Details of the Target

General Information of Target

Target ID LDTP13863
Target Name DnaJ homolog subfamily C member 16 (DNAJC16)
Gene Name DNAJC16
Gene ID 23341
Synonyms
ERDJ8; KIAA0962; DnaJ homolog subfamily C member 16; Endoplasmic reticulum DNA J domain-containing protein 8; ER-resident protein ERdj8; ERdj8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATLSFVFLLLGAVSWPPASASGQEFWPGQSAADILSGAASRRRYLLYDVNPPEGFNLRR
DVYIRIASLLKTLLKTEEWVLVLPPWGRLYHWQSPDIHQVRIPWSEFFDLPSLNKNIPVI
EYEQFIAESGGPFIDQVYVLQSYAEGWKEGTWEEKVDERPCIDQLLYSQDKHEYYRGWFW
GYEETRGLNVSCLSVQGSASIVAPLLLRNTSARSVMLDRAENLLHDHYGGKEYWDTRRSM
VFARHLREVGDEFRSRHLNSTDDADRIPFQEDWMKMKVKLGSALGGPYLGVHLRRKDFIW
GHRQDVPSLEGAVRKIRSLMKTHRLDKVFVATDAVRKEYEELKKLLPEMVRFEPTWEELE
LYKDGGVAIIDQWICAHARFFIGTSVSTFSFRIHEEREILGLDPKTTYNRFCGDQEKACE
QPTHWKITY
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum membrane
Function Plays an important role in regulating the size of autophagosomes during the formation process.
Uniprot ID
Q9Y2G8
Ensemble ID
ENST00000375847.8
HGNC ID
HGNC:29157

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ABC1 SNV: p.E504A .
Ishikawa (Heraklio) 02 ER SNV: p.K687E .
J82 SNV: p.M536I .
OCIAML5 SNV: p.E394Ter .
OVCAR8 SNV: p.Q107L .
OVTOKO SNV: p.I543M .
SNU1196 SNV: p.D351H .
SUPT1 Insertion: p.R113PfsTer5 .
TE8 SNV: p.L398F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C744(0.87)  LDD2093  [1]
DBIA
 Probe Info  		C171(0.99); C174(0.96); C744(0.89)  LDD0531  [2]
DA-P3
 Probe Info  		N.A.  LDD0178  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]
PAL-AfBPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		5.86  LDD1714  [6]
C091
 Probe Info  		10.63  LDD1782  [6]
C092
 Probe Info  		20.11  LDD1783  [6]
C094
 Probe Info  		23.26  LDD1785  [6]
C112
 Probe Info  		17.39  LDD1799  [6]
C158
 Probe Info  		10.06  LDD1838  [6]
C161
 Probe Info  		11.08  LDD1841  [6]
C183
 Probe Info  		5.86  LDD1861  [6]
C185
 Probe Info  		5.90  LDD1863  [6]
C186
 Probe Info  		10.93  LDD1864  [6]
C201
 Probe Info  		26.72  LDD1877  [6]
C206
 Probe Info  		17.75  LDD1881  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C171(0.99); C174(0.96); C744(0.89)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C174(1.32); C744(0.34)  LDD0532  [2]
 LDCM0216  AC100 PaTu 8988t C174(1.59); C171(1.59)  LDD1095  [2]
 LDCM0217  AC101 PaTu 8988t C174(1.31); C171(1.31)  LDD1096  [2]
 LDCM0218  AC102 PaTu 8988t C174(1.33); C171(1.33)  LDD1097  [2]
 LDCM0219  AC103 PaTu 8988t C174(1.29); C171(1.29)  LDD1098  [2]
 LDCM0220  AC104 PaTu 8988t C174(1.46); C171(1.46)  LDD1099  [2]
 LDCM0221  AC105 PaTu 8988t C174(1.19); C171(1.19)  LDD1100  [2]
 LDCM0222  AC106 PaTu 8988t C174(1.51); C171(1.51)  LDD1101  [2]
 LDCM0223  AC107 PaTu 8988t C174(0.99); C171(0.99)  LDD1102  [2]
 LDCM0224  AC108 PaTu 8988t C174(1.39); C171(1.39)  LDD1103  [2]
 LDCM0225  AC109 PaTu 8988t C174(1.49); C171(1.49)  LDD1104  [2]
 LDCM0226  AC11 HCT 116 C174(0.94); C744(0.32)  LDD0543  [2]
 LDCM0227  AC110 PaTu 8988t C174(1.51); C171(1.51)  LDD1106  [2]
 LDCM0228  AC111 PaTu 8988t C174(1.89); C171(1.89)  LDD1107  [2]
 LDCM0229  AC112 PaTu 8988t C174(1.35); C171(1.35)  LDD1108  [2]
 LDCM0230  AC113 HCT 116 C171(1.83); C744(1.08)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C171(1.66)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C171(2.09)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C171(1.56)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C171(1.48)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C171(1.48)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C171(1.27)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C174(0.88); C744(0.32)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C171(1.36)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C171(1.32)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C171(0.90)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C171(1.25)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C171(1.31)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C171(1.52)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C171(1.65)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C171(1.52)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C744(0.51)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C744(1.18)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C744(0.75)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C744(0.63)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C744(0.68)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C744(0.61)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C744(0.57)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C744(0.43)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C744(0.44)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C744(0.43)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C744(0.50)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C744(0.49)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C174(0.88); C744(0.27)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C744(0.60)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C744(0.54)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C744(0.45)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C171(0.98); C174(0.98)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C171(1.54); C174(1.54)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C171(1.26); C174(1.26)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C171(1.37); C174(1.37)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C171(1.58); C174(1.58)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C171(2.41); C174(2.41)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C171(1.62); C174(1.62)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C744(0.25); C174(0.97)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C171(1.29); C174(1.29)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C171(1.16); C174(1.16)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C171(1.79); C174(1.79)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C171(2.50); C174(2.50)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C171(1.37); C174(1.37)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C171(1.69); C174(1.69)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C171(1.05); C174(1.05)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C171(1.26); C174(1.26)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C744(0.62); C171(1.16); C174(1.16)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C744(0.59); C171(1.30); C174(1.30)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C744(0.51); C171(1.18); C174(1.18)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C744(0.78); C171(0.87); C174(0.88)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C744(0.44); C171(1.21); C174(1.21)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C744(0.36); C171(1.29); C174(1.29)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C744(0.33); C171(1.03); C174(1.03)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C744(0.37); C171(1.07); C174(1.07)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C744(0.33); C171(1.10); C174(1.10)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C744(1.18); C171(1.22)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C744(0.98); C171(1.30)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C744(0.84); C171(1.31)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C744(0.94); C171(1.57)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C744(0.53); C171(1.20)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C744(0.73); C171(0.84); C174(0.87)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C744(0.40); C171(1.23)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C744(0.35); C171(1.42)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C744(0.55); C171(1.82)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C744(0.28); C171(1.33)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C744(0.23); C171(1.99)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C744(0.37); C171(0.88)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C744(0.50); C171(0.83)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C171(0.74); C744(0.92)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C744(0.75); C171(0.86)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C744(0.73); C171(0.75)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C744(0.87); C174(0.95); C171(0.95)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C744(0.90); C171(1.06)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C171(0.69); C744(0.71)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C744(0.75); C171(0.85)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C744(0.75); C171(0.80)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C171(0.86); C744(1.04)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C171(0.66); C744(1.02)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C744(1.21)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C744(1.38)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C744(1.09)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C744(1.34)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C174(0.93); C744(0.95); C171(0.96)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C744(1.33)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C744(0.98)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C744(1.05)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C744(1.08)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C744(0.95)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C744(1.15)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C744(1.07)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C375(0.99)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C375(0.93); C174(1.37)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C375(0.90)  LDD1561  [7]
 LDCM0323  AC6 HCT 116 C744(0.76); C174(0.98)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C375(1.02)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C375(1.06)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C375(0.97); C174(0.71)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C375(0.90); C174(1.40)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C375(0.84); C744(0.97); C174(1.21)  LDD1567  [7]
 LDCM0332  AC68 HCT 116 C744(0.80)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C744(0.85)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C174(0.96); C744(1.08)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C744(1.04)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C744(0.59)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C744(0.94)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C744(1.05)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C744(0.69)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C744(0.90)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C744(0.72)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C744(1.04)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C744(0.82)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C744(0.84)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C744(0.70); C174(1.55)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C744(0.66)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C744(0.95)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C744(0.68)  LDD0665  [2]
 LDCM0365  AC98 PaTu 8988t C174(1.25); C171(1.25)  LDD1244  [2]
 LDCM0366  AC99 PaTu 8988t C174(1.45); C171(1.45)  LDD1245  [2]
 LDCM0545  Acetamide MDA-MB-231 C744(0.21)  LDD2138  [1]
 LDCM0248  AKOS034007472 HCT 116 C174(0.91); C744(0.28)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C744(0.32); C174(1.01)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C744(0.31); C174(1.28)  LDD0592  [2]
 LDCM0367  CL1 HCT 116 C744(0.97); C174(0.98); C171(1.02)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C744(0.60); C171(1.38); C174(1.47)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C171(0.90); C744(0.94); C174(0.94)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C744(0.66); C174(1.23)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C744(0.60); C174(0.76)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C744(0.59); C174(0.94)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C744(0.33); C174(1.07)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C744(0.64); C171(1.21); C174(1.21)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C744(0.88); C171(2.02); C174(2.02)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C744(0.61); C171(1.32); C174(1.32)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C744(0.67); C171(2.05); C174(2.05)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C744(0.31); C171(1.66); C174(1.66)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C744(0.56); C171(1.38); C174(1.40)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C744(0.35); C171(1.44); C174(1.44)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C744(0.43); C171(1.45); C174(1.45)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C744(0.77); C171(1.00)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C744(0.27); C171(2.22)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C744(0.33); C171(1.11)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C744(0.29); C171(1.57)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C744(0.29); C171(1.19)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C171(0.73); C744(0.95)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C744(0.60); C171(0.88)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C171(0.73); C744(0.89)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C744(0.59); C174(1.37); C171(1.42)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C171(0.68); C744(0.68)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C744(0.81)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C744(0.98)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C744(0.95)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C744(1.02)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C375(0.94); C174(1.18)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C375(1.02)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C375(0.86); C744(1.07); C171(1.74)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C375(0.86); C744(0.99)  LDD1603  [7]
 LDCM0400  CL13 HCT 116 C744(0.59); C174(1.14); C171(1.34)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C744(0.51); C174(1.01); C171(1.10)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C744(0.65); C171(1.16); C174(1.26)  LDD0719  [2]
 LDCM0403  CL16 HEK-293T C375(0.93); C744(1.16)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C375(1.47)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C375(0.96); C174(1.70)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C375(0.99)  LDD1610  [7]
 LDCM0407  CL2 HCT 116 C174(0.81); C171(0.92); C744(1.16)  LDD0724  [2]
 LDCM0408  CL20 HEK-293T C375(1.23)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C375(1.39)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C375(1.31); C174(1.15)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C375(1.53); C174(1.32)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C375(1.21); C744(1.18); C174(1.03)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C375(1.14); C174(0.87)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C375(0.99)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C375(0.93); C744(1.20); C171(1.51)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C375(1.00); C744(1.08)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C375(1.04)  LDD1621  [7]
 LDCM0418  CL3 HCT 116 C171(1.08); C174(1.05); C744(0.76)  LDD0735  [2]
 LDCM0419  CL30 HEK-293T C375(0.97); C174(1.41)  LDD1623  [7]
 LDCM0420  CL31 HCT 116 C744(0.70)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C744(0.91)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C744(1.03)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C744(1.41)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C744(0.69)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C744(0.84)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C744(0.41)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C744(0.29)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C171(1.05); C174(1.03); C744(0.94)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C744(0.27)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C744(0.21)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C744(0.22)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C744(0.29)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C744(0.23)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C744(0.24)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C171(0.92); C174(0.92); C744(1.39)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C171(0.85); C174(0.85); C744(1.65)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C171(1.03); C174(1.03); C744(1.14)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C171(1.11); C174(1.11); C744(1.43)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C171(1.11); C174(1.05); C744(0.84)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C171(0.95); C174(0.95); C744(0.78)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C171(0.84); C174(0.84); C744(1.03)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C171(0.84); C174(0.84); C744(0.67)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C171(1.00); C174(1.00); C744(0.41)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C171(0.88); C174(0.88); C744(0.42)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C171(0.93); C174(0.93); C744(0.34)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C171(1.05); C174(1.05); C744(0.35)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C171(0.82); C174(0.82); C744(0.26)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C171(0.99); C174(0.99); C744(0.31)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C171(0.99); C174(0.99); C744(0.27)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C171(1.18); C174(1.20); C744(0.83)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C171(1.07); C174(1.07); C744(0.41)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C171(1.20); C744(1.03)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C171(1.54); C744(1.37)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C171(0.96); C744(0.70)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C171(0.98); C744(0.85)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C171(1.45); C744(0.54)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C171(1.22); C744(0.61)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C171(1.29); C744(0.37)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C171(1.19); C744(0.35)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C171(1.29); C744(0.54)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C171(1.19); C174(1.26); C744(0.79)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C171(1.31); C744(0.47)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C171(1.57); C744(0.59)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C171(1.21); C744(0.53)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C171(1.17); C744(0.46)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C171(0.97); C744(0.43)  LDD0784  [2]
 LDCM0469  CL76 PaTu 8988t C174(1.02); C171(0.86)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C174(1.19); C171(0.94)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C174(1.57); C171(1.36)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C174(1.70); C171(1.53)  LDD1351  [2]
 LDCM0473  CL8 HCT 116 C171(1.31); C174(1.31); C744(0.68)  LDD0790  [2]
 LDCM0474  CL80 PaTu 8988t C174(1.44); C171(1.18)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C174(1.58); C171(1.35)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C174(1.39); C171(1.10)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C174(1.81); C171(1.40)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C174(1.33); C171(1.09)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C174(1.53); C171(1.27)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C174(1.87); C171(1.49)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C174(1.79); C171(1.48)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C174(1.98); C171(1.50)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C174(1.38); C171(1.15)  LDD1362  [2]
 LDCM0484  CL9 HCT 116 C171(1.10); C174(1.11); C744(0.85)  LDD0801  [2]
 LDCM0485  CL90 PaTu 8988t C174(1.97); C171(1.52)  LDD1364  [2]
 LDCM0486  CL91 HCT 116 C171(0.72); C174(0.70); C744(1.24)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C171(0.71); C174(0.72); C744(0.88)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C171(0.80); C174(0.81); C744(0.94)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C171(0.85); C174(0.78); C744(1.39)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C171(0.81); C174(0.73); C744(1.06)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C171(0.76); C174(0.75); C744(1.17)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C171(0.91); C174(0.91); C744(0.78)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C171(0.95); C174(0.90); C744(0.83)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C171(0.96); C174(1.00); C744(0.79)  LDD0811  [2]
 LDCM0028  Dobutamine HEK-293T 4.35  LDD0180  [3]
 LDCM0495  E2913 HEK-293T C375(1.14); C744(1.19); C171(1.00)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C171(1.55); C744(0.45)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C744(0.80)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C744(0.90)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C744(0.99)  LDD1497  [7]
 LDCM0024  KB05 COLO792 C63(3.26)  LDD3310  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C744(0.87)  LDD2093  [1]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C744(0.92)  LDD2107  [1]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C744(1.15)  LDD2119  [1]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C744(0.73)  LDD2129  [1]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C744(1.05)  LDD2136  [1]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C744(0.35)  LDD2150  [1]
 LDCM0029  Quercetin HEK-293T 8.04  LDD0181  [3]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840