Details of the Probe

General Information of Probe

Probe ID	LDPC0013
Probe Name	Dyn-2
Synonyms	DYn-2; 1354630-46-8; 4-(Pent-4-yn-1-yl)cyclohexane-1,3-dione; ANTI-DYNAMIN II; 4-pent-4-ynylcyclohexane-1,3-dione; CHEMBL4520299; SCHEMBL15782162; AKOS040756379; HY-116424; CS-0065449; EN300-20983758
Probe Type	ABPP Probe
Structure
Structure	3D MOL		2D MOL
Ro5 Violations (Lipinski): 0	Molecular Weight (mw)	178.23
	Lipid-water partition coefficient (xlogp)	1.5
	Rotatable Bond Count (rotbonds)	3
	Hydrogen Bond Donor Count (hbonddonor)	0
	Hydrogen Bond Acceptor Count (hbondacc)	2
Chemical Identifiers	Formula C11H14O2 IUPAC Name 4-pent-4-ynylcyclohexane-1,3-dione Canonical SMILES C#CCCCC1CCC(=O)CC1=O InChI InChI=1S/C11H14O2/c1-2-3-4-5-9-6-7-10(12)8-11(9)13/h1,9H,3-8H2 InChIKey UNMICBPHYXLMRA-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

7 Enzyme Labeled by This Probe

Target Name	Target ID	Binding Site(Ratio)	Interaction ID
26S proteasome non-ATPase regulatory subunit 12 (PSMD12)	LDTP00224	C255	LDD0013
Bifunctional glutamate/proline--tRNA ligase (EPRS1)	LDTP02222	C856	LDD0013
Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2)	LDTP00624	C342	LDD0013
Fatty acid synthase (FASN)	LDTP04243	C1992	LDD0013
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1)	LDTP11273	C195	LDD0013
Small ribosomal subunit protein uS3 (RPS3)	LDTP03223	C97	LDD0013
Trifunctional purine biosynthetic protein adenosine-3 (GART)	LDTP03156	C41	LDD0013
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⏷ Show the Full List of 7 Enzyme

4 Transporter and channel Labeled by This Probe

Target Name	Target ID	Binding Site(Ratio)	Interaction ID
14-3-3 protein theta (YWHAQ)	LDTP03385	C134	LDD0013
Cystatin-B (CSTB)	LDTP02009	C3	LDD0013
Fatty acid-binding protein 5 (FABP5)	LDTP05292	C120	LDD0013
Filamin-A (FLNA)	LDTP03107	C2543	LDD0013
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3 Other Labeled by This Probe

Target Name	Target ID	Binding Site(Ratio)	Interaction ID
Cofilin-1 (CFL1)	LDTP03244	C139	LDD0013
Poly(rC)-binding protein 3 (PCBP3)	LDTP04793	C86	LDD0013
RNA-binding protein 34 (RBM34)	LDTP14680	C196	LDD0013
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Full Information of The Labelling Profiles of This Probe

Qualitation: Labeling site identification

Experiment 1 Reporting the Labelling Profiles of This Probe

REF [1]

Probe concentration

10 uM

Quantitative Method

Isotope tag

In Vitro Experiment Model

Model Type

Cell lysate

Derived Tissue

Peripheral blood

Disease Model

Normal

Model Name

Human normal cell lysate (HEK-293T)

Interaction Atlas ID

LDD0013

References

1	A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21. Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764