Details of the Target

General Information of Target

Target ID	LDTP11273
Target Name	N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1)
Gene Name	NTMT1
Gene ID	28989
Synonyms	C9orf32; METTL11A; NRMT; NRMT1; N-terminal Xaa-Pro-Lys N-methyltransferase 1; EC 2.1.1.244; Alpha N-terminal protein methyltransferase 1A; Methyltransferase-like protein 11A; N-terminal RCC1 methyltransferase; X-Pro-Lys N-terminal protein methyltransferase 1A; NTM1A) [Cleaved into: N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed]
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MAAVVAKREGPPFISEAAVRGNAAVLDYCRTSVSALSGATAGILGLTGLYGFIFYLLASV LLSLLLILKAGRRWNKYFKSRRPLFTGGLIGGLFTYVLFWTFLYGMVHVY
Target Bioclass	Enzyme
Family	Methyltransferase superfamily, NTM1 family
Subcellular location	Nucleus
Function	Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.
Uniprot ID	Q9BV86
Ensemble ID	ENST00000372480.1
HGNC ID	HGNC:23373
ChEMBL ID	CHEMBL4523442

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
G415	SNV: p.L199F	.
HSC4	SNV: p.Q144P	.
NCIH1155	SNV: p.P211S	DBIA Probe Info
RD	SNV: p.Q144H	.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 30 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
m-APA Probe Info	15.00	LDD0402	[1]
TH211 Probe Info	Y34(15.41); Y215(12.80); Y103(12.12)	LDD0257	[2]
Probe 1 Probe Info	Y103(27.36)	LDD3495	[3]
THZ1-DTB Probe Info	C184(1.16); C64(1.11)	LDD0460	[4]
BTD Probe Info	C64(1.18)	LDD2090	[5]
AHL-Pu-1 Probe Info	C195(2.42)	LDD0169	[6]
EA-probe Probe Info	C195(0.89)	LDD2210	[7]
HHS-482 Probe Info	Y103(1.17)	LDD0285	[8]
HHS-475 Probe Info	Y103(0.72)	LDD0264	[9]
HHS-465 Probe Info	Y103(8.65)	LDD2237	[10]
DBIA Probe Info	C195(1.11); C64(0.88); C68(0.88)	LDD0078	[11]
5E-2FA Probe Info	N.A.	LDD2235	[12]
ATP probe Probe Info	N.A.	LDD0199	[13]
4-Iodoacetamidophenylacetylene Probe Info	C184(0.00); C195(0.00)	LDD0038	[14]
IA-alkyne Probe Info	N.A.	LDD0032	[15]
Lodoacetamide azide Probe Info	C184(0.00); C195(0.00)	LDD0037	[14]
Dyn-2 Probe Info	N.A.	LDD0013	[16]
JW-RF-010 Probe Info	C64(0.00); C68(0.00)	LDD0026	[17]
NAIA_4 Probe Info	N.A.	LDD2226	[18]
TFBX Probe Info	C68(0.00); C64(0.00)	LDD0027	[17]
WYneN Probe Info	C64(0.00); C68(0.00); C195(0.00)	LDD0021	[16]
WYneO Probe Info	N.A.	LDD0022	[16]
aHNE Probe Info	N.A.	LDD0001	[16]
IPM Probe Info	N.A.	LDD0005	[16]
SF Probe Info	Y103(0.00); Y13(0.00)	LDD0028	[19]
Phosphinate-6 Probe Info	N.A.	LDD0018	[20]
Acrolein Probe Info	N.A.	LDD0217	[21]
Methacrolein Probe Info	C184(0.00); C64(0.00); C68(0.00)	LDD0218	[21]
AOyne Probe Info	15.00	LDD0443	[22]
NAIA_5 Probe Info	C184(0.00); C195(0.00); C68(0.00); C64(0.00)	LDD2223	[18]

PAL-AfBPP Probe

Click To Hide/Show 101 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
C010 Probe Info	5.13	LDD1719	[23]
C017 Probe Info	7.01	LDD1725	[23]
C022 Probe Info	32.22	LDD1728	[23]
C023 Probe Info	6.82	LDD1729	[23]
C041 Probe Info	34.54	LDD1741	[23]
C044 Probe Info	7.41	LDD1743	[23]
C055 Probe Info	99.73	LDD1752	[23]
C056 Probe Info	22.16	LDD1753	[23]
C064 Probe Info	11.79	LDD1761	[23]
C068 Probe Info	7.57	LDD1764	[23]
C085 Probe Info	4.92	LDD1777	[23]
C091 Probe Info	34.06	LDD1782	[23]
C107 Probe Info	14.93	LDD1794	[23]
C112 Probe Info	23.10	LDD1799	[23]
C129 Probe Info	9.65	LDD1811	[23]
C130 Probe Info	7.26	LDD1812	[23]
C139 Probe Info	22.47	LDD1821	[23]
C140 Probe Info	7.94	LDD1822	[23]
C153 Probe Info	31.34	LDD1834	[23]
C156 Probe Info	8.46	LDD1836	[23]
C159 Probe Info	11.08	LDD1839	[23]
C160 Probe Info	8.75	LDD1840	[23]
C161 Probe Info	15.56	LDD1841	[23]
C163 Probe Info	6.87	LDD1843	[23]
C169 Probe Info	42.52	LDD1849	[23]
C170 Probe Info	7.46	LDD1850	[23]
C173 Probe Info	6.23	LDD1853	[23]
C183 Probe Info	8.11	LDD1861	[23]
C185 Probe Info	8.40	LDD1863	[23]
C194 Probe Info	13.36	LDD1870	[23]
C198 Probe Info	13.09	LDD1874	[23]
C201 Probe Info	36.76	LDD1877	[23]
C211 Probe Info	85.04	LDD1885	[23]
C212 Probe Info	6.41	LDD1886	[23]
C216 Probe Info	9.38	LDD1890	[23]
C219 Probe Info	7.16	LDD1893	[23]
C220 Probe Info	34.06	LDD1894	[23]
C225 Probe Info	16.34	LDD1898	[23]
C227 Probe Info	4.96	LDD1900	[23]
C228 Probe Info	30.91	LDD1901	[23]
C231 Probe Info	14.72	LDD1904	[23]
C233 Probe Info	67.65	LDD1906	[23]
C238 Probe Info	12.30	LDD1911	[23]
C240 Probe Info	11.96	LDD1913	[23]
C243 Probe Info	13.45	LDD1916	[23]
C244 Probe Info	15.24	LDD1917	[23]
C245 Probe Info	5.10	LDD1918	[23]
C246 Probe Info	25.46	LDD1919	[23]
C249 Probe Info	17.88	LDD1922	[23]
C260 Probe Info	14.32	LDD1932	[23]
C265 Probe Info	25.99	LDD1936	[23]
C277 Probe Info	9.51	LDD1947	[23]
C282 Probe Info	21.56	LDD1952	[23]
C285 Probe Info	22.16	LDD1955	[23]
C288 Probe Info	40.50	LDD1958	[23]
C289 Probe Info	26.35	LDD1959	[23]
C290 Probe Info	13.27	LDD1960	[23]
C292 Probe Info	31.56	LDD1962	[23]
C293 Probe Info	18.51	LDD1963	[23]
C296 Probe Info	14.22	LDD1966	[23]
C297 Probe Info	9.32	LDD1967	[23]
C299 Probe Info	6.02	LDD1968	[23]
C305 Probe Info	12.82	LDD1974	[23]
C307 Probe Info	4.96	LDD1975	[23]
C310 Probe Info	13.45	LDD1977	[23]
C313 Probe Info	18.51	LDD1980	[23]
C314 Probe Info	12.13	LDD1981	[23]
C316 Probe Info	9.00	LDD1982	[23]
C317 Probe Info	5.94	LDD1983	[23]
C333 Probe Info	14.62	LDD1996	[23]
C337 Probe Info	6.63	LDD2000	[23]
C340 Probe Info	5.50	LDD2003	[23]
C342 Probe Info	14.93	LDD2004	[23]
C343 Probe Info	18.64	LDD2005	[23]
C346 Probe Info	17.15	LDD2007	[23]
C348 Probe Info	19.84	LDD2009	[23]
C349 Probe Info	17.03	LDD2010	[23]
C350 Probe Info	29.45	LDD2011	[23]
C353 Probe Info	22.01	LDD2014	[23]
C360 Probe Info	12.64	LDD2021	[23]
C364 Probe Info	15.03	LDD2025	[23]
C376 Probe Info	8.40	LDD2036	[23]
C378 Probe Info	6.28	LDD2037	[23]
C380 Probe Info	9.71	LDD2039	[23]
C382 Probe Info	33.36	LDD2041	[23]
C383 Probe Info	14.03	LDD2042	[23]
C385 Probe Info	6.41	LDD2044	[23]
C386 Probe Info	31.12	LDD2045	[23]
C399 Probe Info	6.68	LDD2058	[23]
C403 Probe Info	23.59	LDD2061	[23]
C408 Probe Info	7.84	LDD2065	[23]
C409 Probe Info	7.21	LDD2066	[23]
C413 Probe Info	66.72	LDD2069	[23]
C414 Probe Info	13.83	LDD2070	[23]
C419 Probe Info	13.64	LDD2074	[23]
C422 Probe Info	11.71	LDD2077	[23]
C424 Probe Info	15.35	LDD2079	[23]
C429 Probe Info	23.92	LDD2084	[23]
C431 Probe Info	14.83	LDD2086	[23]
FFF probe13 Probe Info	20.00	LDD0475	[24]
FFF probe3 Probe Info	6.01	LDD0465	[24]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0502	1-(Cyanoacetyl)piperidine	MDA-MB-231	C64(0.99)	LDD2095	[5]
LDCM0026	4SU-RNA+native RNA	HEK-293T	C195(2.42)	LDD0169	[6]
LDCM0214	AC1	HCT 116	C184(0.54); C195(1.14); C64(0.84); C68(0.89)	LDD0531	[11]
LDCM0215	AC10	HCT 116	C184(1.09); C195(1.15); C64(1.32); C68(1.04)	LDD0532	[11]
LDCM0216	AC100	HCT 116	C184(0.63); C195(1.15); C64(0.35); C68(0.32)	LDD0533	[11]
LDCM0217	AC101	HCT 116	C184(0.68); C195(1.03); C64(0.45); C68(0.43)	LDD0534	[11]
LDCM0218	AC102	HCT 116	C184(0.69); C195(1.15); C64(0.41); C68(0.44)	LDD0535	[11]
LDCM0219	AC103	HCT 116	C184(0.58); C195(1.49); C64(0.26); C68(0.23)	LDD0536	[11]
LDCM0220	AC104	HCT 116	C184(0.54); C195(1.16); C64(0.42); C68(0.44)	LDD0537	[11]
LDCM0221	AC105	HCT 116	C184(0.59); C195(1.23); C64(0.34); C68(0.29)	LDD0538	[11]
LDCM0222	AC106	HCT 116	C184(0.65); C195(1.24); C64(0.28); C68(0.27)	LDD0539	[11]
LDCM0223	AC107	HCT 116	C184(0.64); C195(1.13); C64(0.33); C68(0.29)	LDD0540	[11]
LDCM0224	AC108	HCT 116	C184(0.71); C195(1.16); C64(0.45); C68(0.42)	LDD0541	[11]
LDCM0225	AC109	HCT 116	C184(0.62); C195(1.08); C64(0.56); C68(0.60)	LDD0542	[11]
LDCM0226	AC11	HCT 116	C184(1.10); C195(1.32); C64(1.39); C68(1.00)	LDD0543	[11]
LDCM0227	AC110	HCT 116	C184(0.67); C195(1.19); C64(0.34); C68(0.32)	LDD0544	[11]
LDCM0228	AC111	HCT 116	C184(0.63); C195(1.24); C64(0.39); C68(0.38)	LDD0545	[11]
LDCM0229	AC112	HCT 116	C184(0.57); C195(1.39); C64(0.22); C68(0.21)	LDD0546	[11]
LDCM0230	AC113	HCT 116	C184(0.88); C195(0.76); C64(1.16); C68(1.16)	LDD0547	[11]
LDCM0231	AC114	HCT 116	C184(0.64); C195(1.02); C64(1.04); C68(0.99)	LDD0548	[11]
LDCM0232	AC115	HCT 116	C184(0.48); C195(1.31); C64(0.94); C68(0.96)	LDD0549	[11]
LDCM0233	AC116	HCT 116	C184(0.50); C195(1.16); C64(1.04); C68(1.00)	LDD0550	[11]
LDCM0234	AC117	HCT 116	C184(0.70); C195(1.09); C64(1.07); C68(1.00)	LDD0551	[11]
LDCM0235	AC118	HCT 116	C184(0.76); C195(0.94); C64(1.20); C68(1.17)	LDD0552	[11]
LDCM0236	AC119	HCT 116	C184(0.67); C195(1.10); C64(1.06); C68(1.04)	LDD0553	[11]
LDCM0237	AC12	HCT 116	C184(1.26); C195(1.10); C64(1.60); C68(1.16)	LDD0554	[11]
LDCM0238	AC120	HCT 116	C184(0.55); C195(1.07); C64(1.13); C68(1.08)	LDD0555	[11]
LDCM0239	AC121	HCT 116	C184(0.88); C195(0.83); C64(1.23); C68(1.36)	LDD0556	[11]
LDCM0240	AC122	HCT 116	C184(0.88); C195(1.04); C64(1.17); C68(1.15)	LDD0557	[11]
LDCM0241	AC123	HCT 116	C184(1.01); C195(0.79); C64(1.23); C68(1.38)	LDD0558	[11]
LDCM0242	AC124	HCT 116	C184(0.86); C195(0.78); C64(1.27); C68(1.27)	LDD0559	[11]
LDCM0243	AC125	HCT 116	C184(0.84); C195(1.31); C64(1.26); C68(1.44)	LDD0560	[11]
LDCM0244	AC126	HCT 116	C184(0.50); C195(1.17); C64(1.33); C68(1.50)	LDD0561	[11]
LDCM0245	AC127	HCT 116	C184(0.58); C195(1.12); C64(1.37); C68(1.46)	LDD0562	[11]
LDCM0246	AC128	HCT 116	C184(1.06); C195(1.04); C64(1.39); C68(1.24)	LDD0563	[11]
LDCM0247	AC129	HCT 116	C184(1.41); C195(1.06); C64(1.52); C68(1.29)	LDD0564	[11]
LDCM0249	AC130	HCT 116	C184(1.15); C195(0.99); C64(1.17); C68(0.95)	LDD0566	[11]
LDCM0250	AC131	HCT 116	C184(1.30); C195(1.09); C64(1.04); C68(0.86)	LDD0567	[11]
LDCM0251	AC132	HCT 116	C184(1.28); C195(1.34); C64(0.99); C68(0.68)	LDD0568	[11]
LDCM0252	AC133	HCT 116	C184(1.14); C195(1.16); C64(1.26); C68(0.86)	LDD0569	[11]
LDCM0253	AC134	HCT 116	C184(0.94); C195(1.47); C64(0.72); C68(0.45)	LDD0570	[11]
LDCM0254	AC135	HCT 116	C184(1.01); C195(1.11); C64(0.72); C68(0.54)	LDD0571	[11]
LDCM0255	AC136	HCT 116	C184(0.86); C195(1.48); C64(0.70); C68(0.49)	LDD0572	[11]
LDCM0256	AC137	HCT 116	C184(0.92); C195(1.15); C64(0.59); C68(0.42)	LDD0573	[11]
LDCM0257	AC138	HCT 116	C184(0.83); C195(1.56); C64(0.41); C68(0.25)	LDD0574	[11]
LDCM0258	AC139	HCT 116	C184(0.88); C195(1.87); C64(0.41); C68(0.28)	LDD0575	[11]
LDCM0259	AC14	HCT 116	C184(0.85); C195(1.26); C64(1.32); C68(1.01)	LDD0576	[11]
LDCM0260	AC140	HCT 116	C184(0.82); C195(1.93); C64(0.50); C68(0.23)	LDD0577	[11]
LDCM0261	AC141	HCT 116	C184(0.91); C195(2.11); C64(0.42); C68(0.23)	LDD0578	[11]
LDCM0262	AC142	HCT 116	C184(1.33); C195(1.29); C64(0.62); C68(0.49)	LDD0579	[11]
LDCM0263	AC143	HCT 116	C68(0.64); C64(0.76); C195(1.10); C184(1.11)	LDD0580	[11]
LDCM0264	AC144	HCT 116	C184(0.68); C195(0.70); C64(0.80); C68(0.96)	LDD0581	[11]
LDCM0265	AC145	HCT 116	C195(0.67); C184(0.83); C68(0.92); C64(0.97)	LDD0582	[11]
LDCM0266	AC146	HCT 116	C68(0.57); C195(0.61); C184(0.66); C64(0.79)	LDD0583	[11]
LDCM0267	AC147	HCT 116	C184(0.76); C64(0.79); C195(0.86); C68(1.01)	LDD0584	[11]
LDCM0268	AC148	HCT 116	C195(0.58); C184(0.65); C68(0.73); C64(0.81)	LDD0585	[11]
LDCM0269	AC149	HCT 116	C68(0.59); C195(0.59); C184(0.65); C64(0.81)	LDD0586	[11]
LDCM0270	AC15	HCT 116	C184(0.76); C68(1.02); C64(1.33); C195(1.36)	LDD0587	[11]
LDCM0271	AC150	HCT 116	C68(0.77); C184(0.80); C195(0.87); C64(0.95)	LDD0588	[11]
LDCM0272	AC151	HCT 116	C68(0.71); C184(0.76); C64(0.81); C195(0.88)	LDD0589	[11]
LDCM0273	AC152	HCT 116	C195(0.56); C184(0.62); C64(0.68); C68(0.80)	LDD0590	[11]
LDCM0274	AC153	HCT 116	C195(0.48); C68(0.57); C184(0.60); C64(0.78)	LDD0591	[11]
LDCM0621	AC154	HCT 116	C184(0.78); C195(0.74); C64(0.84); C68(0.71)	LDD2158	[11]
LDCM0622	AC155	HCT 116	C184(0.67); C195(0.59); C64(0.74); C68(0.68)	LDD2159	[11]
LDCM0623	AC156	HCT 116	C184(0.86); C195(0.72); C64(0.96); C68(0.70)	LDD2160	[11]
LDCM0624	AC157	HCT 116	C184(0.90); C195(0.94); C64(0.88); C68(0.63)	LDD2161	[11]
LDCM0276	AC17	HCT 116	C68(0.83); C64(0.85); C184(0.95); C195(1.18)	LDD0593	[11]
LDCM0277	AC18	HCT 116	C184(0.66); C64(0.70); C68(0.80); C195(1.39)	LDD0594	[11]
LDCM0278	AC19	HCT 116	C68(0.86); C64(0.87); C184(0.88); C195(1.34)	LDD0595	[11]
LDCM0279	AC2	HCT 116	C184(0.63); C64(0.84); C68(0.89); C195(1.18)	LDD0596	[11]
LDCM0280	AC20	HCT 116	C68(0.80); C64(0.86); C184(0.96); C195(1.43)	LDD0597	[11]
LDCM0281	AC21	HCT 116	C64(0.70); C184(0.80); C68(0.81); C195(1.30)	LDD0598	[11]
LDCM0282	AC22	HCT 116	C68(0.89); C184(0.98); C64(1.04); C195(1.16)	LDD0599	[11]
LDCM0283	AC23	HCT 116	C68(0.90); C64(0.90); C184(0.91); C195(1.35)	LDD0600	[11]
LDCM0284	AC24	HCT 116	C68(0.89); C64(0.99); C184(1.11); C195(1.37)	LDD0601	[11]
LDCM0285	AC25	HCT 116	C64(1.07); C184(1.07); C195(1.10); C68(1.18)	LDD0602	[11]
LDCM0286	AC26	HCT 116	C184(0.82); C68(0.89); C64(0.91); C195(1.36)	LDD0603	[11]
LDCM0287	AC27	HCT 116	C184(0.77); C68(0.84); C64(0.91); C195(1.55)	LDD0604	[11]
LDCM0288	AC28	HCT 116	C184(0.78); C68(0.87); C64(0.89); C195(1.35)	LDD0605	[11]
LDCM0289	AC29	HCT 116	C68(0.71); C64(0.76); C184(0.97); C195(1.54)	LDD0606	[11]
LDCM0290	AC3	HCT 116	C184(0.60); C64(0.92); C195(0.98); C68(1.01)	LDD0607	[11]
LDCM0291	AC30	HCT 116	C184(0.75); C68(0.78); C64(0.83); C195(1.73)	LDD0608	[11]
LDCM0292	AC31	HCT 116	C184(0.99); C68(1.10); C64(1.14); C195(1.21)	LDD0609	[11]
LDCM0293	AC32	HCT 116	C68(0.45); C64(0.51); C184(0.69); C195(1.93)	LDD0610	[11]
LDCM0294	AC33	HCT 116	C68(0.72); C184(0.76); C64(0.76); C195(1.48)	LDD0611	[11]
LDCM0295	AC34	HCT 116	C68(0.62); C64(0.66); C184(0.71); C195(1.55)	LDD0612	[11]
LDCM0296	AC35	HCT 116	C195(0.79); C184(0.93); C68(1.46); C64(1.49)	LDD0613	[11]
LDCM0297	AC36	HCT 116	C195(0.89); C184(0.94); C68(1.16); C64(1.33)	LDD0614	[11]
LDCM0298	AC37	HCT 116	C195(0.92); C184(1.04); C68(1.34); C64(1.45)	LDD0615	[11]
LDCM0299	AC38	HCT 116	C195(0.91); C184(0.92); C64(1.00); C68(1.01)	LDD0616	[11]
LDCM0300	AC39	HCT 116	C184(0.85); C64(1.02); C68(1.05); C195(1.08)	LDD0617	[11]
LDCM0301	AC4	HCT 116	C184(0.56); C64(0.92); C68(0.98); C195(1.21)	LDD0618	[11]
LDCM0302	AC40	HCT 116	C184(0.79); C64(0.98); C68(0.99); C195(1.30)	LDD0619	[11]
LDCM0303	AC41	HCT 116	C184(0.80); C68(0.96); C64(1.00); C195(1.05)	LDD0620	[11]
LDCM0304	AC42	HCT 116	C184(0.84); C64(0.90); C68(0.90); C195(1.04)	LDD0621	[11]
LDCM0305	AC43	HCT 116	C64(0.78); C184(0.79); C68(0.84); C195(1.14)	LDD0622	[11]
LDCM0306	AC44	HCT 116	C184(0.91); C195(1.15); C64(1.24); C68(1.26)	LDD0623	[11]
LDCM0307	AC45	HCT 116	C184(0.84); C64(1.15); C68(1.26); C195(1.33)	LDD0624	[11]
LDCM0308	AC46	HCT 116	C64(0.68); C68(0.71); C184(0.88); C195(1.04)	LDD0625	[11]
LDCM0309	AC47	HCT 116	C64(0.82); C68(0.84); C184(0.98); C195(1.02)	LDD0626	[11]
LDCM0310	AC48	HCT 116	C64(0.75); C68(0.76); C184(0.85); C195(1.10)	LDD0627	[11]
LDCM0311	AC49	HCT 116	C68(0.74); C64(0.75); C184(0.79); C195(1.47)	LDD0628	[11]
LDCM0312	AC5	HCT 116	C184(0.61); C64(0.87); C68(0.97); C195(1.44)	LDD0629	[11]
LDCM0313	AC50	HCT 116	C68(0.76); C64(0.80); C184(0.82); C195(1.47)	LDD0630	[11]
LDCM0314	AC51	HCT 116	C64(0.75); C68(0.79); C195(0.86); C184(1.05)	LDD0631	[11]
LDCM0315	AC52	HCT 116	C64(0.71); C68(0.76); C184(0.87); C195(1.09)	LDD0632	[11]
LDCM0316	AC53	HCT 116	C64(0.83); C184(0.87); C68(0.87); C195(1.28)	LDD0633	[11]
LDCM0317	AC54	HCT 116	C184(0.79); C64(0.92); C68(1.02); C195(1.16)	LDD0634	[11]
LDCM0318	AC55	HCT 116	C184(0.85); C68(0.94); C64(1.03); C195(1.44)	LDD0635	[11]
LDCM0319	AC56	HCT 116	C64(0.70); C68(0.72); C184(0.86); C195(1.64)	LDD0636	[11]
LDCM0320	AC57	HCT 116	C184(0.73); C64(0.97); C68(0.99)	LDD0637	[11]
LDCM0321	AC58	HCT 116	C184(0.71); C68(0.77); C64(0.81)	LDD0638	[11]
LDCM0322	AC59	HCT 116	C184(0.76); C64(0.90); C68(0.91)	LDD0639	[11]
LDCM0323	AC6	HCT 116	C68(0.82); C64(0.85); C184(0.88); C195(1.44)	LDD0640	[11]
LDCM0324	AC60	HCT 116	C184(0.80); C64(0.86); C68(0.88)	LDD0641	[11]
LDCM0325	AC61	HCT 116	C184(0.75); C68(0.91); C64(0.93)	LDD0642	[11]
LDCM0326	AC62	HCT 116	C184(0.76); C64(0.88); C68(0.91)	LDD0643	[11]
LDCM0327	AC63	HCT 116	C184(0.79); C64(0.94); C68(0.98)	LDD0644	[11]
LDCM0328	AC64	HCT 116	C184(0.85); C64(0.94); C68(0.98)	LDD0645	[11]
LDCM0329	AC65	HCT 116	C184(0.79); C68(0.82); C64(0.85)	LDD0646	[11]
LDCM0330	AC66	HCT 116	C184(0.78); C68(0.85); C64(0.86)	LDD0647	[11]
LDCM0331	AC67	HCT 116	C184(0.73); C68(0.76); C64(0.78)	LDD0648	[11]
LDCM0332	AC68	HCT 116	C184(0.79); C195(0.89); C64(1.02); C68(1.06)	LDD0649	[11]
LDCM0333	AC69	HCT 116	C195(0.69); C184(0.83); C64(0.94); C68(0.99)	LDD0650	[11]
LDCM0334	AC7	HCT 116	C68(0.97); C184(1.01); C64(1.02); C195(1.17)	LDD0651	[11]
LDCM0335	AC70	HCT 116	C184(0.71); C68(0.90); C64(0.91); C195(1.06)	LDD0652	[11]
LDCM0336	AC71	HCT 116	C184(0.85); C195(0.89); C64(1.16); C68(1.23)	LDD0653	[11]
LDCM0337	AC72	HCT 116	C184(0.79); C64(0.91); C68(0.91); C195(0.98)	LDD0654	[11]
LDCM0338	AC73	HCT 116	C184(0.78); C64(0.90); C68(0.91); C195(0.96)	LDD0655	[11]
LDCM0339	AC74	HCT 116	C184(0.76); C195(0.93); C64(1.11); C68(1.16)	LDD0656	[11]
LDCM0340	AC75	HCT 116	C184(0.87); C68(0.94); C64(0.95); C195(1.01)	LDD0657	[11]
LDCM0341	AC76	HCT 116	C195(0.75); C184(0.89); C64(1.11); C68(1.21)	LDD0658	[11]
LDCM0342	AC77	HCT 116	C184(0.71); C195(0.90); C64(0.95); C68(0.97)	LDD0659	[11]
LDCM0343	AC78	HCT 116	C195(0.76); C184(0.77); C64(0.88); C68(0.91)	LDD0660	[11]
LDCM0344	AC79	HCT 116	C64(0.96); C184(0.97); C68(0.99); C195(1.02)	LDD0661	[11]
LDCM0345	AC8	HCT 116	C184(0.81); C68(0.85); C64(1.01); C195(1.47)	LDD0662	[11]
LDCM0346	AC80	HCT 116	C195(0.70); C184(0.83); C64(1.09); C68(1.22)	LDD0663	[11]
LDCM0347	AC81	HCT 116	C195(0.92); C184(1.15); C64(1.25); C68(1.30)	LDD0664	[11]
LDCM0348	AC82	HCT 116	C184(0.88); C195(0.88); C64(1.10); C68(1.18)	LDD0665	[11]
LDCM0349	AC83	HCT 116	C184(0.64); C64(0.87); C68(0.87); C195(1.52)	LDD0666	[11]
LDCM0350	AC84	HCT 116	C184(0.57); C64(0.72); C68(0.72); C195(1.56)	LDD0667	[11]
LDCM0351	AC85	HCT 116	C184(0.61); C64(0.81); C68(0.81); C195(1.45)	LDD0668	[11]
LDCM0352	AC86	HCT 116	C64(0.60); C68(0.60); C184(0.75); C195(1.46)	LDD0669	[11]
LDCM0353	AC87	HCT 116	C64(0.70); C68(0.70); C184(0.92); C195(1.12)	LDD0670	[11]
LDCM0354	AC88	HCT 116	C64(0.66); C68(0.66); C184(0.77); C195(1.34)	LDD0671	[11]
LDCM0355	AC89	HCT 116	C184(0.58); C64(0.69); C68(0.69); C195(1.37)	LDD0672	[11]
LDCM0357	AC90	HCT 116	C64(0.82); C68(0.82); C195(0.99); C184(1.88)	LDD0674	[11]
LDCM0358	AC91	HCT 116	C184(0.71); C64(0.98); C68(0.98); C195(2.03)	LDD0675	[11]
LDCM0359	AC92	HCT 116	C184(0.67); C64(0.88); C68(0.88); C195(1.82)	LDD0676	[11]
LDCM0360	AC93	HCT 116	C184(0.70); C64(0.84); C68(0.84); C195(1.06)	LDD0677	[11]
LDCM0361	AC94	HCT 116	C184(0.79); C195(1.27); C64(1.60); C68(1.60)	LDD0678	[11]
LDCM0362	AC95	HCT 116	C64(0.65); C68(0.65); C184(0.75); C195(1.22)	LDD0679	[11]
LDCM0363	AC96	HCT 116	C184(0.65); C64(1.38); C68(1.38); C195(1.40)	LDD0680	[11]
LDCM0364	AC97	HCT 116	C184(0.54); C64(0.54); C68(0.54); C195(1.46)	LDD0681	[11]
LDCM0365	AC98	HCT 116	C68(0.21); C64(0.25); C184(0.49); C195(1.58)	LDD0682	[11]
LDCM0366	AC99	HCT 116	C68(0.44); C64(0.47); C184(0.74); C195(1.21)	LDD0683	[11]
LDCM0248	AKOS034007472	HCT 116	C184(1.30); C195(1.16); C64(1.35); C68(1.25)	LDD0565	[11]
LDCM0356	AKOS034007680	HCT 116	C68(1.18); C184(1.20); C64(1.38); C195(1.44)	LDD0673	[11]
LDCM0275	AKOS034007705	HCT 116	C68(0.65); C184(0.70); C64(1.00); C195(1.95)	LDD0592	[11]
LDCM0156	Aniline	NCI-H1299	13.11	LDD0403	[1]
LDCM0020	ARS-1620	HCC44	C195(1.11); C64(0.88); C68(0.88)	LDD0078	[11]
LDCM0108	Chloroacetamide	HeLa	N.A.	LDD0222	[21]
LDCM0632	CL-Sc	Hep-G2	C195(1.34)	LDD2227	[18]
LDCM0367	CL1	HCT 116	C64(0.83); C68(0.87); C184(1.02); C195(1.11)	LDD0684	[11]
LDCM0368	CL10	HCT 116	C195(0.87); C184(0.94); C64(0.98); C68(1.04)	LDD0685	[11]
LDCM0369	CL100	HCT 116	C184(0.54); C64(0.85); C68(0.88); C195(1.14)	LDD0686	[11]
LDCM0370	CL101	HCT 116	C68(0.86); C184(0.87); C64(1.00); C195(1.39)	LDD0687	[11]
LDCM0371	CL102	HCT 116	C68(1.09); C195(1.10); C184(1.28); C64(1.29)	LDD0688	[11]
LDCM0372	CL103	HCT 116	C68(1.18); C195(1.25); C184(1.34); C64(1.54)	LDD0689	[11]
LDCM0373	CL104	HCT 116	C68(1.09); C184(1.10); C64(1.20); C195(1.34)	LDD0690	[11]
LDCM0374	CL105	HCT 116	C64(0.70); C68(0.85); C184(0.89); C195(1.33)	LDD0691	[11]
LDCM0375	CL106	HCT 116	C64(0.69); C184(0.72); C68(0.96); C195(2.72)	LDD0692	[11]
LDCM0376	CL107	HCT 116	C64(0.68); C184(0.82); C68(0.95); C195(1.90)	LDD0693	[11]
LDCM0377	CL108	HCT 116	C184(0.72); C64(0.76); C68(0.90); C195(1.82)	LDD0694	[11]
LDCM0378	CL109	HCT 116	C64(0.71); C68(0.79); C184(0.80); C195(1.62)	LDD0695	[11]
LDCM0379	CL11	HCT 116	C64(0.81); C195(0.86); C68(0.89); C184(0.97)	LDD0696	[11]
LDCM0380	CL110	HCT 116	C68(0.66); C184(0.72); C64(0.75); C195(1.59)	LDD0697	[11]
LDCM0381	CL111	HCT 116	C64(0.71); C68(0.76); C184(0.85); C195(1.41)	LDD0698	[11]
LDCM0382	CL112	HCT 116	C184(0.82); C68(1.07); C64(1.07); C195(1.52)	LDD0699	[11]
LDCM0383	CL113	HCT 116	C68(0.54); C64(0.59); C184(0.63); C195(1.79)	LDD0700	[11]
LDCM0384	CL114	HCT 116	C68(0.46); C64(0.52); C184(0.83); C195(1.64)	LDD0701	[11]
LDCM0385	CL115	HCT 116	C68(0.58); C64(0.67); C184(0.74); C195(1.49)	LDD0702	[11]
LDCM0386	CL116	HCT 116	C68(0.65); C64(0.70); C184(0.90); C195(1.42)	LDD0703	[11]
LDCM0387	CL117	HCT 116	C184(0.81); C64(0.85); C68(0.92); C195(1.79)	LDD0704	[11]
LDCM0388	CL118	HCT 116	C184(0.86); C68(1.01); C64(1.02); C195(1.11)	LDD0705	[11]
LDCM0389	CL119	HCT 116	C184(0.82); C68(0.84); C64(0.87); C195(1.23)	LDD0706	[11]
LDCM0390	CL12	HCT 116	C184(0.96); C68(0.96); C195(1.00); C64(1.11)	LDD0707	[11]
LDCM0391	CL120	HCT 116	C68(0.89); C184(0.89); C195(0.96); C64(0.99)	LDD0708	[11]
LDCM0392	CL121	HCT 116	C184(0.77); C64(0.78); C68(0.83); C195(0.99)	LDD0709	[11]
LDCM0393	CL122	HCT 116	C64(0.74); C68(0.78); C184(0.84); C195(1.32)	LDD0710	[11]
LDCM0394	CL123	HCT 116	C64(0.74); C184(0.77); C68(0.88); C195(1.39)	LDD0711	[11]
LDCM0395	CL124	HCT 116	C64(0.71); C68(0.78); C184(0.79); C195(1.43)	LDD0712	[11]
LDCM0396	CL125	HCT 116	C184(0.92); C68(0.97); C64(1.02)	LDD0713	[11]
LDCM0397	CL126	HCT 116	C184(0.71); C68(0.83); C64(0.87)	LDD0714	[11]
LDCM0398	CL127	HCT 116	C68(0.85); C184(0.85); C64(0.88)	LDD0715	[11]
LDCM0399	CL128	HCT 116	C184(0.83); C68(0.86); C64(0.86)	LDD0716	[11]
LDCM0400	CL13	HCT 116	C195(0.87); C68(0.92); C184(0.95); C64(1.14)	LDD0717	[11]
LDCM0401	CL14	HCT 116	C184(0.96); C195(1.01); C68(1.04); C64(1.16)	LDD0718	[11]
LDCM0402	CL15	HCT 116	C195(0.78); C68(1.03); C184(1.05); C64(1.25)	LDD0719	[11]
LDCM0403	CL16	HCT 116	C64(0.57); C68(0.58); C184(0.79); C195(1.16)	LDD0720	[11]
LDCM0404	CL17	HCT 116	C184(0.65); C64(0.75); C68(0.88); C195(0.99)	LDD0721	[11]
LDCM0405	CL18	HCT 116	C64(0.60); C184(0.70); C68(0.71); C195(1.15)	LDD0722	[11]
LDCM0406	CL19	HCT 116	C64(0.56); C68(0.66); C184(0.70); C195(0.99)	LDD0723	[11]
LDCM0407	CL2	HCT 116	C68(0.91); C184(1.03); C64(1.05); C195(1.11)	LDD0724	[11]
LDCM0408	CL20	HCT 116	C64(0.63); C68(0.68); C184(1.04); C195(1.24)	LDD0725	[11]
LDCM0409	CL21	HCT 116	C64(0.66); C68(0.78); C184(0.86); C195(0.94)	LDD0726	[11]
LDCM0410	CL22	HCT 116	C64(0.55); C68(0.62); C184(0.97); C195(1.10)	LDD0727	[11]
LDCM0411	CL23	HCT 116	C68(0.60); C64(0.60); C184(1.02); C195(1.39)	LDD0728	[11]
LDCM0412	CL24	HCT 116	C64(0.53); C68(0.55); C184(0.86); C195(1.13)	LDD0729	[11]
LDCM0413	CL25	HCT 116	C184(0.61); C195(1.24); C64(0.46); C68(0.50)	LDD0730	[11]
LDCM0414	CL26	HCT 116	C184(0.93); C195(1.38); C64(0.52); C68(0.49)	LDD0731	[11]
LDCM0415	CL27	HCT 116	C184(0.74); C195(0.86); C64(0.61); C68(0.63)	LDD0732	[11]
LDCM0416	CL28	HCT 116	C184(0.82); C195(1.29); C64(0.46); C68(0.47)	LDD0733	[11]
LDCM0417	CL29	HCT 116	C184(0.79); C195(1.12); C64(0.53); C68(0.58)	LDD0734	[11]
LDCM0418	CL3	HCT 116	C184(1.24); C195(1.00); C64(1.01); C68(1.08)	LDD0735	[11]
LDCM0419	CL30	HCT 116	C184(0.96); C195(1.26); C64(0.65); C68(0.63)	LDD0736	[11]
LDCM0420	CL31	HCT 116	C184(1.05); C195(0.83); C64(0.73); C68(0.78)	LDD0737	[11]
LDCM0421	CL32	HCT 116	C184(0.71); C195(0.85); C64(0.74); C68(0.74)	LDD0738	[11]
LDCM0422	CL33	HCT 116	C184(0.66); C195(0.84); C64(0.76); C68(0.76)	LDD0739	[11]
LDCM0423	CL34	HCT 116	C184(0.83); C195(0.84); C64(0.58); C68(0.56)	LDD0740	[11]
LDCM0424	CL35	HCT 116	C184(0.86); C195(1.05); C64(0.69); C68(0.66)	LDD0741	[11]
LDCM0425	CL36	HCT 116	C184(0.85); C195(1.24); C64(0.72); C68(0.71)	LDD0742	[11]
LDCM0426	CL37	HCT 116	C184(0.81); C195(0.88); C64(0.75); C68(0.71)	LDD0743	[11]
LDCM0428	CL39	HCT 116	C184(0.75); C195(0.91); C64(0.70); C68(0.72)	LDD0745	[11]
LDCM0429	CL4	HCT 116	C184(0.87); C195(0.96); C64(1.00); C68(0.78)	LDD0746	[11]
LDCM0430	CL40	HCT 116	C184(0.75); C195(0.66); C64(0.66); C68(0.67)	LDD0747	[11]
LDCM0431	CL41	HCT 116	C184(0.85); C195(1.11); C64(0.75); C68(0.73)	LDD0748	[11]
LDCM0432	CL42	HCT 116	C184(0.85); C195(0.87); C64(0.73); C68(0.77)	LDD0749	[11]
LDCM0433	CL43	HCT 116	C184(0.76); C195(1.01); C64(0.74); C68(0.73)	LDD0750	[11]
LDCM0434	CL44	HCT 116	C184(0.70); C195(1.05); C64(0.76); C68(0.73)	LDD0751	[11]
LDCM0435	CL45	HCT 116	C184(0.92); C195(0.97); C64(0.73); C68(0.72)	LDD0752	[11]
LDCM0436	CL46	HCT 116	C184(1.19); C195(1.05); C64(1.42); C68(1.37)	LDD0753	[11]
LDCM0437	CL47	HCT 116	C184(1.18); C195(0.85); C64(1.22); C68(1.32)	LDD0754	[11]
LDCM0438	CL48	HCT 116	C184(1.09); C195(0.83); C64(1.49); C68(1.42)	LDD0755	[11]
LDCM0439	CL49	HCT 116	C184(1.04); C195(1.15); C64(1.22); C68(1.22)	LDD0756	[11]
LDCM0440	CL5	HCT 116	C184(1.15); C195(0.83); C64(1.21); C68(1.15)	LDD0757	[11]
LDCM0441	CL50	HCT 116	C184(1.06); C195(0.85); C64(1.33); C68(1.23)	LDD0758	[11]
LDCM0442	CL51	HCT 116	C184(1.07); C195(1.38); C64(1.40); C68(1.22)	LDD0759	[11]
LDCM0443	CL52	HCT 116	C184(1.07); C195(1.10); C64(1.45); C68(1.28)	LDD0760	[11]
LDCM0444	CL53	HCT 116	C184(0.97); C195(1.30); C64(1.28); C68(1.33)	LDD0761	[11]
LDCM0445	CL54	HCT 116	C184(1.00); C195(0.96); C64(1.20); C68(1.21)	LDD0762	[11]
LDCM0446	CL55	HCT 116	C184(1.07); C195(0.73); C64(1.35); C68(1.38)	LDD0763	[11]
LDCM0447	CL56	HCT 116	C184(1.02); C195(1.44); C64(1.03); C68(0.98)	LDD0764	[11]
LDCM0448	CL57	HCT 116	C184(1.11); C195(1.03); C64(1.47); C68(1.24)	LDD0765	[11]
LDCM0449	CL58	HCT 116	C184(1.17); C195(1.16); C64(1.33); C68(1.28)	LDD0766	[11]
LDCM0450	CL59	HCT 116	C184(0.97); C195(0.94); C64(1.08); C68(1.12)	LDD0767	[11]
LDCM0451	CL6	HCT 116	C184(1.06); C195(1.01); C64(0.89); C68(0.96)	LDD0768	[11]
LDCM0452	CL60	HCT 116	C184(0.90); C195(1.24); C64(0.98); C68(0.91)	LDD0769	[11]
LDCM0453	CL61	HCT 116	C184(0.97); C195(1.15); C64(1.10); C68(1.11)	LDD0770	[11]
LDCM0454	CL62	HCT 116	C184(1.17); C195(1.18); C64(1.03); C68(1.02)	LDD0771	[11]
LDCM0455	CL63	HCT 116	C184(1.03); C195(1.28); C64(0.87); C68(0.86)	LDD0772	[11]
LDCM0456	CL64	HCT 116	C184(0.89); C195(1.44); C64(0.86); C68(0.88)	LDD0773	[11]
LDCM0457	CL65	HCT 116	C184(0.92); C195(1.12); C64(0.93); C68(0.96)	LDD0774	[11]
LDCM0458	CL66	HCT 116	C184(0.79); C195(1.70); C64(0.83); C68(0.84)	LDD0775	[11]
LDCM0459	CL67	HCT 116	C184(0.87); C195(1.48); C64(0.88); C68(0.89)	LDD0776	[11]
LDCM0460	CL68	HCT 116	C184(1.01); C195(1.32); C64(0.93); C68(0.89)	LDD0777	[11]
LDCM0461	CL69	HCT 116	C184(1.28); C195(1.24); C64(1.03); C68(1.00)	LDD0778	[11]
LDCM0462	CL7	HCT 116	C184(0.98); C195(0.85); C64(1.12); C68(1.03)	LDD0779	[11]
LDCM0463	CL70	HCT 116	C184(0.68); C195(1.20); C64(0.91); C68(0.92)	LDD0780	[11]
LDCM0464	CL71	HCT 116	C184(0.90); C195(1.41); C64(0.88); C68(0.83)	LDD0781	[11]
LDCM0465	CL72	HCT 116	C184(0.88); C195(1.11); C64(0.95); C68(0.90)	LDD0782	[11]
LDCM0466	CL73	HCT 116	C184(0.75); C195(1.40); C64(0.89); C68(0.85)	LDD0783	[11]
LDCM0467	CL74	HCT 116	C184(0.96); C195(1.58); C64(0.85); C68(0.82)	LDD0784	[11]
LDCM0469	CL76	HCT 116	C184(0.79); C195(1.25); C64(0.79); C68(0.81)	LDD0786	[11]
LDCM0470	CL77	HCT 116	C184(0.85); C195(1.19); C64(0.85); C68(0.92)	LDD0787	[11]
LDCM0471	CL78	HCT 116	C184(0.88); C195(1.27); C64(0.79); C68(0.88)	LDD0788	[11]
LDCM0472	CL79	HCT 116	C184(0.73); C195(1.57); C64(0.84); C68(0.83)	LDD0789	[11]
LDCM0473	CL8	HCT 116	C184(1.21); C195(1.59); C64(1.07); C68(1.25)	LDD0790	[11]
LDCM0474	CL80	HCT 116	C184(0.84); C195(1.21); C64(0.92); C68(0.95)	LDD0791	[11]
LDCM0475	CL81	HCT 116	C184(0.86); C195(1.21); C64(0.90); C68(1.08)	LDD0792	[11]
LDCM0476	CL82	HCT 116	C184(0.86); C195(2.03); C64(0.82); C68(0.83)	LDD0793	[11]
LDCM0477	CL83	HCT 116	C184(0.76); C195(2.25); C64(0.94); C68(0.97)	LDD0794	[11]
LDCM0478	CL84	HCT 116	C184(0.75); C195(2.73); C64(0.75); C68(0.73)	LDD0795	[11]
LDCM0479	CL85	HCT 116	C184(0.85); C195(1.36); C64(0.79); C68(0.78)	LDD0796	[11]
LDCM0480	CL86	HCT 116	C184(0.90); C195(1.13); C64(0.94); C68(1.33)	LDD0797	[11]
LDCM0481	CL87	HCT 116	C184(0.81); C195(1.51); C64(1.01); C68(1.03)	LDD0798	[11]
LDCM0482	CL88	HCT 116	C184(0.77); C195(1.95); C64(0.88); C68(0.87)	LDD0799	[11]
LDCM0483	CL89	HCT 116	C184(0.83); C195(2.66); C64(0.82); C68(0.81)	LDD0800	[11]
LDCM0484	CL9	HCT 116	C184(0.99); C195(1.08); C64(1.16); C68(0.88)	LDD0801	[11]
LDCM0485	CL90	HCT 116	C184(1.03); C195(0.88); C64(1.20); C68(1.28)	LDD0802	[11]
LDCM0486	CL91	HCT 116	C184(0.63); C195(1.13); C64(0.65); C68(0.66)	LDD0803	[11]
LDCM0487	CL92	HCT 116	C184(0.78); C195(1.06); C64(0.75); C68(0.75)	LDD0804	[11]
LDCM0488	CL93	HCT 116	C184(0.63); C195(1.10); C64(0.90); C68(0.92)	LDD0805	[11]
LDCM0489	CL94	HCT 116	C184(0.55); C195(1.67); C64(0.81); C68(0.85)	LDD0806	[11]
LDCM0490	CL95	HCT 116	C184(0.60); C195(1.62); C64(0.68); C68(0.69)	LDD0807	[11]
LDCM0491	CL96	HCT 116	C184(0.59); C195(1.12); C64(0.60); C68(0.62)	LDD0808	[11]
LDCM0492	CL97	HCT 116	C184(0.51); C195(1.23); C64(0.60); C68(0.60)	LDD0809	[11]
LDCM0493	CL98	HCT 116	C184(0.57); C195(1.40); C64(0.80); C68(0.81)	LDD0810	[11]
LDCM0494	CL99	HCT 116	C184(0.56); C195(1.28); C64(0.79); C68(0.84)	LDD0811	[11]
LDCM0495	E2913	HEK-293T	C68(1.06)	LDD1698	[25]
LDCM0213	Electrophilic fragment 2	MDA-MB-231	C64(15.67)	LDD1702	[5]
LDCM0175	Ethacrynic acid	HeLa	C195(0.89)	LDD2210	[7]
LDCM0625	F8	Ramos	1.11; C184(0.62); C195(0.38)	LDD2187	[26]
LDCM0572	Fragment10	Ramos	1.19; C184(0.76); C195(0.90)	LDD2189	[26]
LDCM0573	Fragment11	Ramos	0.27; C184(2.16)	LDD2190	[26]
LDCM0574	Fragment12	Ramos	1.45; C184(0.91); C195(0.85)	LDD2191	[26]
LDCM0575	Fragment13	Ramos	1.16; C184(1.08); C195(0.30)	LDD2192	[26]
LDCM0576	Fragment14	Ramos	1.83; C184(1.20); C195(0.66)	LDD2193	[26]
LDCM0579	Fragment20	Ramos	1.28; C184(1.04)	LDD2194	[26]
LDCM0580	Fragment21	Ramos	0.91; C184(1.01); C195(0.56)	LDD2195	[26]
LDCM0582	Fragment23	Ramos	0.52; C184(0.87)	LDD2196	[26]
LDCM0578	Fragment27	Ramos	0.87; C184(0.91); C195(0.44)	LDD2197	[26]
LDCM0586	Fragment28	Ramos	0.96; C184(0.79); C195(0.35)	LDD2198	[26]
LDCM0588	Fragment30	Ramos	1.14; C184(0.98); C195(0.36)	LDD2199	[26]
LDCM0589	Fragment31	Ramos	1.31; C184(1.17); C195(0.51)	LDD2200	[26]
LDCM0590	Fragment32	Ramos	1.86; C184(0.90); C195(0.35)	LDD2201	[26]
LDCM0468	Fragment33	HCT 116	C184(0.88); C195(1.43); C64(0.98); C68(0.97)	LDD0785	[11]
LDCM0596	Fragment38	Ramos	0.99; C184(0.86); C195(0.28)	LDD2203	[26]
LDCM0566	Fragment4	Ramos	1.62; C184(0.56); C195(0.58)	LDD2184	[26]
LDCM0427	Fragment51	HCT 116	C184(0.82); C195(0.92); C64(0.65); C68(0.67)	LDD0744	[11]
LDCM0610	Fragment52	Ramos	1.78; C184(0.91); C195(0.18)	LDD2204	[26]
LDCM0614	Fragment56	Ramos	1.11; C184(0.98); C195(0.21)	LDD2205	[26]
LDCM0569	Fragment7	Ramos	0.93; C184(1.01); C195(0.35)	LDD2186	[26]
LDCM0571	Fragment9	Ramos	5.28; C184(0.66)	LDD2188	[26]
LDCM0116	HHS-0101	DM93	Y103(0.72)	LDD0264	[9]
LDCM0117	HHS-0201	DM93	Y103(0.97)	LDD0265	[9]
LDCM0118	HHS-0301	DM93	Y103(1.02)	LDD0266	[9]
LDCM0119	HHS-0401	DM93	Y103(0.85)	LDD0267	[9]
LDCM0120	HHS-0701	DM93	Y103(0.80)	LDD0268	[9]
LDCM0107	IAA	HeLa	N.A.	LDD0221	[21]
LDCM0123	JWB131	DM93	Y103(1.17)	LDD0285	[8]
LDCM0124	JWB142	DM93	Y103(0.83)	LDD0286	[8]
LDCM0125	JWB146	DM93	Y103(0.94)	LDD0287	[8]
LDCM0126	JWB150	DM93	Y103(2.02)	LDD0288	[8]
LDCM0127	JWB152	DM93	Y103(1.49)	LDD0289	[8]
LDCM0128	JWB198	DM93	Y103(0.93)	LDD0290	[8]
LDCM0129	JWB202	DM93	Y103(0.64)	LDD0291	[8]
LDCM0130	JWB211	DM93	Y103(0.92)	LDD0292	[8]
LDCM0022	KB02	HCT 116	C64(9.42); C68(9.42)	LDD0080	[11]
LDCM0023	KB03	HCT 116	C64(20.00); C68(20.00)	LDD0081	[11]
LDCM0024	KB05	HCT 116	C64(6.74); C68(6.74)	LDD0082	[11]
LDCM0528	N-(4-bromophenyl)-2-cyano-N-phenylacetamide	MDA-MB-231	C64(0.85)	LDD2121	[5]
LDCM0497	Nucleophilic fragment 11b	MDA-MB-231	C64(1.18)	LDD2090	[5]
LDCM0506	Nucleophilic fragment 16a	MDA-MB-231	C68(1.06)	LDD2099	[5]
LDCM0532	Nucleophilic fragment 29a	MDA-MB-231	C68(0.64)	LDD2125	[5]
LDCM0544	Nucleophilic fragment 39	MDA-MB-231	C68(0.87)	LDD2137	[5]
LDCM0627	NUDT7-COV-1	HEK-293T	C195(1.32); C195(0.63)	LDD2206	[27]
LDCM0628	OTUB2-COV-1	HEK-293T	C195(1.02); C195(0.75); C195(0.57)	LDD2207	[27]
LDCM0131	RA190	MM1.R	C195(1.12)	LDD0304	[28]
LDCM0021	THZ1	HeLa S3	C184(1.16); C64(1.11)	LDD0460	[4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Regulator of chromosome condensation (RCC1)				.	P18754

References

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2	Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3	An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4	A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
5	Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29. Mass spectrometry data entry: PXD039908 , PXD029761
6	Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z. Mass spectrometry data entry: PXD044625
7	Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
8	Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
9	Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10	Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12	Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print. Mass spectrometry data entry: PXD042377
13	Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14	Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23. Mass spectrometry data entry: PXD028853
15	SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18. Mass spectrometry data entry*: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16	A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21. Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17	Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. Mass spectrometry data entry: PXD029255
18	N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w. Mass spectrometry data entry: PXD041264
19	Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022. Mass spectrometry data entry: PXD039931
20	DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22. Mass spectrometry data entry: PXD033004
21	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22	Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
23	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
24	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402
26	Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7. Mass spectrometry data entry: PXD027578
27	Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
28	Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.

Details of the Target

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Correspondence

Prof. Feng Zhu

Prof. Feng Ni