1263  [16]
 LDCM0385  CL115 PaTu 8988t C187(0.66)  LDD1264  [16]
 LDCM0386  CL116 PaTu 8988t C187(0.91)  LDD1265  [16]
 LDCM0387  CL117 HEK-293T C187(5.60)  LDD0985  [16]
 LDCM0388  CL118 HEK-293T C187(2.09)  LDD0986  [16]
 LDCM0389  CL119 HEK-293T C187(1.32)  LDD0987  [16]
 LDCM0390  CL12 HCT 116 C187(0.10)  LDD0707  [16]
 LDCM0391  CL120 HEK-293T C187(1.58)  LDD0989  [16]
 LDCM0392  CL121 HCT 116 C187(0.93)  LDD0709  [16]
 LDCM0393  CL122 HCT 116 C187(0.83)  LDD0710  [16]
 LDCM0394  CL123 HCT 116 C187(0.48)  LDD0711  [16]
 LDCM0395  CL124 HCT 116 C187(0.20)  LDD0712  [16]
 LDCM0396  CL125 HEK-293T C187(1.18); C171(1.05); C182(1.21)  LDD0994  [16]
 LDCM0397  CL126 HEK-293T C187(1.07); C171(0.70); C182(1.02)  LDD0995  [16]
 LDCM0398  CL127 HEK-293T C187(1.22); C171(0.65); C182(0.99)  LDD0996  [16]
 LDCM0399  CL128 HEK-293T C187(1.08); C171(1.08); C182(1.05)  LDD0997  [16]
 LDCM0400  CL13 HCT 116 C187(0.39)  LDD0717  [16]
 LDCM0401  CL14 HCT 116 C187(1.18)  LDD0718  [16]
 LDCM0402  CL15 HCT 116 C187(0.25)  LDD0719  [16]
 LDCM0403  CL16 HCT 116 C187(0.91)  LDD0720  [16]
 LDCM0404  CL17 HCT 116 C187(0.88)  LDD0721  [16]
 LDCM0405  CL18 HCT 116 C187(1.01)  LDD0722  [16]
 LDCM0406  CL19 HCT 116 C187(0.81)  LDD0723  [16]
 LDCM0407  CL2 HCT 116 C187(0.73)  LDD0724  [16]
 LDCM0408  CL20 HCT 116 C187(0.68)  LDD0725  [16]
 LDCM0409  CL21 HCT 116 C187(0.30)  LDD0726  [16]
 LDCM0410  CL22 HCT 116 C187(0.08)  LDD0727  [16]
 LDCM0411  CL23 HCT 116 C187(0.69)  LDD0728  [16]
 LDCM0412  CL24 HCT 116 C187(0.22)  LDD0729  [16]
 LDCM0413  CL25 HCT 116 C187(0.46)  LDD0730  [16]
 LDCM0414  CL26 HCT 116 C187(0.80)  LDD0731  [16]
 LDCM0415  CL27 HCT 116 C187(0.95)  LDD0732  [16]
 LDCM0416  CL28 HCT 116 C187(0.72)  LDD0733  [16]
 LDCM0417  CL29 HCT 116 C187(0.57)  LDD0734  [16]
 LDCM0418  CL3 HCT 116 C187(0.81)  LDD0735  [16]
 LDCM0419  CL30 HCT 116 C187(0.76)  LDD0736  [16]
 LDCM0420  CL31 HCT 116 C187(0.76)  LDD0737  [16]
 LDCM0421  CL32 HCT 116 C187(0.81)  LDD0738  [16]
 LDCM0422  CL33 HCT 116 C187(0.77)  LDD0739  [16]
 LDCM0423  CL34 HCT 116 C187(0.28)  LDD0740  [16]
 LDCM0424  CL35 HCT 116 C187(0.25)  LDD0741  [16]
 LDCM0425  CL36 HCT 116 C187(0.45)  LDD0742  [16]
 LDCM0426  CL37 HCT 116 C187(0.19)  LDD0743  [16]
 LDCM0428  CL39 HCT 116 C187(0.33)  LDD0745  [16]
 LDCM0429  CL4 HCT 116 C187(0.74)  LDD0746  [16]
 LDCM0430  CL40 HCT 116 C187(0.63)  LDD0747  [16]
 LDCM0431  CL41 HCT 116 C187(0.45)  LDD0748  [16]
 LDCM0432  CL42 HCT 116 C187(0.05)  LDD0749  [16]
 LDCM0433  CL43 HCT 116 C187(0.08)  LDD0750  [16]
 LDCM0434  CL44 HCT 116 C187(0.54)  LDD0751  [16]
 LDCM0435  CL45 HCT 116 C187(0.30)  LDD0752  [16]
 LDCM0436  CL46 HCT 116 C187(1.27)  LDD0753  [16]
 LDCM0437  CL47 HCT 116 C187(1.18)  LDD0754  [16]
 LDCM0438  CL48 HCT 116 C187(1.23)  LDD0755  [16]
 LDCM0439  CL49 HCT 116 C187(1.03)  LDD0756  [16]
 LDCM0440  CL5 HCT 116 C187(0.51)  LDD0757  [16]
 LDCM0441  CL50 HCT 116 C187(1.20)  LDD0758  [16]
 LDCM0442  CL51 HCT 116 C187(1.31)  LDD0759  [16]
 LDCM0443  CL52 HCT 116 C187(1.26)  LDD0760  [16]
 LDCM0444  CL53 HCT 116 C187(1.23)  LDD0761  [16]
 LDCM0445  CL54 HCT 116 C187(1.17)  LDD0762  [16]
 LDCM0446  CL55 HCT 116 C187(1.27)  LDD0763  [16]
 LDCM0447  CL56 HCT 116 C187(1.04)  LDD0764  [16]
 LDCM0448  CL57 HCT 116 C187(1.20)  LDD0765  [16]
 LDCM0449  CL58 HCT 116 C187(1.11)  LDD0766  [16]
 LDCM0450  CL59 HCT 116 C187(1.19)  LDD0767  [16]
 LDCM0451  CL6 HCT 116 C187(3.00)  LDD0768  [16]
 LDCM0452  CL60 HCT 116 C187(1.25)  LDD0769  [16]
 LDCM0453  CL61 HCT 116 C187(0.98)  LDD0770  [16]
 LDCM0454  CL62 HCT 116 C187(1.02)  LDD0771  [16]
 LDCM0455  CL63 HCT 116 C187(0.96)  LDD0772  [16]
 LDCM0456  CL64 HCT 116 C187(0.79)  LDD0773  [16]
 LDCM0457  CL65 HCT 116 C187(1.00)  LDD0774  [16]
 LDCM0458  CL66 HCT 116 C187(0.35)  LDD0775  [16]
 LDCM0459  CL67 HCT 116 C187(0.67)  LDD0776  [16]
 LDCM0460  CL68 HCT 116 C187(1.07)  LDD0777  [16]
 LDCM0461  CL69 HCT 116 C187(1.03)  LDD0778  [16]
 LDCM0462  CL7 HCT 116 C187(0.38)  LDD0779  [16]
 LDCM0463  CL70 HCT 116 C187(0.86)  LDD0780  [16]
 LDCM0464  CL71 HCT 116 C187(0.82)  LDD0781  [16]
 LDCM0465  CL72 HCT 116 C187(1.04)  LDD0782  [16]
 LDCM0466  CL73 HCT 116 C187(1.10)  LDD0783  [16]
 LDCM0467  CL74 HCT 116 C187(0.92)  LDD0784  [16]
 LDCM0469  CL76 HCT 116 C187(0.86)  LDD0786  [16]
 LDCM0470  CL77 HCT 116 C187(0.73)  LDD0787  [16]
 LDCM0471  CL78 HCT 116 C187(0.80)  LDD0788  [16]
 LDCM0472  CL79 HCT 116 C187(0.57)  LDD0789  [16]
 LDCM0473  CL8 HCT 116 C187(0.09)  LDD0790  [16]
 LDCM0474  CL80 HCT 116 C187(1.01)  LDD0791  [16]
 LDCM0475  CL81 HCT 116 C187(0.76)  LDD0792  [16]
 LDCM0476  CL82 HCT 116 C187(0.16)  LDD0793  [16]
 LDCM0477  CL83 HCT 116 C187(0.34)  LDD0794  [16]
 LDCM0478  CL84 HCT 116 C187(0.10)  LDD0795  [16]
 LDCM0479  CL85 HCT 116 C187(0.76)  LDD0796  [16]
 LDCM0480  CL86 HCT 116 C187(1.30)  LDD0797  [16]
 LDCM0481  CL87 HCT 116 C187(1.69)  LDD0798  [16]
 LDCM0482  CL88 HCT 116 C187(0.47)  LDD0799  [16]
 LDCM0483  CL89 HCT 116 C187(0.10)  LDD0800  [16]
 LDCM0484  CL9 HCT 116 C187(0.57)  LDD0801  [16]
 LDCM0485  CL90 HCT 116 C187(0.82)  LDD0802  [16]
 LDCM0486  CL91 PaTu 8988t C92(0.99); C187(0.50)  LDD1365  [16]
 LDCM0487  CL92 PaTu 8988t C92(0.53); C187(0.48)  LDD1366  [16]
 LDCM0488  CL93 PaTu 8988t C92(0.61); C187(0.39)  LDD1367  [16]
 LDCM0489  CL94 PaTu 8988t C92(0.51); C187(0.45)  LDD1368  [16]
 LDCM0490  CL95 PaTu 8988t C92(0.35); C187(0.40)  LDD1369  [16]
 LDCM0491  CL96 PaTu 8988t C92(0.83); C187(0.40)  LDD1370  [16]
 LDCM0492  CL97 PaTu 8988t C92(0.89); C187(0.43)  LDD1371  [16]
 LDCM0493  CL98 PaTu 8988t C92(0.43); C187(0.27)  LDD1372  [16]
 LDCM0494  CL99 PaTu 8988t C92(0.70); C187(0.41)  LDD1373  [16]
 LDCM0189  Compound 16 HEK-293T 16.39  LDD0492  [30]
 LDCM0185  Compound 17 HEK-293T 15.75  LDD0504  [30]
 LDCM0182  Compound 18 HEK-293T 6.09  LDD0501  [30]
 LDCM0184  Compound 20 HEK-293T 15.38  LDD0503  [30]
 LDCM0191  Compound 21 HEK-293T 6.67  LDD0493  [30]
 LDCM0186  Compound 31 HEK-293T 9.22  LDD0506  [30]
 LDCM0187  Compound 32 HEK-293T 21.28  LDD0507  [30]
 LDCM0188  Compound 33 HEK-293T 6.12  LDD0505  [30]
 LDCM0190  Compound 34 HEK-293T 16.67  LDD0497  [30]
 LDCM0192  Compound 35 HEK-293T 11.17  LDD0491  [30]
 LDCM0193  Compound 36 HEK-293T 12.66  LDD0494  [30]
 LDCM0194  Compound 37 HEK-293T 15.75  LDD0498  [30]
 LDCM0195  Compound 38 HEK-293T 9.80  LDD0499  [30]
 LDCM0196  Compound 39 HEK-293T 10.20  LDD0496  [30]
 LDCM0197  Compound 40 HEK-293T 12.82  LDD0495  [30]
 LDCM0181  Compound 41 HEK-293T 6.35  LDD0502  [30]
 LDCM0183  Compound 42 HEK-293T 3.74  LDD0500  [30]
 LDCM0495  E2913 HEK-293T C92(0.98); C187(1.02)  LDD1698  [37]
 LDCM0625  F8 Ramos C92(0.69)  LDD2187  [38]
 LDCM0572  Fragment10 Ramos C92(0.52)  LDD2189  [38]
 LDCM0573  Fragment11 Ramos C92(1.16)  LDD2190  [38]
 LDCM0574  Fragment12 Ramos C92(0.61)  LDD2191  [38]
 LDCM0575  Fragment13 Ramos C92(0.97)  LDD2192  [38]
 LDCM0576  Fragment14 Ramos C92(0.67)  LDD2193  [38]
 LDCM0579  Fragment20 Ramos C92(0.51)  LDD2194  [38]
 LDCM0580  Fragment21 Ramos C92(0.79)  LDD2195  [38]
 LDCM0582  Fragment23 Ramos C92(1.07)  LDD2196  [38]
 LDCM0578  Fragment27 Ramos C92(0.81)  LDD2197  [38]
 LDCM0586  Fragment28 Ramos C92(0.91)  LDD2198  [38]
 LDCM0588  Fragment30 Ramos C92(1.08)  LDD2199  [38]
 LDCM0589  Fragment31 Ramos C92(0.86)  LDD2200  [38]
 LDCM0590  Fragment32 Ramos C92(0.44)  LDD2201  [38]
 LDCM0468  Fragment33 HCT 116 C187(0.88)  LDD0785  [16]
 LDCM0596  Fragment38 Ramos C92(1.00)  LDD2203  [38]
 LDCM0566  Fragment4 Ramos C92(0.65)  LDD2184  [38]
 LDCM0427  Fragment51 HCT 116 C187(0.06)  LDD0744  [16]
 LDCM0610  Fragment52 Ramos C92(1.46)  LDD2204  [38]
 LDCM0614  Fragment56 Ramos C92(1.18)  LDD2205  [38]
 LDCM0569  Fragment7 Ramos C92(0.76)  LDD2186  [38]
 LDCM0571  Fragment9 Ramos C92(0.44)  LDD2188  [38]
 LDCM0116  HHS-0101 DM93 Y149(0.77)  LDD0264  [14]
 LDCM0117  HHS-0201 DM93 Y149(1.52)  LDD0265  [14]
 LDCM0118  HHS-0301 DM93 Y149(1.62)  LDD0266  [14]
 LDCM0119  HHS-0401 DM93 Y149(2.32)  LDD0267  [14]
 LDCM0120  HHS-0701 DM93 Y149(6.23)  LDD0268  [14]
 LDCM0107  IAA HeLa C92(0.00); H53(0.00)  LDD0221  [25]
 LDCM0079  kambe_cp64 PC-3 3.27  LDD0135  [33]
 LDCM0022  KB02 HEK-293T C92(1.03)  LDD1492  [37]
 LDCM0023  KB03 HEK-293T C92(1.02)  LDD1497  [37]
 LDCM0024  KB05 COLO792 C92(2.33); C187(2.47)  LDD3310  [39]
 LDCM0109  NEM HeLa H53(0.00); C92(0.00); C187(0.00)  LDD0223  [25]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C92(1.44)  LDD2093  [13]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C159(0.77)  LDD2097  [13]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C92(2.18)  LDD2099  [13]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C92(0.32)  LDD2106  [13]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C92(1.25)  LDD2107  [13]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C92(0.78); C159(0.65)  LDD2109  [13]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C92(1.54); C159(0.89)  LDD2111  [13]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C92(0.60)  LDD2115  [13]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C92(1.40); C159(1.19)  LDD2119  [13]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C92(1.09); C159(0.61)  LDD2123  [13]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C92(1.12); C159(0.76)  LDD2125  [13]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C92(0.79); C159(0.69)  LDD2127  [13]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C92(1.38); C159(0.98)  LDD2129  [13]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C92(0.79); C159(0.55)  LDD2133  [13]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C187(0.65)  LDD2134  [13]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C92(1.70)  LDD2135  [13]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C92(1.70); C159(0.86)  LDD2136  [13]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C92(1.18); C159(0.70)  LDD2137  [13]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C92(1.35)  LDD2140  [13]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C92(0.36)  LDD2143  [13]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C92(2.45)  LDD2144  [13]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C92(0.05); C159(0.28)  LDD2145  [13]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C92(1.37)  LDD2146  [13]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C92(0.98)  LDD2147  [13]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C92(0.50)  LDD2148  [13]
 LDCM0099  Phenelzine HEK-293T 4.38  LDD0282  [12]
 LDCM0131  RA190 MM1.R C92(0.83)  LDD0304  [40]
 LDCM0090  Rapamycin JHH-7 3.38  LDD0213  [34]
 LDCM0084  Ro 48-8071 A-549 5.13  LDD0145  [32]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Enoyl-CoA delta isomerase 2 (ECI2) Enoyl-CoA hydratase/isomerase family O75521
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Signal transducer and activator of transcription 3 (STAT3) Transcription factor STAT family P40763
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
TNF receptor-associated factor 1 (TRAF1) . Q13077

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3.
Mass spectrometry data entry: PXD014175
3 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
9 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
10 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
11 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD007570
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