Details of the Target

General Information of Target

Target ID LDTP03107
Target Name Filamin-A (FLNA)
Gene Name FLNA
Gene ID 2316
Synonyms
FLN; FLN1; Filamin-A; FLN-A; Actin-binding protein 280; ABP-280; Alpha-filamin; Endothelial actin-binding protein; Filamin-1; Non-muscle filamin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSSHSRAGQSAAGAAPGGGVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCV
SKRIANLQTDLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIK
LVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTPKQRLLGWIQNKL
PQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVTNAREAMQQADDWLGIPQ
VITPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIEPTGNMVKK
RAEFTVETRSAGQGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLF
AGQHIAKSPFEVYVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVI
QDPMGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNP
SACRAVGRGLQPKGVRVKETADFKVYTKGAGSGELKVTVKGPKGEERVKQKDLGDGVYGF
EYYPMVPGTYIVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGVVGKSADFVVE
AIGDDVGTLGFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFM
ADIRDAPQDFHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHGGKAPLRVQVQDNEGCPVE
ALVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVA
KTGLKAHEPTYFTVDCAEAGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTP
RGAGSYTIMVLFADQATPTSPIRVKVEPSHDASKVKAEGPGLSRTGVELGKPTHFTVNAK
AAGKGKLDVQFSGLTKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGVNVTYGGDPIPKSP
FSVAVSPSLDLSKIKVSGLGEKVDVGKDQEFTVKSKGAGGQGKVASKIVGPSGAAVPCKV
EPGLGADNSVVRFLPREEGPYEVEVTYDGVPVPGSPFPLEAVAPTKPSKVKAFGPGLQGG
SAGSPARFTIDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILF
ADTHIPGSPFKAHVVPCFDASKVKCSGPGLERATAGEVGQFQVDCSSAGSAELTIEICSE
AGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQVEPAVDTSGVQC
YGPGIEGQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTETYVQDRGDGMYKVE
YTPYEEGLHSVDVTYDGSPVPSSPFQVPVTEGCDPSRVRVHGPGIQSGTTNKPNKFTVET
RGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKV
PVHDVTDASKVKCSGPGLSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVV
DNADGTQTVNYVPSREGPYSISVLYGDEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGV
PASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILI
KYGGDEIPFSPYRVRAVPTGDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAG
KGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTA
LAGDQPSVQPPLRSQQLAPQYTYAQGGQQTWAPERPLVGVNGLDVTSLRPFDLVIPFTIK
KGEITGEVRMPSGKVAQPTITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYV
DYVNCGHVTAYGPGLTHGVVNKPATFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTC
SVSYLPVLPGDYSILVKYNEQHVPGSPFTARVTGDDSMRMSHLKVGSAADIPINISETDL
SLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVIS
QSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDG
TCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVANVGSHC
DLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGTHTVSVKYKGQH
VPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSK
AEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSL
QESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGVY
LIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGNPAEFVVNTSNAGAG
ALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPR
LVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLGLSKAYVGQKSSFTV
DCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGS
PYRVVVP
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Family
Filamin family
Subcellular location
Cytoplasm, cell cortex
Function
Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking. Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance. During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons.
TTD ID
T66161
Uniprot ID
P21333
DrugMap ID
TTSTRZY
Ensemble ID
ENST00000360319.9
HGNC ID
HGNC:3754
ChEMBL ID
CHEMBL4804243

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.V2629L DBIA    Probe Info 
AN3CA Insertion: p.L1224PfsTer43 DBIA    Probe Info 
CAL33 SNV: p.V21G DBIA    Probe Info 
CAL51 SNV: p.G1013C DBIA    Probe Info 
CHL1 SNV: p.G681R
Substitution: .		 DBIA    Probe Info 
COLO792 SNV: p.P1239L DBIA    Probe Info 
DETROIT562 SNV: p.E82D DBIA    Probe Info 
ETK1 SNV: p.R2073S DBIA    Probe Info 
HCC1395 SNV: p.D2581H DBIA    Probe Info 
HCT15 SNV: p.V528A DBIA    Probe Info 
HDMYZ SNV: p.G475V DBIA    Probe Info 
HEC1 SNV: p.F304L DBIA    Probe Info 
HEC1B SNV: p.A1188V IA-alkyne    Probe Info 
HGC27 SNV: p.P1468S DBIA    Probe Info 
HT SNV: p.H90R DBIA    Probe Info 
IGROV1 SNV: p.I2115T DBIA    Probe Info 
JURKAT SNV: p.M1?; p.S3I; p.Q426Ter; p.A1086T; p.R1831W Compound 10    Probe Info 
KYSE30 SNV: p.T1594K DBIA    Probe Info 
MCC13 SNV: p.G1894E DBIA    Probe Info 
MDAMB436 SNV: p.V923A DBIA    Probe Info 
MOLT4 SNV: p.H147Y; p.A206V IA-alkyne    Probe Info 
NCIH1155 SNV: p.G903S DBIA    Probe Info 
OVCAR8 SNV: p.P2350A DBIA    Probe Info 
SNU1 Deletion: p.Q1716SfsTer23 DBIA    Probe Info 
SUPT1 SNV: p.P2638Q DBIA    Probe Info 
SW403 SNV: p.V21G; p.G1455R DBIA    Probe Info 
TOV21G SNV: p.K1573M DBIA    Probe Info 
WM2664 Insertion: p.Q801PfsTer21 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 65 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.78  LDD0402  [1]
P1
 Probe Info  		10.00  LDD0452  [2]
P2
 Probe Info  		2.75  LDD0449  [2]
P3
 Probe Info  		1.88  LDD0450  [2]
P8
 Probe Info  		2.35  LDD0451  [2]
A-EBA
 Probe Info  		3.20  LDD0215  [3]
DAyne
 Probe Info  		2.61  LDD0261  [4]
CY-1
 Probe Info  		39.47  LDD0243  [5]
CY4
 Probe Info  		13.66  LDD0244  [5]
N1
 Probe Info  		22.39  LDD0242  [5]
TH211
 Probe Info  		Y2571(20.00); Y2505(9.86); Y1938(9.53); Y2501(9.30)  LDD0260  [6]
YN-4
 Probe Info  		100.00  LDD0445  [7]
1oxF11yne
 Probe Info  		N.A.  LDD0193  [8]
Nap-2
 Probe Info  		N.A.  LDD0435  [9]
ONAyne
 Probe Info  		K1071(3.86); K1162(1.30); K1294(2.26); K1372(6.25)  LDD0274  [10]
OPA-S-S-alkyne
 Probe Info  		K2000(1.14); K1164(1.16); K578(1.25); K704(1.62)  LDD3494  [11]
Probe 1
 Probe Info  		Y287(142.43); Y319(18.48); Y775(62.88); Y933(26.54)  LDD3495  [12]
JZ128-DTB
 Probe Info  		C205(0.00); C2293(0.00)  LDD0462  [13]
AZ-9
 Probe Info  		10.00  LDD2154  [14]
AHL-Pu-1
 Probe Info  		C631(2.23); C623(2.02); C574(2.00); C478(4.25)  LDD0168  [15]
HHS-482
 Probe Info  		Y2505(1.03); Y2571(0.96)  LDD0285  [16]
HHS-475
 Probe Info  		Y791(0.63); Y2077(0.71); Y1761(0.76); Y1308(0.79)  LDD0264  [17]
HHS-465
 Probe Info  		Y1308(9.80); Y2077(6.47); Y2571(5.61)  LDD2237  [18]
DBIA
 Probe Info  		C483(1.10); C2476(1.09); C2479(1.09); C2199(1.05)  LDD0078  [19]
5E-2FA
 Probe Info  		H2595(0.00); H1153(0.00); H2159(0.00); H2547(0.00)  LDD2235  [20]
AMP probe
 Probe Info  		K1450(0.00); K1452(0.00); K781(0.00)  LDD0200  [21]
ATP probe
 Probe Info  		K1450(0.00); K1452(0.00); K781(0.00); K1593(0.00)  LDD0199  [21]
4-Iodoacetamidophenylacetylene
 Probe Info  		C796(0.00); C1157(0.00); C2160(0.00); C2543(0.00)  LDD0038  [22]
IA-alkyne
 Probe Info  		C1402(0.00); C2543(0.00); C733(0.00); C2199(0.00)  LDD0032  [23]
IPIAA_H
 Probe Info  		C205(0.00); C649(0.00); C574(0.00)  LDD0030  [24]
IPIAA_L
 Probe Info  		C2601(0.00); C2476(0.00); C205(0.00); C1865(0.00)  LDD0031  [24]
Lodoacetamide azide
 Probe Info  		C796(0.00); C1157(0.00); C2160(0.00); C810(0.00)  LDD0037  [22]
ATP probe
 Probe Info  		K876(0.00); K700(0.00); K891(0.00); K1375(0.00)  LDD0035  [25]
BTD
 Probe Info  		C59(0.00); C2543(0.00); C2601(0.00); C623(0.00)  LDD0004  [26]
Dyn-2
 Probe Info  		N.A.  LDD0013  [26]
JW-RF-010
 Probe Info  		C1157(0.00); C2543(0.00)  LDD0026  [27]
NAIA_4
 Probe Info  		C574(0.00); C1018(0.00); C1157(0.00); C1165(0.00)  LDD2226  [28]
TFBX
 Probe Info  		C2601(0.00); C1165(0.00); C2199(0.00); C2543(0.00)  LDD0027  [27]
WYneC
 Probe Info  		C1157(0.00); C2543(0.00)  LDD0014  [26]
WYneN
 Probe Info  		C2160(0.00); C2476(0.00); C1157(0.00); C1723(0.00)  LDD0021  [26]
WYneO
 Probe Info  		C2543(0.00); C1402(0.00); C2107(0.00); C574(0.00)  LDD0022  [26]
aHNE
 Probe Info  		N.A.  LDD0001  [26]
1d-yne
 Probe Info  		K1964(0.00); K936(0.00); K1491(0.00); K2540(0.00)  LDD0356  [29]
Compound 10
 Probe Info  		C1157(0.00); C2160(0.00); C2543(0.00); C574(0.00)  LDD2216  [30]
Compound 11
 Probe Info  		C1157(0.00); C2543(0.00)  LDD2213  [30]
ENE
 Probe Info  		C574(0.00); C1165(0.00); C483(0.00); C1157(0.00)  LDD0006  [26]
IPM
 Probe Info  		C1723(0.00); C2199(0.00); C2543(0.00); C1157(0.00)  LDD0005  [26]
NHS
 Probe Info  		K973(0.00); K684(0.00); K916(0.00); K1071(0.00)  LDD0010  [26]
NPM
 Probe Info  		N.A.  LDD0016  [26]
PF-06672131
 Probe Info  		N.A.  LDD0017  [31]
PPMS
 Probe Info  		C2601(0.00); C717(0.00); C1018(0.00); C478(0.00)  LDD0008  [26]
SF
 Probe Info  		Y373(0.00); Y1308(0.00); Y2501(0.00); K1538(0.00)  LDD0028  [32]
STPyne
 Probe Info  		N.A.  LDD0009  [26]
VSF
 Probe Info  		C1165(0.00); C1912(0.00); C574(0.00); C2543(0.00)  LDD0007  [26]
Phosphinate-6
 Probe Info  		C574(0.00); C59(0.00); C1157(0.00); C2543(0.00)  LDD0018  [33]
1c-yne
 Probe Info  		K865(0.00); K43(0.00); K1007(0.00); K1071(0.00)  LDD0228  [29]
Acrolein
 Probe Info  		C1260(0.00); H2525(0.00); C2199(0.00); C2378(0.00)  LDD0217  [34]
Cinnamaldehyde
 Probe Info  		C2543(0.00); C1157(0.00); C717(0.00); C2601(0.00)  LDD0220  [34]
Crotonaldehyde
 Probe Info  		C2543(0.00); C2199(0.00); C2102(0.00); C1157(0.00)  LDD0219  [34]
Methacrolein
 Probe Info  		C2199(0.00); C2160(0.00); C2543(0.00); C717(0.00)  LDD0218  [34]
W1
 Probe Info  		C478(0.00); C574(0.00); C717(0.00); C2479(0.00)  LDD0236  [35]
MPP-AC
 Probe Info  		N.A.  LDD0428  [36]
NAIA_5
 Probe Info  		C2601(0.00); C1157(0.00); C2543(0.00); C810(0.00)  LDD2223  [28]
TER-AC
 Probe Info  		N.A.  LDD0426  [36]
TPP-AC
 Probe Info  		N.A.  LDD0427  [36]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [37]
Staurosporine capture compound
 Probe Info  		2.00  LDD0083  [38]
STS-1
 Probe Info  		N.A.  LDD0069  [39]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C717(0.68); C2601(0.36); C2160(0.26); C1402(0.46)  LDD2142  [40]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C717(0.70); C2601(0.60); C2160(0.60); C1165(0.49)  LDD2112  [40]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C717(1.13); C478(0.80); C2601(0.71); C2160(0.70)  LDD2095  [40]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C2601(0.99); C1165(0.99); C1402(0.87); C1157(0.83)  LDD2130  [40]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C717(0.92); C478(0.83); C2601(0.89); C2160(0.98)  LDD2117  [40]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C478(1.12); C2601(1.22); C1165(1.07); C1402(1.24)  LDD2152  [40]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C717(1.06); C478(1.72); C2601(1.15); C2160(1.94)  LDD2103  [40]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1165(0.38); C1402(0.79); C1157(0.56); C2543(0.50)  LDD2132  [40]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C717(0.84); C2601(0.72); C2160(0.87); C1165(0.84)  LDD2131  [40]
 LDCM0025  4SU-RNA HEK-293T C631(2.23); C623(2.02); C574(2.00); C478(4.25)  LDD0168  [15]
 LDCM0026  4SU-RNA+native RNA HEK-293T C631(2.31); C717(2.03); C623(2.16); C478(2.76)  LDD0169  [15]
 LDCM0563  Abegg_cp(+)-11 HeLa C2199(2.43)  LDD0314  [27]
 LDCM0561  Abegg_cp(-)-10 HeLa C2199(2.05)  LDD0312  [27]
 LDCM0214  AC1 HCT 116 C1453(0.89); C2102(1.02); C1157(1.30); C1165(1.55)  LDD0531  [19]
 LDCM0215  AC10 HCT 116 C1453(1.26); C2102(1.35); C1157(1.14); C1165(1.39)  LDD0532  [19]
 LDCM0216  AC100 HCT 116 C1453(0.73); C2102(0.92); C1018(0.70); C1157(1.13)  LDD0533  [19]
 LDCM0217  AC101 HCT 116 C1453(0.75); C2102(0.94); C1018(0.68); C1157(1.06)  LDD0534  [19]
 LDCM0218  AC102 HCT 116 C1453(0.63); C2102(0.98); C1018(0.72); C1157(1.02)  LDD0535  [19]
 LDCM0219  AC103 HCT 116 C1453(0.79); C2102(1.67); C1018(0.75); C1157(1.31)  LDD0536  [19]
 LDCM0220  AC104 HCT 116 C1453(0.61); C2102(1.09); C1018(0.78); C1157(1.21)  LDD0537  [19]
 LDCM0221  AC105 HCT 116 C1453(0.83); C2102(1.48); C1018(0.70); C1157(1.22)  LDD0538  [19]
 LDCM0222  AC106 HCT 116 C1453(0.89); C2102(0.99); C1018(0.73); C1157(1.25)  LDD0539  [19]
 LDCM0223  AC107 HCT 116 C1453(0.69); C2102(1.50); C1018(1.24); C1157(1.45)  LDD0540  [19]
 LDCM0224  AC108 HCT 116 C1453(0.79); C2102(0.98); C1018(0.62); C1157(1.02)  LDD0541  [19]
 LDCM0225  AC109 HCT 116 C1453(0.69); C2102(0.99); C1018(0.66); C1157(0.92)  LDD0542  [19]
 LDCM0226  AC11 HCT 116 C1453(1.13); C2102(1.57); C1157(1.33); C1165(1.27)  LDD0543  [19]
 LDCM0227  AC110 HCT 116 C1453(0.62); C2102(0.87); C1018(0.93); C1157(1.05)  LDD0544  [19]
 LDCM0228  AC111 HCT 116 C1453(0.64); C2102(0.93); C1018(0.78); C1157(0.99)  LDD0545  [19]
 LDCM0229  AC112 HCT 116 C1453(0.59); C2102(1.10); C1018(0.87); C1157(1.26)  LDD0546  [19]
 LDCM0230  AC113 HCT 116 C1453(1.14); C2102(0.95); C1157(0.93); C1165(1.23)  LDD0547  [19]
 LDCM0231  AC114 HCT 116 C1453(1.23); C2102(0.88); C1157(1.12); C1165(1.67)  LDD0548  [19]
 LDCM0232  AC115 HCT 116 C1453(1.20); C2102(1.15); C1157(1.19); C1165(1.23)  LDD0549  [19]
 LDCM0233  AC116 HCT 116 C1453(1.26); C2102(1.12); C1157(1.16); C1165(1.32)  LDD0550  [19]
 LDCM0234  AC117 HCT 116 C1453(1.18); C2102(0.98); C1157(1.08); C1165(1.32)  LDD0551  [19]
 LDCM0235  AC118 HCT 116 C1453(1.36); C2102(1.12); C1157(1.04); C1165(1.38)  LDD0552  [19]
 LDCM0236  AC119 HCT 116 C1453(0.95); C2102(1.56); C1157(1.08); C1165(1.39)  LDD0553  [19]
 LDCM0237  AC12 HCT 116 C1453(0.98); C2102(1.11); C1157(1.24); C1165(1.42)  LDD0554  [19]
 LDCM0238  AC120 HCT 116 C1453(0.83); C2102(0.80); C1157(1.27); C1165(1.23)  LDD0555  [19]
 LDCM0239  AC121 HCT 116 C1453(1.05); C2102(1.05); C1157(1.03); C1165(1.64)  LDD0556  [19]
 LDCM0240  AC122 HCT 116 C1453(1.14); C2102(0.79); C1157(1.09); C1165(0.98)  LDD0557  [19]
 LDCM0241  AC123 HCT 116 C1453(1.27); C2102(1.00); C1157(1.05); C1165(1.50)  LDD0558  [19]
 LDCM0242  AC124 HCT 116 C1453(1.05); C2102(0.84); C1157(0.95); C1165(1.39)  LDD0559  [19]
 LDCM0243  AC125 HCT 116 C1453(1.34); C2102(1.02); C1157(1.05); C1165(1.22)  LDD0560  [19]
 LDCM0244  AC126 HCT 116 C1453(1.11); C2102(1.56); C1157(1.20); C1165(1.71)  LDD0561  [19]
 LDCM0245  AC127 HCT 116 C1453(1.14); C2102(0.85); C1157(1.13); C1165(1.57)  LDD0562  [19]
 LDCM0246  AC128 HCT 116 C1453(0.88); C1018(0.96); C1157(1.11); C1165(1.07)  LDD0563  [19]
 LDCM0247  AC129 HCT 116 C1453(1.42); C1018(0.86); C1157(0.86); C1165(1.15)  LDD0564  [19]
 LDCM0249  AC130 HCT 116 C1453(0.88); C1018(0.84); C1157(1.08); C1165(0.96)  LDD0566  [19]
 LDCM0250  AC131 HCT 116 C1453(1.27); C1018(0.80); C1157(0.95); C1165(0.73)  LDD0567  [19]
 LDCM0251  AC132 HCT 116 C1453(1.19); C1018(0.85); C1157(1.00); C1165(0.93)  LDD0568  [19]
 LDCM0252  AC133 HCT 116 C1453(1.22); C1018(0.81); C1157(1.07); C1165(0.93)  LDD0569  [19]
 LDCM0253  AC134 HCT 116 C1453(0.76); C1018(0.66); C1157(1.24); C1165(0.53)  LDD0570  [19]
 LDCM0254  AC135 HCT 116 C1453(0.83); C1018(0.92); C1157(1.14); C1165(0.71)  LDD0571  [19]
 LDCM0255  AC136 HCT 116 C1453(1.03); C1018(0.75); C1157(1.14); C1165(0.65)  LDD0572  [19]
 LDCM0256  AC137 HCT 116 C1453(0.97); C1018(0.91); C1157(1.08); C1165(0.79)  LDD0573  [19]
 LDCM0257  AC138 HCT 116 C1453(0.86); C1018(0.63); C1157(1.34); C1165(0.64)  LDD0574  [19]
 LDCM0258  AC139 HCT 116 C1453(1.00); C1018(0.89); C1157(1.13); C1165(0.84)  LDD0575  [19]
 LDCM0259  AC14 HCT 116 C1453(1.33); C2102(1.36); C1157(1.16); C1165(1.47)  LDD0576  [19]
 LDCM0260  AC140 HCT 116 C1453(0.87); C1018(0.71); C1157(1.28); C1165(0.61)  LDD0577  [19]
 LDCM0261  AC141 HCT 116 C1453(0.91); C1018(0.64); C1157(1.24); C1165(0.55)  LDD0578  [19]
 LDCM0262  AC142 HCT 116 C1453(1.32); C1018(0.87); C1157(1.01); C1165(0.96)  LDD0579  [19]
 LDCM0263  AC143 HCT 116 C1453(1.00); C1018(0.93); C1157(1.09); C1165(1.00)  LDD0580  [19]
 LDCM0264  AC144 HCT 116 C1260(0.74); C1453(0.88); C2582(0.97); C478(0.98)  LDD0581  [19]
 LDCM0265  AC145 HCT 116 C478(0.85); C1453(0.93); C2107(0.93); C1997(0.94)  LDD0582  [19]
 LDCM0266  AC146 HCT 116 C1453(0.73); C1260(0.88); C2582(0.94); C483(0.99)  LDD0583  [19]
 LDCM0267  AC147 HCT 116 C1997(0.90); C478(0.92); C1453(0.98); C2582(1.00)  LDD0584  [19]
 LDCM0268  AC148 HCT 116 C1453(0.71); C2582(0.89); C810(0.99); C483(1.11)  LDD0585  [19]
 LDCM0269  AC149 HCT 116 C1453(0.63); C733(0.90); C2582(0.96); C483(1.02)  LDD0586  [19]
 LDCM0270  AC15 HCT 116 C1912(0.57); C1920(0.57); C717(0.99); C2543(1.00)  LDD0587  [19]
 LDCM0271  AC150 HCT 116 C1260(0.77); C1453(0.82); C2293(0.92); C2582(0.95)  LDD0588  [19]
 LDCM0272  AC151 HCT 116 C1453(0.90); C810(0.94); C1018(0.96); C483(0.97)  LDD0589  [19]
 LDCM0273  AC152 HCT 116 C1453(0.81); C1260(0.82); C483(0.89); C2582(0.94)  LDD0590  [19]
 LDCM0274  AC153 HCT 116 C1453(0.71); C1260(0.79); C733(0.82); C2582(0.88)  LDD0591  [19]
 LDCM0621  AC154 HCT 116 C1453(0.93); C1018(0.94); C1157(1.17); C1165(1.07)  LDD2158  [19]
 LDCM0622  AC155 HCT 116 C1453(0.88); C1018(0.93); C1157(1.17); C1165(1.02)  LDD2159  [19]
 LDCM0623  AC156 HCT 116 C1453(0.83); C1018(1.06); C1157(1.00); C1165(1.03)  LDD2160  [19]
 LDCM0624  AC157 HCT 116 C1453(0.82); C1018(0.73); C1157(1.00); C1165(0.92)  LDD2161  [19]
 LDCM0276  AC17 HCT 116 C2102(0.73); C2582(0.85); C649(0.88); C1453(0.90)  LDD0593  [19]
 LDCM0277  AC18 HCT 116 C649(0.41); C1453(0.68); C2102(0.93); C2199(1.05)  LDD0594  [19]
 LDCM0278  AC19 HCT 116 C2582(0.70); C2102(0.82); C1997(0.88); C1453(0.89)  LDD0595  [19]
 LDCM0279  AC2 HCT 116 C1453(0.92); C1402(0.95); C2199(0.99); C717(1.02)  LDD0596  [19]
 LDCM0280  AC20 HCT 116 C2582(0.64); C2102(0.68); C2601(0.81); C1453(0.83)  LDD0597  [19]
 LDCM0281  AC21 HCT 116 C2102(0.75); C649(0.87); C2199(0.88); C2107(0.92)  LDD0598  [19]
 LDCM0282  AC22 HCT 116 C2102(0.70); C2582(0.71); C1165(0.87); C2199(0.90)  LDD0599  [19]
 LDCM0283  AC23 HCT 116 C2102(0.68); C649(0.80); C2582(0.81); C1453(0.87)  LDD0600  [19]
 LDCM0284  AC24 HCT 116 C649(0.67); C2582(0.71); C2102(0.84); C1165(0.85)  LDD0601  [19]
 LDCM0285  AC25 HCT 116 C478(0.71); C2107(0.73); C2160(0.78); C1260(0.81)  LDD0602  [19]
 LDCM0286  AC26 HCT 116 C2582(0.50); C1997(0.53); C478(0.61); C1165(0.75)  LDD0603  [19]
 LDCM0287  AC27 HCT 116 C2582(0.53); C478(0.64); C1997(0.64); C2160(0.74)  LDD0604  [19]
 LDCM0288  AC28 HCT 116 C2582(0.51); C1997(0.64); C478(0.70); C2107(0.76)  LDD0605  [19]
 LDCM0289  AC29 HCT 116 C2582(0.37); C478(0.58); C1997(0.69); C1165(0.73)  LDD0606  [19]
 LDCM0290  AC3 HCT 116 C2199(0.89); C2102(0.91); C1402(0.96); C1453(1.00)  LDD0607  [19]
 LDCM0291  AC30 HCT 116 C2582(0.32); C2160(0.65); C478(0.67); C1453(0.68)  LDD0608  [19]
 LDCM0292  AC31 HCT 116 C2582(0.48); C1997(0.52); C2160(0.57); C1165(0.72)  LDD0609  [19]
 LDCM0293  AC32 HCT 116 C2582(0.29); C1997(0.73); C1165(0.77); C2160(0.80)  LDD0610  [19]
 LDCM0294  AC33 HCT 116 C2582(0.62); C1997(0.67); C2160(0.77); C2107(0.79)  LDD0611  [19]
 LDCM0295  AC34 HCT 116 C2582(0.48); C1997(0.58); C478(0.73); C2160(0.77)  LDD0612  [19]
 LDCM0296  AC35 HCT 116 C1453(0.61); C2199(0.64); C1402(0.80); C1912(0.83)  LDD0613  [19]
 LDCM0297  AC36 HCT 116 C1912(0.66); C1920(0.66); C2199(0.83); C1453(0.84)  LDD0614  [19]
 LDCM0298  AC37 HCT 116 C1912(0.66); C1920(0.66); C1157(0.91); C1018(0.93)  LDD0615  [19]
 LDCM0299  AC38 HCT 116 C1912(0.75); C1920(0.75); C1157(0.86); C2543(0.87)  LDD0616  [19]
 LDCM0300  AC39 HCT 116 C1912(0.52); C1920(0.52); C1997(0.81); C1453(0.92)  LDD0617  [19]
 LDCM0301  AC4 HCT 116 C1402(0.90); C2102(0.93); C733(1.02); C1453(1.05)  LDD0618  [19]
 LDCM0302  AC40 HCT 116 C1912(0.58); C1920(0.58); C1997(0.83); C1260(0.93)  LDD0619  [19]
 LDCM0303  AC41 HCT 116 C1912(0.43); C1920(0.43); C1997(0.77); C2199(0.82)  LDD0620  [19]
 LDCM0304  AC42 HCT 116 C1912(0.49); C1920(0.49); C1997(0.72); C1018(0.86)  LDD0621  [19]
 LDCM0305  AC43 HCT 116 C1912(0.61); C1920(0.61); C1997(0.81); C2102(0.92)  LDD0622  [19]
 LDCM0306  AC44 HCT 116 C1912(0.43); C1920(0.43); C1997(0.61); C1018(0.94)  LDD0623  [19]
 LDCM0307  AC45 HCT 116 C1997(0.57); C1912(0.61); C1920(0.61); C2102(1.06)  LDD0624  [19]
 LDCM0308  AC46 HCT 116 C1453(0.28); C2601(0.60); C649(0.73); C2582(0.78)  LDD0625  [19]
 LDCM0309  AC47 HCT 116 C1453(0.27); C2601(0.77); C1165(0.83); C1260(0.87)  LDD0626  [19]
 LDCM0310  AC48 HCT 116 C1453(0.30); C2601(0.62); C2582(0.75); C2293(0.90)  LDD0627  [19]
 LDCM0311  AC49 HCT 116 C1453(0.27); C2601(0.48); C2582(0.76); C1260(0.80)  LDD0628  [19]
 LDCM0312  AC5 HCT 116 C2102(0.77); C1402(0.92); C733(0.97); C2199(0.98)  LDD0629  [19]
 LDCM0313  AC50 HCT 116 C1453(0.30); C2601(0.54); C2160(0.73); C2102(0.79)  LDD0630  [19]
 LDCM0314  AC51 HCT 116 C1453(0.31); C2601(0.50); C1165(0.70); C2160(0.71)  LDD0631  [19]
 LDCM0315  AC52 HCT 116 C1453(0.34); C2601(0.53); C1165(0.80); C649(0.83)  LDD0632  [19]
 LDCM0316  AC53 HCT 116 C1453(0.33); C2601(0.49); C2160(0.60); C1165(0.70)  LDD0633  [19]
 LDCM0317  AC54 HCT 116 C1453(0.36); C2601(0.55); C2582(0.83); C2160(0.83)  LDD0634  [19]
 LDCM0318  AC55 HCT 116 C1453(0.51); C2601(0.77); C2293(0.79); C1165(0.80)  LDD0635  [19]
 LDCM0319  AC56 HCT 116 C1453(0.24); C2601(0.57); C2582(0.71); C1165(0.72)  LDD0636  [19]
 LDCM0320  AC57 HCT 116 C205(0.33); C210(0.33); C1912(0.64); C1920(0.64)  LDD0637  [19]
 LDCM0321  AC58 HCT 116 C205(0.31); C210(0.31); C2160(0.79); C1912(0.80)  LDD0638  [19]
 LDCM0322  AC59 HCT 116 C205(0.33); C210(0.33); C1912(0.59); C1920(0.59)  LDD0639  [19]
 LDCM0323  AC6 HCT 116 C1912(0.57); C1920(0.57); C733(0.86); C2582(0.87)  LDD0640  [19]
 LDCM0324  AC60 HCT 116 C205(0.35); C210(0.35); C1912(0.60); C1920(0.60)  LDD0641  [19]
 LDCM0325  AC61 HCT 116 C205(0.47); C210(0.47); C1912(0.51); C1920(0.51)  LDD0642  [19]
 LDCM0326  AC62 HCT 116 C205(0.27); C210(0.27); C1912(0.76); C1920(0.76)  LDD0643  [19]
 LDCM0327  AC63 HCT 116 C205(0.42); C210(0.42); C1912(0.60); C1920(0.60)  LDD0644  [19]
 LDCM0328  AC64 HCT 116 C205(0.27); C210(0.27); C1912(0.53); C1920(0.53)  LDD0645  [19]
 LDCM0329  AC65 HCT 116 C205(0.33); C210(0.33); C1912(0.44); C1920(0.44)  LDD0646  [19]
 LDCM0330  AC66 HCT 116 C205(0.37); C210(0.37); C1453(0.64); C1912(0.67)  LDD0647  [19]
 LDCM0331  AC67 HCT 116 C205(0.17); C210(0.17); C1912(0.26); C1920(0.26)  LDD0648  [19]
 LDCM0332  AC68 HCT 116 C2601(0.65); C2160(0.76); C1997(0.90); C2543(0.97)  LDD0649  [19]
 LDCM0333  AC69 HCT 116 C2601(0.60); C2160(0.74); C2543(0.86); C1260(0.90)  LDD0650  [19]
 LDCM0334  AC7 HCT 116 C1912(0.52); C1920(0.52); C478(0.82); C733(0.86)  LDD0651  [19]
 LDCM0335  AC70 HCT 116 C2160(0.59); C1260(0.75); C810(0.78); C2601(0.83)  LDD0652  [19]
 LDCM0336  AC71 HCT 116 C2543(0.72); C2160(0.88); C2601(0.92); C2199(0.94)  LDD0653  [19]
 LDCM0337  AC72 HCT 116 C2160(0.61); C1260(0.70); C2601(0.83); C478(0.83)  LDD0654  [19]
 LDCM0338  AC73 HCT 116 C2160(0.58); C1260(0.70); C733(0.71); C1997(0.77)  LDD0655  [19]
 LDCM0339  AC74 HCT 116 C2543(0.85); C1997(0.94); C2601(0.99); C478(1.01)  LDD0656  [19]
 LDCM0340  AC75 HCT 116 C1260(0.59); C2160(0.67); C2601(0.72); C478(0.91)  LDD0657  [19]
 LDCM0341  AC76 HCT 116 C2601(0.74); C2160(0.74); C2543(0.82); C1997(0.90)  LDD0658  [19]
 LDCM0342  AC77 HCT 116 C2160(0.63); C1997(0.71); C2601(0.74); C1260(0.88)  LDD0659  [19]
 LDCM0343  AC78 HCT 116 C2160(0.58); C2601(0.74); C1260(0.79); C1997(0.81)  LDD0660  [19]
 LDCM0344  AC79 HCT 116 C2160(0.55); C2601(0.63); C1997(0.86); C1260(0.86)  LDD0661  [19]
 LDCM0345  AC8 HCT 116 C1912(0.54); C1920(0.54); C1453(0.83); C2582(0.94)  LDD0662  [19]
 LDCM0346  AC80 HCT 116 C2601(0.75); C2543(0.86); C1997(0.96); C2102(0.99)  LDD0663  [19]
 LDCM0347  AC81 HCT 116 C2160(0.67); C2601(0.67); C810(0.72); C733(0.76)  LDD0664  [19]
 LDCM0348  AC82 HCT 116 C2160(0.64); C2601(0.74); C810(0.79); C1260(0.86)  LDD0665  [19]
 LDCM0349  AC83 HCT 116 C205(0.59); C210(0.59); C733(0.68); C1260(0.86)  LDD0666  [19]
 LDCM0350  AC84 HCT 116 C733(0.62); C205(0.82); C210(0.82); C1165(0.84)  LDD0667  [19]
 LDCM0351  AC85 HCT 116 C733(0.58); C2582(0.77); C2601(0.80); C1165(0.80)  LDD0668  [19]
 LDCM0352  AC86 HCT 116 C733(0.46); C1260(0.72); C2293(0.81); C483(0.81)  LDD0669  [19]
 LDCM0353  AC87 HCT 116 C733(0.71); C2601(0.79); C2293(0.81); C1997(0.86)  LDD0670  [19]
 LDCM0354  AC88 HCT 116 C733(0.56); C1260(0.57); C2601(0.70); C2293(0.77)  LDD0671  [19]
 LDCM0355  AC89 HCT 116 C205(0.52); C210(0.52); C733(0.65); C1260(0.77)  LDD0672  [19]
 LDCM0357  AC90 HCT 116 C733(0.41); C2293(0.66); C1260(0.79); C2476(0.80)  LDD0674  [19]
 LDCM0358  AC91 HCT 116 C1260(0.71); C733(0.72); C205(0.80); C210(0.80)  LDD0675  [19]
 LDCM0359  AC92 HCT 116 C733(0.54); C205(0.70); C210(0.70); C1260(0.72)  LDD0676  [19]
 LDCM0360  AC93 HCT 116 C733(0.56); C205(0.77); C210(0.77); C1165(0.77)  LDD0677  [19]
 LDCM0361  AC94 HCT 116 C2601(0.58); C205(0.73); C210(0.73); C2107(0.81)  LDD0678  [19]
 LDCM0362  AC95 HCT 116 C1453(0.84); C2601(0.86); C2107(0.88); C1997(0.88)  LDD0679  [19]
 LDCM0363  AC96 HCT 116 C205(0.65); C210(0.65); C2601(0.89); C2107(0.89)  LDD0680  [19]
 LDCM0364  AC97 HCT 116 C733(0.59); C1260(0.72); C205(0.81); C210(0.81)  LDD0681  [19]
 LDCM0365  AC98 HCT 116 C205(0.25); C210(0.25); C733(0.35); C1260(0.49)  LDD0682  [19]
 LDCM0366  AC99 HCT 116 C733(0.33); C1453(0.54); C2582(0.70); C1260(0.70)  LDD0683  [19]
 LDCM0545  Acetamide MDA-MB-231 C717(0.63); C478(0.63); C2601(0.66); C1165(0.44)  LDD2138  [40]
 LDCM0520  AKOS000195272 MDA-MB-231 C717(0.54); C478(0.91); C2601(0.56); C2160(0.61)  LDD2113  [40]
 LDCM0248  AKOS034007472 HCT 116 C1453(1.29); C2102(1.43); C1157(1.02); C1165(1.20)  LDD0565  [19]
 LDCM0356  AKOS034007680 HCT 116 C1912(0.38); C1920(0.38); C2543(0.94); C2199(0.97)  LDD0673  [19]
 LDCM0275  AKOS034007705 HCT 116 C1912(0.86); C1920(0.86); C2582(1.02); C733(1.03)  LDD0592  [19]
 LDCM0156  Aniline NCI-H1299 C478(0.00); C1157(0.00); C2293(0.00)  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C483(1.10); C2476(1.09); C2479(1.09); C2199(1.05)  LDD0078  [19]
 LDCM0151  AZ-11 HeLa 10.00  LDD2154  [14]
 LDCM0498  BS-3668 MDA-MB-231 C717(0.71); C2601(0.82); C2160(0.77); C1165(0.41)  LDD2091  [40]
 LDCM0630  CCW28-3 231MFP C2543(1.27); C2199(0.86)  LDD2214  [41]
 LDCM0108  Chloroacetamide HeLa C1260(0.00); H2525(0.00); C2293(0.00); C2543(0.00)  LDD0222  [34]
 LDCM0632  CL-Sc Hep-G2 C2107(20.00); C1157(1.79); C2543(1.27); C2601(1.23)  LDD2227  [28]
 LDCM0367  CL1 HCT 116 C1912(0.73); C1920(0.73); C2107(0.78); C2601(0.78)  LDD0684  [19]
 LDCM0368  CL10 HCT 116 C733(0.63); C1912(0.70); C1920(0.70); C2601(0.86)  LDD0685  [19]
 LDCM0369  CL100 HCT 116 C1453(0.96); C717(0.97); C2199(1.00); C1402(1.04)  LDD0686  [19]
 LDCM0370  CL101 HCT 116 C1912(0.49); C1920(0.49); C1165(0.98); C2107(1.05)  LDD0687  [19]
 LDCM0371  CL102 HCT 116 C1912(0.45); C1920(0.45); C2543(0.93); C1402(0.98)  LDD0688  [19]
 LDCM0372  CL103 HCT 116 C1912(0.74); C1920(0.74); C2107(0.93); C1260(0.97)  LDD0689  [19]
 LDCM0373  CL104 HCT 116 C1912(0.91); C1920(0.91); C717(0.98); C2107(0.98)  LDD0690  [19]
 LDCM0374  CL105 HCT 116 C2102(0.87); C1453(0.90); C649(0.99); C717(1.09)  LDD0691  [19]
 LDCM0375  CL106 HCT 116 C1453(0.71); C649(0.96); C2102(1.11); C717(1.17)  LDD0692  [19]
 LDCM0376  CL107 HCT 116 C1453(0.87); C649(0.92); C2102(0.94); C2107(1.13)  LDD0693  [19]
 LDCM0377  CL108 HCT 116 C1453(0.79); C649(0.82); C2582(0.94); C2102(0.95)  LDD0694  [19]
 LDCM0378  CL109 HCT 116 C2102(0.84); C1453(0.88); C1997(0.92); C649(0.94)  LDD0695  [19]
 LDCM0379  CL11 HCT 116 C733(0.72); C2601(0.78); C478(0.79); C1912(0.82)  LDD0696  [19]
 LDCM0380  CL110 HCT 116 C2582(0.67); C2102(0.81); C1453(0.82); C1165(0.88)  LDD0697  [19]
 LDCM0381  CL111 HCT 116 C2582(0.62); C649(0.66); C1997(0.70); C1165(0.73)  LDD0698  [19]
 LDCM0382  CL112 HCT 116 C1997(0.56); C1453(0.57); C2582(0.57); C2160(0.69)  LDD0699  [19]
 LDCM0383  CL113 HCT 116 C2582(0.29); C2160(0.55); C1997(0.67); C1165(0.69)  LDD0700  [19]
 LDCM0384  CL114 HCT 116 C2582(0.25); C1997(0.63); C2160(0.68); C1165(0.71)  LDD0701  [19]
 LDCM0385  CL115 HCT 116 C2582(0.30); C1997(0.58); C478(0.66); C2160(0.68)  LDD0702  [19]
 LDCM0386  CL116 HCT 116 C2582(0.62); C1997(0.63); C2160(0.76); C2107(0.78)  LDD0703  [19]
 LDCM0387  CL117 HCT 116 C1912(0.53); C1920(0.53); C1997(0.87); C478(0.89)  LDD0704  [19]
 LDCM0388  CL118 HCT 116 C1912(0.45); C1920(0.45); C478(0.90); C1453(0.93)  LDD0705  [19]
 LDCM0389  CL119 HCT 116 C2160(0.95); C1018(0.95); C1912(0.96); C1920(0.96)  LDD0706  [19]
 LDCM0390  CL12 HCT 116 C733(0.60); C1260(0.83); C478(0.86); C1912(0.88)  LDD0707  [19]
 LDCM0391  CL120 HCT 116 C1912(0.49); C1920(0.49); C2199(0.83); C1018(0.94)  LDD0708  [19]
 LDCM0392  CL121 HCT 116 C1453(0.40); C483(0.71); C733(0.72); C2601(0.73)  LDD0709  [19]
 LDCM0393  CL122 HCT 116 C1453(0.48); C2601(0.60); C2160(0.85); C2102(0.89)  LDD0710  [19]
 LDCM0394  CL123 HCT 116 C1453(0.31); C2601(0.55); C1165(0.71); C1260(0.76)  LDD0711  [19]
 LDCM0395  CL124 HCT 116 C1453(0.24); C2601(0.61); C1165(0.73); C2582(0.80)  LDD0712  [19]
 LDCM0396  CL125 HCT 116 C205(0.63); C210(0.63); C1912(0.66); C1920(0.66)  LDD0713  [19]
 LDCM0397  CL126 HCT 116 C1912(0.56); C1920(0.56); C205(0.60); C210(0.60)  LDD0714  [19]
 LDCM0398  CL127 HCT 116 C205(0.39); C210(0.39); C2582(0.79); C1912(0.92)  LDD0715  [19]
 LDCM0399  CL128 HCT 116 C205(0.34); C210(0.34); C1912(0.74); C1920(0.74)  LDD0716  [19]
 LDCM0400  CL13 HCT 116 C1402(0.84); C733(0.89); C210(0.93); C2601(0.98)  LDD0717  [19]
 LDCM0401  CL14 HCT 116 C1260(0.72); C733(0.78); C2107(0.81); C1402(0.86)  LDD0718  [19]
 LDCM0402  CL15 HCT 116 C1912(0.70); C1920(0.70); C2107(0.80); C1402(0.82)  LDD0719  [19]
 LDCM0403  CL16 HCT 116 C483(0.78); C1165(0.82); C2102(0.90); C733(0.92)  LDD0720  [19]
 LDCM0404  CL17 HCT 116 C1997(0.65); C1165(0.73); C2199(0.79); C478(0.79)  LDD0721  [19]
 LDCM0405  CL18 HCT 116 C1997(0.73); C478(0.87); C2107(0.88); C2199(0.99)  LDD0722  [19]
 LDCM0406  CL19 HCT 116 C1997(0.62); C483(0.75); C2160(0.81); C478(0.85)  LDD0723  [19]
 LDCM0407  CL2 HCT 116 C1912(0.64); C1920(0.64); C1402(0.78); C2107(0.80)  LDD0724  [19]
 LDCM0408  CL20 HCT 116 C1997(0.58); C483(0.71); C2107(0.77); C2160(0.86)  LDD0725  [19]
 LDCM0409  CL21 HCT 116 C1997(0.61); C2107(0.74); C483(0.81); C733(0.86)  LDD0726  [19]
 LDCM0410  CL22 HCT 116 C2160(0.66); C483(0.77); C1997(0.79); C733(0.89)  LDD0727  [19]
 LDCM0411  CL23 HCT 116 C1997(0.74); C1165(0.74); C483(0.76); C733(0.79)  LDD0728  [19]
 LDCM0412  CL24 HCT 116 C1997(0.67); C2107(0.81); C483(0.86); C733(0.87)  LDD0729  [19]
 LDCM0413  CL25 HCT 116 C1453(1.62); C2102(1.49); C1157(1.27); C1165(0.89)  LDD0730  [19]
 LDCM0414  CL26 HCT 116 C1453(1.13); C2102(1.32); C1157(1.18); C1165(0.73)  LDD0731  [19]
 LDCM0415  CL27 HCT 116 C1453(1.47); C2102(1.11); C1157(1.12); C1165(1.09)  LDD0732  [19]
 LDCM0416  CL28 HCT 116 C1453(1.30); C2102(1.28); C1157(1.15); C1165(0.87)  LDD0733  [19]
 LDCM0417  CL29 HCT 116 C1453(1.43); C2102(1.46); C1157(1.23); C1165(1.10)  LDD0734  [19]
 LDCM0418  CL3 HCT 116 C1453(1.23); C2102(0.90); C1157(1.02); C1165(1.38)  LDD0735  [19]
 LDCM0419  CL30 HCT 116 C1453(1.11); C2102(1.19); C1157(0.99); C1165(0.77)  LDD0736  [19]
 LDCM0420  CL31 HCT 116 C1453(0.95); C2102(0.75); C1157(1.09); C1165(1.03)  LDD0737  [19]
 LDCM0421  CL32 HCT 116 C1453(1.16); C2102(1.07); C1157(1.20); C1165(0.92)  LDD0738  [19]
 LDCM0422  CL33 HCT 116 C1453(1.13); C2102(0.77); C1157(1.11); C1165(0.91)  LDD0739  [19]
 LDCM0423  CL34 HCT 116 C1453(1.05); C2102(1.08); C1157(1.30); C1165(0.83)  LDD0740  [19]
 LDCM0424  CL35 HCT 116 C1453(1.11); C2102(0.82); C1157(1.30); C1165(1.07)  LDD0741  [19]
 LDCM0425  CL36 HCT 116 C1453(1.21); C2102(1.07); C1157(1.28); C1165(0.91)  LDD0742  [19]
 LDCM0426  CL37 HCT 116 C1453(1.16); C2102(0.98); C1157(1.34); C1165(1.12)  LDD0743  [19]
 LDCM0428  CL39 HCT 116 C1453(1.00); C2102(0.84); C1157(1.34); C1165(1.06)  LDD0745  [19]
 LDCM0429  CL4 HCT 116 C1453(1.40); C2102(0.89); C1157(0.89); C1165(0.93)  LDD0746  [19]
 LDCM0430  CL40 HCT 116 C1453(1.08); C2102(0.83); C1157(1.40); C1165(0.79)  LDD0747  [19]
 LDCM0431  CL41 HCT 116 C1453(1.02); C2102(1.02); C1157(1.21); C1165(0.86)  LDD0748  [19]
 LDCM0432  CL42 HCT 116 C1453(1.26); C2102(1.11); C1157(2.07); C1165(0.97)  LDD0749  [19]
 LDCM0433  CL43 HCT 116 C1453(1.14); C2102(0.91); C1157(1.42); C1165(0.90)  LDD0750  [19]
 LDCM0434  CL44 HCT 116 C1453(1.13); C2102(0.91); C1157(1.28); C1165(1.25)  LDD0751  [19]
 LDCM0435  CL45 HCT 116 C1453(1.32); C2102(1.01); C1157(1.41); C1165(1.04)  LDD0752  [19]
 LDCM0436  CL46 HCT 116 C1453(0.96); C2102(0.95); C1157(0.82); C1165(0.68)  LDD0753  [19]
 LDCM0437  CL47 HCT 116 C1453(0.96); C2102(0.87); C1157(0.88); C1165(0.64)  LDD0754  [19]
 LDCM0438  CL48 HCT 116 C1453(0.80); C2102(0.82); C1157(0.83); C1165(0.75)  LDD0755  [19]
 LDCM0439  CL49 HCT 116 C1453(0.91); C2102(0.95); C1157(0.82); C1165(0.81)  LDD0756  [19]
 LDCM0440  CL5 HCT 116 C1453(1.65); C2102(1.19); C1157(0.91); C1165(1.28)  LDD0757  [19]
 LDCM0441  CL50 HCT 116 C1453(1.31); C2102(0.92); C1157(0.84); C1165(0.78)  LDD0758  [19]
 LDCM0442  CL51 HCT 116 C1453(1.60); C2102(1.02); C1157(0.83); C1165(0.72)  LDD0759  [19]
 LDCM0443  CL52 HCT 116 C1453(1.26); C2102(0.82); C1157(0.80); C1165(0.45)  LDD0760  [19]
 LDCM0444  CL53 HCT 116 C1453(1.20); C2102(0.82); C1157(0.81); C1165(0.66)  LDD0761  [19]
 LDCM0445  CL54 HCT 116 C1453(0.90); C2102(0.80); C1157(0.75); C1165(0.82)  LDD0762  [19]
 LDCM0446  CL55 HCT 116 C1453(1.01); C2102(0.87); C1157(0.84); C1165(0.65)  LDD0763  [19]
 LDCM0447  CL56 HCT 116 C1453(0.99); C2102(0.99); C1157(0.93); C1165(0.82)  LDD0764  [19]
 LDCM0448  CL57 HCT 116 C1453(0.88); C2102(0.85); C1157(0.74); C1165(0.70)  LDD0765  [19]
 LDCM0449  CL58 HCT 116 C1453(0.88); C2102(0.84); C1157(0.81); C1165(0.83)  LDD0766  [19]
 LDCM0450  CL59 HCT 116 C1453(1.18); C2102(0.88); C1157(0.88); C1165(0.96)  LDD0767  [19]
 LDCM0451  CL6 HCT 116 C1453(1.81); C2102(0.82); C1157(1.09); C1165(1.39)  LDD0768  [19]
 LDCM0452  CL60 HCT 116 C1453(0.79); C2102(0.87); C1157(0.86); C1165(0.76)  LDD0769  [19]
 LDCM0453  CL61 HCT 116 C1453(1.15); C2102(0.95); C1157(1.07); C1165(1.00)  LDD0770  [19]
 LDCM0454  CL62 HCT 116 C1453(0.97); C2102(0.83); C1157(1.07); C1165(0.90)  LDD0771  [19]
 LDCM0455  CL63 HCT 116 C1453(1.35); C2102(0.98); C1157(1.10); C1165(1.10)  LDD0772  [19]
 LDCM0456  CL64 HCT 116 C1453(1.08); C2102(0.96); C1157(1.15); C1165(1.02)  LDD0773  [19]
 LDCM0457  CL65 HCT 116 C1453(0.86); C2102(1.06); C1157(1.08); C1165(0.96)  LDD0774  [19]
 LDCM0458  CL66 HCT 116 C1453(1.10); C2102(1.20); C1157(1.41); C1165(0.97)  LDD0775  [19]
 LDCM0459  CL67 HCT 116 C1453(1.14); C2102(0.96); C1157(1.24); C1165(1.03)  LDD0776  [19]
 LDCM0460  CL68 HCT 116 C1453(0.98); C2102(1.34); C1157(1.15); C1165(1.09)  LDD0777  [19]
 LDCM0461  CL69 HCT 116 C1453(1.43); C2102(0.93); C1157(0.96); C1165(1.18)  LDD0778  [19]
 LDCM0462  CL7 HCT 116 C1453(2.04); C2102(1.08); C1157(1.08); C1165(1.52)  LDD0779  [19]
 LDCM0463  CL70 HCT 116 C1453(1.12); C2102(1.19); C1157(1.07); C1165(0.94)  LDD0780  [19]
 LDCM0464  CL71 HCT 116 C1453(1.13); C2102(1.00); C1157(1.21); C1165(0.85)  LDD0781  [19]
 LDCM0465  CL72 HCT 116 C1453(1.08); C2102(1.12); C1157(1.07); C1165(0.90)  LDD0782  [19]
 LDCM0466  CL73 HCT 116 C1453(1.36); C2102(0.93); C1157(1.12); C1165(1.04)  LDD0783  [19]
 LDCM0467  CL74 HCT 116 C1453(1.13); C2102(1.25); C1157(1.16); C1165(1.01)  LDD0784  [19]
 LDCM0469  CL76 HCT 116 C1453(1.40); C2102(0.96); C1157(1.03); C1165(1.09)  LDD0786  [19]
 LDCM0470  CL77 HCT 116 C1453(2.44); C2102(0.70); C1157(1.01); C1165(0.89)  LDD0787  [19]
 LDCM0471  CL78 HCT 116 C1453(1.78); C2102(1.36); C1157(1.07); C1165(0.99)  LDD0788  [19]
 LDCM0472  CL79 HCT 116 C1453(2.90); C2102(1.38); C1157(1.21); C1165(1.17)  LDD0789  [19]
 LDCM0473  CL8 HCT 116 C1453(1.00); C2102(1.31); C1157(1.24); C1165(0.99)  LDD0790  [19]
 LDCM0474  CL80 HCT 116 C1453(1.32); C2102(0.93); C1157(0.97); C1165(1.06)  LDD0791  [19]
 LDCM0475  CL81 HCT 116 C1453(3.02); C2102(0.86); C1157(1.07); C1165(1.09)  LDD0792  [19]
 LDCM0476  CL82 HCT 116 C1453(5.85); C2102(1.41); C1157(1.43); C1165(1.49)  LDD0793  [19]
 LDCM0477  CL83 HCT 116 C1453(3.38); C2102(1.27); C1157(1.42); C1165(1.16)  LDD0794  [19]
 LDCM0478  CL84 HCT 116 C1453(1.63); C2102(1.60); C1157(1.69); C1165(1.21)  LDD0795  [19]
 LDCM0479  CL85 HCT 116 C1453(2.62); C2102(0.96); C1157(1.17); C1165(0.91)  LDD0796  [19]
 LDCM0480  CL86 HCT 116 C1453(1.64); C2102(0.80); C1157(1.12); C1165(0.90)  LDD0797  [19]
 LDCM0481  CL87 HCT 116 C1453(1.55); C2102(1.14); C1157(1.11); C1165(0.96)  LDD0798  [19]
 LDCM0482  CL88 HCT 116 C1453(2.80); C2102(1.08); C1157(1.38); C1165(1.26)  LDD0799  [19]
 LDCM0483  CL89 HCT 116 C1453(1.96); C2102(1.39); C1157(2.02); C1165(1.03)  LDD0800  [19]
 LDCM0484  CL9 HCT 116 C1453(1.30); C2102(0.99); C1157(1.05); C1165(1.15)  LDD0801  [19]
 LDCM0485  CL90 HCT 116 C1453(1.13); C2102(0.78); C1157(0.88); C1165(0.80)  LDD0802  [19]
 LDCM0486  CL91 HCT 116 C1453(1.09); C2102(0.79); C1157(1.14); C1165(1.14)  LDD0803  [19]
 LDCM0487  CL92 HCT 116 C1453(0.75); C2102(0.67); C1157(1.16); C1165(1.02)  LDD0804  [19]
 LDCM0488  CL93 HCT 116 C1453(0.92); C2102(0.70); C1157(1.11); C1165(1.35)  LDD0805  [19]
 LDCM0489  CL94 HCT 116 C1453(1.15); C2102(0.70); C1157(1.16); C1165(1.41)  LDD0806  [19]
 LDCM0490  CL95 HCT 116 C1453(0.94); C2102(0.84); C1157(1.23); C1165(1.18)  LDD0807  [19]
 LDCM0491  CL96 HCT 116 C1453(0.99); C2102(0.71); C1157(1.13); C1165(0.99)  LDD0808  [19]
 LDCM0492  CL97 HCT 116 C1453(0.81); C2102(0.89); C1157(1.13); C1165(1.00)  LDD0809  [19]
 LDCM0493  CL98 HCT 116 C1453(0.95); C2102(1.12); C1157(1.26); C1165(1.24)  LDD0810  [19]
 LDCM0494  CL99 HCT 116 C1453(0.87); C2102(0.78); C1157(1.29); C1165(1.46)  LDD0811  [19]
 LDCM0634  CY-0357 Hep-G2 C2543(2.30); C1157(1.02); C2107(0.86); C2582(0.79)  LDD2228  [28]
 LDCM0495  E2913 HEK-293T C1165(0.92); C574(1.07); C2199(0.97); C1402(0.96)  LDD1698  [42]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C717(1.43); C2601(1.38); C574(1.20); C1018(1.15)  LDD1702  [40]
 LDCM0625  F8 Ramos C2543(1.87); C2601(0.72); C574(1.74); C1157(1.56)  LDD2187  [43]
 LDCM0572  Fragment10 Ramos C2543(1.20); C2601(0.60); C574(0.20); C1157(0.53)  LDD2189  [43]
 LDCM0573  Fragment11 Ramos C2543(0.60); C2601(10.44); C1157(2.84)  LDD2190  [43]
 LDCM0574  Fragment12 Ramos C2543(0.68); C2601(0.58); C574(0.12); C1157(0.49)  LDD2191  [43]
 LDCM0575  Fragment13 Ramos C2543(0.88); C2601(0.88); C574(1.01); C1157(0.68)  LDD2192  [43]
 LDCM0576  Fragment14 Ramos C2543(0.72); C2601(0.81); C574(0.43); C1157(1.13)  LDD2193  [43]
 LDCM0579  Fragment20 Ramos C2543(0.67); C2601(0.54); C574(0.22); C1157(0.44)  LDD2194  [43]
 LDCM0580  Fragment21 Ramos C2543(0.92); C2601(0.79); C574(1.41); C1157(0.58)  LDD2195  [43]
 LDCM0582  Fragment23 Ramos C2543(0.97); C2601(0.92); C574(0.28); C1157(0.74)  LDD2196  [43]
 LDCM0578  Fragment27 Ramos C2543(1.00); C2601(0.84); C574(1.20); C1157(0.83)  LDD2197  [43]
 LDCM0586  Fragment28 Ramos C2543(0.69); C2601(0.81); C574(0.80); C1157(0.74)  LDD2198  [43]
 LDCM0588  Fragment30 Ramos C2543(1.12); C2601(0.84); C574(1.36); C1157(0.84)  LDD2199  [43]
 LDCM0589  Fragment31 Ramos C2543(1.00); C2601(1.06); C1157(0.80)  LDD2200  [43]
 LDCM0590  Fragment32 Ramos C2543(1.43); C2601(0.56); C574(0.29); C1157(0.69)  LDD2201  [43]
 LDCM0468  Fragment33 HCT 116 C1453(1.54); C2102(1.09); C1157(1.12); C1165(1.00)  LDD0785  [19]
 LDCM0596  Fragment38 Ramos C2543(0.98); C2601(0.70); C574(0.80); C1157(0.46)  LDD2203  [43]
 LDCM0566  Fragment4 Ramos C2543(0.83); C2601(0.75); C574(1.17); C1157(0.86)  LDD2184  [43]
 LDCM0427  Fragment51 HCT 116 C1453(1.19); C2102(1.07); C1157(1.55); C1165(0.72)  LDD0744  [19]
 LDCM0610  Fragment52 Ramos C2543(1.39); C2601(1.12); C574(1.14)  LDD2204  [43]
 LDCM0614  Fragment56 Ramos C2543(1.47); C2601(1.10); C574(0.16); C1157(0.90)  LDD2205  [43]
 LDCM0569  Fragment7 Ramos C2543(0.79); C2601(0.72); C574(0.26); C1157(0.93)  LDD2186  [43]
 LDCM0571  Fragment9 Ramos C2543(0.80); C2601(0.59); C574(0.17); C1157(0.45)  LDD2188  [43]
 LDCM0116  HHS-0101 DM93 Y791(0.63); Y2077(0.71); Y1761(0.76); Y1308(0.79)  LDD0264  [17]
 LDCM0117  HHS-0201 DM93 Y791(0.55); Y1761(0.68); Y2571(0.79); Y2077(0.83)  LDD0265  [17]
 LDCM0118  HHS-0301 DM93 Y2077(0.59); Y2571(0.79); Y1308(0.80); Y2505(0.86)  LDD0266  [17]
 LDCM0119  HHS-0401 DM93 Y1761(0.53); Y1763(0.68); Y791(0.70); Y1261(0.73)  LDD0267  [17]
 LDCM0120  HHS-0701 DM93 Y791(0.49); Y1761(0.65); Y2077(0.67); Y1308(0.72)  LDD0268  [17]
 LDCM0107  IAA HeLa C2378(0.00); H2528(0.00); H2525(0.00); C1260(0.00)  LDD0221  [34]
 LDCM0123  JWB131 DM93 Y2505(1.03); Y2571(0.96)  LDD0285  [16]
 LDCM0124  JWB142 DM93 Y2505(1.48); Y2571(0.98)  LDD0286  [16]
 LDCM0125  JWB146 DM93 Y2505(1.30); Y2571(0.93)  LDD0287  [16]
 LDCM0126  JWB150 DM93 Y2505(2.82); Y2571(3.68)  LDD0288  [16]
 LDCM0127  JWB152 DM93 Y2505(1.99); Y2571(2.15)  LDD0289  [16]
 LDCM0128  JWB198 DM93 Y2505(1.18); Y2571(1.68)  LDD0290  [16]
 LDCM0129  JWB202 DM93 Y2505(0.93); Y2571(0.91)  LDD0291  [16]
 LDCM0130  JWB211 DM93 Y2505(1.28); Y2571(1.20)  LDD0292  [16]
 LDCM0179  JZ128 PC-3 C205(0.00); C2293(0.00)  LDD0462  [13]
 LDCM0022  KB02 HCT 116 C2476(5.54); C2479(5.54); C478(3.07); C1402(1.74)  LDD0080  [19]
 LDCM0023  KB03 HCT 116 C2476(2.79); C2479(2.79); C478(1.89); C1402(1.68)  LDD0081  [19]
 LDCM0024  KB05 HCT 116 C2476(3.03); C2479(3.03); C478(2.92); C1402(1.81)  LDD0082  [19]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C717(1.07); C478(1.49); C2601(1.24); C1165(2.78)  LDD2102  [40]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C717(0.79); C478(0.84); C2601(0.95); C2160(1.00)  LDD2121  [40]
 LDCM0109  NEM HeLa H2528(0.00); H2525(0.00); C1260(0.00); H326(0.00)  LDD0223  [34]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C717(0.86); C478(1.12); C2601(0.94); C2160(0.91)  LDD2089  [40]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C717(1.13); C478(1.14); C2601(1.64); C2160(1.07)  LDD2090  [40]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C717(0.78); C478(0.91); C2601(1.08); C2160(2.23)  LDD2092  [40]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C478(0.94); C2601(1.16); C2160(1.10); C1165(1.02)  LDD2093  [40]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C478(1.44); C2601(2.33); C1165(4.90); C1402(1.02)  LDD2094  [40]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C478(1.04); C1165(0.20); C1402(0.24); C1157(1.04)  LDD2096  [40]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C478(1.33); C2601(0.62); C2160(0.82); C1165(0.80)  LDD2097  [40]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C717(0.81); C478(1.40); C2601(0.49); C2160(1.21)  LDD2098  [40]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C717(0.94); C2601(0.98); C2160(1.10); C1165(0.74)  LDD2099  [40]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C717(0.71); C2601(0.37); C2160(0.43); C1165(0.38)  LDD2100  [40]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C717(0.76); C478(0.99); C2601(1.00); C2160(0.91)  LDD2101  [40]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C717(0.38); C478(0.69); C2601(0.31); C1165(0.36)  LDD2104  [40]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C717(1.35); C478(1.65); C2601(1.85); C1165(3.04)  LDD2105  [40]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C717(0.41); C478(0.49); C2601(0.25); C2160(0.24)  LDD2106  [40]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C717(1.00); C2601(0.97); C2160(0.91); C1402(0.99)  LDD2107  [40]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C717(0.43); C478(0.63); C2601(0.33); C2160(0.43)  LDD2108  [40]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C717(0.97); C478(0.79); C2601(0.77); C2160(0.68)  LDD2109  [40]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C717(0.63); C2601(0.63); C2543(1.01); C574(1.54)  LDD2110  [40]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C717(1.07); C478(0.77); C2601(1.08); C2160(1.13)  LDD2111  [40]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C717(0.41); C1165(0.42); C1402(0.61); C1157(1.38)  LDD2114  [40]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C717(0.48); C478(0.82); C2601(0.56); C2160(0.49)  LDD2115  [40]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C1165(0.55); C2543(0.91); C574(0.94); C1453(0.65)  LDD2116  [40]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C478(1.09); C1165(0.43); C1402(0.41); C1157(0.66)  LDD2118  [40]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C478(2.27); C2601(1.83); C2160(2.08); C1165(3.30)  LDD2119  [40]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C478(0.72); C2601(0.84); C1165(0.78); C1402(0.72)  LDD2120  [40]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C478(1.25); C2160(0.99); C1165(0.30); C1402(0.30)  LDD2122  [40]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C717(1.06); C478(0.71); C2601(0.96); C2160(0.94)  LDD2123  [40]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C717(0.53); C478(1.06); C2160(2.22); C1165(0.24)  LDD2124  [40]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C717(0.98); C478(0.93); C2601(0.89); C2160(0.82)  LDD2125  [40]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C717(0.74); C478(1.00); C1165(0.34); C2543(0.89)  LDD2126  [40]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C717(0.99); C478(0.67); C2601(0.91); C2160(0.88)  LDD2127  [40]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C478(0.78); C2601(1.01); C1165(0.73); C1402(0.76)  LDD2128  [40]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C717(1.30); C478(0.69); C2601(1.24); C2160(1.19)  LDD2129  [40]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C2601(0.88); C2160(0.53); C1165(0.96); C1402(0.62)  LDD2133  [40]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C478(0.61); C2601(0.45); C2160(0.43); C1165(0.69)  LDD2134  [40]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C717(1.02); C478(0.73); C2601(1.42); C2160(1.70)  LDD2135  [40]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C717(0.93); C478(1.09); C2601(0.95); C2160(1.24)  LDD2136  [40]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C717(1.01); C478(0.70); C2601(0.93); C2160(0.84)  LDD2137  [40]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C2160(2.16); C2601(1.97); C1402(1.57); C1165(1.28)  LDD1700  [40]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C717(0.84); C478(0.82); C2601(0.84); C2160(0.70)  LDD2140  [40]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C717(0.66); C478(0.80); C1165(0.68); C1402(0.67)  LDD2141  [40]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C478(0.99); C2601(0.87); C1165(0.71); C1402(0.86)  LDD2143  [40]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C478(2.16); C2601(2.87); C2160(2.10); C1165(3.33)  LDD2144  [40]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C717(1.62); C478(1.67); C2160(2.57); C1165(0.13)  LDD2145  [40]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C717(1.10); C478(0.96); C2601(1.02); C2160(0.96)  LDD2146  [40]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C2601(1.71); C1165(2.97); C1402(2.03); C1157(2.32)  LDD2147  [40]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C717(1.03); C478(0.60); C2601(0.53); C2160(0.44)  LDD2148  [40]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C478(1.17); C1165(0.40); C1402(0.33); C1157(0.67)  LDD2149  [40]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C717(0.52); C2601(0.65); C2160(0.85); C1165(0.31)  LDD2150  [40]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C478(1.09); C1165(0.28); C1157(0.89); C2543(1.61)  LDD2151  [40]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C717(1.62); C478(3.07); C2601(1.86); C2160(5.01)  LDD2153  [40]
 LDCM0627  NUDT7-COV-1 HEK-293T C2543(0.88); C1157(0.65)  LDD2206  [44]
 LDCM0628  OTUB2-COV-1 HEK-293T C1157(1.69); C2543(0.68)  LDD2207  [44]
 LDCM0131  RA190 MM1.R C2476(1.22); C2479(1.22); C2601(1.18); C1157(1.15)  LDD0304  [45]
 LDCM0019  Staurosporine Hep-G2 2.00  LDD0083  [38]
 LDCM0021  THZ1 HCT 116 C478(1.11); C2199(1.13); C1402(1.16); C1165(1.19)  LDD2173  [19]
 LDCM0110  W12 Hep-G2 C1157(9.89)  LDD0237  [35]
 LDCM0111  W14 Hep-G2 C1157(6.92); C2543(21.49)  LDD0238  [35]
 LDCM0113  W17 Hep-G2 C2543(11.69)  LDD0240  [35]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
Pyridoxal phosphate phosphatase PHOSPHO2 (PHOSPHO2) PHOSPHO family Q8TCD6
Phosphatidate phosphatase LPIN1 (LPIN1) Lipin family Q14693
Calcium/calmodulin-dependent protein kinase type 1G (CAMK1G) CAMK Ser/Thr protein kinase family Q96NX5
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Beclin-1 (BECN1) Beclin family Q14457
G2/mitotic-specific cyclin-B2 (CCNB2) Cyclin family O95067
Filamin-B (FLNB) Filamin family O75369
Integrin beta-1 (ITGB1) Integrin beta chain family P05556
Neuropilin-1 (NRP1) Neuropilin family O14786
Cellular tumor antigen p53 (TP53) P53 family P04637
Secretory carrier-associated membrane protein 2 (SCAMP2) SCAMP family O15127
SH3 and multiple ankyrin repeat domains protein 3 (SHANK3) . Q9BYB0
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Forkhead box protein C1 (FOXC1) . Q12948
Proto-oncogene c-Rel (REL) . Q04864
Transcription factor 4 (TCF4) . P15884
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mu-type opioid receptor (OPRM1) G-protein coupled receptor 1 family P35372
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nectin-3 (NECTIN3) Nectin family Q9NQS3
Coiled-coil domain-containing protein 141 (CCDC141) . Q6ZP82
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytokine receptor-like factor 3 (CRLF3) Cytokine receptor-like factor 3 family Q8IUI8
Other
Click To Hide/Show 35 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (KCTD13) BACURD family Q8WZ19
Beta-crystallin A2 (CRYBA2) Beta/gamma-crystallin family P53672
Fatty acid-binding protein, liver (FABP1) Fatty-acid binding protein (FABP) family P07148
Adapter molecule crk (CRK) CRK family P46108
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
RNA polymerase II elongation factor ELL2 (ELL2) ELL/occludin family O00472
Protein pelota homolog (PELO) Eukaryotic release factor 1 family Q9BRX2
RNA-binding protein FXR1 (FXR1) FMR1 family P51114
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Heat shock 70 kDa protein 6 (HSPA6) Heat shock protein 70 family P17066
Integrin beta-3 (ITGB3) Integrin beta chain family P05106
Integrin beta-7 (ITGB7) Integrin beta chain family P26010
Metallothionein-2 (MT2A) Type 1 family P02795
Myozenin-1 (MYOZ1) Myozenin family Q9NP98
Refilin-A (RFLNA) Refilin family Q6ZTI6
Heat shock protein beta-7 (HSPB7) Small heat shock protein (HSP20) family Q9UBY9
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Sperm protein associated with the nucleus on the X chromosome D (SPANXD) SPAN-X family Q9BXN6
WD repeat domain-containing protein 83 (WDR83) WD repeat MORG1 family Q9BRX9
Histone-binding protein RBBP4 (RBBP4) WD repeat RBAP46/RBAP48/MSI1 family Q09028
BTB/POZ domain-containing protein KCTD17 (KCTD17) . Q8N5Z5
G-protein-signaling modulator 3 (GPSM3) . Q9Y4H4
GA-binding protein subunit beta-2 (GABPB2) . Q8TAK5
Kelch-like protein 12 (KLHL12) . Q53G59
Mitochondrial nucleoid-associated protein 1 (MTNAP1) . Q9BSJ5
Placental protein 13-like (LGALS14) . Q8TCE9
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
Pleckstrin homology-like domain family B member 2 (PHLDB2) . Q86SQ0
Protein FAM117B (FAM117B) . Q6P1L5
Rho GTPase-activating protein 24 (ARHGAP24) . Q8N264
RING1 and YY1-binding protein (RYBP) . Q8N488
Splicing regulator RBM11 (RBM11) . P57052
WW domain binding protein 1-like (WBP1L) . Q9NX94

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pti-125 . D0X2HJ

References

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2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Proteome-Wide Profiling of Cellular Targets Modified by Dopamine Metabolites Using a Bio-Orthogonally Functionalized Catecholamine. ACS Chem Biol. 2021 Nov 19;16(11):2581-2594. doi: 10.1021/acschembio.1c00629. Epub 2021 Nov 2.
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc. 2022 Dec 21;144(50):22890-22901. doi: 10.1021/jacs.2c04039. Epub 2022 Dec 9.
9 Proteome-Wide Identification of On- and Off-Targets of Bcl-2 Inhibitors in Native Biological Systems by Using Affinity-Based Probes (AfBPs). Chembiochem. 2018 Nov 2;19(21):2312-2320. doi: 10.1002/cbic.201800380. Epub 2018 Oct 18.
10 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
11 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
12 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
13 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
14 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
15 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
16 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
17 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
18 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
19 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
20 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
21 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
22 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
23 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
24 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
25 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
26 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
27 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
28 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
29 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
30 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
31 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
32 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
33 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
34 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
35 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
36 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
37 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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