Details of the Target

General Information of Target

Target ID LDTP00624
Target Name Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2)
Gene Name BCAT2
Gene ID 587
Synonyms
BCATM; BCT2; ECA40; Branched-chain-amino-acid aminotransferase, mitochondrial; BCAT(m); EC 2.6.1.42; Placental protein 18; PP18
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKT
FTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRP
WLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSL
GVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLV
QQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQS
LLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIP
TMENGPELILRFQKELKEIQYGIRAHEWMFPV
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Class-IV pyridoxal-phosphate-dependent aminotransferase family
Subcellular location
Mitochondrion
Function Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.
TTD ID
T94788
Uniprot ID
O15382
DrugMap ID
TTF9OQ6
Ensemble ID
ENST00000316273.11
HGNC ID
HGNC:977
ChEMBL ID
CHEMBL3616354

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CASKI SNV: p.L144F DBIA    Probe Info 
HT115 SNV: p.E153K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 2
 Probe Info  		15.00  LDD0391  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y234(16.96); Y228(8.41)  LDD0260  [3]
STPyne
 Probe Info  		K321(7.94); K44(5.30)  LDD0277  [4]
Alkylaryl probe 3
 Probe Info  		17.57  LDD0282  [5]
BTD
 Probe Info  		C342(1.58)  LDD2090  [6]
DBIA
 Probe Info  		C342(1.01)  LDD0078  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C147(0.00); C345(0.00); C342(0.00); C135(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [9]
Lodoacetamide azide
 Probe Info  		C345(0.00); C342(0.00); C135(0.00); C147(0.00)  LDD0037  [8]
Dyn-2
 Probe Info  		N.A.  LDD0013  [10]
JW-RF-010
 Probe Info  		C345(0.00); C342(0.00)  LDD0026  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
WYneN
 Probe Info  		N.A.  LDD0021  [10]
Compound 10
 Probe Info  		N.A.  LDD2216  [12]
Compound 11
 Probe Info  		N.A.  LDD2213  [12]
IPM
 Probe Info  		N.A.  LDD0005  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
Acrolein
 Probe Info  		N.A.  LDD0217  [14]
Crotonaldehyde
 Probe Info  		C342(0.00); C345(0.00)  LDD0219  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
NAIA_5
 Probe Info  		N.A.  LDD2223  [15]
HHS-465
 Probe Info  		Y228(0.00); K229(0.00)  LDD2240  [16]
HHS-482
 Probe Info  		Y228(0.58)  LDD2239  [17]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C311
 Probe Info  		5.62  LDD1978  [18]
C335
 Probe Info  		9.00  LDD1998  [18]
VE-P
 Probe Info  		N.A.  LDD0396  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C342(0.62)  LDD2112  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C342(0.59)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C342(1.00)  LDD2152  [6]
 LDCM0214  AC1 HCT 116 C147(1.02); C342(1.19); C345(1.06)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C135(1.32); C147(1.13); C342(1.52); C345(1.05)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C135(0.87); C342(1.00); C345(0.95)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C135(0.87); C342(0.97); C345(0.95)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C135(0.88); C342(0.99); C345(0.97)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C135(0.93); C342(1.02); C345(1.02)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C135(0.91); C342(1.03); C345(1.05)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C135(0.93); C342(1.05); C345(1.05)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C135(0.90); C342(0.97); C345(0.95)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C135(1.03); C342(1.04); C345(0.97)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C135(0.80); C342(0.86); C345(0.99)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C135(0.76); C342(0.89); C345(0.88)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C135(1.33); C147(1.05); C342(1.45); C345(1.07)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C135(0.82); C342(0.96); C345(1.04)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C135(0.79); C342(0.87); C345(0.97)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C135(0.92); C342(1.08); C345(1.10)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C135(1.03); C147(0.91); C342(0.98); C345(0.95)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C135(0.95); C147(1.06); C342(1.07); C345(1.03)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C135(1.12); C147(1.08); C342(1.07); C345(1.07)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C135(1.14); C147(1.21); C342(1.27); C345(1.18)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C135(1.05); C147(0.88); C342(1.11); C345(1.09)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C135(1.05); C147(1.10); C342(1.11); C345(1.06)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C135(1.08); C147(1.18); C342(1.14); C345(1.07)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C135(1.19); C147(1.00); C342(1.06); C345(0.88)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C135(1.08); C147(0.97); C342(1.16); C345(1.07)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C135(1.02); C147(1.11); C342(1.05); C345(1.08)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C135(0.94); C147(0.93); C342(0.93); C345(0.95)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C135(0.88); C147(0.96); C342(1.16); C345(1.29)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C135(0.97); C147(1.03); C342(1.06); C345(1.00)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C135(0.99); C147(1.13); C342(0.95); C345(0.89)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C135(0.97); C147(1.12); C342(1.05); C345(1.05)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C135(0.97); C147(0.93); C342(1.29); C345(1.31)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C342(0.97); C345(0.97)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C342(0.86); C345(0.86)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C342(0.93); C345(0.94)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C342(0.99); C345(0.97)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C342(0.92); C345(0.91)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C342(0.86); C345(0.87)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C342(1.03); C345(0.98)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C342(0.96); C345(0.94)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C342(0.94); C345(0.94)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C342(0.88); C345(0.83)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C342(1.03); C345(0.96)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C342(1.10); C345(1.10)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C135(1.42); C147(1.12); C342(1.14); C345(0.74)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C342(1.07); C345(1.04)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C342(1.05); C345(1.00)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C342(0.98); C345(0.90)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C147(1.10); C342(1.00); C345(1.03)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C342(1.23); C345(1.28); C147(1.50)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C345(1.04); C342(1.04); C147(1.29)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C345(1.18); C342(1.21); C147(1.32)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C345(1.17); C342(1.20); C147(1.24)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C342(1.34); C345(1.40); C147(1.68)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C342(1.21); C345(1.26); C147(1.48)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C345(0.95); C147(1.08); C342(1.20); C135(1.52)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C342(1.08); C345(1.13); C147(1.25)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C345(1.01); C342(1.02); C147(1.20)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C345(1.10); C342(1.13); C147(1.64)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C342(1.37); C345(1.42); C147(1.91)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C147(1.31); C342(1.06); C345(1.09)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C147(1.34); C342(1.09); C345(1.18)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C147(1.16); C342(1.03); C345(1.05)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C147(1.18); C342(1.04); C345(1.13)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C147(1.08); C342(1.27); C345(1.29)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C342(1.24); C147(1.27); C345(1.37)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C147(1.18); C345(1.26); C342(1.26)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C345(0.84); C147(1.07); C342(1.18)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C147(1.03); C345(1.22); C342(1.28)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C147(1.03); C342(1.25); C345(1.40)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C147(1.03); C342(1.13); C345(1.17)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C147(1.07); C342(1.35); C345(1.51)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C147(1.12); C345(1.26); C342(1.33)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C345(0.85); C135(1.02); C147(1.04); C342(1.27)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C345(0.93); C147(1.07); C135(1.19); C342(1.33)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C345(0.97); C342(1.06); C147(1.09); C135(1.21)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C345(1.02); C147(1.11); C135(1.20); C342(1.58)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C345(0.87); C147(1.02); C135(1.15); C342(1.24)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C345(0.93); C342(1.08); C147(1.15)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C147(0.95); C345(1.19); C135(1.23); C342(1.35)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C345(0.96); C147(1.06); C135(1.21); C342(1.32)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C147(1.01); C345(1.06); C135(1.29); C342(1.51)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C147(0.98); C345(1.06); C135(1.28); C342(1.28)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C147(0.90); C345(1.10); C135(1.26); C342(1.39)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C342(0.84); C147(0.90); C345(1.00)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C342(0.86); C345(0.96); C147(1.00)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C342(0.78); C345(0.87); C147(1.07)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C342(0.84); C147(1.07); C345(1.07)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C345(0.91); C342(0.93); C147(1.05)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C345(0.98); C342(1.10); C147(1.15)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C342(0.82); C345(1.00); C147(1.05)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C345(0.94); C342(0.94); C147(1.04)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C342(0.89); C345(0.90); C147(1.02)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C342(0.99); C147(1.08); C345(1.22)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C342(0.93); C345(0.99); C147(1.05)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C342(1.01); C147(1.08); C345(1.10)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C147(1.05); C342(1.07); C345(1.08)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C345(0.90); C342(0.96); C147(1.02)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C342(0.90); C147(1.02); C345(1.05)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C147(1.08); C342(1.22); C345(1.23)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C345(0.99); C342(1.21); C147(1.22)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C147(1.07); C345(1.10); C342(1.11)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C342(0.77); C345(0.88); C147(0.97)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C345(0.99); C147(1.01); C342(1.04)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C345(1.01); C147(1.08); C342(1.09)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C147(0.99); C345(1.00); C342(1.24)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C147(1.17); C345(1.34); C342(1.34)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C345(1.16); C147(1.28); C342(1.38)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C135(0.86); C147(1.11); C342(1.14); C345(1.20)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C135(0.94); C342(1.17); C345(1.23); C147(1.33)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C135(0.99); C342(1.22); C345(1.23); C147(1.30)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C345(0.98); C342(1.13); C147(1.14); C135(1.39)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C135(1.06); C345(1.07); C342(1.09); C147(1.09)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C135(0.78); C147(1.18); C342(1.21); C345(1.31)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C135(0.94); C342(1.08); C345(1.08); C147(1.25)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C135(0.94); C147(1.17); C345(1.20); C342(1.20)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C135(1.05); C147(1.14); C342(1.27); C345(1.29)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C135(0.90); C147(1.45); C342(1.48); C345(1.52)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C135(0.85); C345(1.29); C342(1.31); C147(1.45)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C135(0.92); C342(1.25); C345(1.27); C147(1.68)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C135(0.85); C342(0.85); C345(0.90)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C342(0.76); C345(0.79); C135(0.89)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C147(1.06); C135(1.24); C345(1.35); C342(1.43)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C342(0.93); C345(0.97); C135(1.08)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C342(0.72); C345(0.76); C135(0.97)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C342(0.91); C345(0.96); C135(1.07)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C345(0.91); C342(0.93); C135(1.16)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C345(1.06); C342(1.10); C135(1.11)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C135(1.12); C345(1.15); C342(1.16)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C345(0.93); C342(0.93); C135(1.10)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C342(0.76); C345(0.79); C135(1.01)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C342(0.74); C345(0.76); C135(1.21)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C342(0.89); C345(0.98); C135(1.11)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C345(0.98); C147(1.03); C342(1.14); C135(1.23)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C342(0.86); C345(0.89); C135(1.02)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C342(0.90); C345(0.92); C135(1.03)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C342(0.73); C345(0.75); C135(1.07)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C342(1.30); C345(1.35); C147(1.49)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C147(1.28); C342(1.33); C345(1.42)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C342(1.12); C345(1.23); C147(1.25)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C342(1.27); C345(1.30); C147(1.30)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C147(0.93); C342(1.12); C345(1.14)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C147(0.99); C342(1.23); C345(1.34)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C342(1.16); C345(1.24); C147(1.26)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C342(1.14); C147(1.22); C345(1.29)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C147(1.34); C342(1.37); C345(1.45)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C147(1.33); C342(1.37); C345(1.66)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C342(1.31); C345(1.36); C147(1.42)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C342(1.07); C147(1.21); C345(1.30)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C147(0.89); C342(1.04); C345(1.04)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C147(1.04); C342(1.17); C345(1.35)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C147(1.16); C345(1.29); C342(1.40)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C342(0.94); C345(1.00); C135(1.00)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C135(0.91); C342(0.97); C345(0.98)  LDD0683  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C342(1.02)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C135(1.30); C147(1.12); C342(1.24); C345(0.92)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C345(1.05); C147(1.08); C135(1.32); C342(1.42)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C345(0.98); C147(1.36); C342(1.52); C135(1.79)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C342(1.01)  LDD0078  [7]
 LDCM0108  Chloroacetamide HeLa C342(0.00); C345(0.00); C147(0.00)  LDD0222  [14]
 LDCM0367  CL1 HCT 116 C147(1.03); C342(1.28); C345(1.87)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C345(1.15); C342(1.19); C147(1.30)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C345(0.96); C342(1.01); C147(1.15)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C345(1.13); C147(1.14); C342(1.34); C135(1.63)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C147(1.10); C135(1.28); C342(1.47); C345(1.59)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C345(1.13); C147(1.14); C135(1.44); C342(1.46)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C345(1.09); C147(1.10); C135(1.24); C342(1.42)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C147(1.23); C342(1.43); C345(1.73)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C147(1.18); C342(1.50); C345(1.70)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C147(1.10); C345(1.26); C342(1.27)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C147(1.24); C345(1.28); C342(1.40)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C147(1.24); C342(1.69); C345(1.85)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C147(1.09); C342(1.55); C345(2.55)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C147(1.45); C342(1.68); C345(2.04)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C147(1.32); C342(1.52); C345(1.53)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C345(1.02); C342(1.20); C147(1.20); C135(1.28)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C147(0.98); C345(1.01); C135(1.40); C342(1.44)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C147(1.00); C135(1.18); C342(1.30); C345(1.41)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C345(1.04); C147(1.13); C135(1.40); C342(1.65)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C345(0.93); C147(1.14); C342(1.26); C135(1.34)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C147(1.30); C342(1.37); C345(1.84)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C342(0.97); C147(1.02); C345(1.09)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C342(1.01); C147(1.03); C345(1.07)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C147(1.13); C345(1.13); C342(1.23)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C342(0.84); C345(0.90); C147(1.11)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C342(0.91); C345(1.06); C147(1.32)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C345(1.04); C147(1.08); C342(1.20)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C342(1.45); C147(1.60); C345(2.06)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C147(1.29); C345(1.59); C342(1.69)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C135(0.98); C147(1.02); C342(1.46); C345(1.56)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C135(0.93); C147(1.13); C342(1.46); C345(1.50)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C135(0.91); C147(0.91); C342(1.15); C345(1.17)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C135(0.80); C342(1.24); C147(1.29); C345(1.31)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C345(0.98); C342(1.02); C147(1.05)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C342(0.87); C147(1.07); C345(1.22)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C342(1.23); C147(1.24); C345(2.46)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C135(1.02); C342(1.03); C345(1.09)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C135(1.02); C342(1.30); C345(1.57)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C345(0.89); C135(0.90); C342(0.91)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C135(1.00); C345(1.00); C342(1.05)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C342(0.76); C147(0.90); C345(1.13)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C135(0.98); C345(1.07); C342(1.08)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C135(1.30); C342(1.96); C345(2.90)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C135(1.13); C342(1.25); C345(1.33)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C135(1.04); C345(1.07); C342(1.08)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C135(0.99); C342(1.04); C345(1.07)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C135(1.12); C342(1.22); C345(1.46)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C135(0.96); C342(1.03); C345(1.04)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C135(1.03); C342(0.93); C345(0.99)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C135(1.15); C342(1.52); C345(1.26)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C135(1.01); C342(1.00); C345(0.99)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C147(0.92); C342(0.97); C345(1.44)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C135(1.13); C342(0.93); C345(0.98)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C135(0.79); C147(1.10); C342(1.34); C345(1.38)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C147(0.92); C342(1.53); C345(1.16)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C147(1.15); C342(2.18); C345(2.03)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C147(1.19); C342(1.52); C345(1.53)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C147(1.06); C342(1.61); C345(1.12)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C147(1.15); C342(1.58); C345(1.37)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C147(1.14); C342(1.45); C345(1.19)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C147(1.28); C342(1.50); C345(1.47)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C147(1.69); C342(1.07); C345(1.91)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C147(1.27); C342(1.58); C345(1.66)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C147(1.05); C342(1.61); C345(1.35)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C147(1.29); C342(1.84); C345(1.50)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C147(1.16); C342(1.44); C345(1.19)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C147(1.31); C342(1.32); C345(1.22)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C147(1.64); C342(1.58); C345(1.92)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C147(1.41); C342(1.00); C345(1.09)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C147(1.26); C342(1.14); C345(1.20)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C147(1.40); C342(0.92); C345(0.96)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C147(1.14); C342(1.03); C345(1.10)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C147(1.16); C342(0.89); C345(0.95)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C147(1.14); C342(1.25); C345(1.35)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C147(1.37); C342(1.02); C345(1.17)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C147(1.26); C342(0.96); C345(1.03)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C147(1.22); C342(1.24); C345(1.29)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C147(1.27); C342(1.28); C345(1.44)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C147(1.14); C342(1.00); C345(1.13)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C147(1.07); C342(1.09); C345(1.05)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C147(1.70); C342(1.33); C345(1.39)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C147(1.16); C342(1.13); C345(1.10)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C147(1.30); C342(1.02); C345(1.10)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C147(1.18); C342(1.00); C345(1.43)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C147(1.58); C342(1.17); C345(1.29)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C342(0.81); C345(0.86)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C342(0.77); C345(0.97)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C342(0.95); C345(1.22)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C342(1.14); C345(1.49)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C342(1.07); C345(0.93)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C342(1.21); C345(1.47)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C342(1.28); C345(1.34)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C342(1.18); C345(1.52)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C342(0.99); C345(1.11)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C147(1.41); C342(1.06); C345(1.14)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C342(1.04); C345(1.08)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C342(0.94); C345(1.11)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C342(0.90); C345(1.17)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C342(1.06); C345(1.25)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C342(1.01); C345(1.16)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C147(0.94); C342(1.14); C345(1.04)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C147(1.19); C342(1.24); C345(1.32)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C147(1.10); C342(1.13); C345(1.08)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C147(1.03); C342(1.29); C345(1.10)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C147(1.24); C342(1.38); C345(1.90)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C147(0.95); C342(1.06); C345(0.99)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C147(0.96); C342(1.14); C345(1.10)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C147(1.19); C342(1.49); C345(1.12)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C147(1.10); C342(1.60); C345(1.48)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C147(1.19); C342(1.76); C345(1.58)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C147(1.02); C342(1.29); C345(1.27)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C147(0.97); C342(1.32); C345(1.15)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C147(0.97); C342(1.34); C345(1.42)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C147(1.14); C342(1.26); C345(1.21)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C147(1.25); C342(1.67); C345(1.39)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C147(1.25); C342(0.99); C345(1.24)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C147(1.14); C342(1.97); C345(2.27)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C147(0.86); C342(0.96); C345(0.86)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C147(1.29); C342(1.22); C345(1.42)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C147(1.11); C342(0.92); C345(1.07)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C147(1.43); C342(1.22); C345(1.13)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C147(1.57); C342(1.26); C345(1.62)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C147(1.28); C342(1.14); C345(1.25)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C147(1.20); C342(1.11); C345(1.29)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C147(1.21); C342(1.22); C345(1.25)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C147(1.20); C342(1.15); C345(1.06)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C135(0.88); C147(1.01); C342(1.16); C345(0.88)  LDD1698  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C342(0.93)  LDD1702  [6]
 LDCM0625  F8 Ramos 1.65  LDD2187  [21]
 LDCM0574  Fragment12 Ramos 1.02  LDD2191  [21]
 LDCM0575  Fragment13 Ramos 1.79  LDD2192  [21]
 LDCM0579  Fragment20 Ramos 0.93  LDD2194  [21]
 LDCM0580  Fragment21 Ramos 0.97  LDD2195  [21]
 LDCM0578  Fragment27 Ramos 2.62  LDD2197  [21]
 LDCM0588  Fragment30 Ramos 1.25  LDD2199  [21]
 LDCM0589  Fragment31 Ramos 2.03  LDD2200  [21]
 LDCM0468  Fragment33 HCT 116 C342(1.42); C345(1.30)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos 0.77  LDD2203  [21]
 LDCM0566  Fragment4 Ramos 1.33  LDD2184  [21]
 LDCM0427  Fragment51 HCT 116 C147(1.34); C342(1.59); C345(1.59)  LDD0744  [7]
 LDCM0569  Fragment7 Ramos 1.00  LDD2186  [21]
 LDCM0107  IAA HeLa C147(0.00); C345(0.00)  LDD0221  [14]
 LDCM0022  KB02 HCT 116 C342(2.67); C345(2.67)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C342(3.09); C345(3.09)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C342(3.05); C345(3.05)  LDD0082  [7]
 LDCM0109  NEM HeLa N.A.  LDD0224  [14]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C342(1.58)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C342(1.24)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C342(1.10)  LDD2093  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C342(0.76)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C342(0.86)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C342(0.92)  LDD2099  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C342(1.04); C135(1.23)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C342(0.43)  LDD2104  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C342(0.33); C147(0.46)  LDD2106  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C342(0.57)  LDD2108  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C147(0.45)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C342(0.84)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C147(0.65)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C342(0.57)  LDD2115  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C342(1.65)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C135(0.76)  LDD2120  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C342(0.83); C135(1.03)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C342(0.78)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C342(0.78)  LDD2127  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C342(0.68)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C342(0.72)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C135(1.21)  LDD2135  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C342(0.91); C135(1.13); C345(0.75)  LDD2137  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C135(1.05)  LDD2140  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C342(2.31); C135(1.23)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C342(1.01)  LDD2146  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C342(0.55); C135(0.37)  LDD2148  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C342(1.92)  LDD2153  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C342(0.92); C342(0.68)  LDD2206  [22]
 LDCM0628  OTUB2-COV-1 HEK-293T C342(0.65); C342(0.49)  LDD2207  [22]
 LDCM0099  Phenelzine HEK-293T 17.57  LDD0282  [5]
 LDCM0131  RA190 MM1.R C342(1.23); C135(1.07)  LDD0304  [23]
 LDCM0021  THZ1 HCT 116 C342(1.09); C345(1.07)  LDD2173  [7]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Glutamic Acid Small molecular drug DB00142
Pyridoxal Phosphate Small molecular drug DB00114
Investigative
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alpha-ketoisovalerate Small molecular drug D03NOU
Alpha-ketoisovalerate Small molecular drug DB04074
Isoleucine Small molecular drug DB00167
Leucine Small molecular drug DB00149
N'-(Phenylsulfonyl)Benzofuran-2-carbohydrazide Small molecular drug D0AW6C
N'-(Phenylsulfonyl)Quinoline-6-carbohydrazide Small molecular drug D0W0FI
N-[O-phosphono-pyridoxyl]-isoleucine Small molecular drug D05QCG
Pyridoxamine-5'-phosphate Small molecular drug D01NBK

References

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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD022279
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Mass spectrometry data entry: PXD033004
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD038010
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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