Details of the Target

General Information of Target

Target ID LDTP12383
Target Name Protein GPR108 (GPR108)
Gene Name GPR108
Gene ID 56927
Synonyms
LUSTR2; Protein GPR108; Lung seven transmembrane receptor 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFL
RFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQC
SFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLED
GKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAF
VASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRW
TSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV
FTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVL
NFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVG
PRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARD
PYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCEQVQ
FQPNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLLLVGTQQLGEFQCWSLE
EGFQQLVASYCPEVVEDGVADQTDEGGSVPVIISTSRVSAPAGGKASWGADRSYWKEFLV
MCTLFVLAVLLPVLFLLYRHRNSMKVFLKQGECASVHPKTCPVVLPPETRPLNGLGPPST
PLDHRGYQSLSDSPPGSRVFTESEKRPLSIQDSFVEVSPVCPRPRVRLGSEIRDSVV
Target Bioclass
Transporter and channel
Family
LU7TM family
Subcellular location
Golgi apparatus, cis-Golgi network membrane
Function
May play a role in intracellular immune modulation by activating NF-kappaB response and attenuating Toll-like-receptor response.; (Microbial infection) Plays an essential function in adeno-associated virus (AAV) transduction across multiple serotypes except AAV5. May play a critical role in mediating the endosomal virus escape or in the AAV virions trafficking from endosomes to the nucleus.
Uniprot ID
Q9NPR9
Ensemble ID
ENST00000264080.12
HGNC ID
HGNC:17829

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C104(1.73)  LDD3325  [1]
PAL-AfBPP Probe
Click To Hide/Show 103 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		6.92  LDD1711  [2]
C004
 Probe Info  		8.69  LDD1714  [2]
C007
 Probe Info  		6.59  LDD1716  [2]
C008
 Probe Info  		6.59  LDD1717  [2]
C010
 Probe Info  		6.96  LDD1719  [2]
C011
 Probe Info  		5.46  LDD1720  [2]
C055
 Probe Info  		29.86  LDD1752  [2]
C056
 Probe Info  		32.45  LDD1753  [2]
C059
 Probe Info  		10.06  LDD1756  [2]
C064
 Probe Info  		11.39  LDD1761  [2]
C067
 Probe Info  		5.74  LDD1763  [2]
C070
 Probe Info  		13.55  LDD1766  [2]
C071
 Probe Info  		8.88  LDD1767  [2]
C072
 Probe Info  		10.70  LDD1768  [2]
C091
 Probe Info  		19.70  LDD1782  [2]
C092
 Probe Info  		23.75  LDD1783  [2]
C094
 Probe Info  		24.59  LDD1785  [2]
C106
 Probe Info  		18.00  LDD1793  [2]
C107
 Probe Info  		11.88  LDD1794  [2]
C108
 Probe Info  		14.62  LDD1795  [2]
C129
 Probe Info  		6.06  LDD1811  [2]
C134
 Probe Info  		71.01  LDD1816  [2]
C135
 Probe Info  		50.91  LDD1817  [2]
C139
 Probe Info  		45.89  LDD1821  [2]
C140
 Probe Info  		32.67  LDD1822  [2]
C141
 Probe Info  		9.38  LDD1823  [2]
C158
 Probe Info  		18.64  LDD1838  [2]
C159
 Probe Info  		22.47  LDD1839  [2]
C160
 Probe Info  		19.29  LDD1840  [2]
C161
 Probe Info  		26.91  LDD1841  [2]
C163
 Probe Info  		14.32  LDD1843  [2]
C165
 Probe Info  		14.93  LDD1845  [2]
C166
 Probe Info  		13.64  LDD1846  [2]
C169
 Probe Info  		24.59  LDD1849  [2]
C170
 Probe Info  		7.94  LDD1850  [2]
C177
 Probe Info  		16.34  LDD1856  [2]
C178
 Probe Info  		31.34  LDD1857  [2]
C194
 Probe Info  		18.38  LDD1870  [2]
C196
 Probe Info  		16.68  LDD1872  [2]
C197
 Probe Info  		9.13  LDD1873  [2]
C198
 Probe Info  		29.04  LDD1874  [2]
C225
 Probe Info  		8.75  LDD1898  [2]
C226
 Probe Info  		9.00  LDD1899  [2]
C228
 Probe Info  		22.16  LDD1901  [2]
C229
 Probe Info  		22.16  LDD1902  [2]
C231
 Probe Info  		33.59  LDD1904  [2]
C232
 Probe Info  		54.95  LDD1905  [2]
C233
 Probe Info  		35.51  LDD1906  [2]
C234
 Probe Info  		19.03  LDD1907  [2]
C235
 Probe Info  		42.22  LDD1908  [2]
C238
 Probe Info  		21.11  LDD1911  [2]
C239
 Probe Info  		9.71  LDD1912  [2]
C240
 Probe Info  		19.56  LDD1913  [2]
C272
 Probe Info  		5.39  LDD1942  [2]
C273
 Probe Info  		10.85  LDD1943  [2]
C277
 Probe Info  		15.78  LDD1947  [2]
C278
 Probe Info  		97.01  LDD1948  [2]
C280
 Probe Info  		46.85  LDD1950  [2]
C281
 Probe Info  		6.41  LDD1951  [2]
C282
 Probe Info  		99.73  LDD1952  [2]
C284
 Probe Info  		95.01  LDD1954  [2]
C285
 Probe Info  		23.43  LDD1955  [2]
C286
 Probe Info  		9.71  LDD1956  [2]
C287
 Probe Info  		19.29  LDD1957  [2]
C288
 Probe Info  		14.42  LDD1958  [2]
C289
 Probe Info  		29.86  LDD1959  [2]
C290
 Probe Info  		8.88  LDD1960  [2]
C296
 Probe Info  		12.13  LDD1966  [2]
C314
 Probe Info  		11.31  LDD1981  [2]
C339
 Probe Info  		7.94  LDD2002  [2]
C342
 Probe Info  		7.26  LDD2004  [2]
C343
 Probe Info  		38.32  LDD2005  [2]
C344
 Probe Info  		5.50  LDD2006  [2]
C346
 Probe Info  		24.08  LDD2007  [2]
C347
 Probe Info  		6.96  LDD2008  [2]
C348
 Probe Info  		11.55  LDD2009  [2]
C349
 Probe Info  		10.27  LDD2010  [2]
C353
 Probe Info  		7.73  LDD2014  [2]
C354
 Probe Info  		8.46  LDD2015  [2]
C362
 Probe Info  		58.89  LDD2023  [2]
C363
 Probe Info  		32.90  LDD2024  [2]
C364
 Probe Info  		32.00  LDD2025  [2]
C366
 Probe Info  		18.90  LDD2027  [2]
C373
 Probe Info  		6.45  LDD2033  [2]
C376
 Probe Info  		15.24  LDD2036  [2]
C378
 Probe Info  		9.51  LDD2037  [2]
C380
 Probe Info  		6.77  LDD2039  [2]
C382
 Probe Info  		16.22  LDD2041  [2]
C397
 Probe Info  		14.12  LDD2056  [2]
C399
 Probe Info  		25.28  LDD2058  [2]
C400
 Probe Info  		9.71  LDD2059  [2]
C403
 Probe Info  		44.02  LDD2061  [2]
C405
 Probe Info  		10.13  LDD2063  [2]
C407
 Probe Info  		21.71  LDD2064  [2]
C408
 Probe Info  		6.77  LDD2065  [2]
C409
 Probe Info  		6.15  LDD2066  [2]
C420
 Probe Info  		13.55  LDD2075  [2]
C424
 Probe Info  		14.22  LDD2079  [2]
C426
 Probe Info  		35.26  LDD2081  [2]
C429
 Probe Info  		17.15  LDD2084  [2]
C430
 Probe Info  		8.57  LDD2085  [2]
C431
 Probe Info  		16.68  LDD2086  [2]
C433
 Probe Info  		11.63  LDD2088  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C104(1.01)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C104(1.07)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C104(1.24)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C104(0.95)  LDD1510  [3]
 LDCM0270  AC15 HEK-293T C104(1.03)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C104(1.05)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C104(1.10)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C104(1.07)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C104(1.03)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C104(0.88)  LDD1519  [3]
 LDCM0283  AC23 HEK-293T C104(1.02)  LDD1522  [3]
 LDCM0285  AC25 HEK-293T C104(0.96)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C104(1.08)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C104(1.14)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C104(0.90)  LDD1527  [3]
 LDCM0290  AC3 HEK-293T C104(1.05)  LDD1529  [3]
 LDCM0292  AC31 HEK-293T C104(1.00)  LDD1531  [3]
 LDCM0294  AC33 HEK-293T C104(1.08)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C104(1.09)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C104(1.15)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C104(0.87)  LDD1536  [3]
 LDCM0300  AC39 HEK-293T C104(0.93)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C104(0.82)  LDD1540  [3]
 LDCM0303  AC41 HEK-293T C104(1.01)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C104(1.13)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C104(1.23)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C104(1.04)  LDD1545  [3]
 LDCM0309  AC47 HEK-293T C104(0.92)  LDD1548  [3]
 LDCM0311  AC49 HEK-293T C104(1.06)  LDD1550  [3]
 LDCM0313  AC50 HEK-293T C104(1.06)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C104(0.94)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C104(0.98)  LDD1554  [3]
 LDCM0318  AC55 HEK-293T C104(0.93)  LDD1557  [3]
 LDCM0320  AC57 HEK-293T C104(1.05)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C104(1.13)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C104(1.05)  LDD1561  [3]
 LDCM0324  AC60 HEK-293T C104(0.91)  LDD1563  [3]
 LDCM0327  AC63 HEK-293T C104(1.00)  LDD1566  [3]
 LDCM0334  AC7 HEK-293T C104(1.05)  LDD1568  [3]
 LDCM0356  AKOS034007680 HEK-293T C104(1.04)  LDD1570  [3]
 LDCM0369  CL100 HEK-293T C104(1.06)  LDD1573  [3]
 LDCM0371  CL102 HEK-293T C104(1.16)  LDD1575  [3]
 LDCM0373  CL104 HEK-293T C104(1.02)  LDD1577  [3]
 LDCM0375  CL106 HEK-293T C104(0.97)  LDD1579  [3]
 LDCM0377  CL108 HEK-293T C104(1.09)  LDD1581  [3]
 LDCM0379  CL11 HEK-293T C104(1.22)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C104(1.18)  LDD1584  [3]
 LDCM0382  CL112 HEK-293T C104(1.02)  LDD1586  [3]
 LDCM0384  CL114 HEK-293T C104(1.11)  LDD1588  [3]
 LDCM0386  CL116 HEK-293T C104(1.05)  LDD1590  [3]
 LDCM0388  CL118 HEK-293T C104(1.06)  LDD1592  [3]
 LDCM0391  CL120 HEK-293T C104(0.98)  LDD1595  [3]
 LDCM0393  CL122 HEK-293T C104(0.86)  LDD1597  [3]
 LDCM0395  CL124 HEK-293T C104(1.18)  LDD1599  [3]
 LDCM0397  CL126 HEK-293T C104(0.97)  LDD1601  [3]
 LDCM0399  CL128 HEK-293T C104(1.01)  LDD1603  [3]
 LDCM0401  CL14 HEK-293T C104(0.99)  LDD1605  [3]
 LDCM0403  CL16 HEK-293T C104(1.13)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C104(1.31)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C104(1.08)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C104(1.17)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C104(0.90)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C104(0.88)  LDD1612  [3]
 LDCM0411  CL23 HEK-293T C104(1.08)  LDD1615  [3]
 LDCM0414  CL26 HEK-293T C104(0.88)  LDD1618  [3]
 LDCM0416  CL28 HEK-293T C104(1.05)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C104(0.97)  LDD1621  [3]
 LDCM0419  CL30 HEK-293T C104(1.04)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C104(1.37)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C104(0.97)  LDD1625  [3]
 LDCM0424  CL35 HEK-293T C104(1.18)  LDD1628  [3]
 LDCM0429  CL4 HEK-293T C104(1.15)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C104(1.02)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C104(1.20)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C104(1.10)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C104(1.19)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C104(0.93)  LDD1638  [3]
 LDCM0437  CL47 HEK-293T C104(1.05)  LDD1641  [3]
 LDCM0440  CL5 HEK-293T C104(0.92)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C104(1.08)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C104(1.09)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C104(1.35)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C104(1.39)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C104(1.09)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C104(1.10)  LDD1650  [3]
 LDCM0450  CL59 HEK-293T C104(1.10)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C104(1.32)  LDD1654  [3]
 LDCM0454  CL62 HEK-293T C104(0.92)  LDD1657  [3]
 LDCM0456  CL64 HEK-293T C104(1.28)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C104(1.05)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C104(1.14)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C104(1.05)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C104(1.13)  LDD1663  [3]
 LDCM0462  CL7 HEK-293T C104(0.98)  LDD1665  [3]
 LDCM0464  CL71 HEK-293T C104(1.17)  LDD1667  [3]
 LDCM0467  CL74 HEK-293T C104(1.00)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C104(1.06)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C104(1.27)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C104(1.09)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C104(1.17)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C104(1.46)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C104(0.98)  LDD1677  [3]
 LDCM0477  CL83 HEK-293T C104(1.04)  LDD1680  [3]
 LDCM0480  CL86 HEK-293T C104(1.04)  LDD1683  [3]
 LDCM0482  CL88 HEK-293T C104(1.05)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C104(1.07)  LDD1686  [3]
 LDCM0485  CL90 HEK-293T C104(1.80)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C104(1.16)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C104(0.93)  LDD1690  [3]
 LDCM0490  CL95 HEK-293T C104(1.44)  LDD1693  [3]
 LDCM0493  CL98 HEK-293T C104(1.15)  LDD1696  [3]
 LDCM0427  Fragment51 HEK-293T C104(1.17)  LDD1631  [3]
 LDCM0022  KB02 HEK-293T C104(0.85)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C104(0.94)  LDD1497  [3]
 LDCM0024  KB05 UACC257 C104(1.73)  LDD3325  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gap junction alpha-8 protein (GJA8) Connexin family P48165
Leukocyte surface antigen CD53 (CD53) Tetraspanin (TM4SF) family P19397
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) Immunoglobulin superfamily P43628
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Transcription termination factor 3, mitochondrial (MTERF3) MTERF family Q96E29
Transmembrane protein 243 (TMEM243) TMEM243 family Q9BU79

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402