Details of the Target

General Information of Target

Target ID LDTP03869
Target Name Protein Mpv17 (MPV17)
Gene Name MPV17
Gene ID 4358
Synonyms
Protein Mpv17
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MALWRAYQRALAAHPWKVQVLTAGSLMGLGDIISQQLVERRGLQEHQRGRTLTMVSLGCG
FVGPVVGGWYKVLDRFIPGTTKVDALKKMLLDQGGFAPCFLGCFLPLVGALNGLSAQDNW
AKLQRDYPDALITNYYLWPAVQLANFYLVPLHYRLAVVQCVAVIWNSYLSWKAHRL
Target Bioclass
Transporter and channel
Family
Peroxisomal membrane protein PXMP2/4 family
Subcellular location
Mitochondrion inner membrane
Function
Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis. Involved in mitochondrial deoxynucleoside triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA) maintenance. May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation.
Uniprot ID
P39210
Ensemble ID
ENST00000233545.6
HGNC ID
HGNC:7224

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Jackson_14
 Probe Info  		4.55  LDD0123  [1]
EA-probe
 Probe Info  		C59(1.18); C59(2.29)  LDD2210  [2]
DBIA
 Probe Info  		C59(0.82)  LDD0531  [3]
1d-yne
 Probe Info  		N.A.  LDD0358  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
STPyne
 Probe Info  		N.A.  LDD0009  [6]
PAL-AfBPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C056
 Probe Info  		17.03  LDD1753  [7]
C091
 Probe Info  		15.67  LDD1782  [7]
C092
 Probe Info  		29.24  LDD1783  [7]
C094
 Probe Info  		35.02  LDD1785  [7]
C143
 Probe Info  		12.64  LDD1825  [7]
C158
 Probe Info  		14.62  LDD1838  [7]
C201
 Probe Info  		28.44  LDD1877  [7]
C206
 Probe Info  		15.56  LDD1881  [7]
C218
 Probe Info  		12.91  LDD1892  [7]
C238
 Probe Info  		12.04  LDD1911  [7]
C299
 Probe Info  		5.70  LDD1968  [7]
C307
 Probe Info  		5.54  LDD1975  [7]
C310
 Probe Info  		10.70  LDD1977  [7]
C311
 Probe Info  		24.08  LDD1978  [7]
C433
 Probe Info  		5.86  LDD2088  [7]
FFF probe11
 Probe Info  		16.25  LDD0471  [8]
FFF probe14
 Probe Info  		20.00  LDD0477  [8]
BD-F
 Probe Info  		A144(0.00); Y147(0.00); N145(0.00)  LDD0024  [9]
OEA-DA
 Probe Info  		7.88  LDD0046  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C59(0.82)  LDD0531  [3]
 LDCM0215  AC10 PaTu 8988t C59(0.86)  LDD1094  [3]
 LDCM0226  AC11 PaTu 8988t C59(1.04)  LDD1105  [3]
 LDCM0230  AC113 PaTu 8988t C59(1.29)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C59(0.87)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C59(1.20)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C59(1.40)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C59(1.38)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C59(0.96)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C59(1.29)  LDD1115  [3]
 LDCM0237  AC12 PaTu 8988t C59(0.93)  LDD1116  [3]
 LDCM0238  AC120 PaTu 8988t C59(1.03)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C59(1.35)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C59(0.99)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C59(1.21)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C59(1.30)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C59(1.00)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C59(0.99)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C59(1.22)  LDD1124  [3]
 LDCM0246  AC128 PaTu 8988t C59(0.67)  LDD1125  [3]
 LDCM0247  AC129 PaTu 8988t C59(0.69)  LDD1126  [3]
 LDCM0249  AC130 PaTu 8988t C59(0.83)  LDD1128  [3]
 LDCM0250  AC131 PaTu 8988t C59(0.84)  LDD1129  [3]
 LDCM0251  AC132 PaTu 8988t C59(0.76)  LDD1130  [3]
 LDCM0252  AC133 PaTu 8988t C59(0.83)  LDD1131  [3]
 LDCM0253  AC134 PaTu 8988t C59(0.97)  LDD1132  [3]
 LDCM0254  AC135 PaTu 8988t C59(0.75)  LDD1133  [3]
 LDCM0255  AC136 PaTu 8988t C59(0.74)  LDD1134  [3]
 LDCM0256  AC137 PaTu 8988t C59(0.71)  LDD1135  [3]
 LDCM0257  AC138 PaTu 8988t C59(0.73)  LDD1136  [3]
 LDCM0258  AC139 PaTu 8988t C59(0.83)  LDD1137  [3]
 LDCM0259  AC14 PaTu 8988t C59(1.06)  LDD1138  [3]
 LDCM0260  AC140 PaTu 8988t C59(0.68)  LDD1139  [3]
 LDCM0261  AC141 PaTu 8988t C59(0.86)  LDD1140  [3]
 LDCM0262  AC142 PaTu 8988t C59(0.78)  LDD1141  [3]
 LDCM0270  AC15 PaTu 8988t C59(0.85)  LDD1149  [3]
 LDCM0276  AC17 HCT 116 C59(1.06)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C59(0.77)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C59(0.89)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C59(0.87)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C59(0.98)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C59(0.90)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C59(1.01)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C59(1.03)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C59(1.16)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C59(1.08)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C59(1.05)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C59(1.15)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C59(0.99)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C59(1.16)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C59(0.93)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C59(1.17)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C59(1.03)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C59(1.08)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C59(1.10)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C59(1.41)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C59(1.19)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C59(1.08)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C59(1.02)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C59(1.17)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C59(0.94)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C59(0.77)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C59(1.09)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C59(0.91)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C59(1.15)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C59(0.94)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C59(1.09)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C59(1.07)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C59(0.87)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C59(1.02)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C59(0.79)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C59(0.96)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C59(0.96)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C59(0.84)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C59(0.91)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C59(0.94)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C59(1.03)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C59(0.91)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C59(1.08)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C59(1.07)  LDD0636  [3]
 LDCM0320  AC57 PaTu 8988t C59(0.83)  LDD1199  [3]
 LDCM0321  AC58 PaTu 8988t C59(0.84)  LDD1200  [3]
 LDCM0322  AC59 PaTu 8988t C59(0.89)  LDD1201  [3]
 LDCM0323  AC6 PaTu 8988t C59(0.85)  LDD1202  [3]
 LDCM0324  AC60 PaTu 8988t C59(0.76)  LDD1203  [3]
 LDCM0325  AC61 PaTu 8988t C59(0.85)  LDD1204  [3]
 LDCM0326  AC62 PaTu 8988t C59(0.80)  LDD1205  [3]
 LDCM0327  AC63 PaTu 8988t C59(0.99)  LDD1206  [3]
 LDCM0328  AC64 PaTu 8988t C59(0.99)  LDD1207  [3]
 LDCM0329  AC65 PaTu 8988t C59(0.75)  LDD1208  [3]
 LDCM0330  AC66 PaTu 8988t C59(0.87)  LDD1209  [3]
 LDCM0331  AC67 PaTu 8988t C59(0.87)  LDD1210  [3]
 LDCM0332  AC68 PaTu 8988t C59(0.60)  LDD1211  [3]
 LDCM0333  AC69 PaTu 8988t C59(0.52)  LDD1212  [3]
 LDCM0334  AC7 PaTu 8988t C59(1.03)  LDD1213  [3]
 LDCM0335  AC70 PaTu 8988t C59(0.54)  LDD1214  [3]
 LDCM0336  AC71 PaTu 8988t C59(0.57)  LDD1215  [3]
 LDCM0337  AC72 PaTu 8988t C59(0.72)  LDD1216  [3]
 LDCM0338  AC73 PaTu 8988t C59(0.65)  LDD1217  [3]
 LDCM0339  AC74 PaTu 8988t C59(0.62)  LDD1218  [3]
 LDCM0340  AC75 PaTu 8988t C59(0.49)  LDD1219  [3]
 LDCM0341  AC76 PaTu 8988t C59(0.60)  LDD1220  [3]
 LDCM0342  AC77 PaTu 8988t C59(0.49)  LDD1221  [3]
 LDCM0343  AC78 PaTu 8988t C59(0.68)  LDD1222  [3]
 LDCM0344  AC79 PaTu 8988t C59(0.56)  LDD1223  [3]
 LDCM0345  AC8 PaTu 8988t C59(0.85)  LDD1224  [3]
 LDCM0346  AC80 PaTu 8988t C59(0.69)  LDD1225  [3]
 LDCM0347  AC81 PaTu 8988t C59(0.56)  LDD1226  [3]
 LDCM0348  AC82 PaTu 8988t C59(0.56)  LDD1227  [3]
 LDCM0349  AC83 PaTu 8988t C59(1.05)  LDD1228  [3]
 LDCM0350  AC84 PaTu 8988t C59(0.92)  LDD1229  [3]
 LDCM0351  AC85 PaTu 8988t C59(0.98)  LDD1230  [3]
 LDCM0352  AC86 PaTu 8988t C59(1.34)  LDD1231  [3]
 LDCM0353  AC87 PaTu 8988t C59(1.02)  LDD1232  [3]
 LDCM0354  AC88 PaTu 8988t C59(0.89)  LDD1233  [3]
 LDCM0355  AC89 PaTu 8988t C59(1.05)  LDD1234  [3]
 LDCM0357  AC90 PaTu 8988t C59(1.30)  LDD1236  [3]
 LDCM0358  AC91 PaTu 8988t C59(0.99)  LDD1237  [3]
 LDCM0359  AC92 PaTu 8988t C59(1.19)  LDD1238  [3]
 LDCM0360  AC93 PaTu 8988t C59(1.45)  LDD1239  [3]
 LDCM0361  AC94 PaTu 8988t C59(0.96)  LDD1240  [3]
 LDCM0362  AC95 PaTu 8988t C59(1.04)  LDD1241  [3]
 LDCM0363  AC96 PaTu 8988t C59(0.97)  LDD1242  [3]
 LDCM0364  AC97 PaTu 8988t C59(1.15)  LDD1243  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C59(0.88)  LDD1127  [3]
 LDCM0356  AKOS034007680 PaTu 8988t C59(0.82)  LDD1235  [3]
 LDCM0275  AKOS034007705 PaTu 8988t C59(0.82)  LDD1154  [3]
 LDCM0367  CL1 HCT 116 C59(1.12)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C59(0.87)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C59(0.76)  LDD0686  [3]
 LDCM0370  CL101 PaTu 8988t C59(1.14)  LDD1249  [3]
 LDCM0371  CL102 PaTu 8988t C59(0.93)  LDD1250  [3]
 LDCM0372  CL103 PaTu 8988t C59(0.88)  LDD1251  [3]
 LDCM0373  CL104 PaTu 8988t C59(1.00)  LDD1252  [3]
 LDCM0374  CL105 HCT 116 C59(0.86)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C59(0.76)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C59(0.80)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C59(0.95)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C59(0.93)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C59(0.90)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C59(0.84)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C59(0.88)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C59(0.96)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C59(1.10)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C59(1.12)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C59(1.19)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C59(1.16)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C59(1.41)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C59(1.14)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C59(1.08)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C59(1.12)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C59(1.00)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C59(0.99)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C59(0.81)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C59(1.01)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C59(0.99)  LDD0712  [3]
 LDCM0396  CL125 PaTu 8988t C59(0.89)  LDD1275  [3]
 LDCM0397  CL126 PaTu 8988t C59(0.98)  LDD1276  [3]
 LDCM0398  CL127 PaTu 8988t C59(1.01)  LDD1277  [3]
 LDCM0399  CL128 PaTu 8988t C59(0.83)  LDD1278  [3]
 LDCM0400  CL13 HCT 116 C59(0.91)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C59(1.05)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C59(0.71)  LDD0719  [3]
 LDCM0403  CL16 HEK-293T C59(0.93)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C59(1.51)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C59(0.99)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C59(0.97)  LDD1610  [11]
 LDCM0407  CL2 HCT 116 C59(1.11)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C59(1.07)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C59(1.37)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C59(1.03)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C59(1.03)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C59(1.01)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C59(1.36)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C59(0.96)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C59(0.94)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C59(0.98)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C59(0.98)  LDD1621  [11]
 LDCM0418  CL3 HCT 116 C59(1.20)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C59(0.97)  LDD1623  [11]
 LDCM0420  CL31 HCT 116 C59(0.79)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C59(0.46)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C59(0.58)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C59(0.79)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C59(0.53)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C59(0.62)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C59(0.44)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C59(0.72)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C59(1.05)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C59(0.59)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C59(0.95)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C59(0.66)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C59(0.70)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C59(0.47)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C59(0.56)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C59(1.06)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C59(0.91)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C59(1.01)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C59(1.02)  LDD1643  [11]
 LDCM0440  CL5 HCT 116 C59(1.21)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C59(1.00)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C59(0.94)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C59(1.38)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C59(1.42)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C59(0.95)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C59(1.05)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C59(1.09)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C59(1.05)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C59(0.93)  LDD1653  [11]
 LDCM0451  CL6 HCT 116 C59(0.94)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C59(1.09)  LDD1655  [11]
 LDCM0453  CL61 HCT 116 C59(0.64)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C59(0.94)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C59(0.67)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C59(0.74)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C59(0.85)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C59(1.16)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C59(1.37)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C59(0.68)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C59(0.77)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C59(1.07)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C59(1.07)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C59(0.97)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C59(0.99)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C59(0.98)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C59(0.86)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C59(0.92)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C59(1.15)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C59(0.92)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C59(1.08)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C59(1.39)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C59(1.86)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C59(1.26)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C59(1.14)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C59(1.11)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C59(1.15)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C59(1.17)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C59(1.02)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C59(1.07)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C59(1.25)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C59(1.27)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C59(1.12)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C59(1.00)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C59(0.75)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C59(0.61)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C59(0.74)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C59(0.92)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C59(0.86)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C59(1.35)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C59(0.70)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C59(0.78)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C59(0.68)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C59(0.87)  LDD1698  [11]
 LDCM0175  Ethacrynic acid HeLa C59(1.18); C59(2.29)  LDD2210  [2]
 LDCM0468  Fragment33 HCT 116 C59(0.54)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C59(1.09)  LDD0744  [3]
 LDCM0022  KB02 HEK-293T C59(0.74)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C59(0.88)  LDD1497  [11]
 LDCM0024  KB05 COLO792 C59(3.01)  LDD3310  [12]
 LDCM0627  NUDT7-COV-1 HEK-293T C59(0.53)  LDD2206  [13]
 LDCM0628  OTUB2-COV-1 HEK-293T C59(0.84)  LDD2207  [13]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 4.55  LDD0123  [1]

References

1 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
2 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
9 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
10 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
13 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.