Details of the Target

General Information of Target

Target ID LDTP04712
Target Name Puromycin-sensitive aminopeptidase (NPEPPS)
Gene Name NPEPPS
Gene ID 9520
Synonyms
PSA; Puromycin-sensitive aminopeptidase; PSA; EC 3.4.11.14; Cytosol alanyl aminopeptidase; AAP-S
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSP
INYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIHATGF
NYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSKYTTPSGEVRYAAVTQFE
ATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPV
MSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPY
PLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFG
NLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIE
VSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWE
SLENASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQW
MVPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLES
LLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLG
ILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKA
TLEEARRRFKDHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIE
RVLGATLLPDLIQKVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYN
RYQGGFLISRLIKLSVEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKR
DAESIHQYLLQRKASPPTV
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Peptidase M1 family
Subcellular location
Cytoplasm, cytosol
Function
Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain.
TTD ID
T15610
Uniprot ID
P55786
DrugMap ID
TT371QC
Ensemble ID
ENST00000322157.9
HGNC ID
HGNC:7900
ChEMBL ID
CHEMBL2264

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
JURKAT SNV: p.E674Ter; p.A770V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 41 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.83  LDD0402  [2]
A-EBA
 Probe Info  		3.43  LDD0215  [3]
FBPP2
 Probe Info  		2.24  LDD0324  [4]
CY-1
 Probe Info  		100.00  LDD0243  [5]
CY4
 Probe Info  		100.00  LDD0244  [5]
N1
 Probe Info  		100.00  LDD0242  [5]
TH211
 Probe Info  		Y438(5.86)  LDD0257  [6]
TH214
 Probe Info  		Y164(20.00); Y908(20.00)  LDD0258  [6]
TH216
 Probe Info  		Y224(12.14)  LDD0259  [6]
YN-1
 Probe Info  		100.00  LDD0444  [7]
STPyne
 Probe Info  		K163(9.09); K455(10.00); K458(9.19); K459(0.66)  LDD0277  [8]
BTD
 Probe Info  		C339(3.55)  LDD1699  [9]
ONAyne
 Probe Info  		K715(1.45)  LDD0275  [8]
Probe 1
 Probe Info  		Y839(47.76); Y842(10.16)  LDD3495  [10]
JZ128-DTB
 Probe Info  		C527(0.00); C887(0.00); C190(0.00)  LDD0462  [11]
DA-P3
 Probe Info  		4.01  LDD0184  [12]
AHL-Pu-1
 Probe Info  		C537(2.19)  LDD0168  [13]
HHS-482
 Probe Info  		Y438(1.04)  LDD0285  [14]
HHS-475
 Probe Info  		Y224(0.79); Y438(0.89)  LDD0264  [15]
HHS-465
 Probe Info  		Y173(5.57); Y224(10.00); Y438(10.00)  LDD2237  [16]
DBIA
 Probe Info  		C190(1.01); C537(0.98)  LDD0078  [17]
5E-2FA
 Probe Info  		N.A.  LDD2235  [18]
ATP probe
 Probe Info  		K821(0.00); K863(0.00); K455(0.00); K458(0.00)  LDD0199  [19]
4-Iodoacetamidophenylacetylene
 Probe Info  		C66(0.00); C190(0.00); C265(0.00); C339(0.00)  LDD0038  [20]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [21]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [22]
Lodoacetamide azide
 Probe Info  		C190(0.00); C66(0.00); C339(0.00); C265(0.00)  LDD0037  [20]
WYneN
 Probe Info  		C265(0.00); C339(0.00)  LDD0021  [23]
IPM
 Probe Info  		N.A.  LDD0005  [23]
NHS
 Probe Info  		K163(0.00); K279(0.00); K208(0.00)  LDD0010  [23]
PF-06672131
 Probe Info  		N.A.  LDD0152  [24]
SF
 Probe Info  		Y908(0.00); K712(0.00)  LDD0028  [25]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [26]
Ox-W18
 Probe Info  		N.A.  LDD2175  [27]
1c-yne
 Probe Info  		K695(0.00); K524(0.00); K471(0.00); K488(0.00)  LDD0228  [28]
Acrolein
 Probe Info  		C190(0.00); H754(0.00); C265(0.00)  LDD0217  [29]
Methacrolein
 Probe Info  		C339(0.00); C265(0.00)  LDD0218  [29]
W1
 Probe Info  		N.A.  LDD0236  [30]
AOyne
 Probe Info  		4.40  LDD0443  [31]
MPP-AC
 Probe Info  		N.A.  LDD0428  [32]
NAIA_5
 Probe Info  		C190(0.00); C66(0.00); C265(0.00); C887(0.00)  LDD2223  [33]
PAL-AfBPP Probe
Click To Hide/Show 151 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
PARPYnD
 Probe Info  		1.72  LDD0374  [34]
IMP2070
 Probe Info  		3.51  LDD0367  [35]
C006
 Probe Info  		5.90  LDD1715  [36]
C010
 Probe Info  		5.28  LDD1719  [36]
C017
 Probe Info  		6.73  LDD1725  [36]
C027
 Probe Info  		7.01  LDD1733  [36]
C039
 Probe Info  		7.01  LDD1739  [36]
C040
 Probe Info  		10.20  LDD1740  [36]
C041
 Probe Info  		11.88  LDD1741  [36]
C059
 Probe Info  		6.02  LDD1756  [36]
C063
 Probe Info  		13.83  LDD1760  [36]
C064
 Probe Info  		8.88  LDD1761  [36]
C065
 Probe Info  		5.43  LDD1762  [36]
C070
 Probe Info  		9.78  LDD1766  [36]
C071
 Probe Info  		10.20  LDD1767  [36]
C072
 Probe Info  		7.21  LDD1768  [36]
C082
 Probe Info  		7.84  LDD1774  [36]
C085
 Probe Info  		13.64  LDD1777  [36]
C087
 Probe Info  		12.47  LDD1779  [36]
C091
 Probe Info  		13.45  LDD1782  [36]
C095
 Probe Info  		5.62  LDD1786  [36]
C102
 Probe Info  		7.16  LDD1790  [36]
C107
 Probe Info  		10.48  LDD1794  [36]
C112
 Probe Info  		17.75  LDD1799  [36]
C122
 Probe Info  		5.35  LDD1808  [36]
C129
 Probe Info  		7.36  LDD1811  [36]
C139
 Probe Info  		16.11  LDD1821  [36]
C141
 Probe Info  		10.85  LDD1823  [36]
C142
 Probe Info  		6.32  LDD1824  [36]
C145
 Probe Info  		19.03  LDD1827  [36]
C147
 Probe Info  		16.80  LDD1829  [36]
C158
 Probe Info  		13.93  LDD1838  [36]
C159
 Probe Info  		8.94  LDD1839  [36]
C160
 Probe Info  		9.19  LDD1840  [36]
C161
 Probe Info  		25.28  LDD1841  [36]
C166
 Probe Info  		13.09  LDD1846  [36]
C173
 Probe Info  		14.93  LDD1853  [36]
C174
 Probe Info  		7.46  LDD1854  [36]
C176
 Probe Info  		6.11  LDD1855  [36]
C177
 Probe Info  		11.00  LDD1856  [36]
C183
 Probe Info  		10.34  LDD1861  [36]
C185
 Probe Info  		13.55  LDD1863  [36]
C186
 Probe Info  		15.14  LDD1864  [36]
C187
 Probe Info  		22.32  LDD1865  [36]
C191
 Probe Info  		10.93  LDD1868  [36]
C198
 Probe Info  		13.00  LDD1874  [36]
C205
 Probe Info  		7.84  LDD1880  [36]
C206
 Probe Info  		16.91  LDD1881  [36]
C211
 Probe Info  		9.32  LDD1885  [36]
C212
 Probe Info  		6.32  LDD1886  [36]
C216
 Probe Info  		6.32  LDD1890  [36]
C217
 Probe Info  		7.52  LDD1891  [36]
C218
 Probe Info  		16.11  LDD1892  [36]
C219
 Probe Info  		6.73  LDD1893  [36]
C222
 Probe Info  		5.90  LDD1896  [36]
C226
 Probe Info  		6.19  LDD1899  [36]
C229
 Probe Info  		13.18  LDD1902  [36]
C231
 Probe Info  		12.47  LDD1904  [36]
C233
 Probe Info  		14.62  LDD1906  [36]
C234
 Probe Info  		7.84  LDD1907  [36]
C235
 Probe Info  		17.39  LDD1908  [36]
C238
 Probe Info  		14.42  LDD1911  [36]
C239
 Probe Info  		7.16  LDD1912  [36]
C243
 Probe Info  		15.56  LDD1916  [36]
C244
 Probe Info  		20.82  LDD1917  [36]
C246
 Probe Info  		12.73  LDD1919  [36]
C249
 Probe Info  		19.97  LDD1922  [36]
C252
 Probe Info  		9.45  LDD1925  [36]
C256
 Probe Info  		5.17  LDD1929  [36]
C258
 Probe Info  		5.74  LDD1931  [36]
C260
 Probe Info  		4.92  LDD1932  [36]
C266
 Probe Info  		10.93  LDD1937  [36]
C269
 Probe Info  		9.71  LDD1939  [36]
C270
 Probe Info  		12.38  LDD1940  [36]
C271
 Probe Info  		6.41  LDD1941  [36]
C274
 Probe Info  		5.10  LDD1944  [36]
C286
 Probe Info  		5.03  LDD1956  [36]
C288
 Probe Info  		12.91  LDD1958  [36]
C290
 Probe Info  		11.24  LDD1960  [36]
C292
 Probe Info  		15.67  LDD1962  [36]
C293
 Probe Info  		16.34  LDD1963  [36]
C296
 Probe Info  		14.03  LDD1966  [36]
C297
 Probe Info  		6.59  LDD1967  [36]
C299
 Probe Info  		7.26  LDD1968  [36]
C300
 Probe Info  		8.46  LDD1969  [36]
C302
 Probe Info  		8.00  LDD1971  [36]
C305
 Probe Info  		14.12  LDD1974  [36]
C310
 Probe Info  		11.88  LDD1977  [36]
C313
 Probe Info  		16.00  LDD1980  [36]
C314
 Probe Info  		15.78  LDD1981  [36]
C317
 Probe Info  		9.58  LDD1983  [36]
C322
 Probe Info  		15.56  LDD1988  [36]
C326
 Probe Info  		10.70  LDD1990  [36]
C333
 Probe Info  		10.70  LDD1996  [36]
C338
 Probe Info  		13.74  LDD2001  [36]
C339
 Probe Info  		11.08  LDD2002  [36]
C347
 Probe Info  		9.85  LDD2008  [36]
C348
 Probe Info  		21.56  LDD2009  [36]
C349
 Probe Info  		18.00  LDD2010  [36]
C353
 Probe Info  		29.86  LDD2014  [36]
C354
 Probe Info  		12.38  LDD2015  [36]
C355
 Probe Info  		28.84  LDD2016  [36]
C356
 Probe Info  		9.06  LDD2017  [36]
C361
 Probe Info  		32.90  LDD2022  [36]
C366
 Probe Info  		5.86  LDD2027  [36]
C367
 Probe Info  		13.36  LDD2028  [36]
C373
 Probe Info  		5.24  LDD2033  [36]
C378
 Probe Info  		8.69  LDD2037  [36]
C380
 Probe Info  		6.59  LDD2039  [36]
C382
 Probe Info  		13.83  LDD2041  [36]
C383
 Probe Info  		22.32  LDD2042  [36]
C386
 Probe Info  		6.92  LDD2045  [36]
C389
 Probe Info  		9.13  LDD2048  [36]
C390
 Probe Info  		31.56  LDD2049  [36]
C391
 Probe Info  		28.25  LDD2050  [36]
C393
 Probe Info  		6.77  LDD2052  [36]
C394
 Probe Info  		6.73  LDD2053  [36]
C396
 Probe Info  		5.28  LDD2055  [36]
C399
 Probe Info  		8.75  LDD2058  [36]
C403
 Probe Info  		21.56  LDD2061  [36]
C407
 Probe Info  		11.16  LDD2064  [36]
C408
 Probe Info  		5.50  LDD2065  [36]
C413
 Probe Info  		16.80  LDD2069  [36]
C416
 Probe Info  		6.36  LDD2071  [36]
C419
 Probe Info  		16.45  LDD2074  [36]
C420
 Probe Info  		29.45  LDD2075  [36]
C423
 Probe Info  		14.72  LDD2078  [36]
C424
 Probe Info  		15.14  LDD2079  [36]
C426
 Probe Info  		17.03  LDD2081  [36]
C429
 Probe Info  		26.35  LDD2084  [36]
C430
 Probe Info  		8.88  LDD2085  [36]
C431
 Probe Info  		14.22  LDD2086  [36]
C433
 Probe Info  		9.71  LDD2088  [36]
FFF probe11
 Probe Info  		5.88  LDD0471  [37]
FFF probe12
 Probe Info  		12.64  LDD0473  [37]
FFF probe13
 Probe Info  		14.60  LDD0475  [37]
FFF probe14
 Probe Info  		13.02  LDD0477  [37]
FFF probe15
 Probe Info  		5.36  LDD0478  [37]
FFF probe2
 Probe Info  		9.62  LDD0463  [37]
FFF probe3
 Probe Info  		20.00  LDD0464  [37]
FFF probe4
 Probe Info  		12.95  LDD0466  [37]
FFF probe6
 Probe Info  		8.39  LDD0467  [37]
FFF probe9
 Probe Info  		9.33  LDD0470  [37]
JN0003
 Probe Info  		16.05  LDD0469  [37]
STS-2
 Probe Info  		N.A.  LDD0138  [38]
Alk-rapa
 Probe Info  		4.09  LDD0213  [39]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [40]
Diazir
 Probe Info  		N.A.  LDD0011  [23]
DA-2
 Probe Info  		N.A.  LDD0070  [41]
OEA-DA
 Probe Info  		4.71  LDD0046  [42]
STS-1
 Probe Info  		N.A.  LDD0068  [43]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C339(0.81)  LDD2142  [9]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C339(0.79)  LDD2112  [9]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C339(0.63)  LDD2095  [9]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C339(1.02)  LDD2130  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C339(0.66); C265(0.91)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C339(1.11)  LDD2152  [9]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C265(0.35)  LDD2132  [9]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C339(0.68)  LDD2131  [9]
 LDCM0025  4SU-RNA HEK-293T C537(2.19)  LDD0168  [13]
 LDCM0026  4SU-RNA+native RNA HEK-293T C537(4.55)  LDD0169  [13]
 LDCM0214  AC1 HCT 116 C339(0.85); C190(1.13); C527(1.04); C537(1.04)  LDD0531  [17]
 LDCM0215  AC10 HCT 116 C339(0.99); C527(0.69); C537(0.69)  LDD0532  [17]
 LDCM0216  AC100 HCT 116 C527(0.97); C537(0.97)  LDD0533  [17]
 LDCM0217  AC101 HCT 116 C527(0.97); C537(0.97)  LDD0534  [17]
 LDCM0218  AC102 HCT 116 C527(0.98); C537(0.98)  LDD0535  [17]
 LDCM0219  AC103 HCT 116 C527(0.44); C537(0.44)  LDD0536  [17]
 LDCM0220  AC104 HCT 116 C527(0.81); C537(0.81)  LDD0537  [17]
 LDCM0221  AC105 HCT 116 C527(0.66); C537(0.66)  LDD0538  [17]
 LDCM0222  AC106 HCT 116 C527(0.60); C537(0.60)  LDD0539  [17]
 LDCM0223  AC107 HCT 116 C527(0.40); C537(0.40)  LDD0540  [17]
 LDCM0224  AC108 HCT 116 C527(0.39); C537(0.39)  LDD0541  [17]
 LDCM0225  AC109 HCT 116 C527(0.37); C537(0.37)  LDD0542  [17]
 LDCM0226  AC11 HCT 116 C339(0.96); C527(0.69); C537(0.69)  LDD0543  [17]
 LDCM0227  AC110 HCT 116 C527(0.49); C537(0.49)  LDD0544  [17]
 LDCM0228  AC111 HCT 116 C527(0.37); C537(0.37)  LDD0545  [17]
 LDCM0229  AC112 HCT 116 C527(0.45); C537(0.45)  LDD0546  [17]
 LDCM0230  AC113 HCT 116 C339(0.70); C265(0.91)  LDD0547  [17]
 LDCM0231  AC114 HCT 116 C265(1.23)  LDD0548  [17]
 LDCM0232  AC115 HCT 116 C265(0.96)  LDD0549  [17]
 LDCM0233  AC116 HCT 116 C265(1.01)  LDD0550  [17]
 LDCM0234  AC117 HCT 116 C265(0.86)  LDD0551  [17]
 LDCM0235  AC118 HCT 116 C265(0.96)  LDD0552  [17]
 LDCM0236  AC119 HCT 116 C265(0.82)  LDD0553  [17]
 LDCM0237  AC12 HCT 116 C339(0.90); C527(0.75); C537(0.75)  LDD0554  [17]
 LDCM0238  AC120 HCT 116 C265(0.49)  LDD0555  [17]
 LDCM0239  AC121 HCT 116 C265(0.72)  LDD0556  [17]
 LDCM0240  AC122 HCT 116 C265(0.70)  LDD0557  [17]
 LDCM0241  AC123 HCT 116 C265(0.64)  LDD0558  [17]
 LDCM0242  AC124 HCT 116 C265(0.39)  LDD0559  [17]
 LDCM0243  AC125 HCT 116 C265(0.30)  LDD0560  [17]
 LDCM0244  AC126 HCT 116 C265(0.55)  LDD0561  [17]
 LDCM0245  AC127 HCT 116 C265(0.57)  LDD0562  [17]
 LDCM0246  AC128 HCT 116 C190(1.13)  LDD0563  [17]
 LDCM0247  AC129 HCT 116 C190(1.08)  LDD0564  [17]
 LDCM0249  AC130 HCT 116 C190(1.27)  LDD0566  [17]
 LDCM0250  AC131 HCT 116 C190(1.19)  LDD0567  [17]
 LDCM0251  AC132 HCT 116 C190(1.23)  LDD0568  [17]
 LDCM0252  AC133 HCT 116 C190(1.19)  LDD0569  [17]
 LDCM0253  AC134 HCT 116 C190(1.04)  LDD0570  [17]
 LDCM0254  AC135 HCT 116 C190(1.33)  LDD0571  [17]
 LDCM0255  AC136 HCT 116 C190(1.36)  LDD0572  [17]
 LDCM0256  AC137 HCT 116 C190(1.22)  LDD0573  [17]
 LDCM0257  AC138 HCT 116 C190(1.06)  LDD0574  [17]
 LDCM0258  AC139 HCT 116 C190(1.35)  LDD0575  [17]
 LDCM0259  AC14 HCT 116 C339(0.81); C527(0.89); C537(0.89)  LDD0576  [17]
 LDCM0260  AC140 HCT 116 C190(1.27)  LDD0577  [17]
 LDCM0261  AC141 HCT 116 C190(1.14)  LDD0578  [17]
 LDCM0262  AC142 HCT 116 C190(1.39)  LDD0579  [17]
 LDCM0263  AC143 HCT 116 C339(0.91); C527(0.67); C190(0.70); C887(0.75)  LDD0580  [17]
 LDCM0264  AC144 HCT 116 C190(0.27); C537(0.69); C887(0.78); C888(0.78)  LDD0581  [17]
 LDCM0265  AC145 HCT 116 C190(0.47); C887(0.76); C888(0.76); C339(0.81)  LDD0582  [17]
 LDCM0266  AC146 HCT 116 C190(0.51); C527(0.78); C339(0.97); C537(1.04)  LDD0583  [17]
 LDCM0267  AC147 HCT 116 C190(0.23); C537(0.49); C887(0.51); C888(0.51)  LDD0584  [17]
 LDCM0268  AC148 HCT 116 C887(0.11); C888(0.11); C537(0.14); C190(0.15)  LDD0585  [17]
 LDCM0269  AC149 HCT 116 C190(0.25); C537(0.50); C887(0.52); C888(0.52)  LDD0586  [17]
 LDCM0270  AC15 HCT 116 C527(0.78); C537(0.78); C339(0.96)  LDD0587  [17]
 LDCM0271  AC150 HCT 116 C190(0.69); C339(0.73); C537(0.90); C527(0.93)  LDD0588  [17]
 LDCM0272  AC151 HCT 116 C190(0.51); C887(0.83); C888(0.83); C339(0.99)  LDD0589  [17]
 LDCM0273  AC152 HCT 116 C190(0.19); C537(0.36); C887(0.56); C888(0.56)  LDD0590  [17]
 LDCM0274  AC153 HCT 116 C887(0.09); C888(0.09); C537(0.12); C190(0.15)  LDD0591  [17]
 LDCM0621  AC154 HCT 116 C339(0.78); C190(0.35); C527(0.82); C537(0.62)  LDD2158  [17]
 LDCM0622  AC155 HCT 116 C339(0.85); C190(0.34); C527(0.88); C537(0.93)  LDD2159  [17]
 LDCM0623  AC156 HCT 116 C339(1.01); C190(1.04); C527(0.68); C537(0.75)  LDD2160  [17]
 LDCM0624  AC157 HCT 116 C339(0.78); C190(0.55); C527(1.01); C537(1.29)  LDD2161  [17]
 LDCM0276  AC17 HCT 116 C190(0.98); C339(1.15); C527(1.34); C537(1.34)  LDD0593  [17]
 LDCM0277  AC18 HCT 116 C190(0.74); C527(0.88); C537(0.88); C339(0.93)  LDD0594  [17]
 LDCM0278  AC19 HCT 116 C190(0.92); C527(1.09); C537(1.09); C339(1.11)  LDD0595  [17]
 LDCM0279  AC2 HCT 116 C339(1.16); C190(1.19); C527(1.23); C537(1.23)  LDD0596  [17]
 LDCM0280  AC20 HCT 116 C190(0.89); C339(1.14); C527(1.63); C537(1.63)  LDD0597  [17]
 LDCM0281  AC21 HCT 116 C190(0.91); C527(1.03); C537(1.03); C339(1.07)  LDD0598  [17]
 LDCM0282  AC22 HCT 116 C527(0.81); C537(0.81); C190(0.86); C339(1.22)  LDD0599  [17]
 LDCM0283  AC23 HCT 116 C527(0.79); C537(0.79); C190(0.95); C339(1.15)  LDD0600  [17]
 LDCM0284  AC24 HCT 116 C339(0.87); C190(0.95); C527(1.23); C537(1.23)  LDD0601  [17]
 LDCM0285  AC25 HCT 116 C190(1.06); C339(1.38)  LDD0602  [17]
 LDCM0286  AC26 HCT 116 C190(1.05); C339(1.72)  LDD0603  [17]
 LDCM0287  AC27 HCT 116 C190(1.05); C339(1.36)  LDD0604  [17]
 LDCM0288  AC28 HCT 116 C190(1.07); C339(1.22)  LDD0605  [17]
 LDCM0289  AC29 HCT 116 C190(1.12); C339(1.30)  LDD0606  [17]
 LDCM0290  AC3 HCT 116 C527(0.94); C537(0.94); C339(0.95); C190(1.11)  LDD0607  [17]
 LDCM0291  AC30 HCT 116 C190(1.03); C339(1.21)  LDD0608  [17]
 LDCM0292  AC31 HCT 116 C190(1.14); C339(1.43)  LDD0609  [17]
 LDCM0293  AC32 HCT 116 C190(1.14); C339(1.66)  LDD0610  [17]
 LDCM0294  AC33 HCT 116 C190(1.16); C339(1.43)  LDD0611  [17]
 LDCM0295  AC34 HCT 116 C190(1.01); C339(1.33)  LDD0612  [17]
 LDCM0296  AC35 HCT 116 C339(0.83); C527(1.28); C537(1.28)  LDD0613  [17]
 LDCM0297  AC36 HCT 116 C527(1.12); C537(1.12); C339(1.15)  LDD0614  [17]
 LDCM0298  AC37 HCT 116 C339(1.06); C527(1.68); C537(1.68)  LDD0615  [17]
 LDCM0299  AC38 HCT 116 C339(0.99); C527(1.19); C537(1.19)  LDD0616  [17]
 LDCM0300  AC39 HCT 116 C527(0.88); C537(0.88); C339(1.22)  LDD0617  [17]
 LDCM0301  AC4 HCT 116 C339(0.99); C190(1.01); C527(1.10); C537(1.10)  LDD0618  [17]
 LDCM0302  AC40 HCT 116 C527(0.57); C537(0.57); C339(1.35)  LDD0619  [17]
 LDCM0303  AC41 HCT 116 C339(1.01); C527(1.05); C537(1.05)  LDD0620  [17]
 LDCM0304  AC42 HCT 116 C527(0.87); C537(0.87); C339(1.10)  LDD0621  [17]
 LDCM0305  AC43 HCT 116 C339(1.17); C527(1.19); C537(1.19)  LDD0622  [17]
 LDCM0306  AC44 HCT 116 C527(0.95); C537(0.95); C339(1.04)  LDD0623  [17]
 LDCM0307  AC45 HCT 116 C527(0.51); C537(0.51); C339(1.18)  LDD0624  [17]
 LDCM0308  AC46 HCT 116 C339(1.17); C527(1.34); C537(1.38)  LDD0625  [17]
 LDCM0309  AC47 HCT 116 C339(1.02); C527(1.10); C537(1.17)  LDD0626  [17]
 LDCM0310  AC48 HCT 116 C527(1.08); C537(1.32); C339(1.38)  LDD0627  [17]
 LDCM0311  AC49 HCT 116 C527(0.53); C537(1.19); C339(1.26)  LDD0628  [17]
 LDCM0312  AC5 HCT 116 C527(0.96); C537(0.96); C190(1.00); C339(1.01)  LDD0629  [17]
 LDCM0313  AC50 HCT 116 C527(0.58); C537(1.04); C339(1.61)  LDD0630  [17]
 LDCM0314  AC51 HCT 116 C339(0.94); C527(1.04); C537(1.32)  LDD0631  [17]
 LDCM0315  AC52 HCT 116 C527(0.96); C339(1.13); C537(1.15)  LDD0632  [17]
 LDCM0316  AC53 HCT 116 C527(0.81); C537(0.97); C339(1.18)  LDD0633  [17]
 LDCM0317  AC54 HCT 116 C527(0.72); C339(0.91); C537(1.03)  LDD0634  [17]
 LDCM0318  AC55 HCT 116 C527(0.59); C537(0.83); C339(1.20)  LDD0635  [17]
 LDCM0319  AC56 HCT 116 C527(0.33); C537(0.85); C339(1.59)  LDD0636  [17]
 LDCM0320  AC57 HCT 116 C537(0.63); C527(0.63); C190(0.83); C265(0.84)  LDD0637  [17]
 LDCM0321  AC58 HCT 116 C527(0.50); C190(0.62); C537(0.71); C265(0.93)  LDD0638  [17]
 LDCM0322  AC59 HCT 116 C527(0.31); C190(0.47); C537(0.57); C265(0.90)  LDD0639  [17]
 LDCM0323  AC6 HCT 116 C527(0.97); C537(0.97); C339(1.09)  LDD0640  [17]
 LDCM0324  AC60 HCT 116 C537(0.77); C527(0.89); C190(0.95); C339(1.21)  LDD0641  [17]
 LDCM0325  AC61 HCT 116 C265(0.50); C537(0.89); C527(0.94); C190(1.11)  LDD0642  [17]
 LDCM0326  AC62 HCT 116 C527(0.25); C190(0.40); C537(0.54); C265(0.90)  LDD0643  [17]
 LDCM0327  AC63 HCT 116 C527(0.55); C537(0.61); C265(0.85); C190(0.86)  LDD0644  [17]
 LDCM0328  AC64 HCT 116 C527(0.28); C190(0.55); C537(0.70); C265(0.81)  LDD0645  [17]
 LDCM0329  AC65 HCT 116 C527(0.46); C190(0.83); C537(0.85); C265(0.89)  LDD0646  [17]
 LDCM0330  AC66 HCT 116 C527(0.72); C265(0.79); C190(0.85); C537(1.00)  LDD0647  [17]
 LDCM0331  AC67 HCT 116 C527(0.12); C190(0.45); C537(0.50); C265(0.77)  LDD0648  [17]
 LDCM0332  AC68 HCT 116 C527(0.69); C537(0.69); C190(0.73); C887(0.90)  LDD0649  [17]
 LDCM0333  AC69 HCT 116 C190(0.68); C527(0.73); C537(0.73); C887(0.91)  LDD0650  [17]
 LDCM0334  AC7 HCT 116 C339(0.82); C527(0.82); C537(0.82)  LDD0651  [17]
 LDCM0335  AC70 HCT 116 C190(0.26); C527(0.30); C537(0.30); C887(0.53)  LDD0652  [17]
 LDCM0336  AC71 HCT 116 C339(1.00); C527(1.08); C537(1.08); C190(1.08)  LDD0653  [17]
 LDCM0337  AC72 HCT 116 C190(0.39); C527(0.68); C537(0.68); C887(1.07)  LDD0654  [17]
 LDCM0338  AC73 HCT 116 C190(0.13); C527(0.20); C537(0.20); C887(0.47)  LDD0655  [17]
 LDCM0339  AC74 HCT 116 C190(0.14); C527(0.22); C537(0.22); C887(0.52)  LDD0656  [17]
 LDCM0340  AC75 HCT 116 C190(0.09); C527(0.13); C537(0.13); C887(0.29)  LDD0657  [17]
 LDCM0341  AC76 HCT 116 C190(0.39); C527(0.41); C537(0.41); C887(0.96)  LDD0658  [17]
 LDCM0342  AC77 HCT 116 C190(0.34); C527(0.48); C537(0.48); C887(0.99)  LDD0659  [17]
 LDCM0343  AC78 HCT 116 C527(0.78); C537(0.78); C190(1.00); C887(1.08)  LDD0660  [17]
 LDCM0344  AC79 HCT 116 C527(0.75); C537(0.75); C190(0.76); C887(1.06)  LDD0661  [17]
 LDCM0345  AC8 HCT 116 C527(0.80); C537(0.80); C339(0.83)  LDD0662  [17]
 LDCM0346  AC80 HCT 116 C190(0.42); C527(0.62); C537(0.62); C339(0.82)  LDD0663  [17]
 LDCM0347  AC81 HCT 116 C527(0.43); C537(0.43); C887(0.78); C888(0.78)  LDD0664  [17]
 LDCM0348  AC82 HCT 116 C190(0.08); C527(0.11); C537(0.11); C887(0.20)  LDD0665  [17]
 LDCM0349  AC83 HCT 116 C190(0.66); C339(1.46)  LDD0666  [17]
 LDCM0350  AC84 HCT 116 C190(0.71); C339(0.96)  LDD0667  [17]
 LDCM0351  AC85 HCT 116 C190(1.03); C339(1.34)  LDD0668  [17]
 LDCM0352  AC86 HCT 116 C190(0.90); C339(1.43)  LDD0669  [17]
 LDCM0353  AC87 HCT 116 C190(0.98); C339(1.05)  LDD0670  [17]
 LDCM0354  AC88 HCT 116 C190(0.93); C339(1.49)  LDD0671  [17]
 LDCM0355  AC89 HCT 116 C190(0.89); C339(1.42)  LDD0672  [17]
 LDCM0357  AC90 HCT 116 C190(1.10); C339(1.68)  LDD0674  [17]
 LDCM0358  AC91 HCT 116 C190(0.69); C339(1.14)  LDD0675  [17]
 LDCM0359  AC92 HCT 116 C190(0.77); C339(1.27)  LDD0676  [17]
 LDCM0360  AC93 HCT 116 C339(0.83); C190(1.00)  LDD0677  [17]
 LDCM0361  AC94 HCT 116 C339(0.75); C190(1.09)  LDD0678  [17]
 LDCM0362  AC95 HCT 116 C190(1.04); C339(1.36)  LDD0679  [17]
 LDCM0363  AC96 HCT 116 C339(0.86); C190(0.98)  LDD0680  [17]
 LDCM0364  AC97 HCT 116 C190(0.91); C339(1.25)  LDD0681  [17]
 LDCM0365  AC98 HCT 116 C527(0.04); C537(0.04)  LDD0682  [17]
 LDCM0366  AC99 HCT 116 C527(0.73); C537(0.73)  LDD0683  [17]
 LDCM0545  Acetamide MDA-MB-231 C339(0.17); C265(0.42)  LDD2138  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C339(0.69)  LDD2113  [9]
 LDCM0248  AKOS034007472 HCT 116 C339(0.99); C527(1.01); C537(1.01)  LDD0565  [17]
 LDCM0356  AKOS034007680 HCT 116 C527(0.79); C537(0.79); C339(1.11)  LDD0673  [17]
 LDCM0275  AKOS034007705 HCT 116 C527(0.27); C537(0.27); C339(1.46)  LDD0592  [17]
 LDCM0156  Aniline NCI-H1299 C537(0.00); C66(0.00)  LDD0404  [2]
 LDCM0020  ARS-1620 HCC44 C190(1.01); C537(0.98)  LDD0078  [17]
 LDCM0498  BS-3668 MDA-MB-231 C339(0.25); C265(0.41)  LDD2091  [9]
 LDCM0108  Chloroacetamide HeLa C190(0.00); H754(0.00); C265(0.00)  LDD0222  [29]
 LDCM0367  CL1 HCT 116 C887(0.71); C888(0.71); C537(0.80); C527(0.87)  LDD0684  [17]
 LDCM0368  CL10 HCT 116 C190(0.38); C887(0.41); C888(0.41); C527(0.47)  LDD0685  [17]
 LDCM0369  CL100 HCT 116 C339(0.89); C190(1.08); C527(1.13); C537(1.13)  LDD0686  [17]
 LDCM0370  CL101 HCT 116 C527(0.91); C537(0.91); C339(1.38)  LDD0687  [17]
 LDCM0371  CL102 HCT 116 C527(0.77); C537(0.77); C339(1.24)  LDD0688  [17]
 LDCM0372  CL103 HCT 116 C339(0.99); C527(1.03); C537(1.03)  LDD0689  [17]
 LDCM0373  CL104 HCT 116 C339(0.88); C527(0.98); C537(0.98)  LDD0690  [17]
 LDCM0374  CL105 HCT 116 C190(0.80); C527(0.82); C537(0.82); C339(1.59)  LDD0691  [17]
 LDCM0375  CL106 HCT 116 C190(0.60); C527(0.76); C537(0.76); C339(1.51)  LDD0692  [17]
 LDCM0376  CL107 HCT 116 C190(0.52); C527(0.54); C537(0.54); C339(1.80)  LDD0693  [17]
 LDCM0377  CL108 HCT 116 C190(0.31); C527(0.33); C537(0.33); C339(1.55)  LDD0694  [17]
 LDCM0378  CL109 HCT 116 C190(0.73); C527(0.99); C537(0.99); C339(1.66)  LDD0695  [17]
 LDCM0379  CL11 HCT 116 C190(0.19); C887(0.22); C888(0.22); C527(0.26)  LDD0696  [17]
 LDCM0380  CL110 HCT 116 C190(0.55); C527(0.77); C537(0.77); C339(1.77)  LDD0697  [17]
 LDCM0381  CL111 HCT 116 C527(0.83); C537(0.83); C190(0.87); C339(1.60)  LDD0698  [17]
 LDCM0382  CL112 HCT 116 C190(0.92); C339(1.01)  LDD0699  [17]
 LDCM0383  CL113 HCT 116 C190(0.99); C339(1.24)  LDD0700  [17]
 LDCM0384  CL114 HCT 116 C190(1.01); C339(1.49)  LDD0701  [17]
 LDCM0385  CL115 HCT 116 C190(0.86); C339(1.21)  LDD0702  [17]
 LDCM0386  CL116 HCT 116 C190(1.06); C339(1.39)  LDD0703  [17]
 LDCM0387  CL117 HCT 116 C527(0.31); C537(0.31); C339(1.53)  LDD0704  [17]
 LDCM0388  CL118 HCT 116 C527(0.91); C537(0.91); C339(1.47)  LDD0705  [17]
 LDCM0389  CL119 HCT 116 C527(0.85); C537(0.85); C339(1.22)  LDD0706  [17]
 LDCM0390  CL12 HCT 116 C887(0.16); C888(0.16); C190(0.18); C527(0.26)  LDD0707  [17]
 LDCM0391  CL120 HCT 116 C527(1.11); C537(1.11); C339(1.26)  LDD0708  [17]
 LDCM0392  CL121 HCT 116 C527(0.91); C339(0.94); C537(1.07)  LDD0709  [17]
 LDCM0393  CL122 HCT 116 C527(1.00); C537(1.06); C339(1.71)  LDD0710  [17]
 LDCM0394  CL123 HCT 116 C527(0.69); C537(0.85); C339(1.31)  LDD0711  [17]
 LDCM0395  CL124 HCT 116 C527(0.60); C537(1.01); C339(1.46)  LDD0712  [17]
 LDCM0396  CL125 HCT 116 C537(0.92); C190(0.93); C527(1.18); C265(1.18)  LDD0713  [17]
 LDCM0397  CL126 HCT 116 C537(0.74); C527(0.78); C190(0.90); C265(1.06)  LDD0714  [17]
 LDCM0398  CL127 HCT 116 C527(0.70); C190(0.86); C537(0.91); C265(1.13)  LDD0715  [17]
 LDCM0399  CL128 HCT 116 C527(0.40); C190(0.61); C537(0.67); C265(1.04)  LDD0716  [17]
 LDCM0400  CL13 HCT 116 C887(0.61); C888(0.61); C190(0.64); C527(0.72)  LDD0717  [17]
 LDCM0401  CL14 HCT 116 C537(0.81); C190(0.87); C527(0.88); C887(0.95)  LDD0718  [17]
 LDCM0402  CL15 HCT 116 C190(0.33); C887(0.70); C888(0.70); C527(0.80)  LDD0719  [17]
 LDCM0403  CL16 HCT 116 C190(0.88); C887(1.00); C888(1.00); C537(1.09)  LDD0720  [17]
 LDCM0404  CL17 HCT 116 C887(0.93); C888(0.93); C190(1.07); C537(1.15)  LDD0721  [17]
 LDCM0405  CL18 HCT 116 C190(1.22); C537(1.39); C887(1.45); C888(1.45)  LDD0722  [17]
 LDCM0406  CL19 HCT 116 C887(0.92); C888(0.92); C190(0.96); C537(1.24)  LDD0723  [17]
 LDCM0407  CL2 HCT 116 C887(0.71); C888(0.71); C537(0.89); C527(0.92)  LDD0724  [17]
 LDCM0408  CL20 HCT 116 C190(0.49); C537(0.65); C887(0.67); C888(0.67)  LDD0725  [17]
 LDCM0409  CL21 HCT 116 C190(0.30); C887(0.40); C888(0.40); C537(0.41)  LDD0726  [17]
 LDCM0410  CL22 HCT 116 C887(0.11); C888(0.11); C190(0.12); C537(0.22)  LDD0727  [17]
 LDCM0411  CL23 HCT 116 C190(0.80); C887(0.82); C888(0.82); C537(0.85)  LDD0728  [17]
 LDCM0412  CL24 HCT 116 C190(0.25); C537(0.33); C887(0.33); C888(0.33)  LDD0729  [17]
 LDCM0413  CL25 HCT 116 C339(3.31); C190(0.28); C527(0.79); C537(0.33)  LDD0730  [17]
 LDCM0414  CL26 HCT 116 C339(1.88); C190(0.75); C527(1.27); C537(0.84)  LDD0731  [17]
 LDCM0415  CL27 HCT 116 C339(2.45); C190(0.90); C527(1.27); C537(1.22)  LDD0732  [17]
 LDCM0416  CL28 HCT 116 C339(3.79); C190(0.59); C527(1.15); C537(0.88)  LDD0733  [17]
 LDCM0417  CL29 HCT 116 C339(2.27); C190(0.57); C527(1.08); C537(0.75)  LDD0734  [17]
 LDCM0418  CL3 HCT 116 C339(1.22); C190(0.91); C527(0.92); C537(1.04)  LDD0735  [17]
 LDCM0419  CL30 HCT 116 C339(3.82); C190(0.86); C527(1.23); C537(1.06)  LDD0736  [17]
 LDCM0420  CL31 HCT 116 C190(0.80); C527(0.92); C537(0.92)  LDD0737  [17]
 LDCM0421  CL32 HCT 116 C339(1.00); C190(0.96); C527(0.76); C537(0.76)  LDD0738  [17]
 LDCM0422  CL33 HCT 116 C339(1.14); C190(1.28); C527(0.91); C537(0.91)  LDD0739  [17]
 LDCM0423  CL34 HCT 116 C339(0.59); C190(0.59); C527(0.30); C537(0.30)  LDD0740  [17]
 LDCM0424  CL35 HCT 116 C339(1.03); C190(0.56); C527(0.26); C537(0.26)  LDD0741  [17]
 LDCM0425  CL36 HCT 116 C339(1.38); C190(0.57); C527(0.30); C537(0.30)  LDD0742  [17]
 LDCM0426  CL37 HCT 116 C339(0.88); C190(0.52); C527(0.24); C537(0.24)  LDD0743  [17]
 LDCM0428  CL39 HCT 116 C339(1.61); C190(0.58); C527(0.24); C537(0.24)  LDD0745  [17]
 LDCM0429  CL4 HCT 116 C339(1.35); C190(0.90); C527(0.82); C537(0.97)  LDD0746  [17]
 LDCM0430  CL40 HCT 116 C339(0.70); C190(0.68); C527(0.38); C537(0.38)  LDD0747  [17]
 LDCM0431  CL41 HCT 116 C339(2.32); C190(0.77); C527(0.50); C537(0.50)  LDD0748  [17]
 LDCM0432  CL42 HCT 116 C339(0.53); C190(0.52); C527(0.13); C537(0.13)  LDD0749  [17]
 LDCM0433  CL43 HCT 116 C339(0.85); C190(0.58); C527(0.22); C537(0.22)  LDD0750  [17]
 LDCM0434  CL44 HCT 116 C339(1.32); C190(0.88); C527(0.67); C537(0.67)  LDD0751  [17]
 LDCM0435  CL45 HCT 116 C339(1.07); C190(0.69); C527(0.35); C537(0.35)  LDD0752  [17]
 LDCM0436  CL46 HCT 116 C339(0.83); C527(1.24); C537(1.24)  LDD0753  [17]
 LDCM0437  CL47 HCT 116 C339(0.92); C527(1.32); C537(1.32)  LDD0754  [17]
 LDCM0438  CL48 HCT 116 C339(1.24); C527(1.10); C537(1.10)  LDD0755  [17]
 LDCM0439  CL49 HCT 116 C339(1.02); C527(0.99); C537(0.99)  LDD0756  [17]
 LDCM0440  CL5 HCT 116 C339(1.39); C190(0.90); C527(0.83); C537(0.98)  LDD0757  [17]
 LDCM0441  CL50 HCT 116 C339(0.97); C527(1.19); C537(1.19)  LDD0758  [17]
 LDCM0442  CL51 HCT 116 C339(1.01); C527(1.39); C537(1.39)  LDD0759  [17]
 LDCM0443  CL52 HCT 116 C339(0.93); C527(1.18); C537(1.18)  LDD0760  [17]
 LDCM0444  CL53 HCT 116 C339(0.95); C527(1.21); C537(1.21)  LDD0761  [17]
 LDCM0445  CL54 HCT 116 C339(0.94); C527(1.53); C537(1.53)  LDD0762  [17]
 LDCM0446  CL55 HCT 116 C339(0.94); C527(2.50); C537(2.50)  LDD0763  [17]
 LDCM0447  CL56 HCT 116 C339(0.84); C527(0.91); C537(0.91)  LDD0764  [17]
 LDCM0448  CL57 HCT 116 C339(1.16); C527(0.84); C537(0.84)  LDD0765  [17]
 LDCM0449  CL58 HCT 116 C339(0.95); C527(1.26); C537(1.26)  LDD0766  [17]
 LDCM0450  CL59 HCT 116 C339(1.11); C527(0.85); C537(0.85)  LDD0767  [17]
 LDCM0451  CL6 HCT 116 C339(1.77); C190(1.03); C527(0.95); C537(0.84)  LDD0768  [17]
 LDCM0452  CL60 HCT 116 C339(1.09); C527(1.04); C537(1.04)  LDD0769  [17]
 LDCM0453  CL61 HCT 116 C339(1.63); C265(0.37); C527(1.35); C537(1.35)  LDD0770  [17]
 LDCM0454  CL62 HCT 116 C339(1.47); C265(0.82); C527(1.12); C537(1.12)  LDD0771  [17]
 LDCM0455  CL63 HCT 116 C339(1.78); C265(1.06); C527(1.08); C537(1.08)  LDD0772  [17]
 LDCM0456  CL64 HCT 116 C339(1.71); C265(1.14); C527(0.76); C537(0.76)  LDD0773  [17]
 LDCM0457  CL65 HCT 116 C339(1.49); C265(0.79); C527(1.05); C537(1.05)  LDD0774  [17]
 LDCM0458  CL66 HCT 116 C339(1.67); C265(1.21); C527(0.34); C537(0.34)  LDD0775  [17]
 LDCM0459  CL67 HCT 116 C339(1.46); C265(1.04); C527(0.69); C537(0.69)  LDD0776  [17]
 LDCM0460  CL68 HCT 116 C339(1.68); C265(0.40); C527(1.00); C537(1.00)  LDD0777  [17]
 LDCM0461  CL69 HCT 116 C339(1.46); C265(1.47); C527(1.15); C537(1.15)  LDD0778  [17]
 LDCM0462  CL7 HCT 116 C339(1.42); C190(0.37); C527(0.38); C537(0.72)  LDD0779  [17]
 LDCM0463  CL70 HCT 116 C339(1.55); C265(0.47); C527(1.01); C537(1.01)  LDD0780  [17]
 LDCM0464  CL71 HCT 116 C339(1.36); C265(0.88); C527(0.97); C537(0.97)  LDD0781  [17]
 LDCM0465  CL72 HCT 116 C339(1.32); C265(0.96); C527(1.05); C537(1.05)  LDD0782  [17]
 LDCM0466  CL73 HCT 116 C339(1.57); C265(1.30); C527(0.98); C537(0.98)  LDD0783  [17]
 LDCM0467  CL74 HCT 116 C339(1.75); C265(1.32); C527(1.00); C537(1.00)  LDD0784  [17]
 LDCM0469  CL76 HCT 116 C339(1.08); C265(1.24); C527(0.97); C537(1.02)  LDD0786  [17]
 LDCM0470  CL77 HCT 116 C339(1.02); C265(1.03); C527(1.23); C537(1.17)  LDD0787  [17]
 LDCM0471  CL78 HCT 116 C339(1.09); C265(0.92); C527(0.95); C537(1.07)  LDD0788  [17]
 LDCM0472  CL79 HCT 116 C339(1.21); C265(1.00); C527(0.47); C537(1.07)  LDD0789  [17]
 LDCM0473  CL8 HCT 116 C339(1.40); C190(0.18); C527(0.25); C537(0.72)  LDD0790  [17]
 LDCM0474  CL80 HCT 116 C339(1.14); C265(0.65); C527(1.10); C537(1.08)  LDD0791  [17]
 LDCM0475  CL81 HCT 116 C339(1.16); C265(0.94); C527(1.34); C537(1.24)  LDD0792  [17]
 LDCM0476  CL82 HCT 116 C339(1.62); C265(0.58); C527(0.26); C537(1.20)  LDD0793  [17]
 LDCM0477  CL83 HCT 116 C339(1.96); C265(0.76); C527(0.31); C537(1.01)  LDD0794  [17]
 LDCM0478  CL84 HCT 116 C339(2.14); C265(0.83); C527(0.24); C537(1.06)  LDD0795  [17]
 LDCM0479  CL85 HCT 116 C339(1.30); C265(0.67); C527(0.94); C537(1.07)  LDD0796  [17]
 LDCM0480  CL86 HCT 116 C339(1.04); C265(0.69); C527(0.92); C537(1.09)  LDD0797  [17]
 LDCM0481  CL87 HCT 116 C339(2.13); C265(0.65); C527(0.84); C537(0.91)  LDD0798  [17]
 LDCM0482  CL88 HCT 116 C339(1.38); C265(0.72); C527(0.43); C537(1.05)  LDD0799  [17]
 LDCM0483  CL89 HCT 116 C339(2.14); C265(0.69); C527(0.18); C537(0.83)  LDD0800  [17]
 LDCM0484  CL9 HCT 116 C339(1.67); C190(0.57); C527(0.61); C537(0.88)  LDD0801  [17]
 LDCM0485  CL90 HCT 116 C339(1.17); C265(0.53); C527(0.78); C537(1.02)  LDD0802  [17]
 LDCM0486  CL91 HCT 116 C339(0.95); C190(0.98); C527(1.26); C537(1.26)  LDD0803  [17]
 LDCM0487  CL92 HCT 116 C339(1.27); C190(1.00); C527(0.81); C537(0.81)  LDD0804  [17]
 LDCM0488  CL93 HCT 116 C339(0.88); C190(1.18); C527(0.93); C537(0.93)  LDD0805  [17]
 LDCM0489  CL94 HCT 116 C339(1.06); C190(0.98); C527(0.89); C537(0.89)  LDD0806  [17]
 LDCM0490  CL95 HCT 116 C339(1.02); C190(1.00); C527(0.79); C537(0.79)  LDD0807  [17]
 LDCM0491  CL96 HCT 116 C339(0.95); C190(1.03); C527(0.90); C537(0.90)  LDD0808  [17]
 LDCM0492  CL97 HCT 116 C339(1.01); C190(1.02); C527(1.06); C537(1.06)  LDD0809  [17]
 LDCM0493  CL98 HCT 116 C339(1.25); C190(1.00); C527(0.80); C537(0.80)  LDD0810  [17]
 LDCM0494  CL99 HCT 116 C339(1.25); C190(0.97); C527(1.03); C537(1.03)  LDD0811  [17]
 LDCM0191  Compound 21 HEK-293T 9.05  LDD0508  [37]
 LDCM0190  Compound 34 HEK-293T 6.33  LDD0510  [37]
 LDCM0192  Compound 35 HEK-293T 6.35  LDD0509  [37]
 LDCM0193  Compound 36 HEK-293T 8.93  LDD0511  [37]
 LDCM0495  E2913 HEK-293T C339(1.75); C190(1.09); C66(0.94); C537(1.01)  LDD1698  [44]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C339(1.05); C265(0.98)  LDD1702  [9]
 LDCM0625  F8 Ramos C339(3.44); C265(2.06); C190(2.53)  LDD2187  [45]
 LDCM0572  Fragment10 Ramos C339(7.05); C265(1.23); C190(0.72)  LDD2189  [45]
 LDCM0573  Fragment11 Ramos C339(0.14); C265(0.23); C190(7.15)  LDD2190  [45]
 LDCM0574  Fragment12 Ramos C339(1.37); C265(0.75); C190(0.53)  LDD2191  [45]
 LDCM0575  Fragment13 Ramos C339(5.69); C265(1.21); C190(0.76)  LDD2192  [45]
 LDCM0576  Fragment14 Ramos C339(0.98); C265(0.75); C190(0.77)  LDD2193  [45]
 LDCM0579  Fragment20 Ramos C339(6.06); C265(0.73); C190(0.50)  LDD2194  [45]
 LDCM0580  Fragment21 Ramos C339(1.36); C265(1.11); C190(0.62)  LDD2195  [45]
 LDCM0582  Fragment23 Ramos C339(1.21); C265(1.15); C190(0.96)  LDD2196  [45]
 LDCM0578  Fragment27 Ramos C339(1.30); C265(1.53); C190(1.98)  LDD2197  [45]
 LDCM0586  Fragment28 Ramos C339(3.68); C265(0.92); C190(0.66)  LDD2198  [45]
 LDCM0588  Fragment30 Ramos C339(4.23); C265(1.22); C190(0.81)  LDD2199  [45]
 LDCM0589  Fragment31 Ramos C339(0.72); C265(0.86); C190(1.12)  LDD2200  [45]
 LDCM0590  Fragment32 Ramos C339(5.44); C265(2.49); C190(0.47)  LDD2201  [45]
 LDCM0468  Fragment33 HCT 116 C339(1.34); C265(0.98); C527(1.33); C537(1.33)  LDD0785  [17]
 LDCM0596  Fragment38 Ramos C339(0.56); C265(1.04); C190(0.94)  LDD2203  [45]
 LDCM0566  Fragment4 Ramos C339(1.94); C265(0.97); C190(1.01)  LDD2184  [45]
 LDCM0427  Fragment51 HCT 116 C339(0.96); C190(0.51); C527(0.17); C537(0.17)  LDD0744  [17]
 LDCM0610  Fragment52 Ramos C339(2.27); C265(0.96); C190(1.31)  LDD2204  [45]
 LDCM0614  Fragment56 Ramos C339(1.30); C265(1.20); C190(1.03)  LDD2205  [45]
 LDCM0569  Fragment7 Ramos C339(10.39); C265(1.02); C190(0.81)  LDD2186  [45]
 LDCM0571  Fragment9 Ramos C339(5.46); C265(0.73); C190(1.02)  LDD2188  [45]
 LDCM0116  HHS-0101 DM93 Y224(0.79); Y438(0.89)  LDD0264  [15]
 LDCM0117  HHS-0201 DM93 Y224(0.69); Y438(1.07)  LDD0265  [15]
 LDCM0118  HHS-0301 DM93 Y224(0.70)  LDD0266  [15]
 LDCM0119  HHS-0401 DM93 Y224(0.66); Y438(1.48)  LDD0267  [15]
 LDCM0120  HHS-0701 DM93 Y224(0.76); Y438(3.22)  LDD0268  [15]
 LDCM0107  IAA HeLa H754(0.00); C190(0.00)  LDD0221  [29]
 LDCM0123  JWB131 DM93 Y438(1.04)  LDD0285  [14]
 LDCM0124  JWB142 DM93 Y438(0.41)  LDD0286  [14]
 LDCM0125  JWB146 DM93 Y438(1.37)  LDD0287  [14]
 LDCM0126  JWB150 DM93 Y438(3.04)  LDD0288  [14]
 LDCM0127  JWB152 DM93 Y438(1.12)  LDD0289  [14]
 LDCM0128  JWB198 DM93 Y438(1.19)  LDD0290  [14]
 LDCM0129  JWB202 DM93 Y438(0.15)  LDD0291  [14]
 LDCM0130  JWB211 DM93 Y438(0.76)  LDD0292  [14]
 LDCM0179  JZ128 PC-3 C527(0.00); C887(0.00); C190(0.00)  LDD0462  [11]
 LDCM0022  KB02 HCT 116 C527(1.60)  LDD0080  [17]
 LDCM0023  KB03 HCT 116 C527(1.55)  LDD0081  [17]
 LDCM0024  KB05 HCT 116 C527(1.70)  LDD0082  [17]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C339(0.31)  LDD2121  [9]
 LDCM0109  NEM HeLa H875(0.00); H449(0.00)  LDD0223  [29]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C339(0.29); C265(0.64)  LDD2089  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C339(0.88)  LDD2092  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C339(0.74)  LDD2093  [9]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C339(1.18)  LDD2094  [9]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C339(0.36); C265(0.46)  LDD2096  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C339(0.73); C265(0.61)  LDD2097  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C339(0.53)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C339(0.56); C265(0.88)  LDD2099  [9]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C339(0.94)  LDD2100  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C339(0.87)  LDD2101  [9]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C339(0.90)  LDD2104  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C339(1.03)  LDD2105  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C339(0.69); C265(0.94)  LDD2107  [9]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C339(0.82)  LDD2108  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C339(0.51)  LDD2109  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C339(0.83); C265(0.93)  LDD2111  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C339(0.89)  LDD2114  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C339(1.28)  LDD2115  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C265(0.70)  LDD2116  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C339(0.40); C265(0.68)  LDD2118  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C339(2.79)  LDD2119  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C339(1.15)  LDD2120  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C339(0.64); C265(0.46)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C339(0.90); C265(1.14)  LDD2123  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C339(0.43); C265(0.44)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C339(0.90); C265(0.96)  LDD2125  [9]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C339(0.38); C265(0.38)  LDD2126  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C339(0.70); C265(1.03)  LDD2127  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C339(0.97); C265(0.29)  LDD2128  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C339(0.72); C265(0.85)  LDD2129  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C339(0.49)  LDD2133  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C339(0.44)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C339(0.70); C265(1.01)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C339(0.69); C265(1.42)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C339(0.87)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C265(1.56); C339(0.86)  LDD1700  [9]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C339(0.59)  LDD2141  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C339(1.18)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C339(3.35)  LDD2144  [9]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C339(10.24)  LDD2145  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C339(0.58); C265(0.66)  LDD2146  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C339(0.50)  LDD2148  [9]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C339(0.58); C265(0.59)  LDD2149  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C339(0.25)  LDD2150  [9]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C265(0.52)  LDD2151  [9]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C265(0.62)  LDD2153  [9]
 LDCM0032  Oleacein HEK-293T 4.01  LDD0184  [12]
 LDCM0628  OTUB2-COV-1 HEK-293T C265(0.59)  LDD2207  [46]
 LDCM0131  RA190 MM1.R C265(1.13)  LDD0304  [47]
 LDCM0090  Rapamycin JHH-7 4.09  LDD0213  [39]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [40]
 LDCM0021  THZ1 HCT 116 C527(1.09); C537(1.09); C190(1.10)  LDD2173  [17]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Chr-2797 Small molecular drug D0F2JS
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Antaq Small molecular drug D0J0IY
Tosedostat Small molecular drug DB11781

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
5 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
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