Details of the Probe

General Information of Probe

Probe ID
LDPC0511
Probe Name
C281
Synonyms
Z3433405896
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 302.37
Lipid-water partition coefficient (xlogp) 0.9
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C16H22N4O2
IUPAC Name
N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]-3-oxa-6-azatricyclo[6.1.1.01,6]decane-4-carboxamide
Canonical SMILES
C#CCCC1(N=N1)CCNC(=O)C2CN3CC4CC3(C4)CO2
InChI
InChI=1S/C16H22N4O2/c1-2-3-4-16(18-19-16)5-6-17-14(21)13-10-20-9-12-7-15(20,8-12)11-22-13/h1,12-13H,3-11H2,(H,17,21)
InChIKey
CRIOXLPYBOVUMY-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

84 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
5'-3' exonuclease PLD3 (PLD3) LDTP08476 6.11  LDD1951 
5'-3' exonuclease PLD3 (PLD3) LDTP08476 6.11  LDD1951 
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) LDTP13287 5.03  LDD1951 
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) LDTP13287 5.03  LDD1951 
Acid ceramidase (ASAH1) LDTP05905 5.54  LDD1951 
Acid ceramidase (ASAH1) LDTP05905 5.54  LDD1951 
Alpha-galactosidase A (GLA) LDTP02141 8.63  LDD1951 
Alpha-galactosidase A (GLA) LDTP02141 8.63  LDD1951 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 7.01  LDD1951 
Alpha-N-acetylglucosaminidase (NAGLU) LDTP04634 7.01  LDD1951 
Beta-1,4-glucuronyltransferase 1 (B4GAT1) LDTP00783 4.96  LDD1951 
Beta-1,4-glucuronyltransferase 1 (B4GAT1) LDTP00783 4.96  LDD1951 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 8.51  LDD1951 
Beta-hexosaminidase subunit alpha (HEXA) LDTP02169 8.51  LDD1951 
Beta-hexosaminidase subunit beta (HEXB) LDTP02216 5.50  LDD1951 
Beta-hexosaminidase subunit beta (HEXB) LDTP02216 5.50  LDD1951 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 11.96  LDD1951 
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) LDTP01241 11.96  LDD1951 
Carboxypeptidase D (CPD) LDTP01372 10.93  LDD1951 
Carboxypeptidase D (CPD) LDTP01372 10.93  LDD1951 
Cathepsin B (CTSB) LDTP02223 14.83  LDD1951 
Cathepsin B (CTSB) LDTP02223 14.83  LDD1951 
Delta(24)-sterol reductase (DHCR24) LDTP06375 12.04  LDD1951 
Delta(24)-sterol reductase (DHCR24) LDTP06375 12.04  LDD1951 
Di-N-acetylchitobiase (CTBS) LDTP14801 9.58  LDD1951 
Di-N-acetylchitobiase (CTBS) LDTP14801 9.58  LDD1951 
Dipeptidyl peptidase 1 (CTSC) LDTP04572 6.77  LDD1951 
Dipeptidyl peptidase 1 (CTSC) LDTP04572 6.77  LDD1951 
E3 ubiquitin-protein ligase RNF13 (RNF13) LDTP00804 5.24  LDD1951 
E3 ubiquitin-protein ligase RNF13 (RNF13) LDTP00804 5.24  LDD1951 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 11.47  LDD1951 
Endothelin-converting enzyme 1 (ECE1) LDTP04008 11.47  LDD1951 
Ethanolamine kinase 1 (ETNK1) LDTP12197 8.17  LDD1951 
Ethanolamine kinase 1 (ETNK1) LDTP12197 8.17  LDD1951 
Gamma-glutamyl hydrolase (GGH) LDTP09886 6.11  LDD1951 
Gamma-glutamyl hydrolase (GGH) LDTP09886 6.11  LDD1951 
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) LDTP12763 5.46  LDD1951 
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) LDTP12763 5.46  LDD1951 
Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) LDTP07990 6.36  LDD1951 
Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) LDTP07990 6.36  LDD1951 
Histone-arginine methyltransferase CARM1 (CARM1) LDTP08352 4.99  LDD1951 
Histone-arginine methyltransferase CARM1 (CARM1) LDTP08352 4.99  LDD1951 
Lactadherin (MFGE8) LDTP05561 10.56  LDD1951 
Lactadherin (MFGE8) LDTP05561 10.56  LDD1951 
Legumain (LGMN) LDTP10888 8.51  LDD1951 
Legumain (LGMN) LDTP10888 8.51  LDD1951 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 12.82  LDD1951 
Leucyl-cystinyl aminopeptidase (LNPEP) LDTP13358 12.82  LDD1951 
Lysosomal acid phosphatase (ACP2) LDTP02539 8.40  LDD1951 
Lysosomal acid phosphatase (ACP2) LDTP02539 8.40  LDD1951 
Lysosomal alpha-glucosidase (GAA) LDTP02486 6.54  LDD1951 
Lysosomal alpha-glucosidase (GAA) LDTP02486 6.54  LDD1951 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 4.99  LDD1951 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 4.99  LDD1951 
Lysosomal protective protein (CTSA) LDTP02505 5.98  LDD1951 
Lysosomal protective protein (CTSA) LDTP02505 5.98  LDD1951 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 10.63  LDD1951 
Lysosomal thioesterase PPT2 (PPT2) LDTP13620 10.63  LDD1951 
N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 6.92  LDD1951 
N-acetylglucosamine-6-sulfatase (GNS) LDTP02799 6.92  LDD1951 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 6.92  LDD1951 
Palmitoyl-protein thioesterase 1 (PPT1) LDTP04388 6.92  LDD1951 
Peptidyl-glycine alpha-amidating monooxygenase (PAM) LDTP02976 6.92  LDD1951 
Peptidyl-glycine alpha-amidating monooxygenase (PAM) LDTP02976 6.92  LDD1951 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 7.89  LDD1951 
Plasma alpha-L-fucosidase (FUCA2) LDTP11215 7.89  LDD1951 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 10.70  LDD1951 
Probable serine carboxypeptidase CPVL (CPVL) LDTP15988 10.70  LDD1951 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 5.70  LDD1951 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 5.70  LDD1951 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 8.82  LDD1951 
Putative phospholipase B-like 2 (PLBD2) LDTP09256 8.82  LDD1951 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 7.94  LDD1951 
Retinoid-inducible serine carboxypeptidase (SCPEP1) LDTP16032 7.94  LDD1951 
Ribonuclease T2 (RNASET2) LDTP00316 10.85  LDD1951 
Ribonuclease T2 (RNASET2) LDTP00316 10.85  LDD1951 
Sialate O-acetylesterase (SIAE) LDTP12135 6.77  LDD1951 
Sialate O-acetylesterase (SIAE) LDTP12135 6.77  LDD1951 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 5.13  LDD1951 
Sphingomyelin phosphodiesterase (SMPD1) LDTP02896 5.13  LDD1951 
Tissue alpha-L-fucosidase (FUCA1) LDTP02006 8.82  LDD1951 
Tissue alpha-L-fucosidase (FUCA1) LDTP02006 8.82  LDD1951 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 10.93  LDD1951 
Tripeptidyl-peptidase 1 (TPP1) LDTP00428 10.93  LDD1951 
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⏷ Show the Full List of 84 Enzyme
40 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Amyloid-beta precursor protein (APP) LDTP02071 12.13  LDD1951 
Amyloid-beta precursor protein (APP) LDTP02071 12.13  LDD1951 
Cation-independent mannose-6-phosphate receptor (IGF2R) LDTP02586 10.34  LDD1951 
Cation-independent mannose-6-phosphate receptor (IGF2R) LDTP02586 10.34  LDD1951 
Ceroid-lipofuscinosis neuronal protein 6 (CLN6) LDTP12738 5.13  LDD1951 
Ceroid-lipofuscinosis neuronal protein 6 (CLN6) LDTP12738 5.13  LDD1951 
H(+)/Cl(-) exchange transporter 3 (CLCN3) LDTP04459 5.94  LDD1951 
H(+)/Cl(-) exchange transporter 3 (CLCN3) LDTP04459 5.94  LDD1951 
Integral membrane protein 2B (ITM2B) LDTP13833 10.85  LDD1951 
Integral membrane protein 2B (ITM2B) LDTP13833 10.85  LDD1951 
Low-density lipoprotein receptor-related protein 2 (LRP2) LDTP05218 11.88  LDD1951 
Low-density lipoprotein receptor-related protein 2 (LRP2) LDTP05218 11.88  LDD1951 
Lysosome membrane protein 2 (SCARB2) LDTP06034 8.46  LDD1951 
Lysosome membrane protein 2 (SCARB2) LDTP06034 8.46  LDD1951 
Prosaposin (PSAP) LDTP02215 14.03  LDD1951 
Prosaposin (PSAP) LDTP02215 14.03  LDD1951 
Protein GPR107 (GPR107) LDTP07236 4.92  LDD1951 
Protein GPR107 (GPR107) LDTP07236 4.92  LDD1951 
Protein GPR108 (GPR108) LDTP12383 6.41  LDD1951 
Protein GPR108 (GPR108) LDTP12383 6.41  LDD1951 
Protein tweety homolog 3 (TTYH3) LDTP11615 12.82  LDD1951 
Protein tweety homolog 3 (TTYH3) LDTP11615 12.82  LDD1951 
Proton-activated chloride channel (PACC1) LDTP12042 23.75  LDD1951 
Proton-activated chloride channel (PACC1) LDTP12042 23.75  LDD1951 
Slit homolog 2 protein (SLIT2) LDTP01427 6.41  LDD1951 
Slit homolog 2 protein (SLIT2) LDTP01427 6.41  LDD1951 
Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) LDTP11826 9.92  LDD1951 
Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) LDTP11826 9.92  LDD1951 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 5.54  LDD1951 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 5.54  LDD1951 
Sortilin (SORT1) LDTP10885 14.72  LDD1951 
Sortilin (SORT1) LDTP10885 14.72  LDD1951 
Tetraspanin-3 (TSPAN3) LDTP16813 12.38  LDD1951 
Tetraspanin-3 (TSPAN3) LDTP16813 12.38  LDD1951 
Transferrin receptor protein 1 (TFRC) LDTP01969 10.06  LDD1951 
Transferrin receptor protein 1 (TFRC) LDTP01969 10.06  LDD1951 
Transmembrane protein 87A (TMEM87A) LDTP15481 7.36  LDD1951 
Transmembrane protein 87A (TMEM87A) LDTP15481 7.36  LDD1951 
V-type proton ATPase subunit S1 (ATP6AP1) LDTP06499 6.77  LDD1951 
V-type proton ATPase subunit S1 (ATP6AP1) LDTP06499 6.77  LDD1951 
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⏷ Show the Full List of 40 Transporter and channel
6 Immunoglobulin Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Cell adhesion molecule 1 (CADM1) LDTP11441 6.23  LDD1951 
Cell adhesion molecule 1 (CADM1) LDTP11441 6.23  LDD1951 
Cell surface glycoprotein MUC18 (MCAM) LDTP04020 5.46  LDD1951 
Cell surface glycoprotein MUC18 (MCAM) LDTP04020 5.46  LDD1951 
Neogenin (NEO1) LDTP09907 10.27  LDD1951 
Neogenin (NEO1) LDTP09907 10.27  LDD1951 
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⏷ Show the Full List of 6 Immunoglobulin
32 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Amyloid beta precursor like protein 2 (APLP2) LDTP05491 11.16  LDD1951 
Amyloid beta precursor like protein 2 (APLP2) LDTP05491 11.16  LDD1951 
C-type mannose receptor 2 (MRC2) LDTP13114 7.01  LDD1951 
C-type mannose receptor 2 (MRC2) LDTP13114 7.01  LDD1951 
Caprin-1 (CAPRIN1) LDTP06121 7.67  LDD1951 
Caprin-1 (CAPRIN1) LDTP06121 7.67  LDD1951 
Collectin-12 (COLEC12) LDTP07031 8.82  LDD1951 
Collectin-12 (COLEC12) LDTP07031 8.82  LDD1951 
Desmocollin-3 (DSC3) LDTP06154 9.32  LDD1951 
Desmocollin-3 (DSC3) LDTP06154 9.32  LDD1951 
EF-hand calcium-binding domain-containing protein 14 (EFCAB14) LDTP19021 10.56  LDD1951 
EF-hand calcium-binding domain-containing protein 14 (EFCAB14) LDTP19021 10.56  LDD1951 
Galectin-3-binding protein (LGALS3BP) LDTP05558 6.87  LDD1951 
Galectin-3-binding protein (LGALS3BP) LDTP05558 6.87  LDD1951 
Ganglioside GM2 activator (GM2A) LDTP02927 12.38  LDD1951 
Ganglioside GM2 activator (GM2A) LDTP02927 12.38  LDD1951 
Golgi apparatus protein 1 (GLG1) LDTP09920 6.82  LDD1951 
Golgi apparatus protein 1 (GLG1) LDTP09920 6.82  LDD1951 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 14.52  LDD1951 
Keratinocyte-associated transmembrane protein 2 (KCT2) LDTP19780 14.52  LDD1951 
Protein GOLM2 (GOLM2) LDTP15115 15.56  LDD1951 
Protein GOLM2 (GOLM2) LDTP15115 15.56  LDD1951 
Protein unc-119 homolog B (UNC119B) LDTP00105 5.03  LDD1951 
Protein unc-119 homolog B (UNC119B) LDTP00105 5.03  LDD1951 
Seizure 6-like protein 2 (SEZ6L2) LDTP07703 16.00  LDD1951 
Seizure 6-like protein 2 (SEZ6L2) LDTP07703 16.00  LDD1951 
Synaptic vesicle glycoprotein 2A (SV2A) LDTP07934 5.58  LDD1951 
Synaptic vesicle glycoprotein 2A (SV2A) LDTP07934 5.58  LDD1951 
Trans-Golgi network integral membrane protein 2 (TGOLN2) LDTP00779 8.51  LDD1951 
Trans-Golgi network integral membrane protein 2 (TGOLN2) LDTP00779 8.51  LDD1951 
Trophoblast glycoprotein (TPBG) LDTP05960 12.04  LDD1951 
Trophoblast glycoprotein (TPBG) LDTP05960 12.04  LDD1951 
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⏷ Show the Full List of 32 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1951 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587