Details of the Target

General Information of Target

Target ID LDTP14218
Target Name Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7)
Gene Name FKBP7
Gene ID 51661
Synonyms
FKBP23; Peptidyl-prolyl cis-trans isomerase FKBP7; PPIase FKBP7; EC 5.2.1.8; 23 kDa FK506-binding protein; 23 kDa FKBP; FKBP-23; FK506-binding protein 7; FKBP-7; Rotamase
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
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Sequence
MELPSGPGPERLFDSHRLPGDCFLLLVLLLYAPVGFCLLVLRLFLGIHVFLVSCALPDSV
LRRFVVRTMCAVLGLVARQEDSGLRDHSVRVLISNHVTPFDHNIVNLLTTCSTPLLNSPP
SFVCWSRGFMEMNGRGELVESLKRFCASTRLPPTPLLLFPEEEATNGREGLLRFSSWPFS
IQDVVQPLTLQVQRPLVSVTVSDASWVSELLWSLFVPFTVYQVRWLRPVHRQLGEANEEF
ALRVQQLVAKELGQTGTRLTPADKAEHMKRQRHPRLRPQSAQSSFPPSPGPSPDVQLATL
AQRVKEVLPHVPLGVIQRDLAKTGCVDLTITNLLEGAVAFMPEDITKGTQSLPTASASKF
PSSGPVTPQPTALTFAKSSWARQESLQERKQALYEYARRRFTERRAQEAD
Target Bioclass
Enzyme
Subcellular location
Endoplasmic reticulum lumen
Function PPIases accelerate the folding of proteins during protein synthesis.
TTD ID
T01634
Uniprot ID
Q9Y680
DrugMap ID
TTO1ENI
Ensemble ID
ENST00000233092.10
HGNC ID
HGNC:3723

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K52(8.33)  LDD0277  [1]
HHS-475
 Probe Info  		Y189(0.06); Y60(0.88)  LDD0264  [2]
DBIA
 Probe Info  		C46(1.01)  LDD1492  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
SF
 Probe Info  		Y173(0.00); Y60(0.00)  LDD0028  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
AOyne
 Probe Info  		13.90  LDD0443  [8]
HHS-465
 Probe Info  		N.A.  LDD2240  [9]
HHS-482
 Probe Info  		Y60(0.50)  LDD2239  [10]
PAL-AfBPP Probe
Click To Hide/Show 117 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		11.39  LDD1714  [11]
C010
 Probe Info  		7.73  LDD1719  [11]
C017
 Probe Info  		11.71  LDD1725  [11]
C022
 Probe Info  		26.35  LDD1728  [11]
C026
 Probe Info  		6.50  LDD1732  [11]
C027
 Probe Info  		5.82  LDD1733  [11]
C039
 Probe Info  		8.82  LDD1739  [11]
C040
 Probe Info  		12.21  LDD1740  [11]
C041
 Probe Info  		10.93  LDD1741  [11]
C055
 Probe Info  		32.90  LDD1752  [11]
C056
 Probe Info  		35.51  LDD1753  [11]
C059
 Probe Info  		7.41  LDD1756  [11]
C064
 Probe Info  		8.34  LDD1761  [11]
C067
 Probe Info  		6.45  LDD1763  [11]
C070
 Probe Info  		9.13  LDD1766  [11]
C083
 Probe Info  		10.13  LDD1775  [11]
C087
 Probe Info  		11.63  LDD1779  [11]
C091
 Probe Info  		10.27  LDD1782  [11]
C092
 Probe Info  		37.01  LDD1783  [11]
C094
 Probe Info  		34.78  LDD1785  [11]
C100
 Probe Info  		9.13  LDD1789  [11]
C106
 Probe Info  		41.64  LDD1793  [11]
C107
 Probe Info  		14.83  LDD1794  [11]
C108
 Probe Info  		11.63  LDD1795  [11]
C112
 Probe Info  		32.22  LDD1799  [11]
C129
 Probe Info  		10.06  LDD1811  [11]
C134
 Probe Info  		34.54  LDD1816  [11]
C139
 Probe Info  		19.16  LDD1821  [11]
C141
 Probe Info  		27.47  LDD1823  [11]
C143
 Probe Info  		51.27  LDD1825  [11]
C147
 Probe Info  		10.06  LDD1829  [11]
C153
 Probe Info  		32.00  LDD1834  [11]
C156
 Probe Info  		8.75  LDD1836  [11]
C158
 Probe Info  		18.13  LDD1838  [11]
C159
 Probe Info  		13.83  LDD1839  [11]
C160
 Probe Info  		25.11  LDD1840  [11]
C161
 Probe Info  		56.49  LDD1841  [11]
C163
 Probe Info  		25.81  LDD1843  [11]
C169
 Probe Info  		47.18  LDD1849  [11]
C183
 Probe Info  		5.86  LDD1861  [11]
C186
 Probe Info  		26.17  LDD1864  [11]
C194
 Probe Info  		56.10  LDD1870  [11]
C196
 Probe Info  		36.76  LDD1872  [11]
C197
 Probe Info  		6.73  LDD1873  [11]
C198
 Probe Info  		26.35  LDD1874  [11]
C201
 Probe Info  		31.34  LDD1877  [11]
C210
 Probe Info  		48.84  LDD1884  [11]
C211
 Probe Info  		12.38  LDD1885  [11]
C213
 Probe Info  		32.00  LDD1887  [11]
C214
 Probe Info  		48.17  LDD1888  [11]
C216
 Probe Info  		10.13  LDD1890  [11]
C217
 Probe Info  		9.92  LDD1891  [11]
C218
 Probe Info  		25.99  LDD1892  [11]
C219
 Probe Info  		25.28  LDD1893  [11]
C220
 Probe Info  		99.73  LDD1894  [11]
C225
 Probe Info  		10.41  LDD1898  [11]
C226
 Probe Info  		22.94  LDD1899  [11]
C228
 Probe Info  		41.36  LDD1901  [11]
C231
 Probe Info  		19.03  LDD1904  [11]
C238
 Probe Info  		40.22  LDD1911  [11]
C240
 Probe Info  		13.18  LDD1913  [11]
C243
 Probe Info  		52.71  LDD1916  [11]
C244
 Probe Info  		21.86  LDD1917  [11]
C245
 Probe Info  		6.59  LDD1918  [11]
C246
 Probe Info  		35.51  LDD1919  [11]
C249
 Probe Info  		14.83  LDD1922  [11]
C251
 Probe Info  		40.50  LDD1924  [11]
C252
 Probe Info  		16.45  LDD1925  [11]
C264
 Probe Info  		23.26  LDD1935  [11]
C265
 Probe Info  		40.22  LDD1936  [11]
C269
 Probe Info  		6.28  LDD1939  [11]
C270
 Probe Info  		35.75  LDD1940  [11]
C277
 Probe Info  		28.84  LDD1947  [11]
C282
 Probe Info  		53.08  LDD1952  [11]
C284
 Probe Info  		29.04  LDD1954  [11]
C287
 Probe Info  		11.24  LDD1957  [11]
C288
 Probe Info  		8.75  LDD1958  [11]
C289
 Probe Info  		36.00  LDD1959  [11]
C293
 Probe Info  		46.85  LDD1963  [11]
C296
 Probe Info  		13.09  LDD1966  [11]
C307
 Probe Info  		16.68  LDD1975  [11]
C310
 Probe Info  		17.39  LDD1977  [11]
C311
 Probe Info  		5.13  LDD1978  [11]
C313
 Probe Info  		23.10  LDD1980  [11]
C314
 Probe Info  		15.03  LDD1981  [11]
C322
 Probe Info  		27.86  LDD1988  [11]
C326
 Probe Info  		9.19  LDD1990  [11]
C338
 Probe Info  		29.86  LDD2001  [11]
C339
 Probe Info  		5.74  LDD2002  [11]
C343
 Probe Info  		30.70  LDD2005  [11]
C348
 Probe Info  		22.47  LDD2009  [11]
C349
 Probe Info  		17.75  LDD2010  [11]
C350
 Probe Info  		67.65  LDD2011  [11]
C353
 Probe Info  		9.25  LDD2014  [11]
C354
 Probe Info  		7.73  LDD2015  [11]
C355
 Probe Info  		24.25  LDD2016  [11]
C356
 Probe Info  		19.84  LDD2017  [11]
C357
 Probe Info  		12.73  LDD2018  [11]
C361
 Probe Info  		18.64  LDD2022  [11]
C362
 Probe Info  		27.28  LDD2023  [11]
C363
 Probe Info  		29.04  LDD2024  [11]
C366
 Probe Info  		24.59  LDD2027  [11]
C367
 Probe Info  		8.17  LDD2028  [11]
C376
 Probe Info  		30.27  LDD2036  [11]
C380
 Probe Info  		7.52  LDD2039  [11]
C383
 Probe Info  		18.00  LDD2042  [11]
C386
 Probe Info  		13.55  LDD2045  [11]
C388
 Probe Info  		52.35  LDD2047  [11]
C407
 Probe Info  		35.51  LDD2064  [11]
C419
 Probe Info  		15.56  LDD2074  [11]
C429
 Probe Info  		11.96  LDD2084  [11]
C431
 Probe Info  		31.12  LDD2086  [11]
FFF probe11
 Probe Info  		20.00  LDD0471  [12]
FFF probe13
 Probe Info  		20.00  LDD0475  [12]
FFF probe14
 Probe Info  		20.00  LDD0477  [12]
JN0003
 Probe Info  		20.00  LDD0469  [12]
OEA-DA
 Probe Info  		20.00  LDD0046  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C46(1.25)  LDD1507  [3]
 LDCM0226  AC11 HEK-293T C46(1.01)  LDD1509  [3]
 LDCM0270  AC15 HEK-293T C46(0.84)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C46(0.98)  LDD1515  [3]
 LDCM0278  AC19 HEK-293T C46(1.29)  LDD1517  [3]
 LDCM0283  AC23 HEK-293T C46(0.82)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C46(1.02)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C46(0.99)  LDD1524  [3]
 LDCM0287  AC27 HEK-293T C46(1.07)  LDD1526  [3]
 LDCM0290  AC3 HEK-293T C46(1.04)  LDD1529  [3]
 LDCM0292  AC31 HEK-293T C46(1.15)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C46(0.94)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C46(1.56)  LDD1533  [3]
 LDCM0296  AC35 HEK-293T C46(1.15)  LDD1535  [3]
 LDCM0300  AC39 HEK-293T C46(0.92)  LDD1539  [3]
 LDCM0302  AC40 HEK-293T C46(1.03)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C46(1.26)  LDD1542  [3]
 LDCM0305  AC43 HEK-293T C46(1.16)  LDD1544  [3]
 LDCM0309  AC47 HEK-293T C46(1.04)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C46(1.20)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C46(1.40)  LDD1550  [3]
 LDCM0314  AC51 HEK-293T C46(1.07)  LDD1553  [3]
 LDCM0318  AC55 HEK-293T C46(1.04)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C46(0.80)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C46(1.12)  LDD1559  [3]
 LDCM0322  AC59 HEK-293T C46(1.09)  LDD1561  [3]
 LDCM0327  AC63 HEK-293T C46(0.84)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C46(0.83)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C46(0.87)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C46(0.98)  LDD1569  [3]
 LDCM0356  AKOS034007680 HEK-293T C46(1.06)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C46(1.05)  LDD1514  [3]
 LDCM0371  CL102 HEK-293T C46(0.87)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C46(1.01)  LDD1576  [3]
 LDCM0375  CL106 HEK-293T C46(0.91)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C46(1.09)  LDD1580  [3]
 LDCM0379  CL11 HEK-293T C46(0.90)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C46(0.88)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C46(0.85)  LDD1585  [3]
 LDCM0384  CL114 HEK-293T C46(0.87)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C46(0.90)  LDD1589  [3]
 LDCM0388  CL118 HEK-293T C46(0.97)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C46(0.95)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C46(1.00)  LDD1594  [3]
 LDCM0393  CL122 HEK-293T C46(0.83)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C46(0.88)  LDD1598  [3]
 LDCM0397  CL126 HEK-293T C46(0.87)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C46(0.89)  LDD1602  [3]
 LDCM0401  CL14 HEK-293T C46(0.91)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C46(0.75)  LDD1606  [3]
 LDCM0404  CL17 HEK-293T C46(1.10)  LDD1608  [3]
 LDCM0406  CL19 HEK-293T C46(1.02)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C46(0.76)  LDD1611  [3]
 LDCM0411  CL23 HEK-293T C46(0.88)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C46(1.23)  LDD1616  [3]
 LDCM0414  CL26 HEK-293T C46(1.08)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C46(0.85)  LDD1619  [3]
 LDCM0417  CL29 HEK-293T C46(1.06)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C46(0.86)  LDD1622  [3]
 LDCM0420  CL31 HEK-293T C46(1.01)  LDD1624  [3]
 LDCM0424  CL35 HEK-293T C46(1.08)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C46(0.90)  LDD1629  [3]
 LDCM0428  CL39 HEK-293T C46(0.88)  LDD1632  [3]
 LDCM0431  CL41 HEK-293T C46(1.45)  LDD1635  [3]
 LDCM0433  CL43 HEK-293T C46(0.96)  LDD1637  [3]
 LDCM0437  CL47 HEK-293T C46(0.99)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C46(0.82)  LDD1642  [3]
 LDCM0440  CL5 HEK-293T C46(1.36)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C46(0.78)  LDD1645  [3]
 LDCM0444  CL53 HEK-293T C46(1.28)  LDD1647  [3]
 LDCM0446  CL55 HEK-293T C46(1.10)  LDD1649  [3]
 LDCM0450  CL59 HEK-293T C46(1.11)  LDD1653  [3]
 LDCM0452  CL60 HEK-293T C46(0.95)  LDD1655  [3]
 LDCM0454  CL62 HEK-293T C46(0.86)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C46(0.99)  LDD1658  [3]
 LDCM0457  CL65 HEK-293T C46(1.53)  LDD1660  [3]
 LDCM0459  CL67 HEK-293T C46(1.12)  LDD1662  [3]
 LDCM0462  CL7 HEK-293T C46(1.02)  LDD1665  [3]
 LDCM0464  CL71 HEK-293T C46(0.97)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C46(0.99)  LDD1668  [3]
 LDCM0467  CL74 HEK-293T C46(0.93)  LDD1670  [3]
 LDCM0470  CL77 HEK-293T C46(0.93)  LDD1673  [3]
 LDCM0472  CL79 HEK-293T C46(1.02)  LDD1675  [3]
 LDCM0477  CL83 HEK-293T C46(0.83)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C46(0.82)  LDD1681  [3]
 LDCM0480  CL86 HEK-293T C46(0.97)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C46(1.05)  LDD1684  [3]
 LDCM0483  CL89 HEK-293T C46(1.29)  LDD1686  [3]
 LDCM0486  CL91 HEK-293T C46(1.11)  LDD1689  [3]
 LDCM0490  CL95 HEK-293T C46(0.87)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C46(1.02)  LDD1694  [3]
 LDCM0493  CL98 HEK-293T C46(1.00)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C46(0.96)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C46(1.07)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C46(0.83)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C46(1.01)  LDD1631  [3]
 LDCM0116  HHS-0101 DM93 Y189(0.06); Y60(0.88)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y189(0.14); Y60(0.92)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y189(0.23); Y60(0.97)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y189(0.24); Y60(0.87)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y189(0.11); Y60(0.83)  LDD0268  [2]
 LDCM0022  KB02 HEK-293T C46(1.01)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C46(1.02)  LDD1497  [3]
 LDCM0024  KB05 HEK-293T C46(1.05)  LDD1502  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 21 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidylserine lipase ABHD16A (ABHD16A) ABHD16 family O95870
ATPase GET3 (GET3) ArsA ATPase family O43681
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) CDP-alcohol phosphatidyltransferase class-I family O14735
rRNA methyltransferase 1, mitochondrial (MRM1) RNA methyltransferase TrmH family Q6IN84
Phenylalanine--tRNA ligase, mitochondrial (FARS2) Class-II aminoacyl-tRNA synthetase family O95363
Threonine--tRNA ligase, mitochondrial (TARS2) Class-II aminoacyl-tRNA synthetase family Q9BW92
Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF) Cyclophilin-type PPIase family P30405
Choline-phosphate cytidylyltransferase A (PCYT1A) Cytidylyltransferase family P49585
Epididymis-specific alpha-mannosidase (MAN2B2) Glycosyl hydrolase 38 family Q9Y2E5
Inactive glycosyltransferase 25 family member 3 (CERCAM) Glycosyltransferase 25 family Q5T4B2
Protein-cysteine N-palmitoyltransferase HHAT-like protein (HHATL) Membrane-bound acyltransferase family Q9HCP6
Peroxynitrite isomerase THAP4 (THAP4) Nitrobindin family Q8WY91
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 (PLPP6) PA-phosphatase related phosphoesterase family Q8IY26
Tyrosine-protein phosphatase non-receptor type 9 (PTPN9) Protein-tyrosine phosphatase family P43378
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (SUCLA2) Succinate/malate CoA ligase beta subunit family Q9P2R7
Lysoplasmalogenase TMEM86A (TMEM86A) TMEM86 family Q8N2M4
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) UbiA prenyltransferase family Q9Y5Z9
Josephin-2 (JOSD2) . Q8TAC2
Oxidoreductase NAD-binding domain-containing protein 1 (OXNAD1) . Q96HP4
Thioredoxin domain-containing protein 12 (TXNDC12) . O95881
Transporter and channel
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
Solute carrier family 7 member 14 (SLC7A14) Cationic amino acid transporter (CAT) (TC 2.A.3.3) family Q8TBB6
Sodium-coupled neutral amino acid transporter 7 (SLC38A7) Amino acid/polyamine transporter 2 family Q9NVC3
Interferon-induced transmembrane protein 3 (IFITM3) CD225/Dispanin family Q01628
Peroxisomal biogenesis factor 19 (PEX19) Peroxin-19 family P40855
Sorting nexin-1 (SNX1) Sorting nexin family Q13596
Uroplakin-1b (UPK1B) Tetraspanin (TM4SF) family O75841
Sigma intracellular receptor 2 (TMEM97) TMEM97/sigma-2 receptor family Q5BJF2
Translocating chain-associated membrane protein 1-like 1 (TRAM1L1) TRAM family Q8N609
Adiponectin (ADIPOQ) . Q15848
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
V-set and transmembrane domain-containing protein 4 (VSTM4) . Q8IW00
Other
Click To Hide/Show 27 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein D (APOD) Lipocalin family P05090
Protein FAM3C (FAM3C) FAM3 family Q92520
Histone H4-like protein type G (H4C7) Histone H4 family Q99525
Heat shock factor-binding protein 1-like protein 1 (HSBP1L1) HSBP1 family C9JCN9
Radiation-inducible immediate-early gene IEX-1 (IER3) IER3 family P46695
Cytosolic iron-sulfur assembly component 2A (CIAO2A) MIP18 family Q9H5X1
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1) NifU family Q9UMS0
OCIA domain-containing protein 1 (OCIAD1) OCIAD1 family Q9NX40
Pentatricopeptide repeat-containing protein 1, mitochondrial (PTCD1) PTCD1 family O75127
Putative ribosome-binding factor A, mitochondrial (RBFA) RbfA family Q8N0V3
Protein reprimo (RPRM) Reprimo family Q9NS64
RUS family member 1 (RUSF1) RUS1 family Q96GQ5
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765
Syntaxin-7 (STX7) Syntaxin family O15400
Syntaxin-8 (STX8) Syntaxin family Q9UNK0
Tetraspanin-2 (TSPAN2) Tetraspanin (TM4SF) family O60636
Bone morphogenetic protein 10 (BMP10) TGF-beta family O95393
Transmembrane protein 120B (TMEM120B) TMEM120 family A0PK00
Transmembrane protein 229B (TMEM229B) TMEM229 family Q8NBD8
Transmembrane protein 54 (TMEM54) TMEM54 family Q969K7
Protein YIPF6 (YIPF6) YIP1 family Q96EC8
Zinc finger protein-like 1 (ZFPL1) ZFPL1 family O95159
Alpha-tocopherol transfer protein (TTPA) . P49638
Diablo IAP-binding mitochondrial protein (DIABLO) . Q9NR28
Thrombospondin type-1 domain-containing protein 7B (THSD7B) . Q9C0I4
Transmembrane protein 108 (TMEM108) . Q6UXF1
WAP four-disulfide core domain protein 2 (WFDC2) . Q14508

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570