Details of the Target

General Information of Target

Target ID LDTP12738
Target Name Ceroid-lipofuscinosis neuronal protein 6 (CLN6)
Gene Name CLN6
Gene ID 54982
Synonyms
Ceroid-lipofuscinosis neuronal protein 6; Protein CLN6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEVAEPSSPTEEEEEEEEHSAEPRPRTRSNPEGAEDRAVGAQASVGSRSEGEGEAASADD
GSLNTSGAGPKSWQVPPPAPEVQIRTPRVNCPEKVIICLDLSEEMSLPKLESFNGSKTNA
LNVSQKMIEMFVRTKHKIDKSHEFALVVVNDDTAWLSGLTSDPRELCSCLYDLETASCST
FNLEGLFSLIQQKTELPVTENVQTIPPPYVVRTILVYSRPPCQPQFSLTEPMKKMFQCPY
FFFDVVYIHNGTEEKEEEMSWKDMFAFMGSLDTKGTSYKYEVALAGPALELHNCMAKLLA
HPLQRPCQSHASYSLLEEEDEAIEVEATV
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Subcellular location
Endoplasmic reticulum membrane
TTD ID
T63191
Uniprot ID
Q9NWW5
DrugMap ID
TTJCOQ7
Ensemble ID
ENST00000249806.11
HGNC ID
HGNC:2077

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.P291S .
COLO679 SNV: p.S165F .
HEC1B SNV: p.L224M .
LNCaP clone FGC SNV: p.V225I .
NOMO1 SNV: p.K78Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		2.02  LDD0197  [1]
Curcusone 37
 Probe Info  		7.77  LDD0188  [2]
Johansson_61
 Probe Info  		_(4.82)  LDD1487  [3]
Acrolein
 Probe Info  		N.A.  LDD0217  [4]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [4]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		13.27  LDD1752  [5]
C056
 Probe Info  		23.75  LDD1753  [5]
C092
 Probe Info  		22.47  LDD1783  [5]
C094
 Probe Info  		48.17  LDD1785  [5]
C112
 Probe Info  		19.97  LDD1799  [5]
C169
 Probe Info  		24.93  LDD1849  [5]
C278
 Probe Info  		89.26  LDD1948  [5]
C280
 Probe Info  		14.12  LDD1950  [5]
C281
 Probe Info  		5.13  LDD1951  [5]
C282
 Probe Info  		25.63  LDD1952  [5]
C284
 Probe Info  		29.24  LDD1954  [5]
C343
 Probe Info  		20.25  LDD2005  [5]
C388
 Probe Info  		44.32  LDD2047  [5]
OEA-DA
 Probe Info  		9.08  LDD0046  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0033  Curcusone1d MCF-7 7.77  LDD0188  [2]
 LDCM0615  Fragment63-R Jurkat _(4.82)  LDD1487  [3]
 LDCM0617  Fragment63-S Jurkat _(5.05)  LDD1490  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2) . O00308
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable proton-coupled zinc antiporter SLC30A4 (SLC30A4) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family O14863
Claudin-7 (CLDN7) Claudin family O95471
Gap junction alpha-8 protein (GJA8) Connexin family P48165
Syntaxin-1A (STX1A) Syntaxin family Q16623
Transmembrane protein 139 (TMEM139) . Q8IV31
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) Immunoglobulin superfamily P43628
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CDGSH iron-sulfur domain-containing protein 2 (CISD2) CISD protein family Q8N5K1
Complexin-4 (CPLX4) Complexin/synaphin family Q7Z7G2
Cytochrome b-245 chaperone 1 (CYBC1) CYBC1 family Q9BQA9
Protein FAM209A (FAM209A) FAM209 family Q5JX71
RAB6-interacting golgin (GORAB) GORAB family Q5T7V8
C-type lectin domain family 10 member A (CLEC10A) . Q8IUN9
Fibronectin type III domain-containing protein 9 (FNDC9) . Q8TBE3
Lck-interacting transmembrane adapter 1 (LIME1) . Q9H400
Leucine-rich repeat-containing protein 25 (LRRC25) . Q8N386
Receptor-binding cancer antigen expressed on SiSo cells (EBAG9) . O00559
Testis-expressed protein 264 (TEX264) . Q9Y6I9

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
2 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
3 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570