Details of the Target

General Information of Target

Target ID	LDTP02837
Target Name	Beta-galactosidase (GLB1)
Gene Name	GLB1
Gene ID	2720
Synonyms	ELNR1; Beta-galactosidase; EC 3.2.1.23; Acid beta-galactosidase; Lactase; Elastin receptor 1
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MPGFLVRILPLLLVLLLLGPTRGLRNATQRMFEIDYSRDSFLKDGQPFRYISGSIHYSRV PRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVIL RPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPV ITVQVENEYGSYFACDFDYLRFLQKRFRHHLGDDVVLFTTDGAHKTFLKCGALQGLYTTV DFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQPHSTIKTEAVASSLYDILARG ASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKV PEGPIPPSTPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGFVLYRT TLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLDLLVENM GRVNYGAYINDFKGLVSNLTLSSNILTDWTIFPLDTEDAVRSHLGGWGHRDSGHHDEAWA HNSSNYTLPAFYMGNFSIPSGIPDLPQDTFIQFPGWTKGQVWINGFNLGRYWPARGPQLT LFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVTFVDRPVIGSSVTYDHPSKPVEKR LMPPPPQKNKDSWLDHV
Target Type	Clinical trial
Target Bioclass	Enzyme
Family	Glycosyl hydrolase 35 family
Subcellular location	Lysosome; Cytoplasm, perinuclear region
Function	[Isoform 1]: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.; [Isoform 2]: Has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.
TTD ID	T73134
Uniprot ID	P16278
DrugMap ID	TTNGJPH
Ensemble ID	ENST00000307363.10
HGNC ID	HGNC:4298
ChEMBL ID	CHEMBL2522

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 22 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
Alkylaryl probe 1 Probe Info	12.00	LDD0385	[1]
Alkylaryl probe 2 Probe Info	6.00	LDD0391	[1]
FBPP2 Probe Info	9.03	LDD0318	[2]
TH211 Probe Info	Y488(20.00); Y485(12.23)	LDD0260	[3]
YN-1 Probe Info	100.00	LDD0444	[4]
STPyne Probe Info	K356(10.00)	LDD0277	[5]
IPM Probe Info	N.A.	LDD0241	[6]
Probe 1 Probe Info	Y154(15.08); Y444(28.14)	LDD3495	[7]
P11 Probe Info	20.00	LDD0201	[8]
DBIA Probe Info	C426(1.11); C393(1.75)	LDD3312	[9]
1d-yne Probe Info	N.A.	LDD0358	[10]
4-Iodoacetamidophenylacetylene Probe Info	C426(0.00); C393(0.00)	LDD0038	[11]
IA-alkyne Probe Info	N.A.	LDD0032	[12]
Lodoacetamide azide Probe Info	C426(0.00); C393(0.00)	LDD0037	[11]
WYneN Probe Info	N.A.	LDD0021	[13]
SF Probe Info	N.A.	LDD0028	[14]
TFBX Probe Info	C393(0.00); C426(0.00)	LDD0148	[15]
1c-yne Probe Info	K43(0.00); K383(0.00)	LDD0228	[10]
Acrolein Probe Info	N.A.	LDD0217	[16]
Methacrolein Probe Info	N.A.	LDD0218	[16]
NAIA_5 Probe Info	N.A.	LDD2223	[17]
HHS-482 Probe Info	Y485(0.53)	LDD2239	[18]

PAL-AfBPP Probe

Click To Hide/Show 114 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
C004 Probe Info	14.03	LDD1714	[19]
C006 Probe Info	8.51	LDD1715	[19]
C007 Probe Info	8.22	LDD1716	[19]
C008 Probe Info	4.92	LDD1717	[19]
C010 Probe Info	14.83	LDD1719	[19]
C022 Probe Info	16.91	LDD1728	[19]
C026 Probe Info	20.97	LDD1732	[19]
C039 Probe Info	5.82	LDD1739	[19]
C040 Probe Info	10.06	LDD1740	[19]
C041 Probe Info	15.35	LDD1741	[19]
C045 Probe Info	6.36	LDD1744	[19]
C063 Probe Info	16.91	LDD1760	[19]
C067 Probe Info	7.41	LDD1763	[19]
C068 Probe Info	5.62	LDD1764	[19]
C070 Probe Info	11.96	LDD1766	[19]
C071 Probe Info	8.51	LDD1767	[19]
C082 Probe Info	5.94	LDD1774	[19]
C085 Probe Info	5.74	LDD1777	[19]
C087 Probe Info	8.11	LDD1779	[19]
C106 Probe Info	28.64	LDD1793	[19]
C107 Probe Info	18.38	LDD1794	[19]
C108 Probe Info	12.13	LDD1795	[19]
C129 Probe Info	6.54	LDD1811	[19]
C130 Probe Info	11.16	LDD1812	[19]
C140 Probe Info	18.00	LDD1822	[19]
C141 Probe Info	20.25	LDD1823	[19]
C143 Probe Info	14.12	LDD1825	[19]
C147 Probe Info	9.85	LDD1829	[19]
C149 Probe Info	6.77	LDD1830	[19]
C153 Probe Info	20.53	LDD1834	[19]
C159 Probe Info	9.85	LDD1839	[19]
C160 Probe Info	7.89	LDD1840	[19]
C161 Probe Info	20.25	LDD1841	[19]
C163 Probe Info	28.84	LDD1843	[19]
C170 Probe Info	33.13	LDD1850	[19]
C171 Probe Info	6.02	LDD1851	[19]
C177 Probe Info	11.31	LDD1856	[19]
C178 Probe Info	39.67	LDD1857	[19]
C183 Probe Info	5.13	LDD1861	[19]
C186 Probe Info	11.63	LDD1864	[19]
C187 Probe Info	22.78	LDD1865	[19]
C193 Probe Info	11.88	LDD1869	[19]
C194 Probe Info	16.34	LDD1870	[19]
C197 Probe Info	11.55	LDD1873	[19]
C198 Probe Info	21.41	LDD1874	[19]
C201 Probe Info	29.04	LDD1877	[19]
C206 Probe Info	18.25	LDD1881	[19]
C208 Probe Info	5.94	LDD1883	[19]
C211 Probe Info	8.40	LDD1885	[19]
C213 Probe Info	16.45	LDD1887	[19]
C217 Probe Info	5.78	LDD1891	[19]
C219 Probe Info	16.56	LDD1893	[19]
C220 Probe Info	16.00	LDD1894	[19]
C221 Probe Info	5.78	LDD1895	[19]
C223 Probe Info	9.99	LDD1897	[19]
C225 Probe Info	10.27	LDD1898	[19]
C226 Probe Info	13.36	LDD1899	[19]
C228 Probe Info	18.90	LDD1901	[19]
C229 Probe Info	13.27	LDD1902	[19]
C231 Probe Info	23.10	LDD1904	[19]
C233 Probe Info	13.83	LDD1906	[19]
C237 Probe Info	4.92	LDD1910	[19]
C240 Probe Info	18.51	LDD1913	[19]
C255 Probe Info	5.17	LDD1928	[19]
C270 Probe Info	8.11	LDD1940	[19]
C273 Probe Info	6.77	LDD1943	[19]
C277 Probe Info	8.94	LDD1947	[19]
C287 Probe Info	9.99	LDD1957	[19]
C293 Probe Info	18.77	LDD1963	[19]
C296 Probe Info	23.43	LDD1966	[19]
C302 Probe Info	8.51	LDD1971	[19]
C305 Probe Info	12.21	LDD1974	[19]
C307 Probe Info	6.82	LDD1975	[19]
C310 Probe Info	22.47	LDD1977	[19]
C326 Probe Info	18.25	LDD1990	[19]
C337 Probe Info	5.10	LDD2000	[19]
C339 Probe Info	6.77	LDD2002	[19]
C340 Probe Info	4.96	LDD2003	[19]
C343 Probe Info	11.08	LDD2005	[19]
C346 Probe Info	13.74	LDD2007	[19]
C348 Probe Info	12.47	LDD2009	[19]
C349 Probe Info	14.12	LDD2010	[19]
C350 Probe Info	32.67	LDD2011	[19]
C355 Probe Info	32.00	LDD2016	[19]
C356 Probe Info	16.80	LDD2017	[19]
C357 Probe Info	9.85	LDD2018	[19]
C376 Probe Info	15.24	LDD2036	[19]
C378 Probe Info	14.93	LDD2037	[19]
C380 Probe Info	7.01	LDD2039	[19]
C386 Probe Info	30.48	LDD2045	[19]
C390 Probe Info	49.18	LDD2049	[19]
C399 Probe Info	11.79	LDD2058	[19]
C403 Probe Info	16.00	LDD2061	[19]
C413 Probe Info	22.32	LDD2069	[19]
C419 Probe Info	25.63	LDD2074	[19]
C420 Probe Info	17.51	LDD2075	[19]
C422 Probe Info	15.24	LDD2077	[19]
C425 Probe Info	13.55	LDD2080	[19]
C429 Probe Info	13.18	LDD2084	[19]
C431 Probe Info	29.86	LDD2086	[19]
C433 Probe Info	6.82	LDD2088	[19]
FFF probe11 Probe Info	16.89	LDD0471	[20]
FFF probe12 Probe Info	20.00	LDD0473	[20]
FFF probe13 Probe Info	20.00	LDD0475	[20]
FFF probe14 Probe Info	20.00	LDD0477	[20]
FFF probe15 Probe Info	9.67	LDD0478	[20]
FFF probe2 Probe Info	13.79	LDD0463	[20]
FFF probe3 Probe Info	15.12	LDD0464	[20]
FFF probe4 Probe Info	18.01	LDD0466	[20]
FFF probe7 Probe Info	13.12	LDD0483	[20]
FFF probe9 Probe Info	20.00	LDD0470	[20]
JN0003 Probe Info	20.00	LDD0469	[20]
STS-2 Probe Info	N.A.	LDD0139	[21]
OEA-DA Probe Info	17.99	LDD0046	[22]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0214	AC1	HEK-293T	C393(0.73)	LDD0812	[23]
LDCM0215	AC10	PaTu 8988t	C393(0.37)	LDD1094	[23]
LDCM0226	AC11	PaTu 8988t	C393(0.38)	LDD1105	[23]
LDCM0230	AC113	HEK-293T	C393(1.46)	LDD0828	[23]
LDCM0231	AC114	HEK-293T	C393(1.02)	LDD0829	[23]
LDCM0232	AC115	HEK-293T	C393(1.26)	LDD0830	[23]
LDCM0233	AC116	HEK-293T	C393(1.73)	LDD0831	[23]
LDCM0234	AC117	HEK-293T	C393(1.53)	LDD0832	[23]
LDCM0235	AC118	HEK-293T	C393(2.21)	LDD0833	[23]
LDCM0236	AC119	HEK-293T	C393(1.56)	LDD0834	[23]
LDCM0237	AC12	PaTu 8988t	C393(0.42)	LDD1116	[23]
LDCM0238	AC120	HEK-293T	C393(2.15)	LDD0836	[23]
LDCM0239	AC121	HEK-293T	C393(1.84)	LDD0837	[23]
LDCM0240	AC122	HEK-293T	C393(2.47)	LDD0838	[23]
LDCM0241	AC123	HEK-293T	C393(2.24)	LDD0839	[23]
LDCM0242	AC124	HEK-293T	C393(3.09)	LDD0840	[23]
LDCM0243	AC125	HEK-293T	C393(2.26)	LDD0841	[23]
LDCM0244	AC126	HEK-293T	C393(2.88)	LDD0842	[23]
LDCM0245	AC127	HEK-293T	C393(3.09)	LDD0843	[23]
LDCM0259	AC14	PaTu 8988t	C393(1.09)	LDD1138	[23]
LDCM0270	AC15	PaTu 8988t	C393(0.57)	LDD1149	[23]
LDCM0276	AC17	HEK-293T	C393(1.78)	LDD0874	[23]
LDCM0277	AC18	HEK-293T	C393(1.41)	LDD0875	[23]
LDCM0278	AC19	HEK-293T	C393(1.27)	LDD0876	[23]
LDCM0279	AC2	HEK-293T	C393(1.33)	LDD0877	[23]
LDCM0280	AC20	HEK-293T	C393(1.70)	LDD0878	[23]
LDCM0281	AC21	HEK-293T	C393(1.95)	LDD0879	[23]
LDCM0282	AC22	HEK-293T	C393(2.03)	LDD0880	[23]
LDCM0283	AC23	HEK-293T	C393(2.09)	LDD0881	[23]
LDCM0284	AC24	HEK-293T	C393(1.51)	LDD0882	[23]
LDCM0285	AC25	HEK-293T	C426(1.10); C393(0.93)	LDD1524	[24]
LDCM0286	AC26	HEK-293T	C426(1.14); C393(0.92)	LDD1525	[24]
LDCM0287	AC27	HEK-293T	C426(1.48); C393(0.97)	LDD1526	[24]
LDCM0288	AC28	HEK-293T	C426(0.97); C393(1.08)	LDD1527	[24]
LDCM0289	AC29	HEK-293T	C426(1.08); C393(1.08)	LDD1528	[24]
LDCM0290	AC3	HEK-293T	C393(1.03)	LDD0888	[23]
LDCM0291	AC30	HEK-293T	C426(0.83); C393(0.99)	LDD1530	[24]
LDCM0292	AC31	HEK-293T	C426(1.17); C393(1.00)	LDD1531	[24]
LDCM0293	AC32	HEK-293T	C426(1.13); C393(0.96)	LDD1532	[24]
LDCM0294	AC33	HEK-293T	C426(0.97); C393(0.92)	LDD1533	[24]
LDCM0295	AC34	HEK-293T	C426(1.09); C393(1.03)	LDD1534	[24]
LDCM0296	AC35	HEK-293T	C426(1.40); C393(1.00)	LDD1535	[24]
LDCM0297	AC36	HEK-293T	C426(0.94); C393(1.10)	LDD1536	[24]
LDCM0298	AC37	HEK-293T	C426(1.11); C393(1.05)	LDD1537	[24]
LDCM0299	AC38	HEK-293T	C426(0.95); C393(0.92)	LDD1538	[24]
LDCM0300	AC39	HEK-293T	C426(1.15); C393(0.94)	LDD1539	[24]
LDCM0301	AC4	HEK-293T	C393(1.10)	LDD0899	[23]
LDCM0302	AC40	HEK-293T	C426(1.09); C393(0.92)	LDD1541	[24]
LDCM0303	AC41	HEK-293T	C426(0.86); C393(0.95)	LDD1542	[24]
LDCM0304	AC42	HEK-293T	C426(1.03); C393(1.00)	LDD1543	[24]
LDCM0305	AC43	HEK-293T	C426(1.25); C393(1.07)	LDD1544	[24]
LDCM0306	AC44	HEK-293T	C426(1.15); C393(1.08)	LDD1545	[24]
LDCM0307	AC45	HEK-293T	C426(1.17); C393(1.00)	LDD1546	[24]
LDCM0308	AC46	PaTu 8988t	C393(1.01)	LDD1187	[23]
LDCM0309	AC47	PaTu 8988t	C393(0.85)	LDD1188	[23]
LDCM0310	AC48	PaTu 8988t	C393(0.76)	LDD1189	[23]
LDCM0311	AC49	PaTu 8988t	C393(0.38)	LDD1190	[23]
LDCM0312	AC5	HEK-293T	C393(1.29)	LDD0910	[23]
LDCM0313	AC50	PaTu 8988t	C393(0.36)	LDD1192	[23]
LDCM0314	AC51	PaTu 8988t	C393(0.51)	LDD1193	[23]
LDCM0315	AC52	PaTu 8988t	C393(0.55)	LDD1194	[23]
LDCM0316	AC53	PaTu 8988t	C393(0.28)	LDD1195	[23]
LDCM0317	AC54	PaTu 8988t	C393(0.22)	LDD1196	[23]
LDCM0318	AC55	PaTu 8988t	C393(0.86)	LDD1197	[23]
LDCM0319	AC56	PaTu 8988t	C393(1.02)	LDD1198	[23]
LDCM0320	AC57	HEK-293T	C426(0.83); C393(0.94)	LDD1559	[24]
LDCM0321	AC58	HEK-293T	C426(1.07); C393(1.07)	LDD1560	[24]
LDCM0322	AC59	HEK-293T	C426(1.04); C393(0.92)	LDD1561	[24]
LDCM0323	AC6	PaTu 8988t	C393(0.79)	LDD1202	[23]
LDCM0324	AC60	HEK-293T	C426(0.92); C393(1.03)	LDD1563	[24]
LDCM0325	AC61	HEK-293T	C426(1.01); C393(1.05)	LDD1564	[24]
LDCM0326	AC62	HEK-293T	C426(0.92); C393(1.03)	LDD1565	[24]
LDCM0327	AC63	HEK-293T	C426(1.54); C393(1.13)	LDD1566	[24]
LDCM0328	AC64	HEK-293T	C426(1.19); C393(0.98)	LDD1567	[24]
LDCM0332	AC68	HEK-293T	C393(0.94)	LDD0930	[23]
LDCM0333	AC69	HEK-293T	C393(0.93)	LDD0931	[23]
LDCM0334	AC7	PaTu 8988t	C393(0.72)	LDD1213	[23]
LDCM0335	AC70	HEK-293T	C393(1.22)	LDD0933	[23]
LDCM0336	AC71	HEK-293T	C393(1.10)	LDD0934	[23]
LDCM0337	AC72	HEK-293T	C393(1.22)	LDD0935	[23]
LDCM0338	AC73	HEK-293T	C393(1.16)	LDD0936	[23]
LDCM0339	AC74	HEK-293T	C393(0.95)	LDD0937	[23]
LDCM0340	AC75	HEK-293T	C393(1.09)	LDD0938	[23]
LDCM0341	AC76	HEK-293T	C393(1.06)	LDD0939	[23]
LDCM0342	AC77	HEK-293T	C393(1.39)	LDD0940	[23]
LDCM0343	AC78	HEK-293T	C393(1.17)	LDD0941	[23]
LDCM0344	AC79	HEK-293T	C393(1.06)	LDD0942	[23]
LDCM0345	AC8	PaTu 8988t	C393(0.92)	LDD1224	[23]
LDCM0346	AC80	HEK-293T	C393(1.35)	LDD0944	[23]
LDCM0347	AC81	HEK-293T	C393(1.30)	LDD0945	[23]
LDCM0348	AC82	HEK-293T	C393(1.87)	LDD0946	[23]
LDCM0248	AKOS034007472	PaTu 8988t	C393(1.18)	LDD1127	[23]
LDCM0356	AKOS034007680	PaTu 8988t	C393(0.24)	LDD1235	[23]
LDCM0275	AKOS034007705	PaTu 8988t	C393(0.30)	LDD1154	[23]
LDCM0088	C45	HEK-293T	20.00	LDD0201	[8]
LDCM0108	Chloroacetamide	HeLa	N.A.	LDD0222	[16]
LDCM0367	CL1	HEK-293T	C426(1.11); C393(1.00)	LDD1571	[24]
LDCM0368	CL10	HEK-293T	C426(1.06); C393(1.14)	LDD1572	[24]
LDCM0369	CL100	HEK-293T	C393(1.74)	LDD0967	[23]
LDCM0370	CL101	PaTu 8988t	C393(0.55)	LDD1249	[23]
LDCM0371	CL102	PaTu 8988t	C393(0.47)	LDD1250	[23]
LDCM0372	CL103	PaTu 8988t	C393(0.47)	LDD1251	[23]
LDCM0373	CL104	PaTu 8988t	C393(0.46)	LDD1252	[23]
LDCM0374	CL105	HEK-293T	C393(1.38)	LDD0972	[23]
LDCM0375	CL106	HEK-293T	C393(1.31)	LDD0973	[23]
LDCM0376	CL107	HEK-293T	C393(1.14)	LDD0974	[23]
LDCM0377	CL108	HEK-293T	C393(1.21)	LDD0975	[23]
LDCM0378	CL109	HEK-293T	C393(1.26)	LDD0976	[23]
LDCM0379	CL11	HEK-293T	C426(1.17); C393(1.31)	LDD1583	[24]
LDCM0380	CL110	HEK-293T	C393(1.23)	LDD0978	[23]
LDCM0381	CL111	HEK-293T	C393(1.23)	LDD0979	[23]
LDCM0382	CL112	HEK-293T	C426(1.29); C393(1.01)	LDD1586	[24]
LDCM0383	CL113	HEK-293T	C426(0.90); C393(0.97)	LDD1587	[24]
LDCM0384	CL114	HEK-293T	C195(0.76); C393(0.91)	LDD1588	[24]
LDCM0385	CL115	HEK-293T	C426(1.16); C195(0.93); C393(0.99)	LDD1589	[24]
LDCM0386	CL116	HEK-293T	C426(1.30); C393(0.99)	LDD1590	[24]
LDCM0387	CL117	HEK-293T	C426(0.89); C393(0.96)	LDD1591	[24]
LDCM0388	CL118	HEK-293T	C195(0.91); C393(0.90)	LDD1592	[24]
LDCM0389	CL119	HEK-293T	C426(1.08); C195(1.34); C393(1.06)	LDD1593	[24]
LDCM0390	CL12	HEK-293T	C426(0.93); C393(1.04)	LDD1594	[24]
LDCM0391	CL120	HEK-293T	C426(1.15); C393(0.94)	LDD1595	[24]
LDCM0392	CL121	PaTu 8988t	C393(0.76)	LDD1271	[23]
LDCM0393	CL122	PaTu 8988t	C393(0.75)	LDD1272	[23]
LDCM0394	CL123	PaTu 8988t	C393(0.46)	LDD1273	[23]
LDCM0395	CL124	PaTu 8988t	C393(0.46)	LDD1274	[23]
LDCM0396	CL125	HEK-293T	C426(0.98); C393(1.02)	LDD1600	[24]
LDCM0397	CL126	HEK-293T	C195(0.82); C393(0.92)	LDD1601	[24]
LDCM0398	CL127	HEK-293T	C426(1.08); C195(0.96); C393(1.07)	LDD1602	[24]
LDCM0399	CL128	HEK-293T	C426(1.21); C393(0.99)	LDD1603	[24]
LDCM0400	CL13	HEK-293T	C426(0.90); C393(0.94)	LDD1604	[24]
LDCM0401	CL14	HEK-293T	C195(0.96); C393(0.93)	LDD1605	[24]
LDCM0402	CL15	HEK-293T	C426(0.87); C195(1.03); C393(1.18)	LDD1606	[24]
LDCM0403	CL16	HEK-293T	C393(0.72)	LDD1001	[23]
LDCM0404	CL17	HEK-293T	C393(0.79)	LDD1002	[23]
LDCM0405	CL18	HEK-293T	C393(1.07)	LDD1003	[23]
LDCM0406	CL19	HEK-293T	C393(0.97)	LDD1004	[23]
LDCM0407	CL2	HEK-293T	C195(1.27); C393(1.03)	LDD1611	[24]
LDCM0408	CL20	HEK-293T	C393(0.98)	LDD1006	[23]
LDCM0409	CL21	HEK-293T	C393(1.22)	LDD1007	[23]
LDCM0410	CL22	HEK-293T	C393(1.01)	LDD1008	[23]
LDCM0411	CL23	HEK-293T	C393(0.81)	LDD1009	[23]
LDCM0412	CL24	HEK-293T	C393(0.82)	LDD1010	[23]
LDCM0413	CL25	HEK-293T	C393(0.86)	LDD1011	[23]
LDCM0414	CL26	HEK-293T	C393(1.10)	LDD1012	[23]
LDCM0415	CL27	HEK-293T	C393(0.91)	LDD1013	[23]
LDCM0416	CL28	HEK-293T	C393(0.72)	LDD1014	[23]
LDCM0417	CL29	HEK-293T	C393(0.88)	LDD1015	[23]
LDCM0418	CL3	HEK-293T	C426(1.16); C195(1.27); C393(1.10)	LDD1622	[24]
LDCM0419	CL30	HEK-293T	C393(2.00)	LDD1017	[23]
LDCM0420	CL31	PaTu 8988t	C393(0.90)	LDD1299	[23]
LDCM0421	CL32	PaTu 8988t	C393(0.97)	LDD1300	[23]
LDCM0422	CL33	PaTu 8988t	C393(0.77)	LDD1301	[23]
LDCM0423	CL34	PaTu 8988t	C393(0.95)	LDD1302	[23]
LDCM0424	CL35	PaTu 8988t	C393(0.68)	LDD1303	[23]
LDCM0425	CL36	PaTu 8988t	C393(1.36)	LDD1304	[23]
LDCM0426	CL37	PaTu 8988t	C393(0.60)	LDD1305	[23]
LDCM0428	CL39	PaTu 8988t	C393(1.38)	LDD1307	[23]
LDCM0429	CL4	HEK-293T	C426(1.30); C393(1.03)	LDD1633	[24]
LDCM0430	CL40	PaTu 8988t	C393(1.04)	LDD1309	[23]
LDCM0431	CL41	PaTu 8988t	C393(0.57)	LDD1310	[23]
LDCM0432	CL42	PaTu 8988t	C393(0.47)	LDD1311	[23]
LDCM0433	CL43	PaTu 8988t	C393(0.59)	LDD1312	[23]
LDCM0434	CL44	PaTu 8988t	C393(0.62)	LDD1313	[23]
LDCM0435	CL45	PaTu 8988t	C393(1.11)	LDD1314	[23]
LDCM0436	CL46	HEK-293T	C426(1.13); C393(1.03)	LDD1640	[24]
LDCM0437	CL47	HEK-293T	C426(1.16); C393(1.17)	LDD1641	[24]
LDCM0438	CL48	HEK-293T	C426(1.01); C393(0.92)	LDD1642	[24]
LDCM0439	CL49	HEK-293T	C426(0.96); C393(0.92)	LDD1643	[24]
LDCM0440	CL5	HEK-293T	C426(0.94); C393(1.02)	LDD1644	[24]
LDCM0441	CL50	HEK-293T	C195(1.33); C393(0.96)	LDD1645	[24]
LDCM0443	CL52	HEK-293T	C426(1.25); C393(1.02)	LDD1646	[24]
LDCM0444	CL53	HEK-293T	C426(0.83); C393(0.85)	LDD1647	[24]
LDCM0445	CL54	HEK-293T	C426(1.09); C393(1.01)	LDD1648	[24]
LDCM0446	CL55	HEK-293T	C426(0.94); C393(1.06)	LDD1649	[24]
LDCM0447	CL56	HEK-293T	C426(1.04); C393(1.18)	LDD1650	[24]
LDCM0448	CL57	HEK-293T	C426(0.99); C393(1.13)	LDD1651	[24]
LDCM0449	CL58	HEK-293T	C426(1.01); C393(1.04)	LDD1652	[24]
LDCM0450	CL59	HEK-293T	C426(0.88); C393(1.20)	LDD1653	[24]
LDCM0451	CL6	HEK-293T	C426(1.07); C393(1.08)	LDD1654	[24]
LDCM0452	CL60	HEK-293T	C426(0.87); C393(1.09)	LDD1655	[24]
LDCM0453	CL61	HEK-293T	C426(0.88); C393(1.02)	LDD1656	[24]
LDCM0454	CL62	HEK-293T	C195(0.44); C393(0.96)	LDD1657	[24]
LDCM0455	CL63	HEK-293T	C426(1.07); C195(1.54); C393(1.03)	LDD1658	[24]
LDCM0456	CL64	HEK-293T	C426(1.08); C393(0.95)	LDD1659	[24]
LDCM0457	CL65	HEK-293T	C426(0.83); C393(0.88)	LDD1660	[24]
LDCM0458	CL66	HEK-293T	C426(1.02); C393(1.08)	LDD1661	[24]
LDCM0459	CL67	HEK-293T	C426(0.88); C393(0.94)	LDD1662	[24]
LDCM0460	CL68	HEK-293T	C426(0.91); C393(1.21)	LDD1663	[24]
LDCM0461	CL69	HEK-293T	C426(1.04); C393(1.09)	LDD1664	[24]
LDCM0462	CL7	HEK-293T	C426(1.13); C393(0.95)	LDD1665	[24]
LDCM0463	CL70	HEK-293T	C426(1.01); C393(1.01)	LDD1666	[24]
LDCM0464	CL71	HEK-293T	C426(1.17); C393(1.02)	LDD1667	[24]
LDCM0465	CL72	HEK-293T	C426(1.20); C393(0.98)	LDD1668	[24]
LDCM0466	CL73	HEK-293T	C426(0.99); C393(0.94)	LDD1669	[24]
LDCM0467	CL74	HEK-293T	C195(0.70); C393(1.01)	LDD1670	[24]
LDCM0469	CL76	HEK-293T	C426(1.14); C393(0.94)	LDD1672	[24]
LDCM0470	CL77	HEK-293T	C426(0.71); C393(0.95)	LDD1673	[24]
LDCM0471	CL78	HEK-293T	C426(1.00); C393(0.95)	LDD1674	[24]
LDCM0472	CL79	HEK-293T	C426(1.05); C393(1.01)	LDD1675	[24]
LDCM0473	CL8	HEK-293T	C426(0.90); C393(1.33)	LDD1676	[24]
LDCM0474	CL80	HEK-293T	C426(0.90); C393(1.06)	LDD1677	[24]
LDCM0475	CL81	HEK-293T	C426(1.09); C393(1.06)	LDD1678	[24]
LDCM0476	CL82	HEK-293T	C426(0.87); C393(0.97)	LDD1679	[24]
LDCM0477	CL83	HEK-293T	C426(1.12); C393(1.03)	LDD1680	[24]
LDCM0478	CL84	HEK-293T	C426(0.90); C393(0.92)	LDD1681	[24]
LDCM0479	CL85	HEK-293T	C426(0.94); C393(1.02)	LDD1682	[24]
LDCM0480	CL86	HEK-293T	C195(0.99); C393(1.12)	LDD1683	[24]
LDCM0481	CL87	HEK-293T	C426(1.35); C195(1.01); C393(1.00)	LDD1684	[24]
LDCM0482	CL88	HEK-293T	C426(1.47); C393(0.97)	LDD1685	[24]
LDCM0483	CL89	HEK-293T	C426(0.98); C393(1.03)	LDD1686	[24]
LDCM0484	CL9	HEK-293T	C426(1.26); C393(1.08)	LDD1687	[24]
LDCM0485	CL90	HEK-293T	C426(1.08); C393(1.06)	LDD1688	[24]
LDCM0486	CL91	HEK-293T	C393(1.15)	LDD1084	[23]
LDCM0487	CL92	HEK-293T	C393(1.49)	LDD1085	[23]
LDCM0488	CL93	HEK-293T	C393(1.10)	LDD1086	[23]
LDCM0489	CL94	HEK-293T	C393(1.65)	LDD1087	[23]
LDCM0490	CL95	HEK-293T	C393(2.03)	LDD1088	[23]
LDCM0491	CL96	HEK-293T	C393(1.18)	LDD1089	[23]
LDCM0492	CL97	HEK-293T	C393(1.21)	LDD1090	[23]
LDCM0493	CL98	HEK-293T	C393(1.59)	LDD1091	[23]
LDCM0494	CL99	HEK-293T	C393(1.59)	LDD1092	[23]
LDCM0189	Compound 16	HEK-293T	34.43	LDD0492	[20]
LDCM0185	Compound 17	HEK-293T	5.39	LDD0504	[20]
LDCM0184	Compound 20	HEK-293T	14.39	LDD0503	[20]
LDCM0191	Compound 21	HEK-293T	5.60	LDD0493	[20]
LDCM0186	Compound 31	HEK-293T	9.13	LDD0506	[20]
LDCM0187	Compound 32	HEK-293T	52.63	LDD0507	[20]
LDCM0188	Compound 33	HEK-293T	8.26	LDD0505	[20]
LDCM0190	Compound 34	HEK-293T	32.02	LDD0497	[20]
LDCM0193	Compound 36	HEK-293T	4.65	LDD0494	[20]
LDCM0194	Compound 37	HEK-293T	10.35	LDD0498	[20]
LDCM0196	Compound 39	HEK-293T	6.12	LDD0496	[20]
LDCM0495	E2913	HEK-293T	C426(1.34); C195(0.98); C393(1.09)	LDD1698	[24]
LDCM0468	Fragment33	HEK-293T	C426(1.24); C195(1.13); C393(1.09)	LDD1671	[24]
LDCM0427	Fragment51	PaTu 8988t	C393(1.00)	LDD1306	[23]
LDCM0107	IAA	HeLa	N.A.	LDD0221	[16]
LDCM0022	KB02	HEK-293T	C393(1.09)	LDD1492	[24]
LDCM0023	KB03	HEK-293T	C393(1.05)	LDD1497	[24]
LDCM0024	KB05	HMCB	C426(1.11); C393(1.75)	LDD3312	[9]
LDCM0109	NEM	HeLa	N.A.	LDD0225	[16]
LDCM0099	Phenelzine	HEK-293T	3.00	LDD0386	[1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel

Click To Hide/Show 3 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
High affinity cationic amino acid transporter 1 (SLC7A1)	Cationic amino acid transporter (CAT) (TC 2.A.3.3) family	P30825
Sodium-dependent organic anion transporter (SLC10A6)	Bile acid:sodium symporter (BASS) family	Q3KNW5
Proton-coupled zinc antiporter SLC30A2 (SLC30A2)	Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	Q9BRI3

Other

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Golgi membrane protein 1 (GOLM1)				GOLM family	Q8NBJ4

The Drug(s) Related To This Target

Approved

Click To Hide/Show 1 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Lactose				Small molecular drug	DB04465

Preclinical

Click To Hide/Show 2 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
5n,6s-(N'-butyliminomethylidene)-6-thio-1-deoxygalactonojirimycin				Small molecular drug	D2DLN9
N-octyl-4-epi-beta-valienamine				Small molecular drug	DBJ5Z0

References

1	Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2	Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1. Mass spectrometry data entry: PXD018580
3	Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4	Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5	A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10. Mass spectrometry data entry: PXD028270
6	Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
7	An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8	Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
9	DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22. Mass spectrometry data entry: PXD047840
10	Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
11	Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23. Mass spectrometry data entry: PXD028853
12	SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18. Mass spectrometry data entry*: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13	A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21. Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14	Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022. Mass spectrometry data entry: PXD039931
15	Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. Mass spectrometry data entry: PXD029255
16	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17	N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w. Mass spectrometry data entry: PXD041264
18	Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
19	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
20	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21	Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
22	Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20. Mass spectrometry data entry: PXD007570
23	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
24	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402

Details of the Target

Citation

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Correspondence

Prof. Feng Zhu

Prof. Feng Ni