Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name	C068			Probe Info
Probe concentration	Probe:50uM; negative probe:50uM
Criteria	Quantification: AfBPP Probe vs Negative Probe
Quantitative Method	TMT
*In Vivo* Experiment Model**	Model Type		Living cell
	Derived Tissue		Peripheral blood
	Disease Model	Normal
	Model Name	Human normal cells (HEK-293T)
Note	Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme

Click to Show/Hide to Show 6 Protein Related to This Bioclass

Target ID	Target Name	Binding Ratio
LDTP10188	FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1)	15.2
LDTP01389	Delta(14)-sterol reductase TM7SF2 (TM7SF2)	7.8
LDTP11273	N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1)	7.6
LDTP06618	ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP)	6.6
LDTP02837	Beta-galactosidase (GLB1)	5.6
LDTP06200	Delta(14)-sterol reductase LBR (LBR)	4.9

Transporter and channel

Click to Show/Hide to Show 3 Protein Related to This Bioclass

Target ID	Target Name	Binding Ratio
LDTP00865	Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20)	6.2
LDTP01059	Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B)	6.1
LDTP06945	Sigma intracellular receptor 2 (TMEM97)	5.2

Other

Click to Show/Hide to Show 2 Protein Related to This Bioclass

Target ID	Target Name					Binding Ratio
LDTP09297	Large ribosomal subunit protein mL64 (GADD45GIP1)					7.1
LDTP13755	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2)					5.0

References

1	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587