Details of the Target

General Information of Target

Target ID LDTP14058
Target Name Rap guanine nucleotide exchange factor 2 (RAPGEF2)
Gene Name RAPGEF2
Gene ID 9693
Synonyms
KIAA0313; NRAPGEP; PDZGEF1; Rap guanine nucleotide exchange factor 2; Cyclic nucleotide ras GEF; CNrasGEF; Neural RAP guanine nucleotide exchange protein; nRap GEP; PDZ domain-containing guanine nucleotide exchange factor 1; PDZ-GEF1; RA-GEF-1; Ras/Rap1-associating GEF-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVALSLKICVRHCNVVKTMQFEPSTAVYDACRVIRERVPEAQTGQASDYGLFLSDEDPRK
GIWLEAGRTLDYYMLRNGDILEYKKKQRPQKIRMLDGSVKTVMVDDSKTVGELLVTICSR
IGITNYEEYSLIQETIEEKKEEGTGTLKKDRTLLRDERKMEKLKAKLHTDDDLNWLDHSR
TFREQGVDENETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFEKACEF
GGFQAQIQFGPHVEHKHKPGFLDLKEFLPKEYIKQRGAEKRIFQEHKNCGEMSEIEAKVK
YVKLARSLRTYGVSFFLVKEKMKGKNKLVPRLLGITKDSVMRVDEKTKEVLQEWPLTTVK
RWAASPKSFTLDFGEYQESYYSVQTTEGEQISQLIAGYIDIILKKKQSKDRFGLEGDEES
TMLEESVSPKKSTILQQQFNRTGKAEHGSVALPAVMRSGSSGPETFNVGSMPSPQQQVMV
GQMHRGHMPPLTSAQQALMGTINTSMHAVQQAQDDLSELDSLPPLGQDMASRVWVQNKVD
ESKHEIHSQVDAITAGTASVVNLTAGDPADTDYTAVGCAITTISSNLTEMSKGVKLLAAL
MDDEVGSGEDLLRAARTLAGAVSDLLKAVQPTSGEPRQTVLTAAGSIGQASGDLLRQIGE
NETDERFQDVLMSLAKAVANAAAMLVLKAKNVAQVAEDTVLQNRVIAAATQCALSTSQLV
ACAKVVSPTISSPVCQEQLIEAGKLVDRSVENCVRACQAATTDSELLKQVSAAASVVSQA
LHDLLQHVRQFASRGEPIGRYDQATDTIMCVTESIFSSMGDAGEMVRQARVLAQATSDLV
NAMRSDAEAEIDMENSKKLLAAAKLLADSTARMVEAAKGAAANPENEDQQQRLREAAEGL
RVATNAAAQNAIKKKIVNRLEVAAKQAAAAATQTIAASQNAAVSNKNPAAQQQLVQSCKA
VADHIPQLVQGVRGSQAQAEDLSAQLALIISSQNFLQPGSKMVSSAKAAVPTVSDQAAAM
QLSQCAKNLATSLAELRTASQKAHEACGPMEIDSALNTVQTLKNELQDAKMAAVESQLKP
LPGETLEKCAQDLGSTSKAVGSSMAQLLTCAAQGNEHYTGVAARETAQALKTLAQAARGV
AASTTDPAAAHAMLDSARDVMEGSAMLIQEAKQALIAPGDAERQQRLAQVAKAVSHSLNN
CVNCLPGQKDVDVALKSIGESSKKLLVDSLPPSTKPFQEAQSELNQAAADLNQSAGEVVH
ATRGQSGELAAASGKFSDDFDEFLDAGIEMAGQAQTKEDQIQVIGNLKNISMASSKLLLA
AKSLSVDPGAPNAKNLLAAAARAVTESINQLITLCTQQAPGQKECDNALRELETVKGMLD
NPNEPVSDLSYFDCIESVMENSKVLGESMAGISQNAKTGDLPAFGECVGIASKALCGLTE
AAAQAAYLVGISDPNSQAGHQGLVDPIQFARANQAIQMACQNLVDPGSSPSQVLSAATIV
AKHTSALCNACRIASSKTANPVAKRHFVQSAKEVANSTANLVKTIKALDGDFSEDNRNKC
RIATAPLIEAVENLTAFASNPEFVSIPAQISSEGSQAQEPILVSAKTMLESSSYLIRTAR
SLAINPKDPPTWSVLAGHSHTVSDSIKSLITSIRDKAPGQRECDYSIDGINRCIRDIEQA
SLAAVSQSLATRDDISVEALQEQLTSVVQEIGHLIDPIATAARGEAAQLGHKVTQLASYF
EPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQMLYAAKEGGGNPKAQHTHDAITEA
AQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTVVK
YSKAIAVTAQEMMTKSVTNPEELGGLASQMTSDYGHLAFQGQMAAATAEPEEIGFQIRTR
VQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAVTEKVSLVLSALQAGNKGTQACI
TAATAVSGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGAAS
TPDKLAQAAQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISATK
GAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVEDEATRGTRALEATIECIKQELTV
FQSKDVPEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLTAC
KQASFHPDVSDEVRTRALRFGTECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVAGA
VTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIEAAAKKLEQLKPRAKPKQADETL
DFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAARM
VAAATSSLCEAANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQAA
GNAVKRASDNLVRAAQKAAFGKADDDDVVVKTKFVGGIAQIIAAQEEMLKKERELEEARK
KLAQIRQQQYKFLPTELREDEG
Target Bioclass
Other
Family
RAPGEF2 family
Subcellular location
Cytoplasm
Function
Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Provides also inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions.
Uniprot ID
Q9Y4G8
Ensemble ID
ENST00000264431.8
HGNC ID
HGNC:16854

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C194(3.77)  LDD3318  [1]
AHL-Pu-1
 Probe Info  		C1252(6.41)  LDD0170  [2]
IA-alkyne
 Probe Info  		C377(0.00); C798(0.00)  LDD0166  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
PAL-AfBPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C010
 Probe Info  		6.59  LDD1719  [6]
C083
 Probe Info  		6.41  LDD1775  [6]
C086
 Probe Info  		6.02  LDD1778  [6]
C095
 Probe Info  		4.99  LDD1786  [6]
C145
 Probe Info  		8.94  LDD1827  [6]
C173
 Probe Info  		9.65  LDD1853  [6]
C185
 Probe Info  		4.92  LDD1863  [6]
C193
 Probe Info  		7.31  LDD1869  [6]
C214
 Probe Info  		5.39  LDD1888  [6]
C252
 Probe Info  		9.65  LDD1925  [6]
C255
 Probe Info  		7.62  LDD1928  [6]
C272
 Probe Info  		4.96  LDD1942  [6]
C288
 Probe Info  		6.68  LDD1958  [6]
C297
 Probe Info  		7.94  LDD1967  [6]
C347
 Probe Info  		6.63  LDD2008  [6]
C356
 Probe Info  		8.00  LDD2017  [6]
C366
 Probe Info  		5.54  LDD2027  [6]
C380
 Probe Info  		5.24  LDD2039  [6]
C394
 Probe Info  		5.86  LDD2053  [6]
C419
 Probe Info  		9.99  LDD2074  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C1252(6.41)  LDD0170  [2]
 LDCM0214  AC1 HEK-293T C377(0.86)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C377(0.94)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C377(0.94)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C377(0.96); C194(1.22)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C377(1.05); C194(1.00)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C377(0.91)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C377(0.98)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C377(0.97)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C377(0.92)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C377(0.90)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C377(0.94); C194(1.09)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C377(0.98); C194(1.12)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C377(1.02); C194(0.82)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C377(1.04)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C377(1.01); C194(1.01)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C377(0.93)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C377(0.96)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C377(1.06)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C377(1.05); C194(0.97)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C377(1.00); C194(1.19)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C377(0.85)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C377(1.07); C194(0.93)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C377(1.03)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C377(0.99); C194(0.93)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C377(0.89)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C377(0.93)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C377(0.90)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C377(0.95); C194(0.98)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C377(1.00); C194(1.27)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C377(1.09); C194(1.00)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C377(0.93)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C377(0.85); C194(1.03)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C377(0.85); C194(0.93)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C377(0.89)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C377(0.93)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C377(0.95)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C377(0.91); C194(1.08)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C377(1.03); C194(1.38)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C377(0.99); C194(0.94)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C377(1.03)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C377(0.88); C194(1.00)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C377(0.99)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C377(0.97); C194(1.09)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C377(0.98)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C377(0.91)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C377(0.95); C194(0.97)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C377(1.00); C194(1.22)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C377(0.94); C194(0.91)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C377(0.95)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C377(0.97); C194(0.97)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C377(0.98)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C377(0.97)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C377(0.93)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C377(0.95); C194(1.15)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C377(1.01); C194(1.16)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C377(0.99); C194(1.25)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C377(0.94); C194(0.99)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C377(0.94)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C377(0.87); C194(0.99)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C377(0.89)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C377(0.86); C194(0.97)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C377(0.96); C194(1.18)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C377(0.93)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C377(0.94); C194(0.98)  LDD1514  [7]
 LDCM0367  CL1 HEK-293T C377(1.11)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C377(1.73); C194(0.96)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C377(0.90)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C377(1.00)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C377(0.97)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C377(0.96); C194(0.89)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C377(0.98)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C377(1.06)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C377(1.11)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C377(0.98); C194(0.99)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C377(0.98)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C377(1.09)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C377(0.98)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C377(1.06)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C377(0.93); C194(0.87)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C377(1.10)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C377(0.95)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C377(1.03)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C377(0.96); C194(0.73)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C377(0.95)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C377(1.02)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C377(0.98)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C377(0.90); C194(0.83)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C377(1.13); C194(1.02)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C377(0.98)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C377(0.98)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C377(0.99)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C377(1.09); C194(0.86)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C377(0.97)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C377(1.03)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C377(0.93)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C377(0.95); C194(1.06)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C377(0.99)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C377(0.96)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C377(0.95)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C377(0.85); C194(0.86)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C377(0.94)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C377(0.98)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C377(0.87)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C377(0.90)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C377(0.93)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C377(0.98); C194(1.30)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C377(1.08); C194(0.54)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C377(1.45); C194(0.99)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C377(0.97)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C377(1.21); C194(1.04)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C377(1.03)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C377(0.98)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C377(0.88); C194(0.97)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C377(0.94)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C377(1.02)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C377(0.92); C194(1.06)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C377(0.94)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C377(0.96)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C377(0.99); C194(1.03)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C377(1.10); C194(1.24)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C377(1.47); C194(0.93)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C377(1.12)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C377(1.24); C194(0.96)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C377(1.13)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C377(1.05); C194(1.08)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C377(1.00)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C377(0.97)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C377(0.97)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C377(1.05)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C377(1.00)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C377(1.05); C194(1.02)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C377(1.14); C194(0.92)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C377(1.38); C194(1.18)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C377(1.09)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C377(1.16); C194(0.87)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C377(1.00)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C377(0.91)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C377(1.01)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C377(0.92)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C377(0.97)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C377(0.92)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C377(0.96)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C377(1.01); C194(1.28)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C377(0.99); C194(0.92)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C377(1.11); C194(1.20)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C377(0.97)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C377(1.03)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C377(1.08); C194(0.98)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C377(0.96)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C377(0.98)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C377(0.99); C194(0.99)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C377(1.03)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C377(0.99)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C377(0.94)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C377(0.86)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C377(1.04); C194(1.22)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C377(1.07); C194(1.03)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C377(0.89)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C377(1.46); C194(1.02)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C377(1.05)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C377(1.06); C194(1.07)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C377(1.19)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C377(1.06)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C377(0.91)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C377(1.03)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C377(0.84)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C377(0.99)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C377(1.13); C194(1.03)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C377(1.00); C194(0.87)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C377(1.04); C194(1.17)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C377(1.47); C194(0.93)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C377(1.08)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C377(1.08); C194(1.00)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C377(0.96)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C377(1.12)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C377(0.92); C194(0.81)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C377(0.91)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C377(0.94)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C377(1.00); C194(1.11)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C377(1.06)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C377(1.02)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C377(1.03); C194(0.98)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C377(1.06); C194(1.32)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C377(1.21); C194(0.93)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C377(1.12)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C377(1.20); C194(0.82)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C377(1.16)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C377(1.03)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C377(0.96); C194(0.84)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C377(1.07); C194(0.93)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C377(0.91); C194(0.92)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C377(1.01)  LDD1631  [7]
 LDCM0022  KB02 Calu-1 C194(1.41)  LDD2292  [1]
 LDCM0023  KB03 Calu-1 C194(1.47)  LDD2709  [1]
 LDCM0024  KB05 MELHO C194(3.77)  LDD3318  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402