Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C311  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 17 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 17.1
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 14.5
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 11.2
 LDTP00697  Cytochrome b5 type B (CYB5B) 8.3
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 8.1
 LDTP00988  Protein O-GlcNAcase (OGA) 7.6
 LDTP02359  Heme oxygenase 1 (HMOX1) 7.2
 LDTP08455  Palmitoyltransferase ZDHHC13 (ZDHHC13) 6.9
 LDTP05493  Sulfotransferase 2A1 (SULT2A1) 6.5
 LDTP01640  CCR4-NOT transcription complex subunit 4 (CNOT4) 6.3
 LDTP01769  Dihydrofolate reductase (DHFR) 6.1
 LDTP03540  Heme oxygenase 2 (HMOX2) 6.1
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) 6.0
 LDTP00624  Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) 5.6
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 5.6
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 5.2
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 5.1
Transporter and channel
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03869  Protein Mpv17 (MPV17) 24.1
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 6.6
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 5.8
 LDTP15948  Transmembrane protein 126A (TMEM126A) 5.6
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 5.5
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) 7.3
Other
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 14.2
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 12.7
 LDTP00105  Protein unc-119 homolog B (UNC119B) 11.1
 LDTP05160  Nucleobindin-2 (NUCB2) 9.5
 LDTP10200  60S ribosomal export protein NMD3 (NMD3) 5.9
 LDTP03520  Phosphatidylethanolamine-binding protein 1 (PEBP1) 5.4

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587