Details of the Target

General Information of Target

Target ID LDTP04246
Target Name Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA)
Gene Name FNTA
Gene ID 2339
Synonyms
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; EC 2.5.1.58; EC 2.5.1.59; CAAX farnesyltransferase subunit alpha; FTase-alpha; Ras proteins prenyltransferase subunit alpha; Type I protein geranyl-geranyltransferase subunit alpha; GGTase-I-alpha
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAATEGVGEAAQGGEPGQPAQPPPQPHPPPPQQQHKEEMAAEAGEAVASPMDDGFVSLDS
PSYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSDKFRDVYDYFRAVLQRDERSERAFKLT
RDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLR
DPSQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQR
YFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLL
DLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIG
RSLQSKHSTENDSPTNVQQ
Target Bioclass
Enzyme
Family
Protein prenyltransferase subunit alpha family
Function
Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.
Uniprot ID
P49354
Ensemble ID
ENST00000302279.8
HGNC ID
HGNC:3782
ChEMBL ID
CHEMBL271

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HDQP1 SNV: p.P304S .
MFE319 SNV: p.Ter380QextTer33 .
NCIH1703 SNV: p.W72C .
REH SNV: p.Q21H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K142(10.00)  LDD0277  [1]
DBIA
 Probe Info  		C341(1.61)  LDD3330  [2]
HHS-482
 Probe Info  		Y166(1.32)  LDD0285  [3]
HHS-465
 Probe Info  		Y166(8.92)  LDD2237  [4]
ATP probe
 Probe Info  		K346(0.00); K348(0.00)  LDD0199  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
KY-26
 Probe Info  		Y166(0.00); K164(0.00)  LDD0301  [7]
IPM
 Probe Info  		N.A.  LDD2156  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
PAL-AfBPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C065
 Probe Info  		5.98  LDD1762  [10]
C072
 Probe Info  		18.77  LDD1768  [10]
C083
 Probe Info  		8.63  LDD1775  [10]
C112
 Probe Info  		23.43  LDD1799  [10]
C140
 Probe Info  		21.86  LDD1822  [10]
C161
 Probe Info  		21.86  LDD1841  [10]
C201
 Probe Info  		35.02  LDD1877  [10]
C220
 Probe Info  		25.63  LDD1894  [10]
C242
 Probe Info  		6.36  LDD1915  [10]
C286
 Probe Info  		11.24  LDD1956  [10]
C299
 Probe Info  		6.45  LDD1968  [10]
C300
 Probe Info  		14.22  LDD1969  [10]
C303
 Probe Info  		11.39  LDD1972  [10]
C320
 Probe Info  		5.70  LDD1986  [10]
C333
 Probe Info  		5.62  LDD1996  [10]
C382
 Probe Info  		9.00  LDD2041  [10]
C407
 Probe Info  		12.73  LDD2064  [10]
FFF probe14
 Probe Info  		13.22  LDD0477  [11]
FFF probe3
 Probe Info  		9.21  LDD0465  [11]
FFF probe6
 Probe Info  		5.85  LDD0468  [11]
JN0003
 Probe Info  		20.00  LDD0469  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C341(0.90)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C341(0.96)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C341(1.10)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C341(1.03)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C341(0.96)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C341(0.98)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C341(0.88)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C341(0.95)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C341(0.93)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C341(1.05)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C341(0.94)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C341(0.96)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C341(0.98)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C341(1.16)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C341(1.04)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C341(0.87)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C341(1.02)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C341(1.01)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C341(1.04)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C341(1.00)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C341(1.03)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C341(1.03)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C341(1.01)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C341(0.98)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C341(0.83)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C341(1.07)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C341(1.03)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C341(0.96)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C341(1.03)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C341(1.02)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C341(1.00)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C341(1.07)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C341(0.99)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C341(0.87)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C341(0.96)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C341(1.06)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C341(0.92)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C341(0.94)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C341(0.98)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C341(1.11)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C341(0.98)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C341(0.84)  LDD1550  [12]
 LDCM0312  AC5 HEK-293T C341(0.94)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C341(1.07)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C341(1.08)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C341(0.91)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C341(0.98)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C341(0.98)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C341(1.03)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C341(0.97)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C341(0.82)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C341(1.03)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C341(1.01)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C341(0.96)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C341(0.96)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C341(0.90)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C341(1.00)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C341(1.02)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C341(0.94)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C341(1.03)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C341(1.00)  LDD1569  [12]
 LDCM0248  AKOS034007472 HEK-293T C341(0.99)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C341(0.80)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C341(0.97)  LDD1514  [12]
 LDCM0108  Chloroacetamide HeLa C341(0.00); H201(0.00)  LDD0222  [9]
 LDCM0367  CL1 HEK-293T C341(0.87)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C341(0.89)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C341(1.04)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C341(0.89)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C341(0.97)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C341(0.90)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C341(1.02)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C341(0.91)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C341(1.03)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C341(0.95)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C341(1.01)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C341(1.00)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C341(0.88)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C341(0.92)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C341(0.90)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C341(0.94)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C341(0.94)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C341(0.90)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C341(0.94)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C341(1.08)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C341(1.01)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C341(1.03)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C341(1.00)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C341(0.97)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C341(1.12)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C341(0.89)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C341(1.03)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C341(0.91)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C341(0.95)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C341(0.94)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C341(1.01)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C341(0.88)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C341(0.98)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C341(0.80)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C341(0.96)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C341(0.95)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C341(1.03)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C341(0.89)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C341(1.00)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C341(1.13)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C341(1.00)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C341(1.06)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C341(0.91)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C341(1.05)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C341(0.96)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C341(0.95)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C341(0.86)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C341(0.96)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C341(0.89)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C341(1.02)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C341(0.93)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C341(0.96)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C341(1.05)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C341(0.99)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C341(1.01)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C341(0.82)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C341(1.11)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C341(1.03)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C341(0.93)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C341(0.91)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C341(0.91)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C341(1.13)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C341(1.02)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C341(0.86)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C341(1.08)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C341(1.09)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C341(1.06)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C341(0.88)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C341(1.03)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C341(1.11)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C341(1.03)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C341(0.94)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C341(0.92)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C341(1.01)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C341(1.06)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C341(0.90)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C341(1.04)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C341(1.10)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C341(1.03)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C341(0.90)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C341(0.99)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C341(1.08)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C341(0.97)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C341(0.94)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C341(1.02)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C341(1.00)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C341(1.00)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C341(1.00)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C341(0.90)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C341(1.00)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C341(1.07)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C341(0.97)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C341(0.97)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C341(0.98)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C341(1.08)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C341(1.05)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C341(0.95)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C341(0.84)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C341(0.96)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C341(1.07)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C341(0.86)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C341(1.07)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C341(1.12)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C341(0.84)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C341(1.01)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C341(0.98)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C341(1.06)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C341(1.01)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C341(0.96)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C341(0.85)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C341(1.01)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C341(0.90)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C341(1.05)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C341(0.88)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C341(0.95)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C341(0.80)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C341(1.20)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C341(1.01)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C341(0.94)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C341(0.97)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C341(0.93)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C341(0.91)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C341(1.03)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C341(0.90)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C341(0.93)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C341(0.87)  LDD1698  [12]
 LDCM0625  F8 Ramos C341(0.41)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C341(0.64)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C341(1.30)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C341(0.76)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C341(0.98)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C341(0.82)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C341(0.60)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C341(1.28)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C341(0.88)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C341(1.02)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C341(1.03)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C341(0.58)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C341(1.38)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C341(0.59)  LDD2201  [13]
 LDCM0468  Fragment33 HEK-293T C341(0.94)  LDD1671  [12]
 LDCM0596  Fragment38 Ramos C341(0.76)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C341(0.52)  LDD2184  [13]
 LDCM0427  Fragment51 HEK-293T C341(0.93)  LDD1631  [12]
 LDCM0610  Fragment52 Ramos C341(0.73)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C341(0.78)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C341(0.60)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C341(0.83)  LDD2188  [13]
 LDCM0107  IAA HeLa C341(0.00); H367(0.00)  LDD0221  [9]
 LDCM0123  JWB131 DM93 Y166(1.32)  LDD0285  [3]
 LDCM0124  JWB142 DM93 Y166(0.62)  LDD0286  [3]
 LDCM0125  JWB146 DM93 Y166(1.55)  LDD0287  [3]
 LDCM0126  JWB150 DM93 Y166(1.81)  LDD0288  [3]
 LDCM0127  JWB152 DM93 Y166(1.81)  LDD0289  [3]
 LDCM0128  JWB198 DM93 Y166(1.14)  LDD0290  [3]
 LDCM0129  JWB202 DM93 Y166(0.59)  LDD0291  [3]
 LDCM0130  JWB211 DM93 Y166(0.81)  LDD0292  [3]
 LDCM0022  KB02 HEK-293T C341(0.97)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C341(0.94)  LDD1497  [12]
 LDCM0024  KB05 MIA PaCa-2 C341(1.61)  LDD3330  [2]
 LDCM0109  NEM HeLa H367(0.00); C341(0.00)  LDD0223  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Geranylgeranyl transferase type-1 subunit beta (PGGT1B) Protein prenyltransferase subunit beta family P53609
Protein farnesyltransferase subunit beta (FNTB) Protein prenyltransferase subunit beta family P49356
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-4 complex subunit mu-1 (AP4M1) Adaptor complexes medium subunit family O00189

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lonafarnib Small molecular drug DB06448
Investigative
Click To Hide/Show 11 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-[Methyl-(5-geranyl-4-methyl-pent-3-enyl)-amino]-ethyl-diphosphate Small molecular drug DB08180
Alpha-hydroxyfarnesylphosphonic Acid Small molecular drug DB07895
Azd3409 Small molecular drug DB04893
Farnesyl Diphosphate Small molecular drug DB07780
Geranylgeranyl Diphosphate Small molecular drug DB07841
L-778123 Small molecular drug DB07227
(11s)-8-chloro-11-[1-(Methylsulfonyl)Piperidin-4-yl]-6-piperazin-1-yl-11h-benzo[56]Cyclohepta[12-b]Pyridine . DB07216
(20s)-19202122-tetrahydro-19-oxo-5h-1820-ethano-1214-etheno-610-metheno-18h-benz[D]Imidazo[43-k][16912]Oxatriaza-cyclooctadecosine-9-carbonitrile . DB08674
(20s)-19202223-tetrahydro-19-oxo-5h21h-1820-ethano-1214-etheno-610-methenobenz[D]Imidazo[43-l][16913]Oxatriazacyclonoadecosine-9-carbonitrile . DB08676
2-chloro-5-(3-chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-3h-imidazol-4-yl)- Methoxymethyl]-nicotinonitrile . DB06953
[(3711-trimethyl-dodeca-2610-trienyloxycarbamoyl)-methyl]-phosphonic Acid . DB07771

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Direct Target Site Identification of a Sulfonyl-Triazole Covalent Kinase Probe by LC-MS Chemical Proteomics. Anal Chem. 2021 Sep 7;93(35):11946-11955. doi: 10.1021/acs.analchem.1c01591. Epub 2021 Aug 25.
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578