General Information of Experiment

Probe Name C300  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04246  Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA) 14.2
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 8.5
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 7.6
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 7.2
 LDTP03680  DNA replication licensing factor MCM4 (MCM4) 7.2
 LDTP03540  Heme oxygenase 2 (HMOX2) 6.1
 LDTP16040  Glyoxalase domain-containing protein 4 (GLOD4) 5.7
Transporter and channel
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 12.4
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 7.7
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 6.5
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 6.1
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 5.7
 LDTP07236  Protein GPR107 (GPR107) 5.5
 LDTP05900  Metaxin-1 (MTX1) 5.1
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 5.0
Other
Click to Show/Hide to Show 10 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 18.4
 LDTP00105  Protein unc-119 homolog B (UNC119B) 7.5
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 7.0
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 6.7
 LDTP11076  Apolipoprotein L2 (APOL2) 6.3
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 5.8
 LDTP05160  Nucleobindin-2 (NUCB2) 5.7
 LDTP01652  Centrosomal protein 43 (CEP43) 5.5
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 5.4
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 5.2

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587