Details of the Target

General Information of Target

Target ID	LDTP06034
Target Name	Lysosome membrane protein 2 (SCARB2)
Gene Name	SCARB2
Gene ID	950
Synonyms	CD36L2; LIMP2; LIMPII; Lysosome membrane protein 2; 85 kDa lysosomal membrane sialoglycoprotein; LGP85; CD36 antigen-like 2; Lysosome membrane protein II; LIMP II; Scavenger receptor class B member 2; CD antigen CD36
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MGRCCFYTAGTLSLLLLVTSVTLLVARVFQKAVDQSIEKKIVLRNGTEAFDSWEKPPLPV YTQFYFFNVTNPEEILRGETPRVEEVGPYTYRELRNKANIQFGDNGTTISAVSNKAYVFE RDQSVGDPKIDLIRTLNIPVLTVIEWSQVHFLREIIEAMLKAYQQKLFVTHTVDELLWGY KDEILSLIHVFRPDISPYFGLFYEKNGTNDGDYVFLTGEDSYLNFTKIVEWNGKTSLDWW ITDKCNMINGTDGDSFHPLITKDEVLYVFPSDFCRSVYITFSDYESVQGLPAFRYKVPAE ILANTSDNAGFCIPEGNCLGSGVLNVSICKNGAPIIMSFPHFYQADERFVSAIEGMHPNQ EDHETFVDINPLTGIILKAAKRFQINIYVKKLDDFVETGDIRTMVFPVMYLNESVHIDKE TASRLKSMINTTLIITNIPYIIMALGVFFGLVFTWLACKGQGSMDEGTADERAPLIRT
Target Bioclass	Transporter and channel
Family	CD36 family
Subcellular location	Lysosome membrane
Function	Acts as a lysosomal receptor for glucosylceramidase (GBA1) targeting.; (Microbial infection) Acts as a receptor for enterovirus 71.
Uniprot ID	Q14108
Ensemble ID	ENST00000264896.8
HGNC ID	HGNC:1665

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
G415	SNV: p.F453Y	.
NUGC3	SNV: p.L223I	.
OCIAML2	SNV: p.S20T	.
P31FUJ	SNV: p.M1?	.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 13 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
FBPP2 Probe Info	44.37	LDD0318	[2]
CHEMBL5175495 Probe Info	6.39	LDD0196	[3]
TH211 Probe Info	Y284(7.80)	LDD0260	[4]
FBP2 Probe Info	4.43	LDD0317	[2]
YN-1 Probe Info	100.00	LDD0444	[5]
OPA-S-S-alkyne Probe Info	K129(5.93)	LDD3494	[6]
P13 Probe Info	20.00	LDD0203	[7]
Propranolol-CA-4PAP Probe Info	4.60	LDD0271	[8]
D5yne Probe Info	11.37	LDD0055	[9]
HPAP Probe Info	4.04	LDD0062	[10]
DBIA Probe Info	C274(1.04)	LDD0533	[11]
4-Iodoacetamidophenylacetylene Probe Info	N.A.	LDD0038	[12]
IA-alkyne Probe Info	N.A.	LDD0162	[13]

PAL-AfBPP Probe

Click To Hide/Show 183 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
ILS-1 PP Probe Info	2.99	LDD0417	[14]
C004 Probe Info	10.85	LDD1714	[15]
C007 Probe Info	11.08	LDD1716	[15]
C008 Probe Info	11.31	LDD1717	[15]
C010 Probe Info	14.42	LDD1719	[15]
C011 Probe Info	8.63	LDD1720	[15]
C018 Probe Info	13.00	LDD1726	[15]
C022 Probe Info	57.28	LDD1728	[15]
C026 Probe Info	17.75	LDD1732	[15]
C027 Probe Info	9.19	LDD1733	[15]
C036 Probe Info	6.45	LDD1736	[15]
C039 Probe Info	8.88	LDD1739	[15]
C040 Probe Info	25.81	LDD1740	[15]
C041 Probe Info	36.00	LDD1741	[15]
C045 Probe Info	8.46	LDD1744	[15]
C049 Probe Info	5.70	LDD1747	[15]
C052 Probe Info	5.35	LDD1750	[15]
C053 Probe Info	5.46	LDD1751	[15]
C055 Probe Info	15.24	LDD1752	[15]
C056 Probe Info	22.01	LDD1753	[15]
C063 Probe Info	36.76	LDD1760	[15]
C064 Probe Info	22.32	LDD1761	[15]
C067 Probe Info	9.51	LDD1763	[15]
C070 Probe Info	28.44	LDD1766	[15]
C071 Probe Info	22.63	LDD1767	[15]
C072 Probe Info	34.06	LDD1768	[15]
C073 Probe Info	5.74	LDD1769	[15]
C075 Probe Info	5.21	LDD1770	[15]
C078 Probe Info	8.06	LDD1771	[15]
C082 Probe Info	15.03	LDD1774	[15]
C085 Probe Info	8.88	LDD1777	[15]
C087 Probe Info	18.38	LDD1779	[15]
C091 Probe Info	27.10	LDD1782	[15]
C092 Probe Info	27.47	LDD1783	[15]
C094 Probe Info	25.63	LDD1785	[15]
C099 Probe Info	7.01	LDD1788	[15]
C100 Probe Info	5.86	LDD1789	[15]
C106 Probe Info	33.82	LDD1793	[15]
C107 Probe Info	28.44	LDD1794	[15]
C108 Probe Info	24.25	LDD1795	[15]
C110 Probe Info	7.16	LDD1797	[15]
C112 Probe Info	55.72	LDD1799	[15]
C115 Probe Info	8.22	LDD1802	[15]
C117 Probe Info	6.77	LDD1804	[15]
C130 Probe Info	25.99	LDD1812	[15]
C134 Probe Info	36.50	LDD1816	[15]
C135 Probe Info	15.67	LDD1817	[15]
C139 Probe Info	18.38	LDD1821	[15]
C140 Probe Info	14.32	LDD1822	[15]
C141 Probe Info	40.50	LDD1823	[15]
C143 Probe Info	32.90	LDD1825	[15]
C145 Probe Info	27.67	LDD1827	[15]
C147 Probe Info	16.34	LDD1829	[15]
C149 Probe Info	8.94	LDD1830	[15]
C153 Probe Info	40.79	LDD1834	[15]
C156 Probe Info	14.83	LDD1836	[15]
C159 Probe Info	39.40	LDD1839	[15]
C160 Probe Info	18.90	LDD1840	[15]
C161 Probe Info	35.02	LDD1841	[15]
C163 Probe Info	17.39	LDD1843	[15]
C166 Probe Info	12.55	LDD1846	[15]
C169 Probe Info	34.06	LDD1849	[15]
C170 Probe Info	27.47	LDD1850	[15]
C171 Probe Info	9.92	LDD1851	[15]
C177 Probe Info	35.75	LDD1856	[15]
C178 Probe Info	26.54	LDD1857	[15]
C183 Probe Info	15.03	LDD1861	[15]
C186 Probe Info	15.78	LDD1864	[15]
C187 Probe Info	45.25	LDD1865	[15]
C194 Probe Info	18.00	LDD1870	[15]
C197 Probe Info	13.45	LDD1873	[15]
C198 Probe Info	19.43	LDD1874	[15]
C201 Probe Info	57.68	LDD1877	[15]
C205 Probe Info	8.11	LDD1880	[15]
C206 Probe Info	27.67	LDD1881	[15]
C208 Probe Info	13.36	LDD1883	[15]
C211 Probe Info	13.00	LDD1885	[15]
C213 Probe Info	30.70	LDD1887	[15]
C218 Probe Info	13.36	LDD1892	[15]
C219 Probe Info	18.64	LDD1893	[15]
C220 Probe Info	29.86	LDD1894	[15]
C221 Probe Info	8.82	LDD1895	[15]
C222 Probe Info	7.21	LDD1896	[15]
C223 Probe Info	17.75	LDD1897	[15]
C225 Probe Info	25.63	LDD1898	[15]
C226 Probe Info	15.35	LDD1899	[15]
C228 Probe Info	29.45	LDD1901	[15]
C229 Probe Info	23.59	LDD1902	[15]
C231 Probe Info	30.06	LDD1904	[15]
C232 Probe Info	63.56	LDD1905	[15]
C233 Probe Info	44.32	LDD1906	[15]
C234 Probe Info	6.82	LDD1907	[15]
C235 Probe Info	46.53	LDD1908	[15]
C237 Probe Info	7.84	LDD1910	[15]
C239 Probe Info	8.51	LDD1912	[15]
C240 Probe Info	21.56	LDD1913	[15]
C242 Probe Info	5.62	LDD1915	[15]
C243 Probe Info	21.11	LDD1916	[15]
C244 Probe Info	14.03	LDD1917	[15]
C246 Probe Info	14.52	LDD1919	[15]
C249 Probe Info	23.75	LDD1922	[15]
C255 Probe Info	9.25	LDD1928	[15]
C258 Probe Info	8.28	LDD1931	[15]
C264 Probe Info	29.65	LDD1935	[15]
C265 Probe Info	16.68	LDD1936	[15]
C270 Probe Info	7.78	LDD1940	[15]
C273 Probe Info	6.87	LDD1943	[15]
C277 Probe Info	9.38	LDD1947	[15]
C280 Probe Info	15.14	LDD1950	[15]
C281 Probe Info	8.46	LDD1951	[15]
C282 Probe Info	19.56	LDD1952	[15]
C284 Probe Info	37.79	LDD1954	[15]
C286 Probe Info	4.99	LDD1956	[15]
C287 Probe Info	26.17	LDD1957	[15]
C288 Probe Info	11.79	LDD1958	[15]
C289 Probe Info	25.63	LDD1959	[15]
C293 Probe Info	19.84	LDD1963	[15]
C296 Probe Info	21.11	LDD1966	[15]
C297 Probe Info	6.23	LDD1967	[15]
C299 Probe Info	15.89	LDD1968	[15]
C300 Probe Info	7.67	LDD1969	[15]
C301 Probe Info	6.92	LDD1970	[15]
C302 Probe Info	8.51	LDD1971	[15]
C303 Probe Info	9.00	LDD1972	[15]
C305 Probe Info	32.90	LDD1974	[15]
C307 Probe Info	12.64	LDD1975	[15]
C310 Probe Info	12.55	LDD1977	[15]
C314 Probe Info	66.26	LDD1981	[15]
C320 Probe Info	5.54	LDD1986	[15]
C322 Probe Info	7.46	LDD1988	[15]
C326 Probe Info	29.24	LDD1990	[15]
C339 Probe Info	12.73	LDD2002	[15]
C343 Probe Info	14.42	LDD2005	[15]
C346 Probe Info	24.42	LDD2007	[15]
C348 Probe Info	31.12	LDD2009	[15]
C349 Probe Info	38.05	LDD2010	[15]
C350 Probe Info	99.73	LDD2011	[15]
C353 Probe Info	6.87	LDD2014	[15]
C354 Probe Info	14.83	LDD2015	[15]
C355 Probe Info	83.87	LDD2016	[15]
C356 Probe Info	35.75	LDD2017	[15]
C357 Probe Info	8.34	LDD2018	[15]
C360 Probe Info	12.30	LDD2021	[15]
C362 Probe Info	49.18	LDD2023	[15]
C363 Probe Info	49.18	LDD2024	[15]
C364 Probe Info	28.64	LDD2025	[15]
C369 Probe Info	5.43	LDD2030	[15]
C373 Probe Info	15.45	LDD2033	[15]
C376 Probe Info	30.91	LDD2036	[15]
C378 Probe Info	13.27	LDD2037	[15]
C380 Probe Info	13.64	LDD2039	[15]
C382 Probe Info	16.45	LDD2041	[15]
C383 Probe Info	15.89	LDD2042	[15]
C385 Probe Info	6.02	LDD2044	[15]
C386 Probe Info	29.24	LDD2045	[15]
C387 Probe Info	6.59	LDD2046	[15]
C388 Probe Info	44.94	LDD2047	[15]
C390 Probe Info	99.73	LDD2049	[15]
C399 Probe Info	18.25	LDD2058	[15]
C403 Probe Info	21.86	LDD2061	[15]
C405 Probe Info	7.31	LDD2063	[15]
C408 Probe Info	8.00	LDD2065	[15]
C419 Probe Info	50.21	LDD2074	[15]
C420 Probe Info	29.45	LDD2075	[15]
C425 Probe Info	16.34	LDD2080	[15]
C426 Probe Info	22.94	LDD2081	[15]
C429 Probe Info	40.50	LDD2084	[15]
C431 Probe Info	35.26	LDD2086	[15]
C433 Probe Info	11.55	LDD2088	[15]
FFF probe11 Probe Info	20.00	LDD0471	[16]
FFF probe12 Probe Info	20.00	LDD0473	[16]
FFF probe13 Probe Info	20.00	LDD0475	[16]
FFF probe14 Probe Info	20.00	LDD0477	[16]
FFF probe2 Probe Info	20.00	LDD0463	[16]
FFF probe3 Probe Info	17.92	LDD0464	[16]
FFF probe4 Probe Info	20.00	LDD0466	[16]
FFF probe7 Probe Info	20.00	LDD0483	[16]
FFF probe9 Probe Info	20.00	LDD0470	[16]
JN0003 Probe Info	20.00	LDD0469	[16]
STS-1 Probe Info	N.A.	LDD0136	[17]
STS-2 Probe Info	N.A.	LDD0138	[17]
A-DA Probe Info	2.72	LDD0145	[18]
OEA-DA Probe Info	20.00	LDD0046	[19]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0215	AC10	PaTu 8988t	C274(0.70)	LDD1094	[11]
LDCM0216	AC100	HCT 116	C274(1.04)	LDD0533	[11]
LDCM0217	AC101	HCT 116	C274(1.11)	LDD0534	[11]
LDCM0218	AC102	HCT 116	C274(1.10)	LDD0535	[11]
LDCM0219	AC103	HCT 116	C274(1.06)	LDD0536	[11]
LDCM0220	AC104	HCT 116	C274(0.98)	LDD0537	[11]
LDCM0221	AC105	HCT 116	C274(1.01)	LDD0538	[11]
LDCM0222	AC106	HCT 116	C274(1.04)	LDD0539	[11]
LDCM0223	AC107	HCT 116	C274(1.28)	LDD0540	[11]
LDCM0224	AC108	HCT 116	C274(0.86)	LDD0541	[11]
LDCM0225	AC109	HCT 116	C274(1.02)	LDD0542	[11]
LDCM0226	AC11	PaTu 8988t	C274(0.70)	LDD1105	[11]
LDCM0227	AC110	HCT 116	C274(0.99)	LDD0544	[11]
LDCM0228	AC111	HCT 116	C274(1.18)	LDD0545	[11]
LDCM0229	AC112	HCT 116	C274(1.09)	LDD0546	[11]
LDCM0237	AC12	PaTu 8988t	C274(0.46)	LDD1116	[11]
LDCM0246	AC128	HCT 116	C274(1.40)	LDD0563	[11]
LDCM0247	AC129	HCT 116	C274(1.34)	LDD0564	[11]
LDCM0249	AC130	HCT 116	C274(1.14)	LDD0566	[11]
LDCM0250	AC131	HCT 116	C274(1.21)	LDD0567	[11]
LDCM0251	AC132	HCT 116	C274(1.09)	LDD0568	[11]
LDCM0252	AC133	HCT 116	C274(1.09)	LDD0569	[11]
LDCM0253	AC134	HCT 116	C274(1.03)	LDD0570	[11]
LDCM0254	AC135	HCT 116	C274(1.06)	LDD0571	[11]
LDCM0255	AC136	HCT 116	C274(1.11)	LDD0572	[11]
LDCM0256	AC137	HCT 116	C274(0.88)	LDD0573	[11]
LDCM0257	AC138	HCT 116	C274(0.68)	LDD0574	[11]
LDCM0258	AC139	HCT 116	C274(0.77)	LDD0575	[11]
LDCM0259	AC14	PaTu 8988t	C274(1.21)	LDD1138	[11]
LDCM0260	AC140	HCT 116	C274(0.72)	LDD0577	[11]
LDCM0261	AC141	HCT 116	C274(0.71)	LDD0578	[11]
LDCM0262	AC142	HCT 116	C274(0.92)	LDD0579	[11]
LDCM0263	AC143	PaTu 8988t	C274(0.63)	LDD1142	[11]
LDCM0264	AC144	PaTu 8988t	C274(1.27)	LDD1143	[11]
LDCM0265	AC145	PaTu 8988t	C274(0.69)	LDD1144	[11]
LDCM0266	AC146	PaTu 8988t	C274(0.57)	LDD1145	[11]
LDCM0267	AC147	PaTu 8988t	C274(0.78)	LDD1146	[11]
LDCM0268	AC148	PaTu 8988t	C274(1.43)	LDD1147	[11]
LDCM0269	AC149	PaTu 8988t	C274(0.64)	LDD1148	[11]
LDCM0270	AC15	PaTu 8988t	C274(0.95)	LDD1149	[11]
LDCM0271	AC150	PaTu 8988t	C274(0.66)	LDD1150	[11]
LDCM0272	AC151	PaTu 8988t	C274(0.39)	LDD1151	[11]
LDCM0273	AC152	PaTu 8988t	C274(0.66)	LDD1152	[11]
LDCM0274	AC153	PaTu 8988t	C274(0.55)	LDD1153	[11]
LDCM0621	AC154	PaTu 8988t	C274(0.54)	LDD2166	[11]
LDCM0622	AC155	PaTu 8988t	C274(0.39)	LDD2167	[11]
LDCM0623	AC156	PaTu 8988t	C274(0.64)	LDD2168	[11]
LDCM0624	AC157	PaTu 8988t	C274(0.56)	LDD2169	[11]
LDCM0278	AC19	HEK-293T	C329(0.83)	LDD1517	[20]
LDCM0284	AC24	HEK-293T	C274(1.11)	LDD1523	[20]
LDCM0287	AC27	HEK-293T	C329(0.96)	LDD1526	[20]
LDCM0290	AC3	HEK-293T	C329(1.06)	LDD1529	[20]
LDCM0293	AC32	HEK-293T	C274(0.91)	LDD1532	[20]
LDCM0296	AC35	HCT 116	C274(0.90)	LDD0613	[11]
LDCM0297	AC36	HCT 116	C274(1.04)	LDD0614	[11]
LDCM0298	AC37	HCT 116	C274(0.89)	LDD0615	[11]
LDCM0299	AC38	HCT 116	C274(1.05)	LDD0616	[11]
LDCM0300	AC39	HCT 116	C274(0.88)	LDD0617	[11]
LDCM0302	AC40	HCT 116	C274(0.66)	LDD0619	[11]
LDCM0303	AC41	HCT 116	C274(0.78)	LDD0620	[11]
LDCM0304	AC42	HCT 116	C274(0.90)	LDD0621	[11]
LDCM0305	AC43	HCT 116	C274(0.75)	LDD0622	[11]
LDCM0306	AC44	HCT 116	C274(0.82)	LDD0623	[11]
LDCM0307	AC45	HCT 116	C274(0.58)	LDD0624	[11]
LDCM0308	AC46	PaTu 8988t	C274(1.06)	LDD1187	[11]
LDCM0309	AC47	PaTu 8988t	C274(0.88)	LDD1188	[11]
LDCM0310	AC48	PaTu 8988t	C274(1.05)	LDD1189	[11]
LDCM0311	AC49	PaTu 8988t	C274(0.89)	LDD1190	[11]
LDCM0313	AC50	PaTu 8988t	C274(0.74)	LDD1192	[11]
LDCM0314	AC51	PaTu 8988t	C274(1.01)	LDD1193	[11]
LDCM0315	AC52	PaTu 8988t	C274(0.98)	LDD1194	[11]
LDCM0316	AC53	PaTu 8988t	C274(1.02)	LDD1195	[11]
LDCM0317	AC54	PaTu 8988t	C274(0.88)	LDD1196	[11]
LDCM0318	AC55	PaTu 8988t	C274(1.38)	LDD1197	[11]
LDCM0319	AC56	PaTu 8988t	C274(0.89)	LDD1198	[11]
LDCM0320	AC57	HCT 116	C274(0.79)	LDD0637	[11]
LDCM0321	AC58	HCT 116	C274(0.88)	LDD0638	[11]
LDCM0322	AC59	HCT 116	C274(0.70)	LDD0639	[11]
LDCM0323	AC6	PaTu 8988t	C274(0.68)	LDD1202	[11]
LDCM0324	AC60	HCT 116	C274(0.59)	LDD0641	[11]
LDCM0325	AC61	HCT 116	C274(0.75)	LDD0642	[11]
LDCM0326	AC62	HCT 116	C274(0.78)	LDD0643	[11]
LDCM0327	AC63	HCT 116	C274(0.78)	LDD0644	[11]
LDCM0328	AC64	HCT 116	C274(0.63)	LDD0645	[11]
LDCM0329	AC65	HCT 116	C274(0.74)	LDD0646	[11]
LDCM0330	AC66	HCT 116	C274(0.84)	LDD0647	[11]
LDCM0331	AC67	HCT 116	C274(0.50)	LDD0648	[11]
LDCM0334	AC7	PaTu 8988t	C274(0.82)	LDD1213	[11]
LDCM0345	AC8	PaTu 8988t	C274(0.98)	LDD1224	[11]
LDCM0349	AC83	PaTu 8988t	C274(1.34)	LDD1228	[11]
LDCM0350	AC84	PaTu 8988t	C274(1.09)	LDD1229	[11]
LDCM0351	AC85	PaTu 8988t	C274(1.49)	LDD1230	[11]
LDCM0352	AC86	PaTu 8988t	C274(1.51)	LDD1231	[11]
LDCM0353	AC87	PaTu 8988t	C274(1.50)	LDD1232	[11]
LDCM0354	AC88	PaTu 8988t	C274(1.35)	LDD1233	[11]
LDCM0355	AC89	PaTu 8988t	C274(1.38)	LDD1234	[11]
LDCM0357	AC90	PaTu 8988t	C274(1.55)	LDD1236	[11]
LDCM0358	AC91	PaTu 8988t	C274(1.17)	LDD1237	[11]
LDCM0359	AC92	PaTu 8988t	C274(1.27)	LDD1238	[11]
LDCM0360	AC93	PaTu 8988t	C274(1.33)	LDD1239	[11]
LDCM0361	AC94	PaTu 8988t	C274(1.29)	LDD1240	[11]
LDCM0362	AC95	PaTu 8988t	C274(1.37)	LDD1241	[11]
LDCM0363	AC96	PaTu 8988t	C274(1.67)	LDD1242	[11]
LDCM0364	AC97	PaTu 8988t	C274(1.34)	LDD1243	[11]
LDCM0365	AC98	HCT 116	C274(0.82)	LDD0682	[11]
LDCM0366	AC99	HCT 116	C274(0.86)	LDD0683	[11]
LDCM0248	AKOS034007472	PaTu 8988t	C274(0.80)	LDD1127	[11]
LDCM0356	AKOS034007680	PaTu 8988t	C274(0.59)	LDD1235	[11]
LDCM0275	AKOS034007705	PaTu 8988t	C274(0.66)	LDD1154	[11]
LDCM0088	C45	HEK-293T	20.00	LDD0203	[7]
LDCM0369	CL100	HEK-293T	C274(1.07)	LDD1573	[20]
LDCM0370	CL101	PaTu 8988t	C274(0.86)	LDD1249	[11]
LDCM0371	CL102	PaTu 8988t	C274(0.72)	LDD1250	[11]
LDCM0372	CL103	PaTu 8988t	C274(0.56)	LDD1251	[11]
LDCM0373	CL104	PaTu 8988t	C274(0.95)	LDD1252	[11]
LDCM0377	CL108	HEK-293T	C274(1.04)	LDD1581	[20]
LDCM0382	CL112	HEK-293T	C274(0.92)	LDD1586	[20]
LDCM0386	CL116	HEK-293T	C274(0.95)	LDD1590	[20]
LDCM0387	CL117	HCT 116	C274(0.57)	LDD0704	[11]
LDCM0388	CL118	HCT 116	C274(1.12)	LDD0705	[11]
LDCM0389	CL119	HCT 116	C274(0.75)	LDD0706	[11]
LDCM0390	CL12	HEK-293T	C274(1.05)	LDD1594	[20]
LDCM0391	CL120	HCT 116	C274(0.67)	LDD0708	[11]
LDCM0392	CL121	PaTu 8988t	C274(1.09)	LDD1271	[11]
LDCM0393	CL122	PaTu 8988t	C274(1.34)	LDD1272	[11]
LDCM0394	CL123	PaTu 8988t	C274(0.98)	LDD1273	[11]
LDCM0395	CL124	PaTu 8988t	C274(1.10)	LDD1274	[11]
LDCM0396	CL125	HCT 116	C274(1.14)	LDD0713	[11]
LDCM0397	CL126	HCT 116	C274(0.94)	LDD0714	[11]
LDCM0398	CL127	HCT 116	C274(0.85)	LDD0715	[11]
LDCM0399	CL128	HCT 116	C274(0.92)	LDD0716	[11]
LDCM0403	CL16	HCT 116	C274(0.57)	LDD0720	[11]
LDCM0404	CL17	HCT 116	C274(0.64)	LDD0721	[11]
LDCM0405	CL18	HCT 116	C274(0.61)	LDD0722	[11]
LDCM0406	CL19	HCT 116	C274(0.63)	LDD0723	[11]
LDCM0408	CL20	HCT 116	C274(0.70)	LDD0725	[11]
LDCM0409	CL21	HCT 116	C274(0.35)	LDD0726	[11]
LDCM0410	CL22	HCT 116	C274(0.19)	LDD0727	[11]
LDCM0411	CL23	HCT 116	C274(0.62)	LDD0728	[11]
LDCM0412	CL24	HCT 116	C274(0.30)	LDD0729	[11]
LDCM0413	CL25	HCT 116	C274(0.47)	LDD0730	[11]
LDCM0414	CL26	HCT 116	C274(0.63)	LDD0731	[11]
LDCM0415	CL27	HCT 116	C274(0.76)	LDD0732	[11]
LDCM0416	CL28	HCT 116	C274(0.33)	LDD0733	[11]
LDCM0417	CL29	HCT 116	C274(0.56)	LDD0734	[11]
LDCM0419	CL30	HCT 116	C274(0.69)	LDD0736	[11]
LDCM0420	CL31	HCT 116	C274(0.65)	LDD0737	[11]
LDCM0421	CL32	HCT 116	C274(0.62)	LDD0738	[11]
LDCM0422	CL33	HCT 116	C274(0.73)	LDD0739	[11]
LDCM0423	CL34	HCT 116	C274(0.35)	LDD0740	[11]
LDCM0424	CL35	HCT 116	C274(0.44)	LDD0741	[11]
LDCM0425	CL36	HCT 116	C274(0.57)	LDD0742	[11]
LDCM0426	CL37	HCT 116	C274(0.50)	LDD0743	[11]
LDCM0428	CL39	HCT 116	C274(0.46)	LDD0745	[11]
LDCM0429	CL4	HEK-293T	C274(1.00)	LDD1633	[20]
LDCM0430	CL40	HCT 116	C274(0.51)	LDD0747	[11]
LDCM0431	CL41	HCT 116	C274(0.58)	LDD0748	[11]
LDCM0432	CL42	HCT 116	C274(0.22)	LDD0749	[11]
LDCM0433	CL43	HCT 116	C274(0.34)	LDD0750	[11]
LDCM0434	CL44	HCT 116	C274(0.42)	LDD0751	[11]
LDCM0435	CL45	HCT 116	C274(0.30)	LDD0752	[11]
LDCM0436	CL46	PaTu 8988t	C274(1.10)	LDD1315	[11]
LDCM0437	CL47	PaTu 8988t	C274(0.96)	LDD1316	[11]
LDCM0438	CL48	PaTu 8988t	C274(1.12)	LDD1317	[11]
LDCM0439	CL49	PaTu 8988t	C274(0.95)	LDD1318	[11]
LDCM0441	CL50	PaTu 8988t	C274(0.99)	LDD1320	[11]
LDCM0442	CL51	PaTu 8988t	C274(1.17)	LDD1321	[11]
LDCM0443	CL52	PaTu 8988t	C274(0.97)	LDD1322	[11]
LDCM0444	CL53	PaTu 8988t	C274(0.74)	LDD1323	[11]
LDCM0445	CL54	PaTu 8988t	C274(0.71)	LDD1324	[11]
LDCM0446	CL55	PaTu 8988t	C274(0.80)	LDD1325	[11]
LDCM0447	CL56	PaTu 8988t	C274(0.16)	LDD1326	[11]
LDCM0448	CL57	PaTu 8988t	C274(0.38)	LDD1327	[11]
LDCM0449	CL58	PaTu 8988t	C274(0.69)	LDD1328	[11]
LDCM0450	CL59	PaTu 8988t	C274(0.37)	LDD1329	[11]
LDCM0452	CL60	PaTu 8988t	C274(0.56)	LDD1331	[11]
LDCM0453	CL61	PaTu 8988t	C274(0.82)	LDD1332	[11]
LDCM0454	CL62	PaTu 8988t	C274(0.87)	LDD1333	[11]
LDCM0455	CL63	PaTu 8988t	C274(0.85)	LDD1334	[11]
LDCM0456	CL64	PaTu 8988t	C274(0.78)	LDD1335	[11]
LDCM0457	CL65	PaTu 8988t	C274(0.74)	LDD1336	[11]
LDCM0458	CL66	PaTu 8988t	C274(0.71)	LDD1337	[11]
LDCM0459	CL67	PaTu 8988t	C274(0.62)	LDD1338	[11]
LDCM0460	CL68	PaTu 8988t	C274(0.51)	LDD1339	[11]
LDCM0461	CL69	PaTu 8988t	C274(0.60)	LDD1340	[11]
LDCM0462	CL7	HEK-293T	C329(1.06)	LDD1665	[20]
LDCM0463	CL70	PaTu 8988t	C274(0.64)	LDD1342	[11]
LDCM0464	CL71	PaTu 8988t	C274(1.01)	LDD1343	[11]
LDCM0465	CL72	PaTu 8988t	C274(0.57)	LDD1344	[11]
LDCM0466	CL73	PaTu 8988t	C274(0.60)	LDD1345	[11]
LDCM0467	CL74	PaTu 8988t	C274(0.74)	LDD1346	[11]
LDCM0469	CL76	HEK-293T	C274(1.02)	LDD1672	[20]
LDCM0472	CL79	HEK-293T	C329(1.02)	LDD1675	[20]
LDCM0478	CL84	HEK-293T	C274(1.13)	LDD1681	[20]
LDCM0482	CL88	HEK-293T	C274(1.10)	LDD1685	[20]
LDCM0486	CL91	HEK-293T	C329(0.91)	LDD1689	[20]
LDCM0491	CL96	HEK-293T	C274(1.52)	LDD1694	[20]
LDCM0189	Compound 16	HEK-293T	37.74	LDD0492	[16]
LDCM0185	Compound 17	HEK-293T	6.62	LDD0504	[16]
LDCM0184	Compound 20	HEK-293T	15.04	LDD0503	[16]
LDCM0191	Compound 21	HEK-293T	8.33	LDD0493	[16]
LDCM0186	Compound 31	HEK-293T	6.90	LDD0506	[16]
LDCM0187	Compound 32	HEK-293T	19.23	LDD0507	[16]
LDCM0188	Compound 33	HEK-293T	8.73	LDD0505	[16]
LDCM0190	Compound 34	HEK-293T	11.30	LDD0497	[16]
LDCM0192	Compound 35	HEK-293T	5.41	LDD0491	[16]
LDCM0194	Compound 37	HEK-293T	12.82	LDD0498	[16]
LDCM0196	Compound 39	HEK-293T	13.79	LDD0496	[16]
LDCM0095	DC-LC3IN-D5	HeLa	11.37	LDD0055	[9]
LDCM0468	Fragment33	PaTu 8988t	C274(0.79)	LDD1347	[11]
LDCM0427	Fragment51	HCT 116	C274(0.30)	LDD0744	[11]
LDCM0022	KB02	CAL-120	C274(1.74)	LDD2284	[21]
LDCM0023	KB03	CAL-120	C274(2.93)	LDD2701	[21]
LDCM0024	KB05	HMCB	C274(1.94)	LDD3312	[21]
LDCM0014	Panhematin	HEK-293T	4.04	LDD0062	[10]
LDCM0098	Propranolol	K562	4.60	LDD0271	[8]
LDCM0084	Ro 48-8071	A-549	2.72	LDD0145	[18]
LDCM0008	Tranylcypromine	HeLa	2.27	LDD0321	[2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme

Click To Hide/Show 2 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Probable glutathione peroxidase 8 (GPX8)				Glutathione peroxidase family	Q8TED1
3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH)				HIBADH-related family	P31937

Transporter and channel

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Lysosomal-associated transmembrane protein 4B (LAPTM4B)				LAPTM4/LAPTM5 transporter family	Q86VI4

GPCR

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
G-protein coupled receptor 37-like 1 (GPR37L1)				G-protein coupled receptor 1 family	O60883

Other

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3)				ERGIC family	Q9Y282

References

1	Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20. Mass spectrometry data entry: PXD025140
2	Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1. Mass spectrometry data entry: PXD018580
3	Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4	Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5	Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6	A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w. Mass spectrometry data entry: PXD042888
7	Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
8	Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
9	Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. Angew Chem Int Ed Engl. 2021 Dec 6;60(50):26105-26114. doi: 10.1002/anie.202109464. Epub 2021 Nov 5. Mass spectrometry data entry: PXD026874
10	A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12. Mass spectrometry data entry: PXD034651
11	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12	Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23. Mass spectrometry data entry: PXD028853
13	SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18. Mass spectrometry data entry*: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14	A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3. Mass spectrometry data entry: PXD014175
15	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
16	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17	Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
18	A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
19	Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20. Mass spectrometry data entry: PXD007570
20	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402
21	DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22. Mass spectrometry data entry: PXD047840

Details of the Target

Citation

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Correspondence

Prof. Feng Zhu

Prof. Feng Ni