Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C281  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 42 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02223  Cathepsin B (CTSB) 14.8
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 12.8
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 12.0
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 12.0
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 11.5
 LDTP01372  Carboxypeptidase D (CPD) 10.9
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 10.9
 LDTP00316  Ribonuclease T2 (RNASET2) 10.9
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 10.7
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 10.6
 LDTP05561  Lactadherin (MFGE8) 10.6
 LDTP14801  Di-N-acetylchitobiase (CTBS) 9.6
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 8.8
 LDTP02006  Tissue alpha-L-fucosidase (FUCA1) 8.8
 LDTP02141  Alpha-galactosidase A (GLA) 8.6
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 8.5
 LDTP10888  Legumain (LGMN) 8.5
 LDTP02539  Lysosomal acid phosphatase (ACP2) 8.4
 LDTP12197  Ethanolamine kinase 1 (ETNK1) 8.2
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 7.9
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 7.9
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 7.0
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 6.9
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 6.9
 LDTP02976  Peptidyl-glycine alpha-amidating monooxygenase (PAM) 6.9
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) 6.8
 LDTP12135  Sialate O-acetylesterase (SIAE) 6.8
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 6.5
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 6.4
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 6.1
 LDTP09886  Gamma-glutamyl hydrolase (GGH) 6.1
 LDTP02505  Lysosomal protective protein (CTSA) 6.0
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 5.7
 LDTP05905  Acid ceramidase (ASAH1) 5.5
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 5.5
 LDTP12763  Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) 5.5
 LDTP00804  E3 ubiquitin-protein ligase RNF13 (RNF13) 5.2
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 5.1
 LDTP13287  A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) 5.0
 LDTP08352  Histone-arginine methyltransferase CARM1 (CARM1) 5.0
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 5.0
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 5.0
Transporter and channel
Click to Show/Hide to Show 20 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12042  Proton-activated chloride channel (PACC1) 23.8
 LDTP10885  Sortilin (SORT1) 14.7
 LDTP02215  Prosaposin (PSAP) 14.0
 LDTP11615  Protein tweety homolog 3 (TTYH3) 12.8
 LDTP16813  Tetraspanin-3 (TSPAN3) 12.4
 LDTP02071  Amyloid-beta precursor protein (APP) 12.1
 LDTP05218  Low-density lipoprotein receptor-related protein 2 (LRP2) 11.9
 LDTP13833  Integral membrane protein 2B (ITM2B) 10.9
 LDTP02586  Cation-independent mannose-6-phosphate receptor (IGF2R) 10.3
 LDTP01969  Transferrin receptor protein 1 (TFRC) 10.1
 LDTP11826  Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) 9.9
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 8.5
 LDTP15481  Transmembrane protein 87A (TMEM87A) 7.4
 LDTP06499  V-type proton ATPase subunit S1 (ATP6AP1) 6.8
 LDTP12383  Protein GPR108 (GPR108) 6.4
 LDTP01427  Slit homolog 2 protein (SLIT2) 6.4
 LDTP04459  H(+)/Cl(-) exchange transporter 3 (CLCN3) 5.9
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 5.5
 LDTP12738  Ceroid-lipofuscinosis neuronal protein 6 (CLN6) 5.1
 LDTP07236  Protein GPR107 (GPR107) 4.9
Immunoglobulin
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09907  Neogenin (NEO1) 10.3
 LDTP11441  Cell adhesion molecule 1 (CADM1) 6.2
 LDTP04020  Cell surface glycoprotein MUC18 (MCAM) 5.5
Other
Click to Show/Hide to Show 16 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP07703  Seizure 6-like protein 2 (SEZ6L2) 16.0
 LDTP15115  Protein GOLM2 (GOLM2) 15.6
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 14.5
 LDTP02927  Ganglioside GM2 activator (GM2A) 12.4
 LDTP05960  Trophoblast glycoprotein (TPBG) 12.0
 LDTP05491  Amyloid beta precursor like protein 2 (APLP2) 11.2
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 10.6
 LDTP06154  Desmocollin-3 (DSC3) 9.3
 LDTP07031  Collectin-12 (COLEC12) 8.8
 LDTP00779  Trans-Golgi network integral membrane protein 2 (TGOLN2) 8.5
 LDTP06121  Caprin-1 (CAPRIN1) 7.7
 LDTP13114  C-type mannose receptor 2 (MRC2) 7.0
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 6.9
 LDTP09920  Golgi apparatus protein 1 (GLG1) 6.8
 LDTP07934  Synaptic vesicle glycoprotein 2A (SV2A) 5.6
 LDTP00105  Protein unc-119 homolog B (UNC119B) 5.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587