Details of the Probe-central Interaction Altas
General Information of Experiment
| Probe Name | C185 | Probe Info | ||||
|---|---|---|---|---|---|---|
| Probe concentration | Probe:50uM; negative probe:50uM | |||||
| Criteria | Quantification: AfBPP Probe vs Negative Probe | |||||
| Quantitative Method |
TMT
|
|||||
| In Vivo Experiment Model | Model Type |
|
Living cell | |||
| Derived Tissue |
|
Peripheral blood | ||||
| Disease Model | Normal | |||||
| Model Name | Human normal cells (HEK-293T) | |||||
| Note | Negative probe:C#CCCC1(CCC(NC)=O)N=N1 | |||||
Interaction Altas of This Experiment [1]
Enzyme
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP01039 | Protein-S-isoprenylcysteine O-methyltransferase (ICMT) | 27.3 | ||||
| LDTP12363 | Lysophosphatidic acid phosphatase type 6 (ACP6) | 20.4 | ||||
| LDTP06375 | Delta(24)-sterol reductase (DHCR24) | 13.5 | ||||
| LDTP04712 | Puromycin-sensitive aminopeptidase (NPEPPS) | 13.5 | ||||
| LDTP15422 | Prostaglandin reductase 3 (PTGR3) | 13.5 | ||||
| LDTP06227 | Prostaglandin reductase 1 (PTGR1) | 12.6 | ||||
| LDTP12420 | Xaa-Pro aminopeptidase 3 (XPNPEP3) | 9.1 | ||||
| LDTP04333 | GMP synthase [glutamine-hydrolyzing] (GMPS) | 9.0 | ||||
| LDTP05758 | S-methyl-5'-thioadenosine phosphorylase (MTAP) | 8.7 | ||||
| LDTP11273 | N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) | 8.4 | ||||
| LDTP04285 | Proteasome subunit beta type-2 (PSMB2) | 8.4 | ||||
| LDTP03540 | Heme oxygenase 2 (HMOX2) | 8.3 | ||||
| LDTP09395 | Signal peptide peptidase-like 2A (SPPL2A) | 7.6 | ||||
| LDTP02175 | Epoxide hydrolase 1 (EPHX1) | 7.5 | ||||
| LDTP00988 | Protein O-GlcNAcase (OGA) | 7.4 | ||||
| LDTP06325 | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) | 6.9 | ||||
| LDTP01687 | Apoptosis-inducing factor 1, mitochondrial (AIFM1) | 6.9 | ||||
| LDTP09095 | Diacylglycerol lipase-beta (DAGLB) | 6.9 | ||||
| LDTP10032 | 7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) | 6.8 | ||||
| LDTP16070 | Epimerase family protein SDR39U1 (SDR39U1) | 6.6 | ||||
| LDTP05476 | 3-ketodihydrosphingosine reductase (KDSR) | 6.6 | ||||
| LDTP13751 | Exonuclease 1 (EXO1) | 6.6 | ||||
| LDTP00783 | Beta-1,4-glucuronyltransferase 1 (B4GAT1) | 6.4 | ||||
| LDTP13282 | Prenylcysteine oxidase 1 (PCYOX1) | 6.3 | ||||
| LDTP10550 | Dehydrogenase/reductase SDR family member 1 (DHRS1) | 6.2 | ||||
| LDTP04183 | Lanosterol synthase (LSS) | 6.1 | ||||
| LDTP02359 | Heme oxygenase 1 (HMOX1) | 5.9 | ||||
| LDTP01982 | NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) | 5.8 | ||||
| LDTP12586 | Phenylalanine--tRNA ligase beta subunit (FARSB) | 5.7 | ||||
| LDTP04051 | Nicotinamide phosphoribosyltransferase (NAMPT) | 5.5 | ||||
| LDTP00697 | Cytochrome b5 type B (CYB5B) | 5.4 | ||||
| LDTP04004 | Lysosomal Pro-X carboxypeptidase (PRCP) | 5.3 | ||||
| LDTP09666 | Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) | 5.3 | ||||
| LDTP04008 | Endothelin-converting enzyme 1 (ECE1) | 5.2 | ||||
| LDTP10188 | FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) | 5.1 | ||||
| LDTP14030 | V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) | 5.0 | ||||
Transporter and channel
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP10958 | Sigma non-opioid intracellular receptor 1 (SIGMAR1) | 21.3 | ||||
| LDTP03277 | ER lumen protein-retaining receptor 1 (KDELR1) | 21.0 | ||||
| LDTP18459 | StAR-related lipid transfer protein 7, mitochondrial (STARD7) | 19.8 | ||||
| LDTP15948 | Transmembrane protein 126A (TMEM126A) | 12.6 | ||||
| LDTP01059 | Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) | 10.1 | ||||
| LDTP11813 | Solute carrier family 25 member 32 (SLC25A32) | 10.0 | ||||
| LDTP08878 | ER membrane protein complex subunit 5 (MMGT1) | 8.6 | ||||
| LDTP07885 | Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) | 8.3 | ||||
| LDTP10913 | Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) | 8.2 | ||||
| LDTP07236 | Protein GPR107 (GPR107) | 7.8 | ||||
| LDTP16069 | Peroxisomal membrane protein 2 (PXMP2) | 7.0 | ||||
| LDTP00865 | Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) | 6.9 | ||||
| LDTP09968 | V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) | 6.8 | ||||
| LDTP08881 | Transmembrane protein 199 (TMEM199) | 6.2 | ||||
| LDTP14952 | Mpv17-like protein 2 (MPV17L2) | 4.9 | ||||
Other
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP14486 | Clustered mitochondria protein homolog (CLUH) | 13.7 | ||||
| LDTP05160 | Nucleobindin-2 (NUCB2) | 13.4 | ||||
| LDTP04382 | Kinetochore-associated protein 1 (KNTC1) | 12.6 | ||||
| LDTP08000 | Dymeclin (DYM) | 7.1 | ||||
| LDTP00850 | ER lumen protein-retaining receptor 3 (KDELR3) | 7.1 | ||||
| LDTP01652 | Centrosomal protein 43 (CEP43) | 6.7 | ||||
| LDTP05375 | Nucleobindin-1 (NUCB1) | 6.1 | ||||
| LDTP13863 | DnaJ homolog subfamily C member 16 (DNAJC16) | 5.9 | ||||
| LDTP12565 | Mitochondrial import receptor subunit TOM22 homolog (TOMM22) | 5.7 | ||||
| LDTP04094 | Large proline-rich protein BAG6 (BAG6) | 5.7 | ||||
| LDTP13828 | Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) | 5.1 | ||||
| LDTP10847 | Protein Niban 2 (NIBAN2) | 5.1 | ||||
| LDTP13630 | Neudesin (NENF) | 5.1 | ||||
| LDTP14058 | Rap guanine nucleotide exchange factor 2 (RAPGEF2) | 4.9 | ||||
| LDTP15067 | Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) | 4.9 | ||||